专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005069834A3 4-ARYL PIPERIDINES 审中-公开
公开(公告)号：WO2005069834A3
公开(公告)日：2006-04-27
申请号：PCT/US2005001131
申请日：2005-01-13
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , DELEON JOHN E , JIANG YU , LU KAI
发明人： MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , DELEON JOHN E , JIANG YU , LU KAI
IPC分类号： C07D211/26 , A61K31/445 , C07D211/68 , C07D401/04 , C07D401/10 , C07D401/14
CPC分类号： C07D211/26
摘要： This invention is directed to 4-aryl piperidines and related heterocyclic compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的4-芳基哌啶和相关的杂环化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物与药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者的抑郁症和/或焦虑症的本发明化合物。

2. 发明申请

WO2006041635A2 ARYLTHIOBENZYLPIPERIDINE DERIVATES 审中-公开
标题翻译：亚油酸苄酯衍生物
公开(公告)号：WO2006041635A2
公开(公告)日：2006-04-20
申请号：PCT/US2005033870
申请日：2005-09-21
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
发明人： MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
IPC分类号： C07D413/14 , C07D401/14
CPC分类号： C07D211/60 , C07D211/26 , C07D401/04 , C07D401/12 , C07D401/14
摘要： This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体的配体的芳硫基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。

3. 发明申请

WO2006041635A8 ARYLTHIOBENZYLPIPERIDINE DERIVATIVES 审中-公开
标题翻译：芳基硼烷衍生物衍生物
公开(公告)号：WO2006041635A8
公开(公告)日：2007-05-18
申请号：PCT/US2005033870
申请日：2005-09-21
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
发明人： MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
IPC分类号： A61K31/5377 , A61K31/445 , C07D211/06 , C07D413/12
CPC分类号： C07D211/60 , C07D211/26 , C07D401/04 , C07D401/12 , C07D401/14
摘要： This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体的配体的芳硫基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。

4. 发明申请

WO2004064764A3 SUBSTITUTED ALKYL AMIDO PIPERIDINES 审中-公开
标题翻译：取代的烷基氨基哌啶
公开(公告)号：WO2004064764A3
公开(公告)日：2005-01-13
申请号：PCT/US2004000175
申请日：2004-01-06
申请人： SYNAPTIC PHARMA CORP , MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , JIANG YU , LU KAI
发明人： MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , JIANG YU , LU KAI
IPC分类号： A61K31/44 , A61K31/445 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/53 , A61K31/5377 , A61P3/04 , A61P7/12 , A61P25/22 , A61P25/24 , A61P43/00 , C07D211/06 , C07D211/26 , C07D211/28 , C07D211/30 , C07D211/90 , C07D211/94 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/10 , C07D471/04 , C07D495/04 , C07D521/00
CPC分类号： C07D211/26 , C07D211/28 , C07D211/90 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/06 , C07D417/10 , C07D471/04 , C07D495/04
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物与药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者的抑郁症和/或焦虑症的本发明化合物。

5. 发明申请

WO2009137270A3 AZETIDINE DERIVATIVES 审中-公开
公开(公告)号：WO2009137270A3
公开(公告)日：2009-12-30
申请号：PCT/US2009041343
申请日：2009-04-22
申请人： LUNDBECK & CO AS H , JIANG YU , MA GIL , LU KAI
发明人： JIANG YU , MA GIL , LU KAI
IPC分类号： C07D403/14 , C07D205/04 , C07D205/08
CPC分类号： C07D401/14 , C07D403/14
摘要： The present invention relates to azetidine derivatives which bind to the MCH l receptor. In separate aspects, the subject invention is directed to uses of said compounds in the preparation of a pharmaceutical composition for the treatment of metabolic and CNS related disorders and to methods of treating said disorders comprising administering a therapeutically effective amount of a compound of the invention.
摘要翻译：本发明涉及结合MCH 1受体的氮杂环丁烷衍生物。在单独的方面，本发明涉及所述化合物在制备用于治疗代谢和CNS相关病症的药物组合物中的用途，以及治疗所述病症的方法，包括施用治疗有效量的本发明化合物。

6. 发明申请

WO2007114902A2 ALKYLTHIOBENZYLPIPERIDINE COMPOUNDS 审中-公开
标题翻译：烷基二苯基哌啶化合物
公开(公告)号：WO2007114902A2
公开(公告)日：2007-10-11
申请号：PCT/US2007008142
申请日：2007-04-02
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD , ANDERSEN KIM , CHEN BIN , REITMAN MICHAEL , JIANG YU , ELDEMENKY EMAN
发明人： MARZABADI MOHAMMAD , ANDERSEN KIM , CHEN BIN , REITMAN MICHAEL , JIANG YU , ELDEMENKY EMAN
IPC分类号： C02F1/00
CPC分类号： C07D211/26 , C07D405/12
摘要： This invention is directed to alkylthiobenzylpiperidine compounds which are ligands at the MCHl receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention further provides a method of treating a subject suffering from anxiety comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. Furthermore, the present invention is directed to the use of a compound of the subject invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.
摘要翻译：本发明涉及作为MCH1受体的配体的烷硫基苄基哌啶化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了治疗患有抑郁症的受试者的方法，包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，包括向受试者施用治疗有效量的本发明化合物。此外，本发明涉及本发明化合物在制备用于治疗患有抑郁，焦虑或肥胖的受试者的药物中的用途。

7. 发明申请

WO2014057080A3 N-(2-(CYCLIC AMINE)ETHYL)BENZAMIDE DERIVATIVES AS P2X7 INHIBITORS 审中-公开
标题翻译： N-（2-（环丙胺）乙基）苯甲酰胺衍生物作为P2X7抑制剂
公开(公告)号：WO2014057080A3
公开(公告)日：2014-07-10
申请号：PCT/EP2013071253
申请日：2013-10-11
申请人： LUNDBECK & CO AS H
发明人： KILBURN JOHN PAUL , RASMUSSEN LARS KYHN , JESSING MIKKEL , ELDEMENKY EMAN MOHAMMED , CHEN BIN , JIANG YU
IPC分类号： C07D401/06 , A61K31/40 , A61K31/4453 , A61K31/4545 , A61K31/5375 , A61K31/5377 , A61K31/553 , C07D209/52 , C07D213/40 , C07D239/26 , C07D267/10 , C07D295/13 , C07D403/06 , C07D413/06
CPC分类号： A61K31/553 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/625 , C07D209/52 , C07D211/38 , C07D213/40 , C07D239/26 , C07D267/10 , C07D295/13 , C07D401/06 , C07D403/06 , C07D413/06
摘要： The present invention is directed to N-(2-(cyclic amine)ethyl)benzamide derivatives of formula (I), as P2X7 inhibitors, pharmaceutical compositions comprising said compounds and uses of the compounds to treat pain, inflammation, neurological disorders, or neuropsychiatric disorders.
摘要翻译：本发明涉及式（I）的N-（2-（环状胺）乙基）苯甲酰胺衍生物，作为P2X7抑制剂，包含所述化合物的药物组合物和该化合物用于治疗疼痛，炎症，神经障碍或神经精神病学障碍。

8. 发明公开

EP1799223A4 ARYLTHIOBENZYLPIPERIDINE DERIVATES 审中-公开
标题翻译： ARYLTHIOBENZYLPIPERIDIN衍
公开(公告)号：EP1799223A4
公开(公告)日：2008-01-23
申请号：EP05806054
申请日：2005-09-21
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD R , JIANG YU , CHEN CHIEN-AN , LU KAI , ANDERSEN KIM
IPC分类号： A61K31/5377 , A61K31/445 , C07D211/06 , C07D413/12
CPC分类号： C07D211/60 , C07D211/26 , C07D401/04 , C07D401/12 , C07D401/14

9. 发明公开

EP1804796A4 AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES 审中-公开
标题翻译：氨基磺酰苯丙氨酸衍生物
公开(公告)号：EP1804796A4
公开(公告)日：2009-10-21
申请号：EP05804433
申请日：2005-09-20
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD R , CHEN CHIEN-AN , JIANG YU , LU KAI , ANDERSEN KIM
IPC分类号： A61K31/4427 , A61P25/22 , A61P25/24 , C07D401/06
CPC分类号： C07D211/26 , C07D401/12 , C07D403/12

10. 发明公开

EP1708704A4 4-ARYL PIPERIDINES 审中-公开
标题翻译： 4-芳基哌啶
公开(公告)号：EP1708704A4
公开(公告)日：2009-08-05
申请号：EP05711430
申请日：2005-01-13
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , DELEON JOHN E , JIANG YU , LU KAI
IPC分类号： A61K31/445 , C07D211/26 , C07D211/68 , C07D401/04 , C07D401/10
CPC分类号： C07D211/26

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式