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1. 发明申请

US20140052081A1 DONEPEZIL TRANSDERMAL PATCH 审中-公开
标题翻译：多奈米德超声波贴片
公开(公告)号：US20140052081A1
公开(公告)日：2014-02-20
申请号：US13979579
申请日：2012-01-12
申请人： Kuo-Hua Yang , Chih-Sheng Yang , Hsuen-Yau Lin
发明人： Kuo-Hua Yang , Chih-Sheng Yang , Hsuen-Yau Lin
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/7061 , A61K31/445
摘要： The present invention relates to a donepezil transdermal patch comprising a backing layer and a pressure sensitive adhesive matrix layer, wherein the pressure sensitive adhesive matrix layer comprises donepezil free base and an acrylic pressure sensitive adhesive agent selected from the group consisting of a copolymer of 2-ethylhexyl acrylate and vinyl acetate and a copolymer of 2-ethylhexyl acrylate, vinyl acetate, and hydroxyl-containing monomers, and wherein 2-ethylhexyl acrylate is present in an amount of about 65% to about 75%, vinyl acetate is present in an amount of about 25% to about 35%, and the hydroxyl-containing monomers are in an amount of about 0% to about 10%, based on the total weight of the copolymer.
摘要翻译：本发明涉及包含背衬层和压敏粘合剂基质层的多奈哌齐透皮贴剂，其中压敏粘合剂基质层包含多奈哌齐游离碱和丙烯酸压敏粘合剂，其选自2- 丙烯酸乙基己酯和乙酸乙烯酯和丙烯酸2-乙基己酯，乙酸乙烯酯和含羟基单体的共聚物，其中丙烯酸2-乙基己酯以约65％至约75％的量存在，乙酸乙烯酯的存在量为约25％至约35％，并且含羟基单体的量为约0％至约10％，基于共聚物的总重量。

2. 发明申请

US20050129719A1 Concentrated emulsion formulation for silatecan 审中-公开
标题翻译：硅酸盐的浓缩乳液制剂
公开(公告)号：US20050129719A1
公开(公告)日：2005-06-16
申请号：US10736307
申请日：2003-12-15
申请人： Yu-Fang Hu , Yao-Kun Huang , Huei-Tang Lin , Kuo-Hua Yang
发明人： Yu-Fang Hu , Yao-Kun Huang , Huei-Tang Lin , Kuo-Hua Yang
IPC分类号： A61K31/4745 , A61K31/695 , A61K47/10 , A61K47/24 , A61K9/00
CPC分类号： A61K9/0019 , A61K31/4745 , A61K31/695 , A61K47/10 , A61K47/24
摘要： The present application relates to a concentrated emulsion formulation for water-insoluble silatecan comprising silatecan of 0.01-1.0% (W/W), phospholipid of 4.79-75% (W/W); propylene glycol of 24.79˜95% (W/W); optional ethanol of 0.1-40% (W/W); optional surfactant of 0.1-10% (W/W), especially Tween® 80. The present application also relates to a method for manufacturing the concentrated emulsion formulation.
摘要翻译：本申请涉及含有0.01-1.0％（W / W）硅酸盐，4.79-75％（W / W）磷脂的水不溶性硅酸盐的浓缩乳液制剂; 丙二醇为24.79〜95％（W / W）; 可选乙醇为0.1-40％（W / W）; 0.1-10％（W / W）的任选的表面活性剂，特别是80。本申请还涉及一种制备浓缩乳液制剂的方法。

3. 发明授权

US07184131B2 Multifunction rangefinder 有权
标题翻译：多功能测距仪
公开(公告)号：US07184131B2
公开(公告)日：2007-02-27
申请号：US10912358
申请日：2004-08-05
申请人： Peng-Fei Song , Chih-Wei Hung , Pi-Yao Chien , Kuo-Hua Yang
发明人： Peng-Fei Song , Chih-Wei Hung , Pi-Yao Chien , Kuo-Hua Yang
IPC分类号： G01C3/08
CPC分类号： G01C15/002 , G01C3/06 , G01S17/023 , G01S17/10
摘要： A multifunction rangefinder capable of measuring distance, compass location and altitude. A distance measurement unit capable of long and short distance measurements transmits a light beam to a target, receives a reflected light from the target and outputs a distance measurement signal. A compass measurement unit measures terrestrial magnetism and outputs a compass measurement signal. An altitude measurement unit measures atmospheric pressure to generate an altitude measurement signal. A microprocessor calculates a distance between the target and the multifunction rangefinder, altitude and the compass location of the target according to the distance, altitude and compass measurement signals respectively.
摘要翻译：能够测量距离，罗盘位置和高度的多功能测距仪。能够进行长距离和短距离测量的距离测量单元将光束发射到目标，接收来自目标的反射光并输出距离测量信号。罗盘测量单元测量地磁并输出罗盘测量信号。高度测量单元测量大气压力以产生高度测量信号。微处理器根据距离，高度和罗盘测量信号分别计算目标和多功能测距仪之间的距离，高度和目标的罗盘位置。

4. 发明申请

US20050154549A1 METHOD OF MEASURING THE AZIMUTH AND RESETTING ZERO AZIMUTH AUTOMATICALLY 失效
标题翻译：测量AZIMUTH的方法并自动重新设置ZERO AZIMUTH
公开(公告)号：US20050154549A1
公开(公告)日：2005-07-14
申请号：US10756054
申请日：2004-01-12
申请人： Ai-Ling Lin , Kuo-Hua Yang
发明人： Ai-Ling Lin , Kuo-Hua Yang
IPC分类号： G01C1/02 , G01C17/32 , G01C17/38 , G01P21/00
CPC分类号： G01C17/38
摘要： A method of measuring the azimuth and resetting to zero azimuth automatically is disclosed. Multiple azimuths in longitudinal and latitudinal orientations are sampled by two orthogonal magnetic sensors installed in an azimuth meter, and then are output by corresponding first and second sine wave signals. These two sine wave signals are normalized by adjusting them to be of equal amplitude. The maximum and minimum values of the normalized sine wave signals are used to compute the average values of the respective normalized sine wave signals being of equal amplitude on the positive and negative sides. The resultant sine wave signals serve as the zero reference values for comparison with subsequently taken measuring signals to yield the actual azimuth. The numerical computation for the azimuth can be performed by a microprocessor with accuracy and high speed.
摘要翻译：公开了一种自动测量方位和复位到零方位的方法。通过安装在方位计上的两个正交磁传感器对纵向和纬向的多个方位进行采样，然后通过相应的第一和第二正弦波信号输出。这两个正弦波信号通过将它们调整为相等幅度来进行归一化。归一化正弦波信号的最大值和最小值用于计算在正侧和负侧具有相等振幅的相应归一化正弦波信号的平均值。所得的正弦波信号用作零参考值，用于与随后测量的信号进行比较以产生实际的方位角。方位角的数值计算可以由微处理器以精确，高速度进行。

5. 发明授权

US07106422B2 Rangefinder and measuring method 有权
标题翻译：测距仪和测量方法
公开(公告)号：US07106422B2
公开(公告)日：2006-09-12
申请号：US10875774
申请日：2004-06-24
申请人： Jui-Feng Huang , Lung-Pin Chung , Kuo-Hua Yang , Ai-Ling Lin
发明人： Jui-Feng Huang , Lung-Pin Chung , Kuo-Hua Yang , Ai-Ling Lin
IPC分类号： G01B11/00
CPC分类号： G01S7/487 , G01C3/08 , G01C17/30 , G01S7/4868 , G01S17/023 , G01S17/10
摘要： A Rangefinder capable of long and short distance measurement in company with compass measurement. The rangefinder includes distance measurement unit, a compass sensing unit and a processor. The rangefinder can selectively execute a comparison mode or a gain mode. The comparison mode is executed during short-distance measurement and the gain mode is executed during long-distance measurement. The compass measurement unit senses a terrestrial magnetism to obtain first and second magnetic sensing signals. The processor estimates a distance between the target and the rangefinder according to the measurement signal from the distance measurement unit and determines a compass orientation of the target according to the first and second magnetic sensing signals.
摘要翻译：一种距离测距仪，能够进行长距离和短距离测量，并配有罗盘测量。测距仪包括距离测量单元，罗盘感测单元和处理器。测距仪可以选择性地执行比较模式或增益模式。在短距离测量期间执行比较模式，并且在长距离测量期间执行增益模式。罗盘测量单元感测地磁以获得第一和第二磁感测信号。处理器根据距离测量单元的测量信号估计目标和测距仪之间的距离，并根据第一和第二磁感测信号确定目标的罗盘方位。

6. 发明申请

US20050185168A1 Multifunction rangefinder 有权
标题翻译：多功能测距仪
公开(公告)号：US20050185168A1
公开(公告)日：2005-08-25
申请号：US10912358
申请日：2004-08-05
申请人： Peng-Fei Song , Chih-Wei Hung , Pi-Yao Chien , Kuo-Hua Yang
发明人： Peng-Fei Song , Chih-Wei Hung , Pi-Yao Chien , Kuo-Hua Yang
IPC分类号： G01C3/00 , G01C3/06 , G01C3/08 , G01C3/20 , G01C15/00 , G01S1/00 , G01S17/02 , G01S17/10 , H04B7/185
CPC分类号： G01C15/002 , G01C3/06 , G01S17/023 , G01S17/10
摘要： A multifunction rangefinder capable of measuring distance, compass location and altitude. A distance measurement unit capable of long and short distance measurements transmits a light beam to a target, receives a reflected light from the target and outputs a distance measurement signal. A compass measurement unit measures terrestrial magnetism and outputs a compass measurement signal. An altitude measurement unit measures atmospheric pressure to generate an altitude measurement signal. A microprocessor calculates a distance between the target and the multifunction rangefinder, altitude and the compass location of the target according to the distance, altitude and compass measurement signals respectively.
摘要翻译：能够测量距离，罗盘位置和高度的多功能测距仪。能够进行长距离和短距离测量的距离测量单元将光束发射到目标，接收来自目标的反射光并输出距离测量信号。罗盘测量单元测量地磁并输出罗盘测量信号。高度测量单元测量大气压力以产生高度测量信号。微处理器根据距离，高度和罗盘测量信号分别计算目标和多功能测距仪之间的距离，高度和目标的罗盘位置。

7. 发明申请

US20050151956A1 Apparatus for precise distance measurement 有权
标题翻译：用于精确距离测量的设备
公开(公告)号：US20050151956A1
公开(公告)日：2005-07-14
申请号：US10756053
申请日：2004-01-12
申请人： Pie-Yau Chien , Dong Huang , Kuo-Hua Yang , Dan Duan
发明人： Pie-Yau Chien , Dong Huang , Kuo-Hua Yang , Dan Duan
IPC分类号： G01C3/08 , G01S7/491 , G01S17/36
CPC分类号： G01S17/36 , G01S7/4915
摘要： An apparatus for precise distance measurement has a multiple frequency generator, a laser transmitter, an optical receiver, a first measuring unit, a second measuring unit and a central processing unit. The laser transmitter outputs a light signal to a target, and the optical receiver receives the reflected light signal and mixes the base frequency signal from the multiple frequency generator and the reflected light signal and further outputs an measurement signal to the first and second measuring units. The first and second measuring units calculate respectively a time difference and a phase difference between the light signal and the reflected light signal. The central processing unit is connected to the first and second measuring units to calculate a precise distance by the time and the phase difference.
摘要翻译：用于精确距离测量的装置具有多频发生器，激光发射器，光接收器，第一测量单元，第二测量单元和中央处理单元。激光发射器将光信号输出到目标，并且光接收器接收反射光信号并混合来自多频发生器的基频信号和反射光信号，并进一步向第一和第二测量单元输出测量信号。第一和第二测量单元分别计算光信号和反射光信号之间的时间差和相位差。中央处理单元连接到第一和第二测量单元以计算时间和相位差之间的精确距离。

8. 发明申请

US20120027853A1 PROCESS FOR PREPARATION OF ANTI-TUBERCULAR COMBINATION AND PHARMACEUTICAL COMPOSITION PREPARED THEREFROM 有权
标题翻译：制备抗结核药物的方法和制备的药物组合物
公开(公告)号：US20120027853A1
公开(公告)日：2012-02-02
申请号：US12846476
申请日：2010-07-29
申请人： Li-Heng Pao , Nion-Heng Shiao , Kuo-Hua Yang , Jui-Ming Chou
发明人： Li-Heng Pao , Nion-Heng Shiao , Kuo-Hua Yang , Jui-Ming Chou
IPC分类号： A61K9/28 , A61P31/06 , B05D7/00 , A61K31/497
CPC分类号： A61K31/497 , A61K9/2077 , A61K9/209 , A61K9/2866 , A61K31/166 , A61K2300/00
摘要： This invention relates to a process for preparing a pharmaceutical composition comprising four antitubercular drugs: rifampin or a pharmaceutically acceptable salt thereof, isoniazid or a pharmaceutically acceptable salt thereof, pyrazinamide or a pharmaceutically acceptable salt thereof and ethambutol or a pharmaceutically acceptable salt thereof, wherein rifampin and isoniazid are in separate layers. The invention also provides a pharmaceutical composition prepared therefrom having advantageous stability and bioavailability.
摘要翻译：本发明涉及一种制备药物组合物的方法，其包含四种抗结核药物：利福平或其药学上可接受的盐，异烟肼或其药学上可接受的盐，吡嗪酰胺或其药学上可接受的盐和乙胺丁醇或其药学上可接受的盐，其中利福平异烟肼分开。本发明还提供由其制备的药物组合物，其具有有利的稳定性和生物利用度。

9. 发明申请

US20100081669A1 PRESSURE SENSITIVE ADHESIVE MATRIX DEVICE OR SYSTEM FOR THE TREATMENT OR PREVENTION OF ONYCHOMYCOSIS OR TINEA PEDIS 有权
标题翻译：用于治疗或预防结核病或TINEA PEDIS的压敏敏感胶粘剂装置或系统
公开(公告)号：US20100081669A1
公开(公告)日：2010-04-01
申请号：US12570656
申请日：2009-09-30
申请人： Kuo-Hua Yang , Yung-Jin Lee , Li-Chin Lin
发明人： Kuo-Hua Yang , Yung-Jin Lee , Li-Chin Lin
IPC分类号： A61K31/496 , A61K9/70 , A61P31/10
CPC分类号： A61K31/496 , A61K9/7023 , A61K9/7061 , A61K47/14
摘要： Disclosed is a pressure-sensitive adhesive matrix patch device for treatment or prevention of fungal toenails or fingernails or foot infections comprising an antifungal agent or two or more antifungals in combination and adhesively secured to a dorsal site of an infected palm or foot, rather than an area of infection and surrounding skin. A method for the transdermal treatment or prevention of fungal toenails or fingernails or foot infections with an antifungal agent is also disclosed, the method comprising adhesively securing to a dorsal site of an infected palm or foot a pressure-sensitive adhesive matrix patch device for a time sufficient to deliver an effective amount of the antifungal agent to an area of infection.
摘要翻译：公开了一种用于治疗或预防真菌趾甲或指甲或足部感染的压敏粘合剂基质贴片装置，其包含抗真菌剂或两种或更多种抗真菌剂的组合，并且粘附地固定到感染的手掌或足部的背部，而不是感染区域和周围皮肤。还公开了用抗真菌剂透皮治疗或预防真菌脚趾甲或指甲或足部感染的方法，所述方法包括将感染的手掌或足部的背部部位粘合固定一段时间的压敏粘合剂基质贴片装置足以将有效量的抗真菌剂递送至感染区域。

10. 发明申请

US20050134832A1 Rangefinder and measuring method 有权
标题翻译：测距仪和测量方法
公开(公告)号：US20050134832A1
公开(公告)日：2005-06-23
申请号：US10875774
申请日：2004-06-24
申请人： Jui-Feng Huang , Lung-Pin Chung , Kuo-Hua Yang , Ai-Ling Lin
发明人： Jui-Feng Huang , Lung-Pin Chung , Kuo-Hua Yang , Ai-Ling Lin
IPC分类号： G01C15/00 , G01C3/06 , G01C3/08 , G01C17/30 , G01S7/48 , G01S7/487 , G01S17/02 , G01S17/10 , G01S17/42
CPC分类号： G01S7/487 , G01C3/08 , G01C17/30 , G01S7/4868 , G01S17/023 , G01S17/10
摘要： A Rangefinder capable of long and short distance measurement in company with compass measurement. The rangefinder includes distance measurement unit, a compass sensing unit and a processor. The rangefinder can selectively execute a comparison mode or a gain mode. The comparison mode is executed during short-distance measurement and the gain mode is executed during long-distance measurement. The compass measurement unit senses a terrestrial magnetism to obtain first and second magnetic sensing signals. The processor estimates a distance between the target and the rangefinder according to the measurement signal from the distance measurement unit and determines a compass orientation of the target according to the first and second magnetic sensing signals.
摘要翻译：一种距离测距仪，能够进行长距离和短距离测量，并配有罗盘测量。测距仪包括距离测量单元，罗盘感测单元和处理器。测距仪可以选择性地执行比较模式或增益模式。在短距离测量期间执行比较模式，并且在长距离测量期间执行增益模式。罗盘测量单元感测地磁以获得第一和第二磁感测信号。处理器根据距离测量单元的测量信号估计目标和测距仪之间的距离，并根据第一和第二磁感测信号确定目标的罗盘方位。

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