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1. 发明申请

US20110130442A1 NUCLEIC ACID CAPABLE OF CONTROLLING DEGRANULATION OF MAST CELL 审中-公开
标题翻译：控制细胞降解的核酸能力
公开(公告)号：US20110130442A1
公开(公告)日：2011-06-02
申请号：US12996082
申请日：2009-06-04
申请人： Kyoko Kosaka , Yoji Yamada , Kazumi Miura , Tatsuya Miyazawa , Tetsuo Yoshida
发明人： Kyoko Kosaka , Yoji Yamada , Kazumi Miura , Tatsuya Miyazawa , Tetsuo Yoshida
IPC分类号： A61K31/7088 , C07H21/04 , C12N15/63 , C07H21/02 , A61P17/00 , A61P11/06 , A61P37/08 , C12N5/00 , C40B30/06
CPC分类号： A61K31/713 , C12N15/113 , C12N2310/141 , C12N2330/10
摘要： Provided are a mast cell degranulation control agent, a diagnostic agent or therapeutic agent for a disease resulting from mast cell degranulation control, a method of controlling mast cell degranulation, and a screening method for a mast cell degranulation control agent, all of which involve the use of a nucleic acid and the like. These are useful in the diagnosis or treatment of a disease resulting from mast cell degranulation control.
摘要翻译：提供了肥大细胞脱粒控制剂，用于由肥大细胞脱粒控制引起的疾病的诊断剂或治疗剂，控制肥大细胞脱粒的方法和肥大细胞脱粒控制剂的筛选方法，所有这些都涉及使用核酸等。这些可用于诊断或治疗由肥大细胞脱粒控制引起的疾病。

2. 发明授权

US07709234B2 α-1,3-fucosyltransferase 失效
标题翻译： α-1,3-岩藻糖基转移酶
公开(公告)号：US07709234B2
公开(公告)日：2010-05-04
申请号：US11276029
申请日：2006-02-10
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N9/10 , C12N15/54 , C12P19/18
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译：本发明提供由动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法，涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。

3. 发明申请

US20070037178A1 Endocrine cell lines and method of using the same 审中-公开
标题翻译：内分泌细胞系及其使用方法
公开(公告)号：US20070037178A1
公开(公告)日：2007-02-15
申请号：US11332785
申请日：2006-01-17
申请人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
发明人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
IPC分类号： C12Q1/68 , A01K67/027 , C12P21/06 , C12N5/06
CPC分类号： C12Q1/6897
摘要： In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or evaluating a substance capable of acting on the cells using the cell line, (4) a method of screening or isolating a useful gene or useful peptide using the cell line and (5) a highly-sensitive and simple assay system for GPCR ligand used in the above expression cloning system.
摘要翻译：根据本发明，提供了（1）衍生自哺乳动物的下丘脑和朗格汉斯胰岛的各种细胞系，（2）使用细胞系作为宿主的活性肽的生产方法和活性肽前体基因的表达克隆系统（3）使用细胞系筛选或评价能够作用于细胞的物质的方法，（4）使用细胞系筛选或分离有用基因或有用肽的方法，和（5）高度敏感的和用于上述表达克隆系统的GPCR配体的简单测定系统。

4. 发明申请

US20070105096A1 Endocrine cell lines and methods of using same 审中-公开
标题翻译：内分泌细胞系及其使用方法
公开(公告)号：US20070105096A1
公开(公告)日：2007-05-10
申请号：US10511341
申请日：2003-04-16
申请人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
发明人： Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
IPC分类号： C40B30/06 , C12Q1/68 , C07H21/02 , C12N5/06 , C40B40/08
CPC分类号： G01N33/507 , C12N2510/04 , C12N2830/002 , G01N33/5008 , G01N33/5023 , G01N33/5026 , G01N33/5044 , G01N33/74 , G01N2500/10
摘要： In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or evaluating a substance capable of acting on the cells using the cell line, (4) a method of screening or isolating a useful gene or useful peptide using the cell line and (5) a highly-sensitive and simple assay system for GPCR ligand used in the above expression cloning system.
摘要翻译：根据本发明，提供了（1）衍生自哺乳动物的下丘脑和朗格汉斯胰岛的各种细胞系，（2）使用细胞系作为宿主的活性肽的生产方法和活性肽前体基因的表达克隆系统（3）使用细胞系筛选或评价能够作用于细胞的物质的方法，（4）使用细胞系筛选或分离有用基因或有用肽的方法，和（5）高度敏感的和用于上述表达克隆系统的GPCR配体的简单测定系统。

5. 发明申请

US20060246468A1 ALPHA-1,3-FUCOSYLTRANSFERASE 失效
公开(公告)号：US20060246468A1
公开(公告)日：2006-11-02
申请号：US11276029
申请日：2006-02-10
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12Q1/68 , C07H21/04 , C08B37/00 , C12P21/06 , C12N9/10 , C12N15/74 , C12N1/21
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译：本发明提供由从动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法，涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。

6. 发明授权

US07163791B2 α,2,8-sialyltransferase 失效
标题翻译： α，2,8-唾液酸转移酶
公开(公告)号：US07163791B2
公开(公告)日：2007-01-16
申请号：US10430325
申请日：2003-05-07
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N15/54 , C12N15/63 , C12N1/21 , C12Q1/68 , C12N9/10
CPC分类号： C12N9/1081
摘要： The invention provides a novel α-2,8-sialyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-2,8-sialyltransferase, a method of detecting, or suppressing the production of α-2,8-sialyltransferase by using the cDNA, a recombinant vector containing the DNA as an insert and cells harboring the recombinant vector as well as methods of preparing same. The α-2,8-sialyltransferase of the invention is useful, for example, in the production of carbohydrate chains having a useful physiological activity, for example the ganglioside GD3, and modifications thereof.
摘要翻译：本发明提供由从动物细胞克隆的基因表达的新型α-2,8-唾液酸转移酶，编码α-2,8-唾液酸转移酶的cDNA，检测或抑制α-2,8-唾液酸转移酶的产生的方法，唾液酸转移酶，使用含有DNA作为插入片段的重组载体和携带重组载体的细胞以及其制备方法。本发明的α-2,8-唾液酸转移酶可用于例如生产具有有用生理活性的糖链，例如神经节苷脂GD3及其修饰。

7. 发明申请

US20110121563A1 PIPE FASTENING STRUCTURE 有权
标题翻译：管道紧固结构
公开(公告)号：US20110121563A1
公开(公告)日：2011-05-26
申请号：US12948860
申请日：2010-11-18
申请人： Hideki Toyoshima , Kazumi Miura , Masakazu Nomura
发明人： Hideki Toyoshima , Kazumi Miura , Masakazu Nomura
IPC分类号： F16L27/047
CPC分类号： F16L19/025 , F02M55/005 , F16L19/0225
摘要： A pipe fastening structure includes an end member 16 attached to an end part of a metal pipe 10, and a nut 12 for fastening the end member 16 attached to the metal pipe 10 to a counterpart 14. In the pipe fastening structure, the end member has a first spherical part 20 to be brought into contact with a sealing surface 27 of the counterpart 14, a second spherical part 21 formed integrally with the first spherical part 20 so as to be in contact with a sliding surface 25 formed in the nut 12, and a neck 18 continuous with the second spherical part 21 and having the shape of a straight pipe. The outside diameter D1 of the neck 18 is approximately equal to outside diameter D of the metal pipe, the respective centers of spheres respectively defining the first and the second spherical parts are on the axis of the neck, and the ratio of the ratio α=D2/D, where D2 is a diameter of a contact circle on the first spherical part in contact with the sealing surface and D is the outside diameter of the metal pipe to the ratio β=D3/D, where D3 is a diameter of a contact circle on the second spherical part in contact with the sliding surface of the nut and D is the outside diameter of the metal pipe meet an expression: 1.0≧α/β≧0.80
摘要翻译：管紧固结构包括附接到金属管10的端部的端部构件16和用于将附接到金属管10的端部构件16紧固到对应物14的螺母12.在管道紧固结构中，端部构件具有与配对件14的密封面27接触的第一球形部20，与第一球形部20一体地形成为与形成在螺母12中的滑动面25接触的第二球形部21 以及与第二球形部21连续并具有直管形状的颈部18。颈部18的外径D1近似等于金属管的外径D，分别限定第一和第二球形部分的球体的各个中心在颈部的轴线上，比率α= D2 / D，其中D2是与密封表面接触的第一球形部分上的接触圆的直径，D是金属管的外径与比率bgr = D3 / D，其中D3是与螺母的滑动面接触的第二球形部分上的接触圆，D是金属管的外径，满足以下表达式：1.0≥α/＆bgr;≥0.80

8. 发明授权

US07291491B2 Polypeptides 失效
标题翻译：多肽
公开(公告)号：US07291491B2
公开(公告)日：2007-11-06
申请号：US10166098
申请日：2002-06-11
申请人： Minoru Fukuda , Katsutoshi Sasaki , Kazumi Miura , Satoshi Nakagawa , Tatsunari Nishi , Susumu Sekine
发明人： Minoru Fukuda , Katsutoshi Sasaki , Kazumi Miura , Satoshi Nakagawa , Tatsunari Nishi , Susumu Sekine
IPC分类号： C12N9/10 , C07H21/04 , C12P21/06
CPC分类号： C12N9/1051
摘要： The present invention provides pharmaceutical preparations for anti-inflammation, anti-infection, inhibition of cancer metastasis etc., foods such as dairy products etc., and a method for improving proteins, as well as a method for diagnosis of inflammatory diseases and cancer malignancy. According to the present invention, there can be provided a polypeptide having poly-N-acetyllactosamine sugar chains synthesis-related activity, a process for producing the polypeptide, DNA coding for the polypeptide, a process for producing the DNA, a recombinant vector having the DNA integrated therein, a transformant carrying the recombinant vector, an antibody recognizing the polypeptide, a process for producing poly-N-acetyllactosamine sugar chains by use of the DNA or the polypeptide, diagnosis and treatment of diseases such as inflammations, cancers etc. by use of the DNA, the polypeptide or the antibody, determination and immunostaining of the polypeptide of the present invention by use of the antibody, a method for screening a compound varying the expression of a gene coding for the polypeptide, and a method for screening a substance varying the activity of the polypeptide.
摘要翻译：本发明提供抗炎，抗感染，癌转移抑制等药物制剂，乳制品等食品，以及改善蛋白质的方法，以及炎性疾病和癌症恶性肿瘤的诊断方法。根据本发明，可以提供具有聚-N-乙酰乳糖胺糖链合成相关活性的多肽，制备多肽的方法，编码多肽的DNA，制备DNA的方法，具有整合在其中的DNA，携带重组载体的转化体，识别多肽的抗体，使用DNA或多肽产生聚-N-乙酰乳糖胺糖链的方法，诊断和治疗诸如炎症，癌症等疾病，通过使用DNA，多肽或抗体，通过使用抗体测定和免疫染色本发明的多肽，筛选改变编码多肽的基因的表达的化合物的方法，以及筛选方法物质改变多肽的活性。

9. 发明授权

US07094530B1 α-1,3-fucosyltransferase 失效
标题翻译： α-1,3-岩藻糖基转移酶
公开(公告)号：US07094530B1
公开(公告)日：2006-08-22
申请号：US08361306
申请日：1994-11-29
申请人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人： Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
IPC分类号： C12N15/54 , C12N9/10 , C12P19/18 , C12Q1/68
CPC分类号： C12N9/1051
摘要： The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译：本发明提供由从动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型，编码α-1,3-岩藻糖基转移酶的cDNA，检测或抑制α-1,3-岩藻糖基转移酶的产生的方法，涉及使用cDNA的1,3-岩藻糖基转移酶，含有DNA作为插入片段的重组载体，携带重组载体的细胞及其生产方法。本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链，例如唾液酸基路易斯x及其修饰。

10. 发明授权

US09004542B2 Pipe fastening structure 有权
标题翻译：管紧固结构
公开(公告)号：US09004542B2
公开(公告)日：2015-04-14
申请号：US12948860
申请日：2010-11-18
申请人： Hideki Toyoshima , Kazumi Miura , Masakazu Nomura
发明人： Hideki Toyoshima , Kazumi Miura , Masakazu Nomura
IPC分类号： F16L27/04 , F16L19/025 , F02M55/00 , F16L19/02
CPC分类号： F16L19/025 , F02M55/005 , F16L19/0225
摘要： A pipe fastening structure includes an end member attached to an end part of a metal pipe, and a nut for fastening the end member attached to the metal pipe to a counterpart. In the pipe fastening structure, the end member has a first spherical part to be brought into contact with a sealing surface of the counterpart, a second spherical part formed integrally with the first spherical part so as to be in contact with a sliding surface formed in the nut, and a neck continuous with the second spherical part and having the shape of a straight pipe.
摘要翻译：管紧固结构包括附接到金属管的端部的端部构件和用于将附接到金属管的端部构件紧固到对应物的螺母。在管紧固结构中，端部件具有与配件的密封面接触的第一球形部分，与第一球形部分一体形成的第二球形部分，以便与形成在其中的滑动表面接触螺母和与第二球形部分连续并具有直管形状的颈部。

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