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1. 发明申请

US20090005265A1 METHOD OF ISOLATING NUCLEIC ACID USING MATERIAL POSITIVELY CHARGED AT FIRST PH AND CONTAINING AMINO GROUP AND CARBOXYL GROUP 有权
标题翻译：使用在第一个PH和含有氨基和羧基的正电荷充填材料分离核酸的方法
公开(公告)号：US20090005265A1
公开(公告)日：2009-01-01
申请号：US12141894
申请日：2008-06-18
申请人： Kyu-youn HWANG , Joon-ho KIM , Chang-eun YOO , Hun-joo LEE , Hee-kyun LIM , Sung-young JEONG , Jeo-young SHIM
发明人： Kyu-youn HWANG , Joon-ho KIM , Chang-eun YOO , Hun-joo LEE , Hee-kyun LIM , Sung-young JEONG , Jeo-young SHIM
IPC分类号： C40B40/04 , C07C63/26
CPC分类号： C12N15/1006 , B01D15/361 , B01D15/364 , B01J20/3285 , B01J43/00 , C12Q1/6806 , C12Q2527/119 , C12Q2523/308
摘要： A method of isolating nucleic acid from a sample containing nucleic acid is provided. The method includes contacting the sample with a bifunctional material that contains an amino group and a carboxyl group and is positively charged at a first pH to allow binding of the nucleic acid to the bifunctional material; and extracting the nucleic acid at a second pH higher than the first pH from the complex.
摘要翻译：提供了从含有核酸的样品中分离核酸的方法。该方法包括使样品与含有氨基和羧基的双官能材料接触并在第一pH下带正电荷以允许核酸与双功能材料的结合; 以及从所述络合物中提取比所述第一pH高的第二pH的所述核酸。

2. 发明申请

US20090153130A1 FIELD EFFECT TRANSISTOR-BASED BIOSENSOR WITH INORGANIC FILM, METHOD OF MANUFACTURING THE BIOSENSOR, AND METHOD OF DETECTING BIOMOLECULE USING THE BIOSENSOR 审中-公开
标题翻译：基于场效应晶体管的无机膜生物传感器，生物传感器的制造方法和使用生物传感器检测生物分子的方法
公开(公告)号：US20090153130A1
公开(公告)日：2009-06-18
申请号：US11556783
申请日：2006-11-06
申请人： Jeo-young SHIM , Kyu-sang LEE , Chang-eun YOO , Kyu-youn HWANG , Young-a KIM , Kyu-tae YOO , Yeon-ja CHO
发明人： Jeo-young SHIM , Kyu-sang LEE , Chang-eun YOO , Kyu-youn HWANG , Young-a KIM , Kyu-tae YOO , Yeon-ja CHO
IPC分类号： G01N27/00 , H01L29/772 , H01L21/335
CPC分类号： G01N33/54373 , B01J2219/00529 , B01J2219/00596 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , G01N27/4145
摘要： Provided is a Field-Effect Transistor (FET)-based biosensor including: a substrate; a source and a drain, disposed on the substrate, having opposite polarity to the substrate; a gate, disposed on the substrate, contacting the source and the drain; and an inorganic film capable of binding with a biomolecule, disposed on a surface of the gate. A method of manufacturing the FET-based biosensor and a method of detecting a biomolecule using the FET-based biosensor is also provided. The FET-based biosensor can be manufactured using a semiconductor fabrication process without performing an additional process. Therefore, the inorganic film can be selectively deposited on a surface of a specific gate of a single FET, or on the surfaces of some gates of a plurality of FETs using patterning. Furthermore, the FET-based biosensor can be used to effectively detect trace amounts of a target biomolecule in a sample.
摘要翻译：提供了一种基于场效应晶体管（FET）的生物传感器，包括：基板; 源极和漏极，设置在衬底上，具有与衬底相反的极性; 栅极，设置在基板上，与源极和漏极接触; 以及能够与生物分子结合的无机膜，其设置在栅极的表面上。还提供了制造基于FET的生物传感器的方法和使用基于FET的生物传感器检测生物分子的方法。基于FET的生物传感器可以使用半导体制造工艺制造而不执行额外的工艺。因此，无机膜可以选择性地沉积在单个FET的特定栅极的表面上，或者使用图案化沉积在多个FET的一些栅极的表面上。此外，基于FET的生物传感器可以用于有效地检测样品中痕量的目标生物分子。

3. 发明申请

US20080124719A1 PATTERNED SPOT MICROARRAY USING PHOTOCATALYST AND METHOD OF MANUFACTURING THE SAME 失效
标题翻译：使用光催化剂的图案点阵微阵列及其制造方法
公开(公告)号：US20080124719A1
公开(公告)日：2008-05-29
申请号：US11670207
申请日：2007-02-01
申请人： Jong-suk CHUNG , Kyu-youn HWANG , Jeo-young SHIM
发明人： Jong-suk CHUNG , Kyu-youn HWANG , Jeo-young SHIM
IPC分类号： C12Q1/68 , C12M3/00 , B05D3/02
CPC分类号： B81C1/00206 , B01J19/0046 , B01J2219/00387 , B01J2219/0043 , B01J2219/00527 , B01J2219/00585 , B01J2219/00599 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , B81B2201/06 , B82Y30/00 , C40B50/18
摘要： Provided is a method of preparing a patterned spot microarray using a photocatalyst. The method comprises coating the photocatalyst on a substrate to form a photocatalyst layer, coating a composition comprising a functional group to be connected to a biomolecule on the photocatalyst layer to form an organic layer, spotting the biomolecule on the organic layer, positioning a photomask above a spot of the biomolecule; and irradiating the spot through the photomask to pattern the spot.
摘要翻译：提供了使用光催化剂制备图案化斑点微阵列的方法。该方法包括将光催化剂涂覆在基材上以形成光催化剂层，涂覆包含要连接到光催化剂层上的生物分子的官能团的组合物以形成有机层，将生物分子点在有机层上，将光掩模放在上面生物分子的一个点; 并通过光掩模照射斑点以对斑点进行图案化。

4. 发明申请

US20120078527A1 KIT AND METHOD FOR PREDICTING SENSITIVITY OF GASTRIC CANCER PATIENT TO ANTI-CANCER AGENT 审中-公开
标题翻译：用于预防胃癌患者对抗癌剂敏感性的试剂盒和方法
公开(公告)号：US20120078527A1
公开(公告)日：2012-03-29
申请号：US13244095
申请日：2011-09-23
申请人： Chang-eun YOO , Tae-jin AHN , Kyu-sang LEE , Jeo-young SHIM , Ki-eun KIM , Myoung-soon KIM , Sung-woo HONG , Tae-han JEON , Jhin-gook KIM , Se-hoon PARK , In-suk SOHN , Sin-ho JUNG
发明人： Chang-eun YOO , Tae-jin AHN , Kyu-sang LEE , Jeo-young SHIM , Ki-eun KIM , Myoung-soon KIM , Sung-woo HONG , Tae-han JEON , Jhin-gook KIM , Se-hoon PARK , In-suk SOHN , Sin-ho JUNG
IPC分类号： G06F19/00 , C12Q1/68 , C40B30/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： A kit and method for predicting the sensitivity of gastric cancer patient to an anti-cancer agent are disclosed.
摘要翻译：公开了一种用于预测胃癌患者对抗癌剂敏感性的试剂盒和方法。

5. 发明申请

US20100329931A1 SENSING SWITCH AND DETECTING METHOD USING THE SAME 有权
标题翻译：感应开关及其检测方法
公开(公告)号：US20100329931A1
公开(公告)日：2010-12-30
申请号：US12833095
申请日：2010-07-09
申请人： Kyu-tae YOO , Joon-ho KIM , Jun-hong MIN , Sung-ouk JUNG , Ji-na NAMGOONG , Kui-hyun KIM , Jeo-young SHIM , Kak NAMKOONG
发明人： Kyu-tae YOO , Joon-ho KIM , Jun-hong MIN , Sung-ouk JUNG , Ji-na NAMGOONG , Kui-hyun KIM , Jeo-young SHIM , Kak NAMKOONG
IPC分类号： G01N27/00
CPC分类号： G01N33/54373
摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
摘要翻译：提供了一种感测开关和使用该感测开关的感测方法。感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

6. 发明申请

US20090170211A1 SENSING SWITCH AND DETECTING METHOD USING THE SAME 有权
标题翻译：感应开关及其检测方法
公开(公告)号：US20090170211A1
公开(公告)日：2009-07-02
申请号：US12272183
申请日：2008-11-17
申请人： Kyu-tae YOO , Joon-ho KIM , Jun-hong MIN , Sung-ouk JUNG , Ji-na NAMGOONG , Kui-hyun KIM , Jeo-young SHIM , Kak NAMKOONG
发明人： Kyu-tae YOO , Joon-ho KIM , Jun-hong MIN , Sung-ouk JUNG , Ji-na NAMGOONG , Kui-hyun KIM , Jeo-young SHIM , Kak NAMKOONG
IPC分类号： G01N27/00
CPC分类号： G01N33/54373
摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
摘要翻译：提供了一种感测开关和使用该感测开关的感测方法。感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

7. 发明申请

US20110043213A1 FET-BASED SENSOR FOR DETECTING IONIC MATERIAL, IONIC MATERIAL DETECTING DEVICE USING THE FET-BASED SENSOR, AND METHOD OF DETECTING IONIC MATERIAL USING THE FET-BASED SENSOR 有权
标题翻译：用于检测离子材料的基于FET的传感器，使用基于FET的传感器的离子材料检测装置以及使用基于FET的传感器检测离子材料的方法
公开(公告)号：US20110043213A1
公开(公告)日：2011-02-24
申请号：US12912191
申请日：2010-10-26
申请人： Kyu-sang LEE , Kyu-tae YOO , Jeo-young SHIM , Jin-tae KIM , Yeon-ja CHO
发明人： Kyu-sang LEE , Kyu-tae YOO , Jeo-young SHIM , Jin-tae KIM , Yeon-ja CHO
IPC分类号： G01N27/62
CPC分类号： G01N33/54373 , C12Q1/6825 , G01N27/4145
摘要： Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.
摘要翻译：提供了一种用于检测离子材料的基于FET的传感器，包括基于FET的传感器的离子材料检测装置，以及使用基于FET的传感器检测离子材料的方法。基于FET的传感器包括：感测室，包括参考电极和多个感测FET; 以及包括参考电极和多个参考FET的参考室。该方法包括：使第一溶液流入和流出基于FET的传感器的感测室和参考室; 使预期含有离子材料的第二溶液流入和流出感测室，同时使第一溶液持续流入和移出参考室; 测量每个感测和参考FET的源极和漏极之间的沟道区域中的电流; 并校正感测FET的电流。

8. 发明申请

US20140202866A1 NANOSENSOR AND METHOD OF MANUFACTURING SAME 有权
标题翻译：纳米传感器及其制造方法
公开(公告)号：US20140202866A1
公开(公告)日：2014-07-24
申请号：US14224770
申请日：2014-03-25
申请人： Jeo-young SHIM , Tae-han Jeon , Dong-ho Lee , Hee-jeong Jeong , Seong-ho Cho
发明人： Jeo-young SHIM , Tae-han Jeon , Dong-ho Lee , Hee-jeong Jeong , Seong-ho Cho
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , G01N33/48721
摘要： A nanosensor may include a substrate that has a hole formed therein, a first insulating layer that is disposed on the substrate and has a nanopore formed therein, first and second electrodes that are disposed on the first insulating layer and are spaced apart from each other, first and second electrode pads that are disposed on the first and second electrodes, respectively, and a protective layer disposed on the first and second electrode pads. A method of manufacturing a nanosensor may include forming a first insulating layer, graphene, and a metal layer on a substrate, patterning the metal layer and the graphene, forming a protective layer on a portion of the graphene and the metal layer, exposing a portion of the graphene by removing a portion of the protective layer, forming a hole in the substrate, and forming a nanopore in the first insulating layer and the graphene to be connected to the hole.
摘要翻译：纳米传感器可以包括其中形成有孔的基板，设置在基板上并且在其中形成有纳米孔的第一绝缘层，设置在第一绝缘层上并彼此间隔开的第一和第二电极，分别设置在第一和第二电极上的第一和第二电极焊盘以及设置在第一和第二电极焊盘上的保护层。制造纳米传感器的方法可以包括在基板上形成第一绝缘层，石墨烯和金属层，图案化金属层和石墨烯，在石墨烯和金属层的一部分上形成保护层，将部分通过去除保护层的一部分，在衬底中形成孔，并在第一绝缘层中形成纳米孔和与孔连接的石墨烯。

9. 发明申请

US20130265031A1 NANOGAP SENSOR AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译： NANOGAP传感器及其制造方法
公开(公告)号：US20130265031A1
公开(公告)日：2013-10-10
申请号：US13605711
申请日：2012-09-06
申请人： Jeo-young SHIM , Tae-han JEON , Kun-sun EOM , Dong-ho LEE , Hee-jeong JEONG , Seong-ho CHO
发明人： Jeo-young SHIM , Tae-han JEON , Kun-sun EOM , Dong-ho LEE , Hee-jeong JEONG , Seong-ho CHO
IPC分类号： H01L29/15 , H01L21/42 , G01N27/00 , B82Y15/00 , B82Y40/00
CPC分类号： G01N15/1031 , B82Y15/00 , G01N15/1056 , G01N33/48721 , G01N2015/0038
摘要： A nanogap sensor includes a first layer in which a micropore is formed; a graphene sheet disposed on the first layer and including a nanoelectrode region in which a nanogap is formed, the nanogap aligned with the micropore; a first electrode formed on the grapheme sheet; and a second electrode formed on the graphene sheet, wherein the first electrode and the second electrode are connected to respective ends of the nanoelectrode region.
摘要翻译：纳米隙传感器包括其中形成微孔的第一层; 设置在所述第一层上并且包括其中形成有纳米隙的纳米电极区域的所述纳米隙与所述微孔对准的石墨烯片; 形成在所述刻画片上的第一电极; 以及形成在所述石墨烯片上的第二电极，其中所述第一电极和所述第二电极连接到所述纳米电极区域的各个端部。

10. 发明申请

US20120326732A1 NANOSENSOR AND METHOD OF DETECTING TARGET MOLECULE BY USING THE SAME 审中-公开
标题翻译：用它们检测目标分子的纳米传感器和方法
公开(公告)号：US20120326732A1
公开(公告)日：2012-12-27
申请号：US13475643
申请日：2012-05-18
申请人： Seong-ho CHO , Dong-ho LEE , Jeo-young SHIM
发明人： Seong-ho CHO , Dong-ho LEE , Jeo-young SHIM
IPC分类号： G01N27/04 , G01N27/02 , G01N27/22
CPC分类号： G01N33/48721 , B82Y15/00
摘要： The present disclosure includes a sensor and method for detecting a target molecule. In one instance, a sensor comprises a substrate including a hole, a first insulating layer located on the substrate and including a first nanopore corresponding to the hole, a first electrode, a second electrode, wherein the first electrode and the second electrode are located on a surface of the first insulating layer and are spaced apart by the first nanopore forming a nanogap, and a modulation unit configured to apply a unit input signal between the first electrode and the second electrode, wherein at least one unit input signal is applied as a target molecule passes through the nanogap.
摘要翻译：本公开内容包括用于检测靶分子的传感器和方法。在一种情况下，传感器包括基板，其包括孔，位于基板上的第一绝缘层，并且包括对应于该孔的第一纳米孔，第一电极，第二电极，其中第一电极和第二电极位于第一绝缘层的表面并且由形成纳米隙的第一纳米孔间隔开;以及调制单元，被配置为在第一电极和第二电极之间施加单位输入信号，其中至少一个单位输入信号作为靶分子通过纳米隙。

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