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1. 发明专利

CA2163716A1 VEROTOXIN PHARMACEUTICAL COMPOSITIONS AND MEDICAL TREATMENTSTHEREWITH 未知
公开(公告)号：CA2163716A1
公开(公告)日：1997-05-25
申请号：CA2163716
申请日：1995-11-24
申请人： LINGWOOD CLIFFORD A , FARKAS HIMSLEY HANNAH , HILL ROBERT
发明人： LINGWOOD CLIFFORD A , FARKAS-HIMSLEY HANNAH , HILL ROBERT
IPC分类号： A61K38/16 , A61K38/43 , A61K47/12
摘要： Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1 and their pentameric subunit B, have been found to be useful in the treatment of mammalian neoplasia, particularly, brain cancer, ovarian cancer, breast cancer a nd skin cancer. Although verotoxin 1 has previously been shown to have anti-neoplastic activity in vitro, nonlethal doses of verotoxin 1 have been shown to be therapeutically anti-neoplasti c in vivo. Use of a sensitizer, such as sodium butyrate, enhances the efficacy of verotoxins an d their subunit B.

2. 发明专利

CA2163716C VEROTOXIN PHARMACEUTICAL COMPOSITIONS AND MEDICAL TREATMENTSTHEREWITH 未知
公开(公告)号：CA2163716C
公开(公告)日：2009-05-19
申请号：CA2163716
申请日：1995-11-24
申请人： LINGWOOD CLIFFORD A , FARKAS-HIMSLEY HANNAH , HILL ROBERT
发明人： LINGWOOD CLIFFORD A , FARKAS-HIMSLEY HANNAH , HILL ROBERT
IPC分类号： A61K38/47 , A61K38/16 , A61K38/43 , A61K47/12 , A61P35/00
摘要： Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1 and their pentameric subunit B, have been found to be useful in the treatment of mammalian neoplasia, particularly, brain cancer, ovarian cancer, breast canc er and skin cancer. Although verotoxin 1 has previously been shown to have anti-neoplastic activity in vitro, non-lethal doses of verotoxin 1 have been shown to be therapeutically anti- neoplastic in vivo. Use of a sensitizer, such as sodium butyrate, enhances the efficacy of verotoxin s and their subunit B.

3. 发明公开

EP0195014A4 LOCKABLE TUBE ROLLER. 失效
标题翻译：锁定管辊。
公开(公告)号：EP0195014A4
公开(公告)日：1988-02-23
申请号：EP85903952
申请日：1985-07-31
申请人： HILL ROBERT
发明人： HILL ROBERT
IPC分类号： B65D35/32 , B65D35/28
CPC分类号： B65D35/28
摘要： A device for winding up collapsible tubes, having open and closed ends, to allow full expression of contents from the open end and to prevent the wound tube from unwinding. The device includes an elongated slot-shaped opening (44) in one member or mandrel (12) for receiving the closed end of a tube (30), such as a toothpaste tube. After the tube has been inserted into that slot and some amount of tube contents has been expressed, a handle (50), pivotally attached to one end of the member containing the slot, is pivoted to an open position not overlying the slot and substantially normal to the longitudinal axis of the mandrel and is used to wind the tube. After winding, the handle will be pivoted back to its closed position where it is horizontally offset from and overlies at least a part of the mandrel and will rest against the wound layer or layers of tubing therebetween. Because of the cooperative relationship of the handle and the mandrel, the tube is prevented from unwinding.

4. 发明申请

WO0000597A3 NON-SYMBIOTIC PLANT HEMOGLOBINS TO MAINTAIN CELL ENERGY STATUS 审中-公开
标题翻译：非正常植物HEMOGLOBIN以维持细胞能量状态
公开(公告)号：WO0000597A3
公开(公告)日：2000-03-23
申请号：PCT/CA9900587
申请日：1999-06-24
申请人： UNIV MANITOBA , GUY PHILLIP , DUFF STEPHEN , XIANZHOU NIE , HILL ROBERT , DURNIN DOUGLAS , SOWA ALEKSANDER
发明人： GUY PHILLIP , DUFF STEPHEN , XIANZHOU NIE , HILL ROBERT , DURNIN DOUGLAS , SOWA ALEKSANDER
IPC分类号： A01H5/00 , A61K35/12 , C07K14/415 , C07K14/805 , C12N1/20 , C12N15/29 , C12N15/82 , C12N15/00
CPC分类号： C07K14/415 , A61K35/12 , C07K14/805 , C12N1/20 , C12N15/8261 , Y02A40/146
摘要： Nonsymbiotic hemoglobins are broadly present across evolution; however, the function of these proteins is unknown. Cultured maize cells have been transformed to constitutively express a barley hemoglobin gene in either the sense (HB ) or antisense (HB ) orientation. Hemoglobin protein in the transformed cell lines was correspondingly higher or lower than in wild type cells under normal atmospheric conditions. Limiting oxygen availability, by placing the cells in a nitrogen atmosphere for 12 hours, had little effect on the energy status of cells constitutively expressing hemoglobin, but had a pronounced effect on both wild type and HB cells, where ATP levels declined by 27 % and 61 % respectively. Energy charge was relatively unaffected by the treatment in HB and wild type cells, but was reduced from 0.91 to 0.73 in HB cells suggesting that the latter were incapable of maintaining their energy status under the low oxygen regime. Similar results were observed with P. aeruginosa cells transformed with an Hb expression vector. It is suggested that nonsymbiotic hemoglobins act to maintain the energy status of cells in low oxygen environments and that they accomplish this effect by promoting glycolytic flux through NADH oxidation, resulting in increased substrate level phosphorylation. Nonsymbiotic hemoglobins are likely ancestors of an early form of hemoglobin that sequestered oxygen in low oxygen environments, providing a source of oxygen to oxidize NADH to provide ATP for cell growth and development. This in turn suggests that cells containing increased levels of Hb protein will survive longer under low oxygen tension or high energy demand.
摘要翻译：非共生血红蛋白在进化中广泛存在; 然而，这些蛋白质的功能是未知的。培养的玉米细胞已经被转化成在正义（HB +）或反义（HB））取向中组成型表达大麦血红蛋白基因。在正常大气条件下，转化细胞系中的血红蛋白蛋白质相对较高或低于野生型细胞。通过将细胞置于氮气氛中12小时来限制氧气供应对组成型表达血红蛋白的细胞的能量状态几乎没有影响，但对野生型和HB型细胞都有明显的作用，其中ATP水平下降分别为27％和61％。在HB +和野生型细胞中，能量电荷相对不受治疗的影响，但在HB 细胞中，能量电荷从0.91降低到0.73，表明后者在低氧状态下不能保持其能量状态。用Hb表达载体转化的铜绿假单胞菌细胞观察到类似的结果。建议非共生血红蛋白起作用以维持低氧环境中细胞的能量状态，并通过促进糖酵解通过NADH氧化来实现这一作用，从而增加底物水平的磷酸化。非共生血红蛋白可能是早期形式的血红蛋白的祖先，其在低氧环境中螯合氧，提供氧气来氧化NADH以提供ATP用于细胞生长和发育。这反过来表明，含有较高水平的Hb蛋白的细胞将在低氧压力或高能量需求下生存更长时间。

5. 发明授权

US712536A Cop-holder for winding-machines. 失效
标题翻译：卷帘机COP-HOLDER。
公开(公告)号：US712536A
公开(公告)日：1902-11-04
申请号：US1902102325
申请日：1902-04-10
申请人： HILL ROBERT
发明人： HILL ROBERT
CPC分类号： B65H2701/31

6. 发明申请

WO0239538A3 COMPACT ANTENNA WITH MULTIPLE POLARIZATIONS 审中-公开
标题翻译：具有多极化的紧凑天线
公开(公告)号：WO0239538A3
公开(公告)日：2002-08-29
申请号：PCT/US0142777
申请日：2001-10-15
申请人： RANGESTAR WIRELESS INC , KEILEN DONALD H , HILL ROBERT , ZAVALA JUAN
发明人： KEILEN DONALD H , HILL ROBERT , ZAVALA JUAN
IPC分类号： A61M25/09 , H01Q1/24 , H01Q5/00 , H01Q9/04 , H01Q9/40 , H01Q1/38
CPC分类号： H01Q9/40 , H01Q1/243 , H01Q5/30 , H01Q9/0407
摘要： An antenna is disclosed consisting of a planar ground conductor (16), matching network (20), and resonator (18). The antenna is compact, may operate on one or more frequency bands, and is suitable for high volume production. The antenna exhibits simultaneous dual linear polarizations and a unidirectional pattern in at least one of its operation frequency ranges when configured for multiple-ban operation. Applications for the antenna include wireless communication devices such as cellular telephones or data devices.
摘要翻译：公开了一种由平面接地导体（16），匹配网络（20）和谐振器（18）组成的天线。天线紧凑，可以在一个或多个频带上工作，适合大批量生产。当配置为多次禁止操作时，天线在其操作频率范围的至少一个中呈现同时的双线性偏振和单向图案。用于天线的应用包括诸如蜂窝电话或数据设备的无线通信设备。

7. 发明申请

WO2008024172A3 RESERVE ORDER IN AN ELECTRONIC GUARANTEED ENTITLEMENT ENVIRONMENT 审中-公开
标题翻译：在电子保证有限的环境中保留订单
公开(公告)号：WO2008024172A3
公开(公告)日：2008-06-19
申请号：PCT/US2007016718
申请日：2007-07-25
申请人： ARCHIPELAGO HOLDINGS INC , ADCOCK PAUL , CORMACK MICHAEL , FARNSTROM AMY , HALLER THOMAS F , HILL ROBERT
发明人： ADCOCK PAUL , CORMACK MICHAEL , FARNSTROM AMY , HALLER THOMAS F , HILL ROBERT
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q30/06 , G06Q40/00 , G06Q40/06
摘要： An enhanced system and method for handling, matching and executing reserve orders in an electronic options environment is disclosed. Market maker entitlements are integrated with the reserve order processing, so that the market maker is guaranteed an allocation of the trade if the market maker is at the NBBO when a marketable reserve order is received. Once posted to the order book, only the displayed size of a reserve order is eligible for preferential execution in a market maker entitlement process.
摘要翻译：公开了一种用于在电子选项环境中处理，匹配和执行预定订单的增强型系统和方法。做市商权利与储备订单处理结合在一起，因此如果做市商在收到可销售储备订单时位于NBBO，则可以保证做市商的交易分配。一旦发布到订单簿，只有显示的保留订单的大小才有资格在做市商权利流程中优先执行。

8. 发明申请

WO2008013916A3 DISCRETIONARY ORDER IN AN ELECTRONIC GUARANTEED ENTITLEMENT ENVIRONMENT 审中-公开
标题翻译：电子担保环境中的分歧订单
公开(公告)号：WO2008013916A3
公开(公告)日：2008-12-18
申请号：PCT/US2007016856
申请日：2007-07-27
申请人： ARCHIPELAGO HOLDINGS INC , ADCOCK PAUL , CORMACK MICHAEL , FARNSTROM AMY , HALLER THOMAS F , HILL ROBERT
发明人： ADCOCK PAUL , CORMACK MICHAEL , FARNSTROM AMY , HALLER THOMAS F , HILL ROBERT
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q30/06 , G06Q40/00 , G06Q40/06
摘要： An enhanced system and method for handling, matching and executing discretionary orders in an electronic options environment is disclosed. Market maker entitlements are integrated with the discretionary order processing, so that the market maker is guaranteed an allocation of the trade if the market maker is at the NBBO when an incoming discretionary order priced at or better than the NBBO is received. If the incoming discretionary order cannot execute at the NBBO using its display price, then it will use as much discretion as is required to participate in a market maker entitlement if the market maker is quoting at the NBBO, and to execute against the order book and route to away markets quotations at the NBBO. Once posted to the order book, only the display price of a discretionary order is eligible for preferential execution in a market maker entitlement process.
摘要翻译：公开了一种用于在电子选项环境中处理，匹配和执行自由裁量订单的增强的系统和方法。市场商权利与自由裁量订单处理相结合，使得如果收到订单或优于NBBO的订单订单，则营销商处于NBBO时，营销商可以保证交易分配。如果进入的自由裁量的订单不能使用其显示价格在NBBO执行，则如果制造商在NBBO报价时，它将使用所需的酌情决定权参与制造商的权利，并执行对订单和路线在NBBO的市场报价。一旦发布到订单，只有自由裁量权的显示价格才有资格在制造者授权过程中优先执行。

9. 发明申请

WO2006078362A2 UNIVERSAL HANDS FREE KEY AND LOCK SYSTEM AND METHOD 审中-公开
标题翻译：通用手柄钥匙和锁定系统及方法
公开(公告)号：WO2006078362A2
公开(公告)日：2006-07-27
申请号：PCT/US2005044250
申请日：2005-12-05
申请人： SECUREALL CORP , SCHAFFZIN RICHARD , CANDEE DAVID , MASSA JOHN , SCHAFFZIN JEFFREY , GALL JAY , HILL ROBERT
发明人： SCHAFFZIN RICHARD , CANDEE DAVID , MASSA JOHN , SCHAFFZIN JEFFREY , GALL JAY , HILL ROBERT
IPC分类号： B60R25/00 , G05B19/00 , G08B21/00
CPC分类号： G08B29/181 , B60R2325/101 , B60R2325/105 , G07C9/00182 , G07C2009/00793 , G07C2209/64
摘要： Methods and systems are provided for a universal key that enables a user to have access to any type of secured portal, both physical and electronic, in a wireless, hands-free, distance-independent manner without requiring contact or line of sight access between the key and the secured portal. The universal key is not distance-dependent, and each secured portal can be provided with its own prescribed activation range, if desired. Some portals may be provided with long range activation, such as 50 feet, while other portals may be provided with short range activation of a few feet or less. The type of portal being secured and the range of activation may be selected by the user and is not limited by the universal key. In addition, the universal key will provide access to the secured portals in a hands-free fashion so that the user need not push any buttons or take any other action in order to obtain access to the portal. The user need only carry the universal key somewhere on their person in order to access the portal.
摘要翻译：提供了用于通用密钥的方法和系统，其使用户能够以无线，免提，距离独立的方式访问任何类型的物理和电子安全门户，而不需要在两者之间的接触或视线访问密钥和安全门户。通用密钥与距离无关，如果需要，每个安全门户都可以提供自己规定的激活范围。一些门户可以被提供诸如50英尺的远程激活，而其他门户可以被提供几英尺或更短的短距离激活。被保护的门户的类型和激活的范围可以由用户选择，并且不受通用密钥的限制。此外，通用密钥将以免提方式提供对安全门户的访问，以便用户无需推动任何按钮或采取任何其他操作，以获得访问门户。用户只需要在他们的某个地方携带通用密钥才能访问门户。

10. 发明专利

CA353527A RAIL CHAIR 未知
公开(公告)号：CA353527A
公开(公告)日：1935-10-15
申请号：CA353527D
申请人： HILL ROBERT
发明人： HILL ROBERT

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