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1. 发明授权

US08735103B2 Natural convection-driven PCR apparatus and method using disposable polymer chip 有权
标题翻译：自然对流驱动PCR装置及使用一次性聚合物芯片的方法
公开(公告)号：US08735103B2
公开(公告)日：2014-05-27
申请号：US11866979
申请日：2007-10-03
申请人： Kwang-Hyo Chung , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Kwang-Hyo Chung , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： C12P19/62 , C12M1/36 , C12M1/38 , C12Q1/68 , B01L7/00
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2300/088 , B01L2300/1827 , B01L2400/0445 , B01L2400/0472 , B01L2400/0688 , B33Y80/00 , C12Q1/6844
摘要： Provided is a natural convection-driven polymerase chain reaction (PCR) apparatus and method, which can periodically change temperature of a sample to make a natural convection-driven flow in a loop-shaped channel on a disposable polymer chip and contacting heating metal members maintained at different temperatures with channels. The natural convection-driven PCR apparatus includes: a polymer chip having a plurality of channels connected together to form a loop-shaped microchannel, a sample being filled inside the channels; a plurality of heating metal members contacting the loop-shaped microchannel of the polymer chip and transferring heat; a temperature controller connected to the heating metal members to maintain the heating metal members at different temperatures; a plurality of heaters connected to the heating metal members and the temperature controller to supply heat to the heating metal members; and temperature sensors connected to the heating metal members and the temperature controller.
摘要翻译：提供了一种自然对流驱动的聚合酶链反应（PCR）装置和方法，其可以周期性地改变样品的温度以在一次性聚合物芯片上的环形通道中进行自然对流驱动的流动，并且接触保持的加热金属构件在不同的温度与通道。自然对流驱动PCR装置包括：聚合物芯片，具有连接在一起形成环形微通道的多个通道，样品填充在通道内; 与聚合物芯片的环形微通道接触并传递热量的多个加热金属构件; 连接到所述加热金属部件以将所述加热金属部件保持在不同温度的温度控制器; 连接到加热金属部件的多个加热器和温度控制器，以向加热金属部件供热; 温度传感器连接到加热金属部件和温度控制器。

2. 发明申请

US20080131956A1 NATURAL CONVECTION-DRIVEN PCR APPARATUS AND METHOD USING DISPOSABLE POLYMER CHIP 有权
标题翻译：自然对流驱动PCR装置和使用可分散聚合物芯片的方法
公开(公告)号：US20080131956A1
公开(公告)日：2008-06-05
申请号：US11866979
申请日：2007-10-03
申请人： Kwang-Hyo CHUNG , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Kwang-Hyo CHUNG , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： C12M1/36
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2300/088 , B01L2300/1827 , B01L2400/0445 , B01L2400/0472 , B01L2400/0688 , B33Y80/00 , C12Q1/6844
摘要： Provided is a natural convection-driven polymerase chain reaction (PCR) apparatus and method, which can periodically change temperature of a sample to make a natural convection-driven flow in a loop-shaped channel on a disposable polymer chip and contacting heating metal members maintained at different temperatures with channels. The natural convection-driven PCR apparatus includes: a polymer chip having a plurality of channels connected together to form a loop-shaped microchannel, a sample being filled inside the channels; a plurality of heating metal members contacting the loop-shaped microchannel of the polymer chip and transferring heat; a temperature controller connected to the heating metal members to maintain the heating metal members at different temperatures; a plurality of heaters connected to the heating metal members and the temperature controller to supply heat to the heating metal members; and temperature sensors connected to the heating metal members and the temperature controller.
摘要翻译：提供了一种自然对流驱动的聚合酶链反应（PCR）装置和方法，其可以周期性地改变样品的温度以在一次性聚合物芯片上的环形通道中进行自然对流驱动的流动，并且接触保持的加热金属构件在不同的温度与通道。自然对流驱动PCR装置包括：聚合物芯片，具有连接在一起形成环形微通道的多个通道，样品填充在通道内; 与聚合物芯片的环形微通道接触并传递热量的多个加热金属构件; 连接到所述加热金属部件以将所述加热金属部件保持在不同温度的温度控制器; 连接到加热金属部件的多个加热器和温度控制器，以向加热金属部件供热; 温度传感器连接到加热金属部件和温度控制器。

3. 发明申请

US20080128341A1 MICRO FILTRATION DEVICE FOR SEPARATING BLOOD PLASMA AND FABRICATION METHOD THEREFOR 审中-公开
标题翻译：用于分离血浆等离子体的微滤膜装置及其制造方法
公开(公告)号：US20080128341A1
公开(公告)日：2008-06-05
申请号：US11933081
申请日：2007-10-31
申请人： Won-Ick JANG , Kwang-Hyo Chung , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Won-Ick JANG , Kwang-Hyo Chung , Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： B01D21/34 , B29C65/00
CPC分类号： B01L3/50273 , B01L3/502753 , B01L2300/0816 , B01L2300/0887 , B01L2400/0442 , B01L2400/0481 , B01L2400/086 , B29C65/48 , B29C66/54 , B29C66/71 , B29C66/91411 , B29C66/9161 , B29C66/91645 , B29C66/919 , B29C66/929 , B29K2021/00 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2027/06 , B29K2027/12 , B29K2027/16 , B29K2027/18 , B29K2033/12 , B29K2059/00 , B29K2067/006 , B29K2069/00 , B29K2071/00 , B29K2071/12 , B29K2077/00 , B29K2083/00 , B29L2031/14 , B29L2031/753 , B29L2031/756
摘要： Provided is a micro filtration device for separating blood plasma from whole blood without external actuation, and a method for fabricating the micro filtration device. The micro filtration device for separating blood plasma from whole blood includes: a whole blood inlet through which whole blood is introduced; a blood plasma outlet through which blood plasma separated from whole blood is discharged; a micro channel for connecting the whole blood inlet and the blood plasma outlet; a micro pump formed under the whole blood inlet to generate an air pressure without external actuation for moving whole blood from the whole blood inlet toward the blood plasma outlet through the micro channel; and a microstructure formed in the micro channel for separating blood plasma from the whole blood.
摘要翻译：本发明提供一种用于在不进行外部驱动的情况下将血浆与全血分离的微过滤装置，以及微过滤装置的制造方法。用于从全血分离血浆的微过滤装置包括：引入全血的全血入口; 排出从血液中分离出血浆的血浆出口; 用于连接全血入口和血浆出口的微通道; 形成在全血入口下方的微泵，以产生无外部致动的空气压力，以将全血从全血入口通过微通道移动到血浆出口; 以及在微通道中形成的用于从全血中分离血浆的微结构。

4. 发明授权

US07879629B2 Method for manufacturing floating structure of microelectromechanical system 有权
标题翻译：微机电系统浮动结构制造方法
公开(公告)号：US07879629B2
公开(公告)日：2011-02-01
申请号：US11927810
申请日：2007-10-30
申请人： Sang-Choon Ko , Chi-Hoon Jun , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Sang-Choon Ko , Chi-Hoon Jun , Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： H01L21/00 , H01L21/311
CPC分类号： B81C1/00801 , B81C2201/0133 , B81C2201/0136
摘要： Provided is a method for manufacturing a floating structure of a MEMS. The method for manufacturing a floating structure of a microelectromechanical system (MEMS), comprising the steps of: a) forming a sacrificial layer including a thin layer pattern doped with impurities on a substrate; b) forming a support layer on the sacrificial layer; c) forming a structure to be floated on the support layer by using a subsequent process; d) forming an etch hole exposing both side portions of the thin layer pattern; and e) removing the sacrificial layer through the etch hole to form an air gap between the support layer and the substrate.
摘要翻译：提供了一种用于制造MEMS的浮动结构的方法。一种用于制造微机电系统（MEMS）的浮动结构的方法，包括以下步骤：a）在衬底上形成包含掺杂有杂质的薄层图案的牺牲层; b）在牺牲层上形成支撑层; c）通过使用随后的方法形成浮在支撑层上的结构; d）形成暴露薄层图案的两侧部分的蚀刻孔; 以及e）通过所述蚀刻孔去除所述牺牲层，以在所述支撑层和所述基底之间形成气隙。

5. 发明授权

US07963147B2 Micro gas sensor and method for manufacturing the same 有权
标题翻译：微气体传感器及其制造方法
公开(公告)号：US07963147B2
公开(公告)日：2011-06-21
申请号：US11951986
申请日：2007-12-06
申请人： Chi-Hoon Jun , Sang-Choon Ko , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Chi-Hoon Jun , Sang-Choon Ko , Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： G01N7/00 , G01N27/12
CPC分类号： G01N27/128
摘要： Provided are a micro gas sensor for measuring a gas concentration configured to achieve a high heating and cooling rate of a gas sensitive layer, achieve temperature uniformity, and achieve durability against thermal impact and mechanical impact; and a method for manufacturing the micro gas sensor. The micro gas sensor includes: a vacuum cavity disposed in a substrate; a support layer covering the vacuum cavity; a sealing layer sealing the support layer and the vacuum cavity; a micro heater disposed on the sealing layer; a plurality of electrodes disposed on the micro heater, insulated from the micro heater; and a gas sensitive layer covering the electrodes.
摘要翻译：提供一种微气体传感器，用于测量构成为实现气敏感层的高加热和冷却速度的气体浓度，实现温度均匀性，并且实现耐热冲击和机械冲击的耐久性; 以及微气体传感器的制造方法。微气体传感器包括：设置在基板中的真空腔; 覆盖真空腔的支撑层; 密封层，密封支撑层和真空腔; 设置在密封层上的微加热器; 设置在微加热器上的多个电极，与微加热器绝缘; 以及覆盖电极的气敏层。

6. 发明申请

US20110101244A1 TARGET MATERIALS FOR GENERATING PROTONS AND TREATMENT APPARATUSES INCLUDING THE SAME 审中-公开
标题翻译：用于产生原子和处理装置的目标材料，包括它们
公开(公告)号：US20110101244A1
公开(公告)日：2011-05-05
申请号：US12845148
申请日：2010-07-28
申请人： Moon Youn JUNG , Nam Soo Myung , Hyun Woo Song , Hyeon-Bong Pyo , Seon-Hee Park , Gun Yong Sung
发明人： Moon Youn JUNG , Nam Soo Myung , Hyun Woo Song , Hyeon-Bong Pyo , Seon-Hee Park , Gun Yong Sung
IPC分类号： A61N5/00 , B32B15/04 , C23C16/00 , H05H1/24
CPC分类号： H05H6/00 , A61N5/10 , A61N2005/1087 , A61N2005/1088 , C23C16/24
摘要： Provided is a treatment apparatus including a target material for generating protons. The treatment apparatus includes a cylindrical bore member having an inner space to receive a patient; a proton generating target material provided to an inner surface of the bore member; and a laser adapted to supply a laser beam to the proton generating target material so that protons are generated from the proton generating target material and projected to a tumor site of the patient. The proton generating target material includes a supporting film and a hydrogenated amorphous silicon (a-Si:H) film provided on the supporting film.
摘要翻译：提供了包括用于产生质子的靶材料的处理装置。处理装置包括具有用于接收患者的内部空间的圆柱形孔构件; 设置在所述孔构件的内表面上的质子产生靶材料; 以及适于将激光束提供给质子产生靶材料的激光，使得质子从质子产生靶材料产生并投射到患者的肿瘤部位。质子产生靶材料包括支撑膜和设置在支撑膜上的氢化非晶硅（a-Si：H）膜。

7. 发明授权

US07751052B2 Surface plasmon resonance sensor capable of performing absolute calibration 失效
标题翻译：能进行绝对校准的表面等离子体共振传感器
公开(公告)号：US07751052B2
公开(公告)日：2010-07-06
申请号：US11949744
申请日：2007-12-03
申请人： Hyeon-Bong Pyo , Seon-Hee Park
发明人： Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/211 , G01N21/274 , G01N21/8422
摘要： There is provided a surface plasmon resonance imaging sensor capable of performing absolute calibration comprising: a transparent substrate; a first prism and a second prism formed at one surface of the substrate and symmetrically positioned with reference to the center axis of the substrate; an optical system for providing light to the first and second prisms; and a light receiving part for detecting the light reflected from the substrate, wherein a surface plasmon resonance (SPR) angle change of an object to be measured by the first prism is measured, and a refractive index change on each pixel of the object is obtained as a two-dimensional difference image by the second prism.
摘要翻译：提供能够执行绝对校准的表面等离子体共振成像传感器，包括：透明基板; 形成在所述基板的一个表面并相对于所述基板的中心轴对称地定位的第一棱镜和第二棱镜; 用于向第一和第二棱镜提供光的光学系统; 以及用于检测从基板反射的光的光接收部分，其中测量由第一棱镜测量的物体的表面等离子体共振（SPR）角度变化，并且获得物体的每个像素上的折射率变化作为第二棱镜的二维差分图像。

8. 发明申请

US20100135856A1 NANOPARTICLE FOR DETECTING BIOMATERIALS AND BIOSENSOR BY USING THE NANOPARTICLE 审中-公开
标题翻译：用于检测生物体和生物传感器的纳米颗粒使用纳米颗粒
公开(公告)号：US20100135856A1
公开(公告)日：2010-06-03
申请号：US12482223
申请日：2009-06-10
申请人： Hyeon-Bong PYO , Moon-Youn Jung , Seon-Hee Park
发明人： Hyeon-Bong PYO , Moon-Youn Jung , Seon-Hee Park
IPC分类号： G01N33/543 , B32B5/00 , G01N33/544 , G01N33/551 , G01N33/552 , G01N33/553
CPC分类号： G01N33/54346 , B82Y15/00 , G01N2610/00 , Y10T428/2991
摘要： Provided are a nanoparticle for detecting biomaterials and a biosensor by using the nanoparticle. The nanoparticle includes a metal nanostructure around which an electric field is induced by localized surface plasmon resonance when light is irradiated onto a surface of the metal nanostructure, a spacer covering the surface of the metal nanostructure, and capture molecules specifically reacting with fluorophore-labeled target molecules, and immobilized on a surface of the spacer.
摘要翻译：提供了通过使用纳米颗粒检测生物材料的纳米颗粒和生物传感器。纳米颗粒包括金属纳米结构，当光照射到金属纳米结构的表面上时，通过局部表面等离子体共振诱发电场，覆盖金属纳米结构表面的间隔区，并捕获与荧光团标记的靶特异性反应的分子分子，并固定在间隔物的表面上。

9. 发明申请

US20080132598A1 SURFACE MODIFICATION OF CYCLOOLEFIN COPOLYMER SUBSTRATES 审中-公开
标题翻译：环烯烃共聚物基材的表面改性
公开(公告)号：US20080132598A1
公开(公告)日：2008-06-05
申请号：US11930964
申请日：2007-10-31
申请人： Young-Jun Kim , Won-Ick Jang , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Young-Jun Kim , Won-Ick Jang , Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： C08F8/06
CPC分类号： C08J7/123 , C08F8/06 , C08F8/42 , C08J7/14 , C08J2365/00 , C08F132/00
摘要： Provided is a method for modifying the surface of cycloolefin copolymer substrates, which includes oxygen plasma treatment and acid treatment for immobilizing a variety of functional groups or compounds having the functional groups onto the surface so that the surface can be easily modified, or can have hydrophilic property or biocompatibility. The method for modifying surface of cycloolefin copolymer substrates includes the steps of: a) treating the surface of a cycloolefin copolymer substrate with oxygen plasma to form hydroxyl groups on the surface; b) treating the oxygen plasma treated surface with an acid; and c) immobilizing one or more compounds having a functional group to the acid treated surface.
摘要翻译：提供了一种改性环烯共聚物基材表面的方法，其包括氧等离子体处理和酸处理，用于将各种具有官能团的官能团或具有官能团的化合物固定在表面上，使得表面可以容易地改性或可具有亲水性财产或生物相容性。改性环烯共聚物基材表面的方法包括以下步骤：a）用氧等离子体处理环烯烃共聚物基材的表面以在表面上形成羟基; b）用酸处理氧等离子体处理的表面; 和c）将一种或多种具有官能团的化合物固定在酸处理过的表面上。

10. 发明授权

US06430427B1 Method for obtaining trabecular index using trabecular pattern and method for estimating bone mineral density using trabecular indices 有权
标题翻译：使用小梁模式获得小梁指数的方法和使用小梁指数估计骨矿物质密度的方法
公开(公告)号：US06430427B1
公开(公告)日：2002-08-06
申请号：US09371264
申请日：1999-08-10
申请人： Soo-Yeul Lee , Seon-Hee Park , Seung-Hwan Kim , Hyeon-Bong Pyo
发明人： Soo-Yeul Lee , Seon-Hee Park , Seung-Hwan Kim , Hyeon-Bong Pyo
IPC分类号： A61B505
CPC分类号： A61B6/505
摘要： A method for obtaining a trabecular index using a trabecular pattern displayed on an X-ray image and a method for estimating a bone mineral density using trabecular indices are disclosed. The method for obtaining the trabecular index analyzes trabecular pattern changes, due to decalcifications of trabeculae, displayed on the X-ray picture and quantifies the changes, thereby obtaining the trabecular index. The method for estimating the bone mineral density obtains trabecular indices and then estimates the bone mineral density corresponding to the trabecular index using a functional relation between the trabecular index and actual bone mineral density.
摘要翻译：公开了一种使用X射线图像上显示的小梁图案获得小梁指数的方法和使用小梁指数估计骨矿物质密度的方法。获得小梁指数的方法分析了由于小梁解体引起的小梁模式变化，显示在X射线图片上并量化变化，从而获得小梁指数。估计骨矿物质密度的方法获得小梁指数，然后使用小梁指数与实际骨矿物质密度之间的函数关系来估计对应于小梁指数的骨矿物质密度。

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