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1. 发明申请

WO2007114916A3 ARYLBENZYLPIPERIDINE COMPOUNDS 审中-公开
标题翻译：亚苄基哌啶化合物
公开(公告)号：WO2007114916A3
公开(公告)日：2008-07-31
申请号：PCT/US2007008291
申请日：2007-04-02
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD , CHEN CHIEN-AN , YU JIANG , REITMAN MICHAEL , KIM ANDERSEN
发明人： MARZABADI MOHAMMAD , CHEN CHIEN-AN , YU JIANG , REITMAN MICHAEL , KIM ANDERSEN
IPC分类号： G09B3/00
CPC分类号： A61K31/00
摘要： This invention is directed to arylbenzylpiperidine compounds which are ligands at the MCHl receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention further provides a method of treating a subject suffering from anxiety comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. Furthermore, the present invention is directed to the use of a compound of the subject invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.
摘要翻译：本发明涉及作为MCH1受体的配体的芳基苄基哌啶化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了治疗患有抑郁症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，包括向受试者施用治疗有效量的本发明化合物。此外，本发明涉及本发明化合物在制备用于治疗患有抑郁症，焦虑症或肥胖症的受试者的药物中的用途。

2. 发明申请

WO2006041636A2 AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES 审中-公开
标题翻译：氨基取代的芳氧基苯基哌啶衍生物
公开(公告)号：WO2006041636A2
公开(公告)日：2006-04-20
申请号：PCT/US2005033891
申请日：2005-09-20
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD R , CHEN CHIEN-AN , YU JIANG , LU KAI , ANDERSEN KIM
发明人： MARZABADI MOHAMMAD R , CHEN CHIEN-AN , YU JIANG , LU KAI , ANDERSEN KIM
IPC分类号： A61K31/5377 , A61K31/4545 , A61K31/496 , C07D313/14 , C07D403/14
CPC分类号： C07D211/26 , C07D401/12 , C07D403/12
摘要： This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/ or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体配体的氨基取代的芳氧基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了通过混合治疗有效量的本发明化合物和药学上可接受的载体制成的药物组合物。本发明进一步提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的对象的方法，该方法包括给对象施用治疗有效量的本发明化合物。

3. 发明申请

WO2005069834A3 4-ARYL PIPERIDINES 审中-公开
公开(公告)号：WO2005069834A3
公开(公告)日：2006-04-27
申请号：PCT/US2005001131
申请日：2005-01-13
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , DELEON JOHN E , JIANG YU , LU KAI
发明人： MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , DELEON JOHN E , JIANG YU , LU KAI
IPC分类号： C07D211/26 , A61K31/445 , C07D211/68 , C07D401/04 , C07D401/10 , C07D401/14
CPC分类号： C07D211/26
摘要： This invention is directed to 4-aryl piperidines and related heterocyclic compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的4-芳基哌啶和相关的杂环化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物与药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者的抑郁症和/或焦虑症的本发明化合物。

4. 发明申请

WO2006041635A2 ARYLTHIOBENZYLPIPERIDINE DERIVATES 审中-公开
标题翻译：亚油酸苄酯衍生物
公开(公告)号：WO2006041635A2
公开(公告)日：2006-04-20
申请号：PCT/US2005033870
申请日：2005-09-21
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
发明人： MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
IPC分类号： C07D413/14 , C07D401/14
CPC分类号： C07D211/60 , C07D211/26 , C07D401/04 , C07D401/12 , C07D401/14
摘要： This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体的配体的芳硫基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。

5. 发明申请

WO2006041635A8 ARYLTHIOBENZYLPIPERIDINE DERIVATIVES 审中-公开
标题翻译：芳基硼烷衍生物衍生物
公开(公告)号：WO2006041635A8
公开(公告)日：2007-05-18
申请号：PCT/US2005033870
申请日：2005-09-21
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
发明人： MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
IPC分类号： A61K31/5377 , A61K31/445 , C07D211/06 , C07D413/12
CPC分类号： C07D211/60 , C07D211/26 , C07D401/04 , C07D401/12 , C07D401/14
摘要： This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体的配体的芳硫基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。

6. 发明申请

WO2010053861A3 BIOLOGICALLY ACTIVE AMIDES 审中-公开
标题翻译：生物活性酰胺
公开(公告)号：WO2010053861A3
公开(公告)日：2010-09-02
申请号：PCT/US2009062956
申请日：2009-11-02
申请人： LUNDBECK & CO AS H , PETERSON JOHN , CHEN CHIEN-AN , CHEN BIN , WU LINGYUN , SABIO MICHAEL
发明人： PETERSON JOHN , CHEN CHIEN-AN , CHEN BIN , WU LINGYUN , SABIO MICHAEL
IPC分类号： C07D401/12 , A61K31/4427 , A61P3/00 , A61P3/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D411/14 , C07D413/14
CPC分类号： C07D401/12 , A61K31/4427 , C07D211/40 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/048 , C07D513/04
摘要： The present invention is directed to biologically active amides which are ligands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from certain disorders which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from certain disorders.
摘要翻译：本发明涉及生物活性酰胺，其是NPY Y5受体上的配体。本发明还提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了治疗患有某些病症的受试者的方法，其包括给受试者施用一定量的本发明化合物。此外，本发明还提供了本发明化合物在制备用于治疗患有某些病症的受试者的药物中的用途。

7. 发明申请

WO2004064764A3 SUBSTITUTED ALKYL AMIDO PIPERIDINES 审中-公开
标题翻译：取代的烷基氨基哌啶
公开(公告)号：WO2004064764A3
公开(公告)日：2005-01-13
申请号：PCT/US2004000175
申请日：2004-01-06
申请人： SYNAPTIC PHARMA CORP , MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , JIANG YU , LU KAI
发明人： MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , JIANG YU , LU KAI
IPC分类号： A61K31/44 , A61K31/445 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/53 , A61K31/5377 , A61P3/04 , A61P7/12 , A61P25/22 , A61P25/24 , A61P43/00 , C07D211/06 , C07D211/26 , C07D211/28 , C07D211/30 , C07D211/90 , C07D211/94 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/10 , C07D471/04 , C07D495/04 , C07D521/00
CPC分类号： C07D211/26 , C07D211/28 , C07D211/90 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/06 , C07D417/10 , C07D471/04 , C07D495/04
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物与药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者的抑郁症和/或焦虑症的本发明化合物。

8. 发明公开

EP1531816A4 SPIROCYCLIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF 有权
标题翻译：作为MCH1拮抗剂的SPIROCYCLIC哌啶及其用途
公开(公告)号：EP1531816A4
公开(公告)日：2005-12-28
申请号：EP03763351
申请日：2003-07-03
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD , JIANG ALLEN , LU KAI , CHEN CHIEN-AN , DELEON JOHN , WETZEL JOHN , ANDERSEN KIM
IPC分类号： A61K31/438 , C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10 , A61P3/04 , A61P25/00 , A61P25/24
CPC分类号： C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10

9. 发明公开

EP1708704A4 4-ARYL PIPERIDINES 审中-公开
标题翻译： 4-芳基哌啶
公开(公告)号：EP1708704A4
公开(公告)日：2009-08-05
申请号：EP05711430
申请日：2005-01-13
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , DELEON JOHN E , JIANG YU , LU KAI
IPC分类号： A61K31/445 , C07D211/26 , C07D211/68 , C07D401/04 , C07D401/10
CPC分类号： C07D211/26

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