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1. 发明公开

EP2944316A1 PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING NATURAL EXTRACTS FOR PREVENTING OR TREATING DIABETIC COMPLICATIONS OR ANGIODEMA 审中-公开
标题翻译：药物组合物功能食品，开展预防和天然提取物糖尿病并发症或ANGIODEMEN处理情况
公开(公告)号：EP2944316A1
公开(公告)日：2015-11-18
申请号：EP14737578.6
申请日：2014-01-10
申请人： Korea Institute Of Oriental Medicine
发明人： KIM, Jin Sook , KIM, Jung Hyun , KIM, Chan Sik , KIM, Young Sook , SHON, Eun Jin , LEE, Yun Mi , JUNG, Dong Ho , LEE, Ik Soo , JO, Gyu Hyeong , KIM, Joo Hwan
IPC分类号： A61K36/25 , A61K36/718 , A61P3/00 , A61P9/00
CPC分类号： A61K36/25 , A23L33/105 , A23V2002/00 , A61K31/155 , A61K36/16 , A61K36/45 , A61K36/482 , A61K36/488 , A61K36/708 , A61K36/718 , A61K36/73 , A61K36/87 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum , Puerariae radix, Ginkgo leaves, Cassiae semen , blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.
摘要翻译：本发明涉及一种药物组合物和用于预防，治疗或糖尿病并发症或血管性水肿含常春藤叶和黄连的混合提取物作为活性成分的的改善的健康功能食品组合物。更具体地，本发明涉及一种药物组合物和用于预防，治疗或糖尿病并发症或血管性水肿还含有的改善，基数在掌叶大黄葛根，银杏叶，决明子，蓝莓，覆盆子，覆盆子提取物的健康功能食品组合物或葡萄籽作为活性成分的，除了常春藤叶和黄连的混合提取物。

2. 发明公开

EP3146976A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETIC COMPLICATIONS AND ANGIOEDEMA, CONTAINING NATURAL MIXTURE EXTRACT AS ACTIVE INGREDIENT 有权
标题翻译：用于预防的药物组合物和糖尿病并发症与天然混合提取物作为积极治疗和血管性水肿
公开(公告)号：EP3146976A1
公开(公告)日：2017-03-29
申请号：EP15796502.1
申请日：2015-05-21
申请人： Korea Institute of Oriental Medicine
发明人： KIM, Jin Sook , KIM, Junghyun , KIM, Chan-Sik , SHON, Eunjin , LEE, Yun Mi , CHOI, Sojin , LEE, Ik Soo , KIM, Young Sook , JUNG, Dong Ho , PYUN, Bo-Jeong , JUNG, Seung-Hyun
IPC分类号： A61K36/54 , A61P3/10 , A61P3/00 , A61K36/65 , A61P9/00 , A61P35/00
CPC分类号： A61K36/65 , A61K36/54
摘要： The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, have an excellent effect in inhibiting the generation of the advanced glycation end-products in a human retinal pigment epithelial cell line subjected to a hyperglycemic or aging environment, and have excellent effects in delaying, preventing, and treating diabetic complications, muscular degeneration, commotio retinae, and lower extremity edema in various animal models of diabetic complications, macular degeneration, and lower extremity edema, and thus the mixture extract can effectively be used as an active ingredient for a composition for preventing and treating diabetic complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, and angioedema, including macular (retinal) edema, macular degeneration, and varicose veins.
摘要翻译：桂枝和牡丹皮根皮，桂枝和白芍，或桂枝和茯苓雅丁到本发明的混合物的提取物已被证实抑制过度生成的高级糖基化终产物，其中慢性糖尿病的条件下发生表现出片段化的晚期糖基化终产物和基质蛋白之间的交联的效果，具有优异的效果，抑制在经受高血糖或老化的人视网膜色素上皮细胞株的晚期糖基化终产物的生成环境，并具备在延迟优异的效果，预防和治疗糖尿病并发症，肌肉退化，震荡视网膜，和糖尿病并发症，黄斑变性的各种动物模型中下肢水肿，和下肢水肿，因此混合物提取物可有效地用作活性成分为一种组合物用于预防和治疗糖尿病complicati 附加组件，包括糖尿病性视网膜病，糖尿病性肾病和糖尿病性神经病变，血管性水肿，包括黄斑（视网膜）水肿，黄斑变性，和静脉曲张。

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