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1. 发明授权

US08535210B2 System for blood separation with shielded extraction port and optical control 有权
标题翻译：带屏蔽抽取口和光学控制的血液分离系统
公开(公告)号：US08535210B2
公开(公告)日：2013-09-17
申请号：US12959987
申请日：2010-12-03
申请人： Jeremy P. Kolenbrander , Brian M. Holmes , Thomas J. Felt , James R. Ladtkow
发明人： Jeremy P. Kolenbrander , Brian M. Holmes , Thomas J. Felt , James R. Ladtkow
IPC分类号： B04B7/12
CPC分类号： G01N21/51 , A61M1/3693 , A61M1/3696 , A61M2202/0439 , A61M2205/3306 , B04B13/00 , B04B2013/006 , G01N2035/00495 , A61M2202/0071
摘要： A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
摘要翻译：一种离心血液分离系统，包括转子，光源，光学传感器，控制系统，分离容器和分离容器上的光学单元。所述光学单元具有径向向外延伸到所述光学单元中的第一提取端口，所述第一提取端口下游并延伸到所述光学单元超出所述第一提取端口的红细胞提取端口; 以及位于所述第一提取口和所述红细胞提取口之间的坝，具有上边缘和下边缘，其中所述第一提取口和所述红细胞提取口径向地位于所述坝的上边缘和下边缘之间。此外，具有第一直径的孔，具有小于第一直径的第二直径的内腔的第一提取端口和将孔连接到内腔的截头圆锥形通道。

2. 发明授权

US07780618B2 Extracorporeal blood processing apparatus and methods with pressure sensing 有权
标题翻译：体外血液处理装置及压力感测方法
公开(公告)号：US07780618B2
公开(公告)日：2010-08-24
申请号：US11760826
申请日：2007-06-11
申请人： Thomas J. Felt , Marlene Adele Bainbridge
发明人： Thomas J. Felt , Marlene Adele Bainbridge
IPC分类号： A61M37/00
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides an apparatus and method for controlling a fluid separation system, preferably a blood apheresis system, by sensing fluid pressure and comparing the sensed fluid pressure to a threshold value.
摘要翻译：本发明提供了一种用于通过检测流体压力并将感测到的流体压力与阈值进行比较来控制流体分离系统（优选血液分离系统）的装置和方法。

3. 发明授权

US07582049B2 Fluid separation devices, systems and/or methods using a centrifuge and roller pump 失效
标题翻译：流体分离装置，使用离心机和滚子泵的系统和/或方法
公开(公告)号：US07582049B2
公开(公告)日：2009-09-01
申请号：US11307451
申请日：2006-02-08
申请人： Dennis J. Hlavinka , William G Palsulich , Thomas J. Felt , Frank Corbin, III
发明人： Dennis J. Hlavinka , William G Palsulich , Thomas J. Felt , Frank Corbin, III
IPC分类号： B04B5/02
CPC分类号： A61M1/0209 , A61M1/3693 , B04B5/0428
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.
摘要翻译：公开了用于将复合流体离心分离成其组分的离心流体分离系统。该离心分离系统至少包括离心转子，其具有复合流体容纳区域，流体流动通道/管道和限定在其中的至少一个分离的部件收集区域。要分离的复合流体被输送到流体容纳区域，在离心力作用下，复合流体被分离成组分，然后组分通过出口通道行进到流过其中的各自分离的组分流体。还提供了一个集中设置的泵以将分离的部件移动到收集区域。分离的流体组分的界面的光学感测可以与夹具一起使用以阻止流动。还公开了一次性袋和管道系统，用于可重复使用的转子装置。

4. 发明授权

US06736768B2 Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach 有权
标题翻译：使用流体压力驱动和/或平衡方法的流体分离装置，系统和/或方法
公开(公告)号：US06736768B2
公开(公告)日：2004-05-18
申请号：US10008989
申请日：2001-11-02
申请人： Thomas J. Felt , Dennis J. Hlavinka
发明人： Thomas J. Felt , Dennis J. Hlavinka
IPC分类号： B04B100
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal separation device separates a composite fluid, such as blood, into the components thereof. The fluid is delivered to a fluid receiving area in a rotor from which area the fluid travels through a radial inlet channel having an inlet channel height to a proximal end of a circumferential fluid separation channel. Near a distal end of the separation channel, fluid components travel into distinct first and second outlet channels. The height of the first channel is greater than the height of the more distal second channel. The inlet channel height is greater than the height of the first channel. The rotor may be balanced by axially symmetrical sets of inlet channels, separation channels and outlet channels or by a balance channel connected to the separation channel but displaced from the outlet channels.
摘要翻译：离心分离装置将诸如血液的复合流体分离成其组分。流体被输送到转子中的流体接收区域，流体从该区域流过具有到周向流体分离通道的近端的入口通道高度的径向入口通道。在分离通道的远端附近，流体组分行进到不同的第一和第二出口通道。第一通道的高度大于较远端第二通道的高度。入口通道高度大于第一通道的高度。转子可以通过轴向对称的入口通道，分离通道和出口通道组合或通过连接到分离通道但从出口通道移位的平衡通道来平衡。

5. 发明授权

US5876321A Control system for the spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus 失效
标题翻译：用于离心机中稀释组分如单核细胞的溢出收集的控制系统
公开(公告)号：US5876321A
公开(公告)日：1999-03-02
申请号：US871244
申请日：1997-06-09
申请人： Dennis Hlavinka , Thomas J. Felt
发明人： Dennis Hlavinka , Thomas J. Felt
IPC分类号： A61K35/14 , B04B5/04 , B04B11/04
CPC分类号： B04B5/0442 , B04B2005/045
摘要： A centrifuge apparatus is used for collecting white blood cells (WBC), primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. MNC fluid is allowed to pool behind the barrier before collection is started. To collect the MNC pool, the stratified red blood cell layer is raised from below the interface level by slowing or reversing flow in the RBC exit line thereby causing the MNC pool to spill over the barrier into a well in which a collect line is positioned. Collection ceases when a desired percentage of the pool is removed and the normal position of the interface is re-established; thereafter the pool builds again. By raising the MNC pool from below, improvements in purity and collect volume are achieved. The collection procedure can be useful for harvesting granulocytes and, in general, any sparse stratified component of a centrifuged solution where the sparse component is layered between more dense and less dense strata.
摘要翻译：离心机用于从分层成层的全血中收集白细胞（WBC），主要是单核细胞。在红细胞和血浆的界面处形成薄单核（MNC）层。隔离物位于离心机的分离容器中，以拦截薄层。允许MNC流体在收集开始之前集中在障碍物后面。为了收集MNC池，分层的红细胞层通过减缓或逆转RBC出口线中的流动而从界面水平以下升高，从而导致MNC池溢出障碍物进入收集线所在的井中。当池的所需百分比被移除并且接口的正常位置被重新建立时，收集停止; 此后池再次建成。通过从下方提高跨国公司池，实现了纯度和收集量的提高。采集程序可用于收获粒细胞和一般来说，离心溶液的任何稀疏分层组分，其中稀疏组分分层在更致密和较不密集的层之间。

6. 发明授权

US07513882B2 Extracorporeal blood processing methods with multiple alarm levels 有权
标题翻译：体外血液处理方法具有多种报警级别
公开(公告)号：US07513882B2
公开(公告)日：2009-04-07
申请号：US11530111
申请日：2006-09-08
申请人： Thomas J. Felt , Marlene Adele Bainbridge
发明人： Thomas J. Felt , Marlene Adele Bainbridge
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.
摘要翻译：本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。该方法采用三级报警系统。响应于系统中的压降而触发第一级报警条件以小于或等于指定的系统压力并在系统的至少一部分中暂停流体流动。响应于指定时间内的指定数量的所述压降触发二级报警条件，并且降低系统中流体的流量。报警条件也可能触发可见和/或声音报警。当压降由非严重的，自分辨的或易于纠正的条件（例如系统部件的未对准）引起时，这些警报水平允许通过白细胞减少室流动。

7. 发明授权

US07094197B2 Method for fluid separation devices using a fluid pressure balanced configuration 失效
标题翻译：使用流体压力平衡配置的流体分离装置的方法
公开(公告)号：US07094197B2
公开(公告)日：2006-08-22
申请号：US10709079
申请日：2004-04-12
申请人： Dennis J Hlavinka , Thomas J. Felt
发明人： Dennis J Hlavinka , Thomas J. Felt
IPC分类号： B01D21/26
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A method for separating a composite fluid into components in a centrifugal fluid separation system. The system includes a rotor that has a composite fluid containment area, an inlet channel, a peripheral separation channel, outlet channels and separated component collection areas, which together form a processing area. The separation channel may be semi-spiraled. The inlet channel may connect to the center of the separation channel and an outlet channel may connect to each end of the separation channel. The outlet channels have different heights. The ends of the separation channels may have different heights. The separation channels may have extensions. The rotor may have multiple processing areas. The collection areas may be pockets slanted radially outwardly and downwardly. A motor may produce a rotating magnetic field, which co-acts with a magnetically reactive material in the rotor. A disposable bag and tubing system may be used in a processing area of the rotor.
摘要翻译：一种将复合流体分离成离心流体分离系统中的组分的方法。该系统包括具有复合流体容纳区域，入口通道，周边分离通道，出口通道和分离的部件收集区域的转子，它们一起形成处理区域。分离通道可以是半螺旋的。入口通道可以连接到分离通道的中心，并且出口通道可以连接到分离通道的每一端。出口通道具有不同的高度。分离通道的端部可以具有不同的高度。分离通道可以具有扩展。转子可以具有多个处理区域。收集区域可以是径向向外和向下倾斜的袋。电动机可以产生与转子中的磁反应性材料共同作用的旋转磁场。可以在转子的处理区域中使用一次性袋和管道系统。

8. 发明授权

US06773389B2 Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced configuration 失效
标题翻译：使用流体压力驱动和/或平衡配置的流体分离装置，系统和/或方法
公开(公告)号：US06773389B2
公开(公告)日：2004-08-10
申请号：US10005431
申请日：2001-11-02
申请人： Dennis J. Hlavinka , Thomas J. Felt
发明人： Dennis J. Hlavinka , Thomas J. Felt
IPC分类号： B04B100
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal fluid separation system separates a composite fluid into components. The system includes a rotor that has a composite fluid containment area, an inlet channel, a peripheral separation channel, outlet channels and separated component collection areas, which together form a processing area. The separation channel may be semi-spiraled. The inlet channel may connect to the center of the separation channel and an outlet channel may connect to each end of the separation channel. The outlet channels have different heights. The ends of the separation channels may have different heights. The separation channels may have extensions. The rotor may have multiple processing areas. The collection areas may be pockets slanted radially outwardly and downwardly. A motor may produce a rotating magnetic field, which co-acts with a magnetically reactive material in the rotor. A disposable bag and tubing system may be used in a processing area of the rotor.
摘要翻译：离心流体分离系统将复合流体分离成组分。该系统包括具有复合流体容纳区域，入口通道，周边分离通道，出口通道和分离的部件收集区域的转子，它们一起形成处理区域。分离通道可以是半螺旋的。入口通道可以连接到分离通道的中心，并且出口通道可以连接到分离通道的每一端。出口通道具有不同的高度。分离通道的端部可以具有不同的高度。分离通道可以具有扩展。转子可以具有多个处理区域。收集区域可以是径向向外和向下倾斜的袋。电动机可以产生与转子中的磁反应性材料共同作用的旋转磁场。可以在转子的处理区域中使用一次性袋和管道系统。

9. 发明授权

US5879280A Intermittent collection of mononuclear cells in a centrifuge apparatus 失效
标题翻译：在离心机中间歇收集单核细胞
公开(公告)号：US5879280A
公开(公告)日：1999-03-09
申请号：US871207
申请日：1997-06-09
申请人： Dennis Hlavinka , Thomas J. Felt
发明人： Dennis Hlavinka , Thomas J. Felt
IPC分类号： A61K35/14 , B04B5/04 , B04B11/04
CPC分类号： B04B5/0442 , B04B2005/045
摘要： A centrifuge apparatus is used for collecting white blood cells, primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. An MNC collect port is positioned in front of the barrier to collect the thin layer. MNC fluid is allowed to pool behind the barrier to surround the collect port before collection is started. Collection ceases when the pool is removed and allowed to build again. By operating the collect in an intermittent fashion, improvements in purity and collect volume are achieved. The intermittent collection procedure can be useful for harvesting granulocytes and, in general, any sparse stratified component of a centrifuged solution where the sparse component is layered between more dense and less dense strata.
摘要翻译：离心机用于从分层分层的全血中收集白细胞，主要是单核细胞。在红细胞和血浆的界面处形成薄单核（MNC）层。隔离物位于离心机的分离容器中，以拦截薄层。 MNC收集端口位于屏障前面以收集薄层。在收集开始之前，允许MNC流体在障碍物后面集中以围绕收集端口。当池被移除并允许再次建立时，收集将停止。通过间歇操作收集，实现了纯度和收集体积的提高。间歇收集程序可用于收获粒细胞和一般来说，离散溶液的任何稀疏分层组分，其中稀疏组分分层在更致密和较不密集的层之间。

10. 发明授权

US5352371A Method and apparatus for repeatedly passing a fluid through a fluid treatment unit 失效
标题翻译：用于重复使流体通过流体处理单元的方法和装置
公开(公告)号：US5352371A
公开(公告)日：1994-10-04
申请号：US21885
申请日：1993-02-24
申请人： Thomas J. Felt
发明人： Thomas J. Felt
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/3603 , B01D21/262 , A61M2202/10 , B01D2221/10
摘要： A method and apparatus for the multiple passage of fluids through a treatment unit (e.g. a medical apheresis unit). The apparatus includes primary and secondary vessels. Connected to the primary vessel is a first conduit which terminates at the treatment unit outlet, and a second conduit which terminates at the treatment unit inlet. Connected to the secondary vessel is a third conduit which terminates at the treatment unit inlet, and a fourth conduit which terminates at the treatment unit outlet. In use, a clamp is simultaneously secured to the first conduit and second conduit prior to filling the primary vessel with fluid (e.g. bone marrow). The clamp is then removed and placed on the first conduit and the third conduit simultaneously so that fluid flows from the primary vessel, into the treatment unit, and into the secondary vessel. The clamp is then removed and positioned on the second conduit and the fourth conduit simultaneously so that fluid flows from the secondary vessel, through the treatment unit, and back into said primary vessel, thereby completing two passes of fluid through the treatment unit using a single clamp. Additional passes may be accomplished by repeating the foregoing steps. Also, conduit attachment members or clamp position indicating members may be applied to the conduits to facilitate proper use of the entire system.
摘要翻译：一种用于使流体多次通过治疗单元（例如医用单采血液分离单元）的方法和装置。该装置包括主要和次要的容器。连接到主容器的是在处理单元出口处终止的第一导管和终止于处理单元入口处的第二导管。连接到次级容器的是在处理单元入口处终止的第三导管，以及终止于处理单元出口处的第四导管。在使用中，在用流体（例如骨髓）填充主血管之前，夹具同时固定到第一导管和第二导管。然后将夹具移除并同时放置在第一导管和第三导管上，使得流体从主容器流入处理单元并进入次级容器。然后将夹具移除并同时定位在第二导管和第四导管上，使得流体从次级容器流过处理单元，并返回到所述主容器中，从而通过使用单个的流体通过处理单元完成两遍流体钳。可以通过重复上述步骤来实现附加的通行。此外，导管附接构件或夹持位置指示构件可以施加到导管，以便于整个系统的正确使用。

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