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1. 发明申请

WO2005074963A1 COMPOSITION FOR PREVENTION AND TREATMENT OF DIABETIC COMPLICATION 审中-公开
标题翻译：用于预防和治疗糖尿病合并的组合物
公开(公告)号：WO2005074963A1
公开(公告)日：2005-08-18
申请号：PCT/KR2004/003554
申请日：2004-12-31
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, Jin Sook , LEE, Sang Won , LEE, Yin Mi
发明人： KIM, Jin Sook , LEE, Sang Won , LEE, Yin Mi
IPC分类号： A61K35/78
CPC分类号： A61K36/575 , A23L33/105 , A61K36/47 , A61K36/484 , A61K36/488 , A61K2300/00
摘要： The present invention relates to a composition for the prevention and treatment of diabetic complications, which contains an extract obtained by: crushing and drying any one selected from Euphorbiae radix, gingered Magnolia bark, parched Puerariae radix and Glycyrrhizae radix; extracting the dried herbal material with alcohol or aqueous alcohol solution; filtering the extract; and concentrating the filtrate under reduced pressure. Alternatively, the composition contains a mixture of extracts from Euphorbiae radix, gingered Magnolia bark, parched Puerariae radix and Glycyrrhizae radix, the amount of each of the herbal extracts being 5-85% by weight based on 100% by weight of the herbal extract mixture. Alternatively, the composition contains magnolol obtained by: extracting Magnolia bark with aqueous 80% ethanol solution at ambient temperature for 24 hours; systematically separating the extract in the order of normal-hexane, ethyl acetate and normal-butanol; selecting the normal-hexane layer and separating the selected layer into pre-fractions by normal silica gel chromatography; comparing the pre-fractions with the standard form magnolol on TLC to determine a magnolol-enriched fraction; and separating magnolol from the magnolol-enriched fraction by silica gel column chromatography.
摘要翻译：本发明涉及一种预防和治疗糖尿病并发症的组合物，其含有通过以下方法获得的提取物：将来自大戟，，ered的木兰树皮，茯苓和甘草的任何一种粉碎和干燥; 用酒精或醇水溶液提取干草本材料; 过滤提取物; 并在减压下浓缩滤液。或者，组合物含有来自大戟根，ered ered的木兰皮，灼热葛根和甘草的提取物的混合物，基于100重量％的草药提取物混合物，每个草药提取物的量为5-85重量％。或者，组合物含有通过以下方式获得的厚朴酚：用80％乙醇水溶液在室温下提取木兰树皮24小时; 以正己烷，乙酸乙酯和正丁醇的顺序系统分离提取物; 选择正己烷层，并通过常规硅胶色谱法将所选择的层分离成预成分; 在TLC上比较预分数与标准形式的厚朴酚，以测定富含木酚的部分; 并通过硅胶柱色谱从厚朴酚组分中分离厚朴酚。

2. 发明申请

WO2008111763A1 EXTRACTS OF ASTER KORAIENSIS, AND PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING THE SAME 审中-公开
标题翻译： ASTER KORAIENSIS的提取物，以及包括其的药物组合物和功能食品
公开(公告)号：WO2008111763A1
公开(公告)日：2008-09-18
申请号：PCT/KR2008/001292
申请日：2008-03-07
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SHON, Eun Jin , KIM, Chan Sik , KIM, Jung Hyun , KIM, Ohn Soon , JUNG, Dong Ho , YOO, Jeong Lim , KIM, Joo Hwan
发明人： KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SHON, Eun Jin , KIM, Chan Sik , KIM, Jung Hyun , KIM, Ohn Soon , JUNG, Dong Ho , YOO, Jeong Lim , KIM, Joo Hwan
IPC分类号： A61K36/28
CPC分类号： A61K36/28 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2250/21
摘要： Disclosed herein are a leaf and stem extract of Aster koraiensis, a root extract of Aster koraiensis, a flower extract of Aster koraiensis, a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, in which each of the compositions and the foods contain, as an active ingredient, at least one of said Aster koraiensis extracts. Each of the extracts is obtained by drying and finely cutting each of the leaf and stem part, root and flower of Aster koraiensis, extracting the cut plant with alcohol or aqueous alcohol solution, filtering the extracted solution and concentrating the filtrate under reduced pressure. Also disclosed are a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, which contain, as an active ingredient, at least one of fractions obtained by fractionating each of said Aster koraiensis extracts in the order of hexane, ethyl acetate, n-butanol and water fractions. The leaf and stem extract of Aster koraiensis, the root extract of Aster koraiensis and the flower extract of Aster koraiensis have the effect of inhibiting the production of advanced glycation endproducts (AGEs), the causes of diabetic complications, and effectively inhibit aldose redductase (AR) activity. Thus, the disclosed extracts will be highly useful for the prevention or treatment of diabetic complications and the prevention of aging.
摘要翻译：本文公开了白菊的叶和茎提取物，菊科的根提取物，菊苣的花提取物，用于预防或治疗糖尿病并发症的药物组合物，用于改善糖尿病并发症的健康功能性食品，以及一种用于预防或延缓衰老的药物组合物和保健功能食品，其中每种组合物和食物含有至少一种所述菊科植物提取物作为活性成分。每个提取物通过干燥和精细切割菊科的叶子和茎部分，根部和花朵获得，用醇或醇水溶液萃取切割的植物，过滤提取的溶液并在减压下浓缩滤液。还公开了用于预防或治疗糖尿病并发症的药物组合物，用于改善糖尿病并发症的保健功能食品，以及用于预防或延缓衰老的药物组合物和保健功能食品，其含有作为活性成分的，通过以己烷，乙酸乙酯，正丁醇和水组分的顺序对每种所述的所述柯斯萃取物进行分馏得到的至少一种级分。菊科植物的叶和茎提取物，菊科植物的根提取物和白菊的花提取物具有抑制晚期糖基化终产物（AGEs）的产生，糖尿病并发症的原因，并有效抑制醛糖还原酶）活动。因此，所公开的提取物对于预防或治疗糖尿病并发症和预防老化将是非常有用的。

3. 发明申请

WO2007119959A1 COMPOSITION ISOLATED FROM PUERARIAE RADIX FOR PREVENTION OR TREATMENT OF DIABETIC COMPLICATIONS AND A SEPARATION METHOD THEREOF 审中-公开
标题翻译：用于预防或治疗糖尿病并发症的PUERARIAE RADIX分离的组合物及其分离方法
公开(公告)号：WO2007119959A1
公开(公告)日：2007-10-25
申请号：PCT/KR2007/001744
申请日：2007-04-11
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook
发明人： KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook
IPC分类号： A61K31/343
CPC分类号： A61K31/343 , A61K36/488
摘要： The present invention relates to compounds isolated from Puerariae Radix for treatment or prevention of diabetic complications and a method for isolating the same. More particularly, it relates to a method for isolating puerariafuran from Puerariae Radix which is effective in prevention or treatment of diabetic complications, prevention or delay of aging and prevention or treatment of cancers by inhibiting formation of advanced glycation end products (AGEs) which is a critical factor in the development of diabetic complications, and puerariafuran prepared therefrom. Puerariafuran, coumestrol, daidzein and genistein isolated from Puerariae Radix according to the present invention have inhibitive effect on production of AGEs which are factors inducing diabetic complications.
摘要翻译：本发明涉及从葛根分离的用于治疗或预防糖尿病并发症的化合物及其分离方法。更具体地说，本发明涉及从葛根葛根分离葛根呋喃的方法，其有效预防或治疗糖尿病并发症，预防或延缓衰老以及通过抑制晚期糖基化终产物（AGE）的形成来预防或治疗癌症糖尿病并发症发展的关键因素和由此制备的葛根呋喃。根据本发明从葛根分离的葛根呋喃，香豆素，黄豆苷原和染料木素对作为诱导糖尿病并发症的因素的AGEs的产生具有抑制作用。

4. 发明授权

EP2520307B1 COMPOSITION AND FUNCTIONAL FOOD USING POLYGONUM CUSPIDATUM BUTANOL EXTRACT OR ETHYL ACETATE EXTRACT FOR TREATING AND PREVENTING OBESITY 有权
标题翻译：组合物和功能性食物或丁醇的乙酸乙酯萃取物用于治疗虎杖OFF和预防肥胖的
公开(公告)号：EP2520307B1
公开(公告)日：2015-08-05
申请号：EP09852833.4
申请日：2009-12-29
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , KIM, Young Sook , KIM, Junghyun , KIM, Chan-Sik
IPC分类号： A61K36/704 , A61P3/04 , A23L1/307 , A23L1/30
CPC分类号： A61K36/704 , A23L33/105

5. 发明公开

EP2497483A1 COMPOSITIONS FOR TREATMENT AND PREVENTION OF DIABETIC COMPLICATIONS USING OSTEOMELES SCHWERINAE 有权
标题翻译：组合物与华西小石积治疗和糖尿病并发症的预防
公开(公告)号：EP2497483A1
公开(公告)日：2012-09-12
申请号：EP09851125.6
申请日：2009-11-05
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , KIM, Young Sook , LEE, Yun Mi , KIM, Joo-Hwan , SHON, eunjin , KIM, Junghyun , KIM, Chan-Sik , KIM, Ohn Soon , JUNG, Dong Ho , KIM, Nan Hee , YOO, Nam-Hee , LEE, Jun
IPC分类号： A61K36/73 , A61P13/12 , A23L1/30 , A61P39/06 , A61P35/00
CPC分类号： A61K36/73 , A23L33/105
摘要： The present invention relates to a treatment agent for diabetic complications, and a method for the treatment of diabetic complications using the same. The present invention confirmed that Osteomeles sch werinae extract and its fractions inhibited the generation of AGEs, the index for diabetic complications, inhibited the activation of aldose reductase, had anti-cataract activity, and had anti-oxidative activity. Thus, the present invention relates to a preventive and therapeutic agent for diabetic complications containing the said Osteomeles sch werinae extract and its fraction as an active ingredient.
摘要翻译：本发明涉及一种处理剂糖尿病并发症，和糖尿病并发症的使用相同的处理方法。证实本发明做了小石积属SCH werinae提取物及其级分抑制的AGEs的生成，糖尿病并发症的指数，抑制醛糖还原酶的活化，具有抗白内障活性，并具有抗氧化活性。因此，本发明涉及一种用于糖尿病并发症含所述小石积属SCH werinae提取物及其作为有效成分馏分的预防和治疗剂。

6. 发明授权

EP2131850B1 EXTRACTS OF ASTER KORAIENSIS, AND PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING THE SAME 有权
标题翻译： FROM ASTER红松提取物和含有药物组合物和功能性食品
公开(公告)号：EP2131850B1
公开(公告)日：2015-04-29
申请号：EP08723329.2
申请日：2008-03-07
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , LEE, Yun Mi , KIM, Jong Min , KIM, Young Sook , SHON, Eun Jin , KIM, Chan Sik , KIM, Jung Hyun , KIM, Ohn Soon , JUNG, Dong Ho , YOO, Jeong Lim , KIM, Joo Hwan
IPC分类号： A61K36/28 , A61P3/10 , A23L1/30
CPC分类号： A61K36/28 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2250/21

7. 发明公开

EP2944316A1 PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING NATURAL EXTRACTS FOR PREVENTING OR TREATING DIABETIC COMPLICATIONS OR ANGIODEMA 审中-公开
标题翻译：药物组合物功能食品，开展预防和天然提取物糖尿病并发症或ANGIODEMEN处理情况
公开(公告)号：EP2944316A1
公开(公告)日：2015-11-18
申请号：EP14737578.6
申请日：2014-01-10
申请人： Korea Institute Of Oriental Medicine
发明人： KIM, Jin Sook , KIM, Jung Hyun , KIM, Chan Sik , KIM, Young Sook , SHON, Eun Jin , LEE, Yun Mi , JUNG, Dong Ho , LEE, Ik Soo , JO, Gyu Hyeong , KIM, Joo Hwan
IPC分类号： A61K36/25 , A61K36/718 , A61P3/00 , A61P9/00
CPC分类号： A61K36/25 , A23L33/105 , A23V2002/00 , A61K31/155 , A61K36/16 , A61K36/45 , A61K36/482 , A61K36/488 , A61K36/708 , A61K36/718 , A61K36/73 , A61K36/87 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum , Puerariae radix, Ginkgo leaves, Cassiae semen , blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.
摘要翻译：本发明涉及一种药物组合物和用于预防，治疗或糖尿病并发症或血管性水肿含常春藤叶和黄连的混合提取物作为活性成分的的改善的健康功能食品组合物。更具体地，本发明涉及一种药物组合物和用于预防，治疗或糖尿病并发症或血管性水肿还含有的改善，基数在掌叶大黄葛根，银杏叶，决明子，蓝莓，覆盆子，覆盆子提取物的健康功能食品组合物或葡萄籽作为活性成分的，除了常春藤叶和黄连的混合提取物。

8. 发明公开

EP2520307A1 COMPOSITION AND FUNCTIONAL FOOD USING POLYGONUM CUSPIDATUM BUTANOL EXTRACT OR ETHYL ACETATE EXTRACT FOR TREATING AND PREVENTING OBESITY 有权
标题翻译：组合物和功能性食物或丁醇的乙酸乙酯萃取物用于治疗虎杖OFF和预防肥胖的
公开(公告)号：EP2520307A1
公开(公告)日：2012-11-07
申请号：EP09852833.4
申请日：2009-12-29
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , KIM, Young Sook , KIM, Junghyun , KIM, Chan-Sik
IPC分类号： A61K36/70 , A61P3/04 , A23L1/307
CPC分类号： A61K36/704 , A23L33/105
摘要： The present invention relates to the obesity-curative or obesity-preventive effect of a Polygonum cuspidatum butanol fraction and a Polygonum cuspidatum ethylacetate fraction, and more particularly, to a pharmaceutical composition and a functional food for treating obesity, the pharmaceutical composition and the functional food comprising a Polygonum cuspidatum butanol fraction (POCU-1b) and an ethylacetate fraction as active ingredients, wherein the Polygonum cuspidatum butanol fraction and the ethylacetate fraction inhibit effectively the activity of pancreatic lipase, an important enzyme involving in fat absorption in a living body, and have excellent inhibitory effect on fat absorption in the short term fat absorption-inhibitory animal experiments using lipid emulsions.
摘要翻译：本发明涉及一种虎杖丁醇馏分的肥胖治疗或肥胖症的预防效果和虎杖乙酸乙酯组分，并且更具体地，涉及一种药物组合物和用于治疗肥胖症的功能性食品，药物组合物和功能性食品包括虎杖丁醇馏分（迫促-1b）和在乙酸乙酯级分作为有效成分，所述worin虎杖丁醇馏分和乙酸乙酯组分有效抑制在活体中脂肪的吸收涉及重要的酶胰脂肪酶的活性，并有在使用脂质乳剂短期内脂肪吸收抑制动物实验上脂肪吸收优异的抑制效果。

9. 发明公开

EP3146976A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETIC COMPLICATIONS AND ANGIOEDEMA, CONTAINING NATURAL MIXTURE EXTRACT AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于预防的药物组合物和糖尿病并发症与天然混合提取物作为积极治疗和血管性水肿
公开(公告)号：EP3146976A1
公开(公告)日：2017-03-29
申请号：EP15796502.1
申请日：2015-05-21
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , KIM, Junghyun , KIM, Chan-Sik , SHON, Eunjin , LEE, Yun Mi , CHOI, Sojin , LEE, Ik Soo , KIM, Young Sook , JUNG, Dong Ho , PYUN, Bo-Jeong , JUNG, Seung-Hyun
IPC分类号： A61K36/54 , A61P3/10 , A61P3/00 , A61K36/65 , A61P9/00 , A61P35/00
CPC分类号： A61K36/65 , A61K36/54
摘要： The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, have an excellent effect in inhibiting the generation of the advanced glycation end-products in a human retinal pigment epithelial cell line subjected to a hyperglycemic or aging environment, and have excellent effects in delaying, preventing, and treating diabetic complications, muscular degeneration, commotio retinae, and lower extremity edema in various animal models of diabetic complications, macular degeneration, and lower extremity edema, and thus the mixture extract can effectively be used as an active ingredient for a composition for preventing and treating diabetic complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, and angioedema, including macular (retinal) edema, macular degeneration, and varicose veins.
摘要翻译：桂枝和牡丹皮根皮，桂枝和白芍，或桂枝和茯苓雅丁到本发明的混合物的提取物已被证实抑制过度生成的高级糖基化终产物，其中慢性糖尿病的条件下发生表现出片段化的晚期糖基化终产物和基质蛋白之间的交联的效果，具有优异的效果，抑制在经受高血糖或老化的人视网膜色素上皮细胞株的晚期糖基化终产物的生成环境，并具备在延迟优异的效果，预防和治疗糖尿病并发症，肌肉退化，震荡视网膜，和糖尿病并发症，黄斑变性的各种动物模型中下肢水肿，和下肢水肿，因此混合物提取物可有效地用作活性成分为一种组合物用于预防和治疗糖尿病complicati 附加组件，包括糖尿病性视网膜病，糖尿病性肾病和糖尿病性神经病变，血管性水肿，包括黄斑（视网膜）水肿，黄斑变性，和静脉曲张。

10. 发明授权

EP2497483B1 COMPOSITIONS FOR TREATMENT AND PREVENTION OF DIABETIC COMPLICATIONS USING OSTEOMELES SCHWERINAE 有权
标题翻译：组合物与华西小石积治疗和糖尿病并发症的预防
公开(公告)号：EP2497483B1
公开(公告)日：2014-08-20
申请号：EP09851125.6
申请日：2009-11-05
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , JANG, Dae Sik , KIM, Young Sook , LEE, Yun Mi , KIM, Joo-Hwan , SHON, eunjin , KIM, Junghyun , KIM, Chan-Sik , JUNG, Dong Ho , KIM, Nan Hee , YOO, Nam-Hee , LEE, Jun
IPC分类号： A61K36/73 , A61P13/12 , A23L1/30 , A61P39/06 , A61P35/00
CPC分类号： A61K36/73 , A23L33/105

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