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1. 发明申请

US20140052081A1 DONEPEZIL TRANSDERMAL PATCH 审中-公开
标题翻译：多奈米德超声波贴片
公开(公告)号：US20140052081A1
公开(公告)日：2014-02-20
申请号：US13979579
申请日：2012-01-12
申请人： Kuo-Hua Yang , Chih-Sheng Yang , Hsuen-Yau Lin
发明人： Kuo-Hua Yang , Chih-Sheng Yang , Hsuen-Yau Lin
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/7061 , A61K31/445
摘要： The present invention relates to a donepezil transdermal patch comprising a backing layer and a pressure sensitive adhesive matrix layer, wherein the pressure sensitive adhesive matrix layer comprises donepezil free base and an acrylic pressure sensitive adhesive agent selected from the group consisting of a copolymer of 2-ethylhexyl acrylate and vinyl acetate and a copolymer of 2-ethylhexyl acrylate, vinyl acetate, and hydroxyl-containing monomers, and wherein 2-ethylhexyl acrylate is present in an amount of about 65% to about 75%, vinyl acetate is present in an amount of about 25% to about 35%, and the hydroxyl-containing monomers are in an amount of about 0% to about 10%, based on the total weight of the copolymer.
摘要翻译：本发明涉及包含背衬层和压敏粘合剂基质层的多奈哌齐透皮贴剂，其中压敏粘合剂基质层包含多奈哌齐游离碱和丙烯酸压敏粘合剂，其选自2- 丙烯酸乙基己酯和乙酸乙烯酯和丙烯酸2-乙基己酯，乙酸乙烯酯和含羟基单体的共聚物，其中丙烯酸2-乙基己酯以约65％至约75％的量存在，乙酸乙烯酯的存在量为约25％至约35％，并且含羟基单体的量为约0％至约10％，基于共聚物的总重量。

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