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1. 发明申请

WO2008111763A1 EXTRACTS OF ASTER KORAIENSIS, AND PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING THE SAME 审中-公开
标题翻译： ASTER KORAIENSIS的提取物，以及包括其的药物组合物和功能食品
公开(公告)号：WO2008111763A1
公开(公告)日：2008-09-18
申请号：PCT/KR2008/001292
申请日：2008-03-07
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SHON, Eun Jin , KIM, Chan Sik , KIM, Jung Hyun , KIM, Ohn Soon , JUNG, Dong Ho , YOO, Jeong Lim , KIM, Joo Hwan
发明人： KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SHON, Eun Jin , KIM, Chan Sik , KIM, Jung Hyun , KIM, Ohn Soon , JUNG, Dong Ho , YOO, Jeong Lim , KIM, Joo Hwan
IPC分类号： A61K36/28
CPC分类号： A61K36/28 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2250/21
摘要： Disclosed herein are a leaf and stem extract of Aster koraiensis, a root extract of Aster koraiensis, a flower extract of Aster koraiensis, a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, in which each of the compositions and the foods contain, as an active ingredient, at least one of said Aster koraiensis extracts. Each of the extracts is obtained by drying and finely cutting each of the leaf and stem part, root and flower of Aster koraiensis, extracting the cut plant with alcohol or aqueous alcohol solution, filtering the extracted solution and concentrating the filtrate under reduced pressure. Also disclosed are a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, which contain, as an active ingredient, at least one of fractions obtained by fractionating each of said Aster koraiensis extracts in the order of hexane, ethyl acetate, n-butanol and water fractions. The leaf and stem extract of Aster koraiensis, the root extract of Aster koraiensis and the flower extract of Aster koraiensis have the effect of inhibiting the production of advanced glycation endproducts (AGEs), the causes of diabetic complications, and effectively inhibit aldose redductase (AR) activity. Thus, the disclosed extracts will be highly useful for the prevention or treatment of diabetic complications and the prevention of aging.
摘要翻译：本文公开了白菊的叶和茎提取物，菊科的根提取物，菊苣的花提取物，用于预防或治疗糖尿病并发症的药物组合物，用于改善糖尿病并发症的健康功能性食品，以及一种用于预防或延缓衰老的药物组合物和保健功能食品，其中每种组合物和食物含有至少一种所述菊科植物提取物作为活性成分。每个提取物通过干燥和精细切割菊科的叶子和茎部分，根部和花朵获得，用醇或醇水溶液萃取切割的植物，过滤提取的溶液并在减压下浓缩滤液。还公开了用于预防或治疗糖尿病并发症的药物组合物，用于改善糖尿病并发症的保健功能食品，以及用于预防或延缓衰老的药物组合物和保健功能食品，其含有作为活性成分的，通过以己烷，乙酸乙酯，正丁醇和水组分的顺序对每种所述的所述柯斯萃取物进行分馏得到的至少一种级分。菊科植物的叶和茎提取物，菊科植物的根提取物和白菊的花提取物具有抑制晚期糖基化终产物（AGEs）的产生，糖尿病并发症的原因，并有效抑制醛糖还原酶）活动。因此，所公开的提取物对于预防或治疗糖尿病并发症和预防老化将是非常有用的。

2. 发明申请

WO2008020709A1 COMPOSITION AND FUNCTIONAL FOOD FOR PREVENTION AND TREATMENT OF DIABETIC COMPLICATIONS 审中-公开
标题翻译：用于预防和治疗糖尿病并发症的组合物和功能食品
公开(公告)号：WO2008020709A1
公开(公告)日：2008-02-21
申请号：PCT/KR2007/003903
申请日：2007-08-14
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, jin sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SOHN, Eun Jin , KIM, Chan Sik , LEE, Ga Young , CHEUG, Dong Ho
发明人： KIM, jin sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SOHN, Eun Jin , KIM, Chan Sik , LEE, Ga Young , CHEUG, Dong Ho
IPC分类号： A61K36/482 , A23L1/29 , A61P3/08
CPC分类号： A61K36/482 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2250/21
摘要： Disclosed herein are a composition and functional food for preventing or treating diabetic complications, which contain, as an active ingredient, a n-butanol fraction obtained by successively fractionating Cassiae Semenextract. The n-butanol fraction, obtained by successively fractionating the Cassiae Semen extract, has a blood glucose lowering effect and significantly improves proteinuria and creatinine clearance (CCr). Also, it significantly increases or reduce many relevant factors, including VEGF mRNA, ET-I mRNA, ECE mRNA, TGF-βl, type III collagen mRNA, a PKCα/βll protein, an eNOS protein, a type IV collagen protein, an AGE protein, a RAGE protein, etc., which are abnormally expressed in the kidneys due to chronic diabetes and appear on the onset of diabetic complications caused by chronic hyperglycemia. Accordingly, the disclosed n-butanol fraction, obtained by successively fractionating the Cassiae Semen extract, may be used in compositions and functional foods for the prevention or treatment of diabetic complications.
摘要翻译：本文公开了用于预防或治疗糖尿病并发症的组合物和功能性食品，其包含通过连续分馏决明明胶提取物获得的正丁醇馏分作为活性成分。通过连续分馏决明子提取物获得的正丁醇馏分具有降低血糖的作用并显着改善蛋白尿和肌酸酐清除率（CCr）。此外，它显着增加或减少许多相关因素，包括VEGF mRNA，ET-1 mRNA，ECE mRNA，TGF-β1，III型胶原mRNA，PKCα/βII蛋白，eNOS蛋白，IV型胶原蛋白，AGE 蛋白质，RAGE蛋白质等，它们在慢性糖尿病中在肾中异常表达，并且出现在由慢性高血糖症引起的糖尿病并发症的发作上。因此，通过连续分馏决明子提取物获得的公开的正丁醇馏分可以用于预防或治疗糖尿病并发症的组合物和功能性食品中。

3. 发明申请

WO2007119959A1 COMPOSITION ISOLATED FROM PUERARIAE RADIX FOR PREVENTION OR TREATMENT OF DIABETIC COMPLICATIONS AND A SEPARATION METHOD THEREOF 审中-公开
标题翻译：用于预防或治疗糖尿病并发症的PUERARIAE RADIX分离的组合物及其分离方法
公开(公告)号：WO2007119959A1
公开(公告)日：2007-10-25
申请号：PCT/KR2007/001744
申请日：2007-04-11
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook
发明人： KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook
IPC分类号： A61K31/343
CPC分类号： A61K31/343 , A61K36/488
摘要： The present invention relates to compounds isolated from Puerariae Radix for treatment or prevention of diabetic complications and a method for isolating the same. More particularly, it relates to a method for isolating puerariafuran from Puerariae Radix which is effective in prevention or treatment of diabetic complications, prevention or delay of aging and prevention or treatment of cancers by inhibiting formation of advanced glycation end products (AGEs) which is a critical factor in the development of diabetic complications, and puerariafuran prepared therefrom. Puerariafuran, coumestrol, daidzein and genistein isolated from Puerariae Radix according to the present invention have inhibitive effect on production of AGEs which are factors inducing diabetic complications.
摘要翻译：本发明涉及从葛根分离的用于治疗或预防糖尿病并发症的化合物及其分离方法。更具体地说，本发明涉及从葛根葛根分离葛根呋喃的方法，其有效预防或治疗糖尿病并发症，预防或延缓衰老以及通过抑制晚期糖基化终产物（AGE）的形成来预防或治疗癌症糖尿病并发症发展的关键因素和由此制备的葛根呋喃。根据本发明从葛根分离的葛根呋喃，香豆素，黄豆苷原和染料木素对作为诱导糖尿病并发症的因素的AGEs的产生具有抑制作用。

4. 发明公开

EP2944316A1 PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING NATURAL EXTRACTS FOR PREVENTING OR TREATING DIABETIC COMPLICATIONS OR ANGIODEMA 审中-公开
标题翻译：药物组合物功能食品，开展预防和天然提取物糖尿病并发症或ANGIODEMEN处理情况
公开(公告)号：EP2944316A1
公开(公告)日：2015-11-18
申请号：EP14737578.6
申请日：2014-01-10
申请人： Korea Institute Of Oriental Medicine
发明人： KIM, Jin Sook , KIM, Jung Hyun , KIM, Chan Sik , KIM, Young Sook , SHON, Eun Jin , LEE, Yun Mi , JUNG, Dong Ho , LEE, Ik Soo , JO, Gyu Hyeong , KIM, Joo Hwan
IPC分类号： A61K36/25 , A61K36/718 , A61P3/00 , A61P9/00
CPC分类号： A61K36/25 , A23L33/105 , A23V2002/00 , A61K31/155 , A61K36/16 , A61K36/45 , A61K36/482 , A61K36/488 , A61K36/708 , A61K36/718 , A61K36/73 , A61K36/87 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum , Puerariae radix, Ginkgo leaves, Cassiae semen , blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.
摘要翻译：本发明涉及一种药物组合物和用于预防，治疗或糖尿病并发症或血管性水肿含常春藤叶和黄连的混合提取物作为活性成分的的改善的健康功能食品组合物。更具体地，本发明涉及一种药物组合物和用于预防，治疗或糖尿病并发症或血管性水肿还含有的改善，基数在掌叶大黄葛根，银杏叶，决明子，蓝莓，覆盆子，覆盆子提取物的健康功能食品组合物或葡萄籽作为活性成分的，除了常春藤叶和黄连的混合提取物。

5. 发明公开

EP2520307A1 COMPOSITION AND FUNCTIONAL FOOD USING POLYGONUM CUSPIDATUM BUTANOL EXTRACT OR ETHYL ACETATE EXTRACT FOR TREATING AND PREVENTING OBESITY 有权
标题翻译：组合物和功能性食物或丁醇的乙酸乙酯萃取物用于治疗虎杖OFF和预防肥胖的
公开(公告)号：EP2520307A1
公开(公告)日：2012-11-07
申请号：EP09852833.4
申请日：2009-12-29
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , KIM, Young Sook , KIM, Junghyun , KIM, Chan-Sik
IPC分类号： A61K36/70 , A61P3/04 , A23L1/307
CPC分类号： A61K36/704 , A23L33/105
摘要： The present invention relates to the obesity-curative or obesity-preventive effect of a Polygonum cuspidatum butanol fraction and a Polygonum cuspidatum ethylacetate fraction, and more particularly, to a pharmaceutical composition and a functional food for treating obesity, the pharmaceutical composition and the functional food comprising a Polygonum cuspidatum butanol fraction (POCU-1b) and an ethylacetate fraction as active ingredients, wherein the Polygonum cuspidatum butanol fraction and the ethylacetate fraction inhibit effectively the activity of pancreatic lipase, an important enzyme involving in fat absorption in a living body, and have excellent inhibitory effect on fat absorption in the short term fat absorption-inhibitory animal experiments using lipid emulsions.
摘要翻译：本发明涉及一种虎杖丁醇馏分的肥胖治疗或肥胖症的预防效果和虎杖乙酸乙酯组分，并且更具体地，涉及一种药物组合物和用于治疗肥胖症的功能性食品，药物组合物和功能性食品包括虎杖丁醇馏分（迫促-1b）和在乙酸乙酯级分作为有效成分，所述worin虎杖丁醇馏分和乙酸乙酯组分有效抑制在活体中脂肪的吸收涉及重要的酶胰脂肪酶的活性，并有在使用脂质乳剂短期内脂肪吸收抑制动物实验上脂肪吸收优异的抑制效果。

6. 发明授权

EP2497483B1 COMPOSITIONS FOR TREATMENT AND PREVENTION OF DIABETIC COMPLICATIONS USING OSTEOMELES SCHWERINAE 有权
标题翻译：组合物与华西小石积治疗和糖尿病并发症的预防
公开(公告)号：EP2497483B1
公开(公告)日：2014-08-20
申请号：EP09851125.6
申请日：2009-11-05
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , KIM, Young Sook , LEE, Yun Mi , KIM, Joo-Hwan , SHON, eunjin , KIM, Junghyun , KIM, Chan-Sik , JUNG, Dong Ho , KIM, Nan Hee , YOO, Nam-Hee , LEE, Jun
IPC分类号： A61K36/73 , A61P13/12 , A23L1/30 , A61P39/06 , A61P35/00
CPC分类号： A61K36/73 , A23L33/105

7. 发明公开

EP2617702A2 NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES COMPLICATIONS 审中-公开
标题翻译： NEW联苯连接或其药学上可接受的盐，用于生产THE NEW联苯CONNECTION或药物许可盐，和药物组合物，其作为活性治疗糖尿病相关的并发症的预防和治疗
公开(公告)号：EP2617702A2
公开(公告)日：2013-07-24
申请号：EP11816629.7
申请日：2011-08-11
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , KIM, Young Sook , KIM, Jung Hyun , SHON, Eun Jin , KIM, Ki Mo , KIM, Chan-Sik , JUNG, Dong Ho , LEE, Yun Mi , JO, Kyu Hyung , KIM, Ohn Soon , YOO, Nam-Hee
IPC分类号： C07C43/23 , C07C33/26 , A61K36/73 , A23L1/29 , A61P3/10
CPC分类号： C07C43/23 , A21D2/24 , A23C2240/15 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K36/73 , C07C41/38 , A23V2200/328 , A23V2250/156 , A23V2250/70
摘要： The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.
摘要翻译：本发明提供它们的新的联苯基化合物或其药学上可接受的盐，其制备方法，和药物组合物用于预防或治疗糖尿病并发症包含其作为上的活性成分的方法。新的联苯基化合物，雅丁到本发明中，有效地抑制晚期糖化终产物，从而引起糖尿病并发症，并且是评估糖尿病并发症的处理剂的有效性的标准生成活性，和显示在视网膜血管优异的治疗效果增加闭合蛋白，并诱导视网膜实际糖尿病性视网膜病变减少血管生成生长因子。因此，新颖的联苯化合物gemäß到本发明可以在组合物被有效地用作活性成分的用于预防或治疗糖尿病并发症：如糖尿病性视网膜病。

8. 发明公开

EP2131850A1 EXTRACTS OF ASTER KORAIENSIS, AND PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING THE SAME 有权
标题翻译： FROM ASTER红松提取物和含有药物组合物和功能性食品
公开(公告)号：EP2131850A1
公开(公告)日：2009-12-16
申请号：EP08723329.2
申请日：2008-03-07
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SHON, Eun Jin , KIM, Chan Sik , KIM, Jung Hyun , KIM, Ohn Soon , JUNG, Dong Ho , YOO, Jeong Lim , KIM, Joo Hwan
IPC分类号： A61K36/28
CPC分类号： A61K36/28 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2250/21
摘要： Disclosed herein are a leaf and stem extract of Aster koraiensis, a root extract of Aster koraiensis, a flower extract of Aster koraiensis, a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, in which each of the compositions and the foods contain, as an active ingredient, at least one of said Aster koraiensis extracts. Each of the extracts is obtained by drying and finely cutting each of the leaf and stem part, root and flower of Aster koraiensis, extracting the cut plant with alcohol or aqueous alcohol solution, filtering the extracted solution and concentrating the filtrate under reduced pressure. Also disclosed are a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, which contain, as an active ingredient, at least one of fractions obtained by fractionating each of said Aster koraiensis extracts in the order of hexane, ethyl acetate, n-butanol and water fractions. The leaf and stem extract of Aster koraiensis, the root extract of Aster koraiensis and the flower extract of Aster koraiensis have the effect of inhibiting the production of advanced glycation endproducts (AGEs), the causes of diabetic complications, and effectively inhibit aldose redductase (AR) activity. Thus, the disclosed extracts will be highly useful for the prevention or treatment of diabetic complications and the prevention of aging.

9. 发明授权

EP2520307B1 COMPOSITION AND FUNCTIONAL FOOD USING POLYGONUM CUSPIDATUM BUTANOL EXTRACT OR ETHYL ACETATE EXTRACT FOR TREATING AND PREVENTING OBESITY 有权
标题翻译：组合物和功能性食物或丁醇的乙酸乙酯萃取物用于治疗虎杖OFF和预防肥胖的
公开(公告)号：EP2520307B1
公开(公告)日：2015-08-05
申请号：EP09852833.4
申请日：2009-12-29
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , KIM, Young Sook , KIM, Junghyun , KIM, Chan-Sik
IPC分类号： A61K36/704 , A61P3/04 , A23L1/307 , A23L1/30
CPC分类号： A61K36/704 , A23L33/105

10. 发明公开

EP2497483A1 COMPOSITIONS FOR TREATMENT AND PREVENTION OF DIABETIC COMPLICATIONS USING OSTEOMELES SCHWERINAE 有权
标题翻译：组合物与华西小石积治疗和糖尿病并发症的预防
公开(公告)号：EP2497483A1
公开(公告)日：2012-09-12
申请号：EP09851125.6
申请日：2009-11-05
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , KIM, Young Sook , LEE, Yun Mi , KIM, Joo-Hwan , SHON, eunjin , KIM, Junghyun , KIM, Chan-Sik , KIM, Ohn Soon , JUNG, Dong Ho , KIM, Nan Hee , YOO, Nam-Hee , LEE, Jun
IPC分类号： A61K36/73 , A61P13/12 , A23L1/30 , A61P39/06 , A61P35/00
CPC分类号： A61K36/73 , A23L33/105
摘要： The present invention relates to a treatment agent for diabetic complications, and a method for the treatment of diabetic complications using the same. The present invention confirmed that Osteomeles sch werinae extract and its fractions inhibited the generation of AGEs, the index for diabetic complications, inhibited the activation of aldose reductase, had anti-cataract activity, and had anti-oxidative activity. Thus, the present invention relates to a preventive and therapeutic agent for diabetic complications containing the said Osteomeles sch werinae extract and its fraction as an active ingredient.
摘要翻译：本发明涉及一种处理剂糖尿病并发症，和糖尿病并发症的使用相同的处理方法。证实本发明做了小石积属SCH werinae提取物及其级分抑制的AGEs的生成，糖尿病并发症的指数，抑制醛糖还原酶的活化，具有抗白内障活性，并具有抗氧化活性。因此，本发明涉及一种用于糖尿病并发症含所述小石积属SCH werinae提取物及其作为有效成分馏分的预防和治疗剂。

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