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1. 发明授权

US08057376B2 Blood processing apparatus with sealed diffuser in optical control apparatus 有权
标题翻译：血液处理装置在光学控制装置中具有密封扩散器
公开(公告)号：US08057376B2
公开(公告)日：2011-11-15
申请号：US12241441
申请日：2008-09-30
申请人： James R. Ladtkow , Joseph A. Scibona , Jeremy Kolenbrander
发明人： James R. Ladtkow , Joseph A. Scibona , Jeremy Kolenbrander
IPC分类号： B04B15/00 , G02B5/02
CPC分类号： G01N33/491 , G01N15/05 , G01N21/51 , G02B19/0028 , G02B19/0061
摘要： A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.
摘要翻译：一种具有光学照相机控制系统的离心式血液分离装置，其具有聚焦的静止光源。安装在转子上，而不是在光源上或附近的扩散板允许强光束从光源传递到转子，然后在转子处在观察区域上扩散。扩散表面的不同特性允许观察区域内的不同照明区域。扩散板具有在板之间密封的扩散表面的上板和下板。这可防止由于磨损，污垢，血液成分或可能附带地接触扩散表面的其它材料而导致的扩散表面的降解或污染。

2. 发明授权

US07422693B2 Monitoring and control system for blood processing 有权
标题翻译：血液处理监控系统
公开(公告)号：US07422693B2
公开(公告)日：2008-09-09
申请号：US10884877
申请日：2004-07-01
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： B04B9/10
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods, devices and device components for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. In embodiment, two-dimensional distributions of transmitted light intensities, scattered light intensities or both measured by the methods of the present invention comprise images of a separation chamber or component thereof, such as an optical cell of a separation chamber. In another aspect, the present invention relates to multifunctional monitoring and control systems for blood processing, particularly blood processing via density centrifugation. Feedback control systems are provided wherein two-dimensional distributions of transmitted light intensities, scattered light intensities or both are measured, processed in real time and are used as the basis of output signals for controlling blood processing. In another aspect, optical cells and methods of using optical cells for monitoring and control blood processing are provided.
摘要翻译：本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法，装置和装置部件。在实施例中，通过本发明的方法测量的透射光强度，散射光强度或二者的二维分布包括分离室或其分量（诸如分离室的光学单元）的图像。另一方面，本发明涉及用于血液处理的多功能监测和控制系统，特别是通过密度离心进行血液处理。提供反馈控制系统，其中测量透射光强度，散射光强度或二者的二维分布，实时处理，并用作控制血液处理的输出信号的基础。在另一方面，提供了光学单元和使用光学单元来监测和控制血液处理的方法。

3. 发明授权

US07943916B2 Method for controlling a blood processing system by observing a separation region and an extraction port 有权
标题翻译：通过观察分离区域和提取口来控制血液处理系统的方法
公开(公告)号：US07943916B2
公开(公告)日：2011-05-17
申请号：US12561479
申请日：2009-09-17
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： B01D37/04
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components with a two-dimensional optical measurement and control device. The method may comprise the steps of providing a blood processing system comprising a density centrifuge blood processing system and an elutriation blood processing system; filling the elutriation blood processing system with a desired component; measuring a cellular flux of cells entering the elutriation blood processing system with a two-dimensional optical control system; and flushing the elutriation blood processing system.
摘要翻译：本发明一般涉及监测和控制血液和血液样本的处理方法，特别是利用二维光学测量和控制装置将血液和血液样品分离成其组分。该方法可以包括提供包括密度离心机血液处理系统和淘析血液处理系统的血液处理系统的步骤; 用所需组分填充淘析血液处理系统; 用二维光学控制系统测量进入淘析血液处理系统的细胞的细胞通量; 并冲洗淘析血液处理系统。

4. 发明授权

US07906771B2 Predictive method for controlling a blood processing system 有权
标题翻译：用于控制血液处理系统的预测方法
公开(公告)号：US07906771B2
公开(公告)日：2011-03-15
申请号：US12561419
申请日：2009-09-17
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： B04B13/00
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. The method may include performing first and second measurements of an operating condition; analyzing the first and second measurements using a predictive data analysis algorithm; comparing the predicted operating condition to a desired operating condition; and adjusting at least one setting.
摘要翻译：本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法。该方法可以包括执行操作条件的第一和第二测量; 使用预测数据分析算法分析第一和第二测量; 将预测的操作条件与期望的操作条件进行比较; 并调整至少一个设置。

5. 发明授权

US07605388B2 Monitoring and control system for blood processing 有权
标题翻译：血液处理监控系统
公开(公告)号：US07605388B2
公开(公告)日：2009-10-20
申请号：US12168192
申请日：2008-07-07
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： G01N15/06 , G01N21/49 , G01N21/85
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates to an optical cell for a separation chamber of a density centrifuge blood processing system for separating fluid components comprising an extraction chamber having a first external optical surface for transmitting at least a portion of an incident optical beam; and an extraction port having an axial bore for passing fluid components and a first external optical surface for transmitting at least a portion of the incident optical beam; wherein said first external optical surface of said extraction chamber and said first external optical surface of said extraction port are both positioned within the depth of field of a light collection element.
摘要翻译：本发明涉及一种用于分离流体组分的密度离心机血液处理系统的分离室的光学单元，该液体组分包括具有第一外部光学表面的提取室，用于透射入射光束的至少一部分; 以及具有用于通过流体部件的轴向孔的抽出口和用于透射入射光束的至少一部分的第一外部光学表面; 其中所述提取室的所述第一外部光学表面和所述提取端口的所述第一外部光学表面都位于光采集元件的深度范围内。

6. 发明授权

US5693039A Venous reservoir bag assembly 失效
标题翻译：静脉储液袋组装
公开(公告)号：US5693039A
公开(公告)日：1997-12-02
申请号：US190309
申请日：1994-02-02
申请人： Rodger L. Stewart , John T. Buckley , William D. Dalke , Barry D. Reed , Joseph A. Scibona
发明人： Rodger L. Stewart , John T. Buckley , William D. Dalke , Barry D. Reed , Joseph A. Scibona
IPC分类号： A61J1/16 , A61J1/10 , A61M1/14 , A61M1/36 , A61J1/05
CPC分类号： A61M1/3627 , A61M1/3624 , A61M1/3636 , A61M2205/3386 , A61M2205/3389
摘要： A venous reservoir bag subassembly which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, a cooperating mechanism between the subassembly and the mounting assembly to provide against unduly low blood volume, and an angled conduit cooperating with the bag and recesses in the subassembly and assembly to provide further failsafe against passage of the undesirable gas.
摘要翻译：一种静脉储存袋子组件，其适于与具有可重复地相对移动的支架框架和前板的安装组件配合，以使得能够恒定精确地进行血液量读出，该子组件与安装组件之间的配合机构能够防止过低的血液体积以及与组件和组件中的袋和凹部配合的成角度的导管，以提供不利于不期望的气体通过的进一步的故障保护。

7. 发明授权

US08241196B2 Blood processing apparatus with digitally controlled linear voltage regulator for optical pulses 有权
标题翻译：具有光脉冲数字控制线性电压调节器的血液处理设备
公开(公告)号：US08241196B2
公开(公告)日：2012-08-14
申请号：US12631289
申请日：2009-12-04
申请人： Joseph A. Scibona
发明人： Joseph A. Scibona
IPC分类号： B04B15/00
CPC分类号： G01N15/042 , A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. A digital control circuit controls a high amperage linear voltage regulator. The voltage regulator charges a capacitor bank, which in turn powers LED light sources. The digital control circuit comprises an N-channel switched mode FET. The switched mode FET receives a pulsed digital signal from the microprocessor controlling the blood processing apparatus. A by-pass resistor in parallel with the FET allows most of the current to flow past the FET, thus minimizes heating of the FET. The performance of the FET, therefore, remains stable despite extended use of the apparatus.
摘要翻译：本发明涉及用于控制血液加工成血液成分的设备，特别是用于离心机的频闪LED光源的组件。数字控制电路控制高电流强度的线性稳压器。电压调节器为电容器组充电，这反过来为LED光源供电。数字控制电路包括N沟道开关模式FET。开关模式FET从控制血液处理装置的微处理器接收脉冲数字信号。与FET并联的旁路电阻允许大部分电流流过FET，从而最小化FET的加热。因此，即使扩展使用该装置，FET的性能也保持稳定。

8. 发明授权

US07355685B2 Stroboscopic LED light source for blood processing apparatus 有权
标题翻译：射频LED光源用于血液处理设备
公开(公告)号：US07355685B2
公开(公告)日：2008-04-08
申请号：US11867816
申请日：2007-10-05
申请人： Joseph A. Scibona , Shannon Durkee
发明人： Joseph A. Scibona , Shannon Durkee
IPC分类号： G01N33/48
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B13/00 , B04B2013/006 , G01N15/042 , G01N15/05 , G01N33/5002 , G01N2015/047
摘要： The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. The stroboscopic apparatus comprises a first light source with reflective surfaces spaced around a central illumination axis, and light-emitting diodes spaced away from the axis radially outward from the reflective surfaces. An additional light source comprises a modified parabolic reflector surrounding a light emitting diode, the parabolic reflector having walls spaced outwardly from an axis of symmetry such that focal points fall radially outwardly from a center of the LED, forming a circular focal area. A controller that energizes the diodes for selected periods of time comprises a pair of switches connected in series, with an LED connected between the switches. One of the switches is connected to ground and is closed at the end of a period of illumination.
摘要翻译：本发明涉及用于控制血液加工成血液成分的设备，特别是用于离心机的频闪LED光源的组件。频闪设备包括具有围绕中心照明轴线间隔开的反射表面的第一光源和从反射表面径向向外离开轴线的发光二极管。附加的光源包括围绕发光二极管的修改的抛物面反射器，抛物面反射器具有从对称轴向外间隔开的壁，使得焦点从LED的中心径向向外放置，形成圆形焦点区域。在二选一时间段上激励二极管的控制器包括串联连接的一对开关，LED连接在开关之间。其中一个开关连接到地面，并在照明周期结束时关闭。

9. 发明授权

US07327443B2 Stroboscopic LED light source for blood processing apparatus 有权
公开(公告)号：US07327443B2
公开(公告)日：2008-02-05
申请号：US10905353
申请日：2004-12-29
申请人： Joseph A. Scibona , Shannon Durkee
发明人： Joseph A. Scibona , Shannon Durkee
IPC分类号： G01N33/48
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B13/00 , B04B2013/006 , G01N15/042 , G01N15/05 , G01N33/5002 , G01N2015/047
摘要： The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. The stroboscopic apparatus comprises a first light source with reflective surfaces spaced around a central illumination axis, and light-emitting diodes spaced away from the axis radially outward from the reflective surfaces. An additional light source comprises a modified parabolic reflector surrounding a light emitting diode, the parabolic reflector having walls spaced outwardly from an axis of symmetry such that focal points fall radially outwardly from a center of the LED, forming a circular focal area. A controller that energizes the diodes for selected periods of time comprises a pair of switches connected in series, with an LED connected between the switches. One of the switches is connected to ground and is closed at the end of a period of illumination.

10. 发明授权

US5352218A Venous reservoir bag assembly 失效
标题翻译：静脉储液袋组装
公开(公告)号：US5352218A
公开(公告)日：1994-10-04
申请号：US725126
申请日：1991-07-03
申请人： John T. Buckley , William D. Dalke , Barry D. Reed , Joseph A. Scibona , Rodger L. Stewart
发明人： John T. Buckley , William D. Dalke , Barry D. Reed , Joseph A. Scibona , Rodger L. Stewart
IPC分类号： A61J1/16 , A61J1/10 , A61M1/14 , A61M1/36 , A61J1/05
CPC分类号： A61M1/3627 , A61M1/3624 , A61M1/3636 , A61M2205/3386 , A61M2205/3389
摘要： A venous reservoir bag subassembly is provided which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, cooperating means between the subassembly and the mounting assembly to provide against unduly low blood volume, and angled conduit means cooperating with the bag and recesses in the subassembly and assembly to provide further failsafe against passage of the undesirable gas.
摘要翻译：提供了静脉储存袋子组件，其适于与具有可重复地相对移动的支架框架和前板的安装组件配合，以使得能够恒定精确地进行血液量读出，在组件与安装组件之间配合装置以防止过低的血液体积和成角度的管道装置与子组件和组件中的袋和凹部配合以提供进一步的故障保护以防止不期望的气体的通过。

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