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1. 发明专利

JP2009221191A Anticaries oral composition and food and drink 审中-公开
标题翻译： ANTICARIES口腔成分和食物和饮料
公开(公告)号：JP2009221191A
公开(公告)日：2009-10-01
申请号：JP2009034750
申请日：2009-02-18
申请人： Kracie Seiyaku Kk , Toyama Prefecture , クラシエ製薬株式会社 , 富山県
发明人： ITO SHINYA , MATSUNAGA TAKAYUKI , OGASAWARA MASARU , YAMAMOTO KEIICHI , KATSUBE YUJI
IPC分类号： A61K31/353 , A23L1/30 , A23L2/52 , A61K8/49 , A61K8/97 , A61K36/00 , A61P1/02 , A61P43/00 , A61Q11/00
摘要： PROBLEM TO BE SOLVED: To provide a low-concentration good-flavored oral composition very safe for humans which contains substances highly active to inhibit glucosyltransferase for the prevention and amelioration of oral cavity-related diseases, especially caries and being a substitute for highly astringent and bitter epigallocatechin. SOLUTION: The composition contains as active ingredients epitheaflagallin and/or epitheaflagallin-3-O-gallate contained in a green tea extract treated with polyphenol oxidase (laccase). COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供对于含有高度活性的抑制葡糖基转移酶的物质，对于预防和改善口腔相关疾病，特别是龋齿并且是替代的，为人提供非常安全的低浓度好味口味组合物高度收敛和苦涩的表没食子儿茶素。解决方案：组合物含有用多酚氧化酶（漆酶）处理的绿茶提取物中所含的作为活性成分的上皮脂蛋白和/或上皮蛋白凝胶-3-O-没食子酸酯。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2009114079A Inhibitor against rise in postprandial blood neutral fat concentration and food and beverage 有权
标题翻译：抑制剂对抗血浆中性脂肪浓度和食物和饮料的升高
公开(公告)号：JP2009114079A
公开(公告)日：2009-05-28
申请号：JP2007285650
申请日：2007-11-02
申请人： Kracie Seiyaku Kk , Toyama Prefecture , クラシエ製薬株式会社 , 富山県
发明人： ITO SHINYA , MATSUNAGA TAKAYUKI , OGASAWARA MASARU , KATSUBE YUJI , YAMAMOTO KEIICHI
IPC分类号： A61K31/353 , A23L1/30 , A61P3/04 , A61P3/06 , C07D311/60
摘要： PROBLEM TO BE SOLVED: To obtain an inhibitor against rise in postprandial blood neutral fat concentration, having an excellent inhibitory effect on neutral fat absorption and a food and beverage having an inhibitory effect on neutral fat absorption. SOLUTION: The inhibitor against rise in postprandial blood neutral fat concentration includes epitheaflagallin-3-O-gallate as an active ingredient. The food and beverage comprise the inhibitor against rise in postprandial blood neutral fat concentration. Epitheaflagallin-3-O-gallate is obtained by adding gallic acid to a tea extract containing epigallocatechin gallate and treating the resultant substance with polyphenol oxidase. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：获得对中性脂肪吸收具有优异抑制作用的餐后血液中性脂肪浓度升高抑制剂和对中性脂肪吸收具有抑制作用的食品和饮料。解决方案：餐后血液中性脂肪浓度升高的抑制剂包括上皮脂蛋白-3-O-没食子酸酯作为活性成分。食品和饮料包括防止餐后血液中性脂肪浓度升高的抑制剂。通过向含有表没食子儿茶素没食子酸酯的茶提取物中加入没食子酸，并用多酚氧化酶处理所得物质，得到海藻糖苷-3-O-没食子酸酯。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2007319140A Method for producing epitheaflagallins and method for producing beverage containing epitheaflagallins 有权
标题翻译：生产水杨酸的方法和生产含有水杨酸的饮料的方法
公开(公告)号：JP2007319140A
公开(公告)日：2007-12-13
申请号：JP2006156488
申请日：2006-06-05
申请人： Kracie Seiyaku Kk , Toyama Prefecture , クラシエ製薬株式会社 , 富山県
发明人： ITO SHINYA , KATSUBE YUJI , YAMAMOTO KEIICHI , NAKAJIMA NORIYUKI
IPC分类号： C12P17/06 , A23F3/14 , A23F3/16 , A23L2/38 , A23L2/52
CPC分类号： A23F3/166 , A23F3/163 , C12P17/06
摘要： PROBLEM TO BE SOLVED: To provide a simple method for producing epitheaflagallin and epitheaflagallin 3-O-gallate usable directly in food, and to provide a method for producing a bevearge containing epitheaflagallin and/or epitheaflagallin 3-O-gallate utilizing the above simple method. SOLUTION: The method for producing epitheaflagallins comprises making polyphenol oxidase act on epigallocatechin and/or epigallocatechin gallate in the presence of gallic acid to effect conversion to epitheaflagallin and/or epitheaflagallin 3-O-gallate, respectively. The method for producing the bevearge containing epitheaflagallins comprises converting at least part of epigallocatechin and/or epigallocatechin gallate contained in tea extract to epitheaflagallin and/or epitheaflagallin 3-O-gallate, respectively. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于直接在食品中生产上皮脂蛋白和上皮糖蛋白3-O-没食子酸酯的简单方法，并且提供一种用于生产含有上皮脂蛋白和/或上皮蛋白凝集素3-O-没食子酸酯的平均值的方法，以上简单的方法。解决方案：产生上皮蛋白凝胶的方法包括在没食子酸存在下使多酚氧化酶作用于表没食子儿茶素和/或表没食子儿茶素没食子酸酯，分别转化为上皮脂蛋白和/或上皮蛋白3-O-没食子酸酯。用于生产含有上皮蛋白凝胶素的所述方法包括将茶提取物中所含的表没食子儿茶素和/或表没食子儿茶素没食子酸酯的至少一部分分别转化成上皮蛋白凝胶和/或上皮样凝集素3-O-没食子酸酯。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2013179849A Laccase and method for producing epitheaflagallin using the same 有权
标题翻译：使用该方法生产草坪草的薄膜和方法
公开(公告)号：JP2013179849A
公开(公告)日：2013-09-12
申请号：JP2012043815
申请日：2012-02-29
申请人： Toyama Prefecture , 富山県 , Taiyo Kagaku Co Ltd , 太陽化学株式会社 , Kracie Seiyaku Kk , クラシエ製薬株式会社
发明人： ITO SHINYA , KUROKAWA JUNJI , MATSUNAGA TAKAYUKI , OGASAWARA MASARU , OKUBO TSUTOMU , OKONOGI AKIRA , KATSUBE YUJI
IPC分类号： C12N15/09 , A23F3/16 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12P7/18
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a new laccase having high productivity in a method for enhancing the content of epitheaflagallins by oxidizing green tea catechin in the presence of gallic acid, furthermore, a method for producing epitheaflagallins using the laccase and a method for producing beverages containing epitheaflagallins.SOLUTION: There is provided a laccase having the following physico-chemical properties: (i) molecular weight: 67.2 kDa (SDS-PAGE), (ii) subunit structure: monomer, (iii) optimum pH: pH 4.5, (iv) N-terminal amino acid sequence of natural enzyme: Ala-Ile-Gly-Pro-Val-Thr-Asp-Leu-His-Ile. The laccase is applied to epigallocatechins, in the presence of gallic acid, to obtain each epitheaflagallin. In the same way, the epigallocatechins included in the green tea extract are converted into epitheaflagallins.
摘要翻译：要解决的问题：提供一种在没食子酸存在下，通过氧化绿茶儿茶素来提高上皮淀粉蛋白含量的方法中具有高生产率的新漆酶，此外，使用漆酶生产上皮蛋白凝胶的方法和制备饮料的方法提供具有以下物理化学性质的漆酶：（i）分子量：67.2kDa（SDS-PAGE），（ii）亚单位结构：单体，（iii）最适pH：pH 4.5，（ iv）天然酶的N-末端氨基酸序列：Ala-Ile-Gly-Pro-Val-Thr-Asp-Leu-His-Ile。在没食子酸存在下，将漆酶应用于表没食子儿茶素，以获得每种上皮蛋白。以同样的方式，包含在绿茶提取物中的表没食子儿茶素被转化成上皮蛋白。

5. 发明专利

JP2009219484A Oral composition for anti-periodontal disease, and food and beverage 审中-公开
标题翻译：口腔组合物用于抗周期疾病，食物和饮料
公开(公告)号：JP2009219484A
公开(公告)日：2009-10-01
申请号：JP2009034751
申请日：2009-02-18
申请人： Kracie Seiyaku Kk , Toyama Prefecture , クラシエ製薬株式会社 , 富山県
发明人： ITO SHINYA , KATSUBE YUJI , MATSUNAGA TAKAYUKI , OGASAWARA MASARU , YAMAMOTO KEIICHI
IPC分类号： A23L1/30 , A61K8/49 , A61K8/97 , A61Q11/00
摘要： PROBLEM TO BE SOLVED: To provide a low-density oral composition including a substance excellent in inhibition and/or production inhibition of matrix protease for prevention and improvement of oral-related disease, in particular, in periodontal disease patients, used as a substitute for epigallocatechin-3-O-gallate having a strong astringent taste or bitter taste, and having a good flavor and being extremely high safety to the human body. SOLUTION: The oral composition has epitheaflagallin-3-O-gallate or theaflavin-3-O-gallate contained in a black tea extract or laccase-treated green tea extract, as an active ingredient, and has the effects of MMP and MMP production inhibitions. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种低密度口服组合物，其包括基质蛋白酶的抑制和/或抑制作用优异的物质，用于预防和改善口腔相关疾病，特别是在牙周病患者中用作具有强涩味或苦味的表没食子儿茶素-3-邻氯乙酸酯的替代品，具有良好的风味并且对人体的安全性极高。解决方案：口服组合物含有红茶提取物或漆酶处理的绿茶提取物中所含的没有上皮脂酰-III-O-没食子酸酯或无叶黄素-3-O-没食子酸酯作为活性成分，并且具有MMP和 MMP生产抑制。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2014168387A Reductase gene amplification primer set, and reductase gene acquisition method 有权
标题翻译：降低基因扩增引物集和降低基因获得方法
公开(公告)号：JP2014168387A
公开(公告)日：2014-09-18
申请号：JP2013040378
申请日：2013-03-01
申请人： Sumitomo Chemical Co Ltd , 住友化学株式会社 , Toyama Prefecture , 富山県
发明人： ITO SHINYA , KUROKAWA JUNJI , ASAKO HIROYUKI
IPC分类号： C12N15/09 , C12N1/21 , C12N9/02
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently acquiring a nucleic acid which encodes a reductase, and also to provide a nucleic acid encoding reductase and the like acquirable by the method.SOLUTION: A method and the like for acquiring a nucleic acid encoding a reductase are provided, the method comprising: (1) performing a nucleic acid amplification reaction with a DNA sample as a template to acquire an amplification product; (2) fusing the amplification product and a double-stranded vector DNA functionable as an expression vector in a host cell upon cyclization in the presence of a DNA polymerase having an endogenous 3'-5' exonuclease activity to acquire a cyclic recombinant expression vector containing the amplification product; (3) introducing the cyclic recombinant expression vector into the host cell to acquire transformants; (4) selecting a transformant having an activity for reducing the substrate; and (5) acquiring a nucleic acid which encodes a reductase having the activity, from the transformant selected in the step (4).
摘要翻译：要解决的问题：提供一种有效获得编码还原酶的核酸的方法，并且还提供通过该方法获得的编码还原酶等的核酸。解决方案：用于获得核酸编码的方法等提供还原酶，该方法包括：（1）以DNA样品作为模板进行核酸扩增反应以获得扩增产物; （2）在具有内源3'-5'核酸外切酶活性的DNA聚合酶存在下，将扩增产物和可作为表达载体作为表达载体的双链载体DNA在宿主细胞中进行环化以获得含有扩增产物; （3）将环状重组表达载体导入宿主细胞以获得转化体; （4）选择具有降低底物活性的转化体; 和（5）从步骤（4）中选择的转化体获得编码具有活性的还原酶的核酸。

7. 发明专利

JP2011147349A Quinuclidinone reductase and method for producing optically-active 3-quinuclidinol using the same 有权
标题翻译：喹诺酮降低剂及使用其生产光学活性3-喹啉酮的方法
公开(公告)号：JP2011147349A
公开(公告)日：2011-08-04
申请号：JP2010008747
申请日：2010-01-19
申请人： Mitsubishi Rayon Co Ltd , Toyama Prefecture , 三菱レイヨン株式会社 , 富山県
发明人： ITO SHINYA
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12P13/00 , C12P17/10 , C12P21/02
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a new quinuclidinone reductase and its gene; and to provide an industrially-advantageous method for producing an optically-active 3-quinuclidinol useful as a synthetic intermediate for medicines and agricultural chemicals or its salt by asymmetric reduction reaction induced by the reductase. SOLUTION: The quinuclidinone reductase has the following physical and chemical properties: (i) in a molecular weight, a value measured by gel filtration chromatography is in the range of 90,000-95,000 Da, and a value measured by SDS-polyacrylamide gel electrophoresis is in the range of 32,000-36,000 Da; (ii) optimal pH is in the range of 6.0-8.0; and (iii) NADH or its derivative is required as a coenzyme. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供新的奎宁环还原酶及其基因; 并且提供了用于制备用作药物和农药或其盐的合成中间体的光学活性3-奎宁环醇的工业上有利的方法，其通过由还原酶诱导的不对称还原反应。解决方案：奎宁环还原酶具有以下物理和化学性质：（i）在分子量中，通过凝胶过滤色谱法测量的值在90,000-95,000Da的范围内，并且通过SDS-聚丙烯酰胺凝胶测量的值电泳在32,000-36,000 Da范围内; （ii）最佳pH范围为6.0-8.0; 和（iii）NADH或其衍生物作为辅酶是必需的。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2010051207A Quinuclidinone reductase and method for producing optically-active 3-quinuclidinol using the same 有权
标题翻译：喹诺酮降低剂及使用其生产光学活性3-喹啉酮的方法
公开(公告)号：JP2010051207A
公开(公告)日：2010-03-11
申请号：JP2008218142
申请日：2008-08-27
申请人： Mitsubishi Rayon Co Ltd , Toyama Prefecture , 三菱レイヨン株式会社 , 富山県
发明人： ITO SHINYA
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/06 , C12P17/12
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a new quinuclidinone reductase and its gene; and to provide an industrially-advantageous method for producing an optically-active 3-quinuclidinol useful as a synthetic intermediate for medicines and agricultural chemicals or its salt by asymmetric reduction reaction induced by the reductase.
SOLUTION: The quinuclidinone reductase has the following physical and chemical properties: (i) in a molecular weight, a value measured by gel filtration chromatography is in the range of 70,000-73,000 Da, and a value measured by SDS-polyacrylamide gel electrophoresis is in the range of 29,500-31,500 Da; (ii) optimal pH is in the range of 6.0-8.0; and (iii) an NADH or its derivative is required as a coenzyme.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供新的奎宁环还原酶及其基因; 并且提供了用于制备用作药物和农药或其盐的合成中间体的光学活性3-奎宁环醇的工业上有利的方法，其通过由还原酶诱导的不对称还原反应。解决方案：奎宁环还原酶具有以下物理和化学性质：（i）在分子量中，通过凝胶过滤色谱法测量的值在70,000-73,000Da的范围内，并且通过SDS-聚丙烯酰胺凝胶测量的值电泳在29,500-31,500 Da范围内; （ii）最佳pH范围为6.0-8.0; 和（iii）NADH或其衍生物作为辅酶是必需的。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2013172682A Mutation-type reductase and utilization thereof 审中-公开
标题翻译：突变型还原及其利用
公开(公告)号：JP2013172682A
公开(公告)日：2013-09-05
申请号：JP2012039796
申请日：2012-02-27
申请人： Toyama Prefecture , 富山県 , Sumitomo Chemical Co Ltd , 住友化学株式会社
发明人： ITO SHINYA , ASAKO HIROYUKI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12P7/06
CPC分类号： Y02E50/17
摘要： PROBLEM TO BE SOLVED: To provide a mutation-type reductase utilizable in a reduction reaction, and to provide the utilization or the like of the reductase.SOLUTION: There is provided an enzyme having an amino acid sequence equivalent to an original amino acid sequence except having four or more amino acid mutations including the whole of the following basic amino acid mutations (a) to (d) in a specific amino acid sequence originated from Rhodococcus erythropolis, and further having the ability for reducing a substrate. : (a) the amino acid mutation by the substitution of the 12th glutamic acid with glycine; (b) the amino acid mutation by the substitution of the 42th aspartic acid with valine; (c) the amino acid mutation by the substitution of the 67th lysine with arginine; and (d) the amino acid mutation by the substitution of the 317th serine with alanine.
摘要翻译：要解决的问题：提供可用于还原反应的突变型还原酶，并提供还原酶的利用等。溶液：提供具有与原始氨基酸序列等同的氨基酸序列的酶，除了具有四个或更多个氨基酸突变，包括源自红景天红细菌的特定氨基酸序列中的全部以下碱性氨基酸突变（a）至（d），并且还具有还原底物的能力。 <碱性氨基酸突变>：（a）用甘氨酸取代第十二谷氨酸的氨基酸突变; （b）用缬氨酸取代第42天冬氨酸的氨基酸突变; （c）用精氨酸代替第67位赖氨酸的氨基酸突变; 和（d）通过用丙氨酸取代第317位丝氨酸的氨基酸突变。

10. 发明专利

JP2012060913A New styrene monooxygenase, method for producing the same, and method for producing optically active styrene oxide utilizing the same 有权
标题翻译：新型苯乙烯类聚合物，其制造方法以及使用其使用光学活性苯乙烯氧化物的方法
公开(公告)号：JP2012060913A
公开(公告)日：2012-03-29
申请号：JP2010206789
申请日：2010-09-15
申请人： Daicel Corp , Toyama Prefecture , 富山県 , 株式会社ダイセル
发明人： ITO SHINYA , TODA HIROSHI , MATSUYAMA AKIKAZU
IPC分类号： C12N15/09 , C02F1/00 , C12N9/02 , C12P1/00 , C12P7/00
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a new DNA encoding a styrene monooxygenase which produces styrene oxide by adding oxygen to styrene, to provide a styrene monooxygenase encoded by the DNA, and to provide a method for producing the styrene monooxygenase.SOLUTION: In order to isolate a styrene-metabolizing gene involved in decomposing styrene in Rhodococcus sp. ST-5 strain and ST-10 strain, the genomic DNA of the ST-5 strain and the ST-10 strain is subjected to degeneration PCR and TAIL PCR (thermal asymmetric interlaced PCR). As a result, from these strains, the inventors have succeeded in isolating the gene encoding a new styrene monooxygenase(SMO).
摘要翻译：待解决的问题：提供编码通过向苯乙烯中加入氧而产生氧化苯乙烯的苯乙烯单加氧酶的新DNA，以提供由DNA编码的苯乙烯单加氧酶，并提供一种苯乙烯单加氧酶的制备方法。解决方案：为了分离涉及在红球菌属中分解苯乙烯的苯乙烯代谢基因。 ST-5菌株和ST-10菌株，将ST-5菌株和ST-10菌株的基因组DNA进行退化PCR和TAIL PCR（热不对称交错PCR）。结果，从这些菌株中，本发明人成功地分离了编码新的苯乙烯单加氧酶（SMO）的基因。版权所有（C）2012，JPO＆INPIT

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