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1. 发明公开

EP2699930A1 BLACK BLOOD MRI USING A STIMULATED ECHO PULSE SEQUENCE WITH FLOW SENSITIZATION GRADIENTS 审中-公开
标题翻译：与STRÖMUNGSSENSIBILISIERUNGSGRADIENTEN受激回波脉冲序列的黑血MRI
公开(公告)号：EP2699930A1
公开(公告)日：2014-02-26
申请号：EP12724163.6
申请日：2012-04-12
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH , The University of Washington
发明人： WANG, Jinnan , BÖRNERT, Peter , YUAN, Chun
IPC分类号： G01R33/563
CPC分类号： G01R33/30 , G01R33/56316 , G01R33/5635
摘要： A black blood magnetic resonance imaging sequence is performed using a magnetic resonance scanner. The sequence includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice-selective radio frequency excitation pulse after applying the spoiler gradient; and performing a magnetic resonance readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation. The readout acquires magnetic resonance imaging data having blood signal suppression in the region excited by the slice-selective radio frequency excitation pulse. The magnetic resonance imaging data is suitably reconstructed to generate a black blood image that may be displayed.

2. 发明授权

EP2699929B1 INTERLEAVED BLACK AND BRIGHT BLOOD MRI 有权转让
公开(公告)号：EP2699929B1
公开(公告)日：2019-12-11
申请号：EP12722857.5
申请日：2012-04-12
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH , The University of Washington
发明人： WANG, Jinnan , CHEN, Huijun , BÖRNERT, Peter , YUAN, Chun
IPC分类号： G01R33/563

3. 发明公开

EP2699928A1 SIMULTANEOUS NON- CONTRAST MR ANGIOGRAPHY AND INTRAPLAQUE HEMORRHAGE (SNAP) MR IMAGING 有权转让
标题翻译：鲁棒法同时磁共振血管造影WITHOUT造影剂和出血粥样硬化斑块的磁性PICTURE（RSNAP）使用流式细胞MARKER
公开(公告)号：EP2699928A1
公开(公告)日：2014-02-26
申请号：EP12722859.1
申请日：2012-04-13
申请人： Koninklijke Philips N.V. , The University of Washington , Philips Intellectual Property & Standards GmbH
发明人： WANG, Jinnan , HELLE, Michael Günter , KERWIN, William Sean , BOERNERT, Peter , YUAN, Chun
IPC分类号： G01R33/56
CPC分类号： G01R33/5635 , G01R33/5602
摘要： Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse (50). MR signals are acquired at an inversion time (TI) after the IR radio frequency pulse. TI is selected such that a first tissue of interest (e.g., blood) exhibits negative magnetism excited by the IR radio frequency pulse and a second tissue (e.g., intraplaque hemorrhage tissue) exhibits positive magnetism excited by the IR radio frequency pulse. The acquired magnetic resonance signals are reconstructed to generate spatial pixels or voxels wherein positive pixel or voxel values indicate spatial locations of positive magnetism and negative pixel or voxel values indicates spatial locations of negative magnetism. A first image (28) representative of the first tissue is generated from spatial pixels or voxels having negative signal intensities, and a second image (26) representative of the second tissue is generated from spatial pixels or voxels having positive signal intensities.

4. 发明授权

EP2699928B1 ROBUST FLOW-LABELING SIMULTANEOUS NON-CONTRAST MR ANGIOGRAPHY AND INTRAPLAQUE HEMORRHAGE (RSNAP) MR IMAGING 有权转让
标题翻译：鲁棒法同时磁共振血管造影WITHOUT造影剂和出血粥样硬化斑块的磁性PICTURE（RSNAP）使用流式细胞MARKER
公开(公告)号：EP2699928B1
公开(公告)日：2016-08-24
申请号：EP12722859.1
申请日：2012-04-13
申请人： Koninklijke Philips N.V. , The University of Washington , Philips Intellectual Property & Standards GmbH
发明人： WANG, Jinnan , HELLE, Michael Günter , KERWIN, William Sean , BOERNERT, Peter , YUAN, Chun
IPC分类号： G01R33/56 , G01R33/563
CPC分类号： G01R33/5635 , G01R33/5602

5. 发明公开

EP2699929A1 INTERLEAVED BLACK AND BRIGHT BLOOD DYNAMIC CONTRAST ENHANCED (DCE) MRI 有权转让
标题翻译：动态增强MRI隔行黑亮BLOOD
公开(公告)号：EP2699929A1
公开(公告)日：2014-02-26
申请号：EP12722857.5
申请日：2012-04-12
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH , The University of Washington
发明人： WANG, Jinnan , CHEN, Huijun , BÖRNERT, Peter , YUAN, Chun
IPC分类号： G01R33/563
摘要： Interleaved black/bright imaging (IBBI) is performed using a magnetic resonance (MR) scanner wherein the black blood module of the IBBI includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice selective radio frequency excitation pulse after applying the spoiler gradient; and performing a MR readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation wherein the readout acquires MR imaging data having blood signal suppression in the region excited by the slice selective radio frequency excitation pulse. The MR imaging data having blood signal suppression is reconstructed to generate black blood images, and MR imaging data generated by bright blood modules of the IBBI is reconstructed to generate bright blood images.

6. 发明申请

WO2012143823A1 BLACK BLOOD MRI USING A STIMULATED ECHO PULSE SEQUENCE WITH FLOW SENSITIZATION GRADIENTS 审中-公开
标题翻译：使用刺激的ECHO脉冲序列与流感敏感度梯度的BLACK BLOOD MRI
公开(公告)号：WO2012143823A1
公开(公告)日：2012-10-26
申请号：PCT/IB2012/051776
申请日：2012-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , THE UNIVERSITY OF WASHINGTON , WANG, Jinnan , BÖRNERT, Peter , YUAN, Chun
发明人： WANG, Jinnan , BÖRNERT, Peter , YUAN, Chun
IPC分类号： G01R33/563
CPC分类号： G01R33/30 , G01R33/56316 , G01R33/5635
摘要： A black blood magnetic resonance imaging sequence is performed using a magnetic resonance scanner. The sequence includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice-selective radio frequency excitation pulse after applying the spoiler gradient; and performing a magnetic resonance readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation. The readout acquires magnetic resonance imaging data having blood signal suppression in the region excited by the slice-selective radio frequency excitation pulse. The magnetic resonance imaging data is suitably reconstructed to generate a black blood image that may be displayed.
摘要翻译：使用磁共振扫描仪进行黑血液磁共振成像序列。该序列包括：应用第一流感敏化梯度; 在应用第一流感敏化梯度后应用扰流板梯度; 在施加扰流板梯度之后施加第二流动增感梯度，其中第二流动增感梯度具有等于第一流动增感梯度但具有相反极性的面积; 应用扰流板梯度后应用切片选择射频激励脉冲; 以及在施加第二流动增感梯度之后并且在施加切片选择性射频激发之后执行磁共振读出。读出器获取在由片选择射频激励脉冲激发的区域中具有血液信号抑制的磁共振成像数据。适当地重建磁共振成像数据以产生可以显示的黑血图像。

7. 发明申请

WO2012143831A1 SIMULTANEOUS NON- CONTRAST MR ANGIOGRAPHY AND INTRAPLAQUE HEMORRHAGE (SNAP) MR IMAGING 审中-公开
标题翻译：同时非对照MR血管造影和腹腔镜检查（SNAP）MR成像
公开(公告)号：WO2012143831A1
公开(公告)日：2012-10-26
申请号：PCT/IB2012/051812
申请日：2012-04-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , THE UNIVERSITY OF WASHINGTON , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WANG, Jinnan , HELLE, Michael Günter , KERWIN, William Sean , BOERNERT, Peter , YUAN, Chun
发明人： WANG, Jinnan , HELLE, Michael Günter , KERWIN, William Sean , BOERNERT, Peter , YUAN, Chun
IPC分类号： G01R33/56
CPC分类号： G01R33/5635 , G01R33/5602
摘要： Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse (50). MR signals are acquired at an inversion time (TI) after the IR radio frequency pulse. TI is selected such that a first tissue of interest (e.g., blood) exhibits negative magnetism excited by the IR radio frequency pulse and a second tissue (e.g., intraplaque hemorrhage tissue) exhibits positive magnetism excited by the IR radio frequency pulse. The acquired magnetic resonance signals are reconstructed to generate spatial pixels or voxels wherein positive pixel or voxel values indicate spatial locations of positive magnetism and negative pixel or voxel values indicates spatial locations of negative magnetism. A first image (28) representative of the first tissue is generated from spatial pixels or voxels having negative signal intensities, and a second image (26) representative of the second tissue is generated from spatial pixels or voxels having positive signal intensities.
摘要翻译：通过应用反转恢复（IR）射频脉冲（50）来反转磁共振（MR）自旋。在IR射频脉冲之后，在反转时间（TI）获取MR信号。选择TI，使得感兴趣的第一组织（例如血液）表现出由IR射频脉冲激发的负磁性，并且第二组织（例如，intraplaque出血组织）表现出由IR射频脉冲激发的正磁性。所获取的磁共振信号被重建以产生空间像素或像素，其中正像素或体元值表示正磁性的空间位置，负像素或体素值表示负磁性的空间位置。从具有负信号强度的空间像素或体素生成代表第一组织的第一图像（28），并且从具有正信号强度的空间像素或体素生成代表第二组织的第二图像（26）。

8. 发明申请

WO2012143824A1 INTERLEAVED BLACK AND BRIGHT BLOOD DYNAMIC CONTRAST ENHANCED (DCE) MRI 审中-公开
标题翻译：交互式BLACK和BRIGHT BLOOD动态对比增强（DCE）MRI
公开(公告)号：WO2012143824A1
公开(公告)日：2012-10-26
申请号：PCT/IB2012/051779
申请日：2012-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , UNIVERSITY OF WASHINGTON , WANG, Jinnan , CHEN, Huijun , BÖRNERT, Peter , YUAN, Chun
发明人： WANG, Jinnan , CHEN, Huijun , BÖRNERT, Peter , YUAN, Chun
IPC分类号： G01R33/563
CPC分类号： G01R33/48 , G01R33/56316 , G01R33/5635
摘要： Interleaved black/bright imaging (IBBI) is performed using a magnetic resonance (MR) scanner (10) wherein the black blood module (52) of the IBBI includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitation gradient but of opposite polarity; applying a slice selective radio frequency excitation pulse after applying the spoiler gradient; and performing a MR readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation wherein the readout acquires MR imaging data having blood signal suppression in the region excited by the slice selective radio frequency excitation pulse. The MR imaging data having blood signal suppression is reconstructed to generate black blood images (20), and MR imaging data generated by bright blood modules (50) of the IBBI is reconstructed to generate bright blood images (22).
摘要翻译：使用磁共振（MR）扫描器（10）进行交错黑/亮成像（IBBI），其中IBBI的黑血模块（52）包括：施加第一流感敏化梯度; 在应用第一流感敏化梯度后应用扰流板梯度; 在施加扰流板梯度之后施加第二流动增感梯度，其中第二流动增感梯度具有等于第一流动感觉梯度但具有相反极性的面积; 应用扰流板梯度后应用切片选择性射频激励脉冲; 以及在应用所述第二流敏增强梯度之后并且在施加所述切片选择性射频激发之后执行MR读出，其中所述读出器获取在由所述切片选择性射频激励脉冲激发的区域中具有血液信号抑制的MR成像数据。重建具有血液信号抑制的MR成像数据以产生黑血图像（20），并重建由IBBI的亮血模块（50）产生的MR成像数据，以产生亮血图像（22）。

9. 发明申请

WO2015033271A1 PUSH-BUTTON VESSEL WALL MRI WITH 3D SCOUT SCAN 审中-公开
标题翻译：按钮式血管壁MRI与3D扫描扫描
公开(公告)号：WO2015033271A1
公开(公告)日：2015-03-12
申请号：PCT/IB2014/064215
申请日：2014-09-03
申请人： KONINKLIJKE PHILIPS N.V. , UNIVERSITY OF WASHINGTON
发明人： WANG, Jinnan , BOERNERT, Peter , YUAN, Chun
IPC分类号： G01R33/54 , G01R33/563
CPC分类号： G01R33/5635 , A61B5/055 , G01R33/34 , G01R33/385 , G01R33/543 , G01R33/5602
摘要： A medical system (10)and method(100)image a vessel wall automatically. A scout scan of a patient for localizing a target vessel of the patient is automatically performed (102) using magnetic resonance (MR). The scout scan is three-dimensional (3D) and isotropic. An MR data set of the scout scan is automatically reconstructed (104) into foot-to- head (FH), left-to-right (LR) and posterior-to-anterior (PA) projections. A3D imaging volume (16)encompassing the target vessel is automatically determined (106) from the projections, and a diagnostic scan of the 3D imaging volume (16) is performed (108) using MR.
摘要翻译：医疗系统（10）和方法（100）自动对血管壁进行成像。使用磁共振（MR）自动执行用于定位患者的靶容器的患者的侦察扫描（102）。侦察扫描是三维（3D）和各向同性的。侦察扫描的MR数据集被自动地重建（104）成脚到头（FH），从左到右（LR）和后到前（PA）的投影。从投影中自动确定（106）包围目标血管的A3D成像体积（16），并且使用MR执行3D成像体积（16）的诊断扫描（108）。

10. 发明申请

WO2015092619A1 PHASE-SENSITIVE INVERSION RECOVERY MRI WITH WATER/FAT SEPARATION 审中-公开
标题翻译：相位敏感反应恢复MRI与水/脂肪分离
公开(公告)号：WO2015092619A1
公开(公告)日：2015-06-25
申请号：PCT/IB2014/066746
申请日：2014-12-10
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BOERNERT, Peter , WANG, Jinnan
IPC分类号： G01R33/48 , A61B5/055 , G01R33/56
CPC分类号： G01R33/4828 , G01R33/5602
摘要： The invention relates to a method of MR imaging of at least two chemical species having different MR spectra. It is an object of the invention to provide a PSIR-based MR imaging method which enables distinction between myocardial scar and myocardial triglyceride deposition. The method of the invention comprises the steps of: a) generating echo signals at two or more different echo times by subjecting an object (10) positioned in the examination volume of a MR device (1) to an imaging sequence of RF pulses and switched magnetic field gradients, which imaging sequence is an inversion recovery sequence comprising an inversion RF pulse followed by an excitation RF pulse after an inversion recovery time; b) acquiring the echo signals; c) separating signal contributions of the at least two chemical species to the acquired echo signals; and d) reconstructing a phase-sensitive MR image (28, 29) from the signal contributions of at least one of the chemical species. Moreover, the invention relates to a MR device and to a computer program to be run on a MR device.
摘要翻译：本发明涉及至少两种具有不同MR谱的化学物质的MR成像方法。本发明的一个目的是提供一种能够区分心肌瘢痕和心肌甘油三酯沉积的基于PSIR的MR成像方法。本发明的方法包括以下步骤：a）通过使位于MR装置（1）的检查体积中的物体（10）经受RF脉冲的成像序列并切换，产生两个或多个不同回波时间的回波信号磁场梯度，该成像序列是反转恢复序列，其包括反转RF脉冲，随后是反转恢复时间之后的激发RF脉冲; b）获取回波信号; c）将所述至少两种化学物质的信号贡献分离成所获取的回波信号; 以及d）从所述化学物质中的至少一个的信号贡献重建相敏MR图像（28,29）。此外，本发明涉及MR设备和要在MR设备上运行的计算机程序。

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