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1. 发明授权

US07422878B1 Process for microbial production of ubiquinone-10 using Rhodobacter 失效
标题翻译：使用红细菌的微生物生产泛醌-10的方法
公开(公告)号：US07422878B1
公开(公告)日：2008-09-09
申请号：US10110393
申请日：2000-10-13
申请人： Koichiro Miyake , Shin-ichi Hashimoto , Akio Ozaki
发明人： Koichiro Miyake , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C12P7/66
CPC分类号： C12N9/1085 , A61K38/00 , C12N15/52 , C12P7/66
摘要： The present invention provides a process for producing ubiquinone-10 using a microorganism having the ability to form ubiquinone-10 and having one or more properties selected from the group consisting of the property wherein geranylgeranyltransferase activity is reduced or defective, the property wherein decaprenyldiphosphate synthetase activity is strengthened, and the property wherein p-hydroxybenzoic acid-decaprenyltransferase activity is strengthened, DNA and a polypeptide useful for the production process, microorganisms useful for the production, a method for expressing a gene in the microorganisms, and a method for breeding the microorganisms.
摘要翻译：本发明提供使用具有形成泛醌-10的能力的微生物生产泛醌-10的方法，并具有一种或多种选自以下的性质：其中er牛儿基ger酰基转移酶活性降低或缺陷，其中十聚十二烷基二磷酸合成酶活性并且其中对羟基苯甲酸 - 十 - 癸酰基转移酶活性增强的性质，可用于生产过程的DNA和多肽，可用于生产的微生物，在微生物中表达基因的方法以及用于培养微生物的方法。

2. 发明申请

US20090068713A1 PROCESS FOR PRODUCING GAMMA-GLUTAMYLAMIDE COMPOUNDS 审中-公开
标题翻译：生产甘氨酰谷氨酰胺化合物的方法
公开(公告)号：US20090068713A1
公开(公告)日：2009-03-12
申请号：US11913472
申请日：2006-05-09
申请人： Koichiro Miyake , Shin-ichi Hashimoto
发明人： Koichiro Miyake , Shin-ichi Hashimoto
IPC分类号： C12P13/14
CPC分类号： C12P13/02 , C12N9/93
摘要： The present invention provides a process for producing a γ-glutamylamide compound, which comprises forming the γ-glutamylamide compound from a glutamyl donor and an amine compound using γ-glutamylcysteine synthetase, preferably γ-glutamylcysteine synthetase derived from a microorganism, or a culture of cells having the enzyme or a treated culture as an enzyme source.
摘要翻译：本发明提供一种γ-谷氨酰胺化合物的制造方法，其包括使用γ-谷氨酰半胱氨酸合成酶，优选来源于微生物的γ-谷氨酰半胱氨酸合成酶，或来自微生物的培养物，从谷氨酰供体和胺化合物形成γ-谷氨酰胺化合物具有酶或经处理的培养物的细胞作为酶源。

3. 发明申请

US20080261273A1 PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITORS 审中-公开
标题翻译：生产HMG-CoA还原酶抑制剂的方法
公开(公告)号：US20080261273A1
公开(公告)日：2008-10-23
申请号：US12125569
申请日：2008-05-22
申请人： Hirofumi ENDO , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
发明人： Hirofumi ENDO , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C12P21/00 , C12P7/62 , C12P17/06
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to processes for producing compounds by using a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or substituted or unsubstituted aryl, or a ring-closed lactone from thereof.
摘要翻译：本发明涉及通过使用衍生自属于芽孢杆菌属的微生物的蛋白质来生产化合物的方法，其具有使由式（Ia）表示的化合物羟基化的活性：其中R 1表示氢原子，取代或未取代的烷基或碱金属，R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯。

4. 发明授权

US07470528B2 DNA encoding hydroxylase 失效
标题翻译：编码羟化酶的DNA
公开(公告)号：US07470528B2
公开(公告)日：2008-12-30
申请号：US11352308
申请日：2006-02-13
申请人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
发明人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C12N15/00 , C12N5/10 , C12N1/21 , C12P21/00 , C07H21/00 , C12N9/02 , C07K14/00
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
摘要翻译：本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟化的活性：其中R1表示氢原子，取代或未取代的烷基或碱金属并且R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码蛋白质的DNA; 和包含DNA的重组DNA。

5. 发明授权

US06946270B1 Process for producing HMG-CoA reductase inhibitors 失效
标题翻译：生产HMG-CoA还原酶抑制剂的方法
公开(公告)号：US06946270B1
公开(公告)日：2005-09-20
申请号：US09868924
申请日：2000-01-20
申请人： Shin-ichi Hashimoto , Yoshiyuki Yonetani , Akio Ozaki
发明人： Shin-ichi Hashimoto , Yoshiyuki Yonetani , Akio Ozaki
IPC分类号： C12P7/62 , C12P17/06
CPC分类号： C12P17/06 , C12P7/62
摘要： The present invention relates to a process for producing a compound (II-a) or a compound (II-b), each of which is a hydroxylated product of a compound represented by the formula (I-a) (hereinafter referred to as compound (I-a)): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl, or a substituted or unsubstituted aryl; or a ring-closed lactone form thereof (hereinafter referred to as compound (I-b)). wherein the process comprises: treating the compound (I-a) or compound (I-b) in an aqueous medium comprising with a microorganism acting to hydroxylate compound (I-a) or compound (I-b), having no ability to sporulate and showing no hyphal growth, a culture of the microorganism, or a treated product of the culture, as an enzyme source; and collecting a hydroxylated product of compound (I-a) or compound (I-b) from the aqueous medium.
摘要翻译：本发明涉及一种制备化合物（II-a）或化合物（II-b）的方法，其中每种化合物是由式（Ia）表示的化合物的羟基化产物（以下称为化合物（Ia ））：其中R 1表示氢原子，取代或未取代的烷基或碱金属，R 2表示取代或未取代的烷基，或取代或未取代的烷基，未取代的芳基; 或其封闭的内酯形式（以下称为化合物（I-b））。其中所述方法包括：在水性介质中处理化合物（Ia）或化合物（Ib），所述水性介质包含微生物作用于羟化化合物（Ia）或化合物（Ib）的微生物，其不具有孢子形成和不显示菌丝生长的能力，的微生物或培养物的处理产物作为酶源; 并从水性介质中收集化合物（I-a）或化合物（I-b）的羟基化产物。

6. 发明授权

US07897370B2 Process for producing HMG-CoA reductase inhibitor 有权
标题翻译：生产HMG-CoA还原酶抑制剂的方法
公开(公告)号：US07897370B2
公开(公告)日：2011-03-01
申请号：US12272448
申请日：2008-11-17
申请人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
发明人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C12P17/06 , C12P7/62 , C12P7/40 , C12P7/44 , C12P7/42 , C12P7/26 , C12Q1/26 , C07K14/00 , C07H21/00 , C12N1/21 , C12N5/10 , C12N15/00 , C12P21/00
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
摘要翻译：本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟化的活性：其中R1表示氢原子，取代或未取代的烷基或碱金属并且R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码蛋白质的DNA; 和包含DNA的重组DNA。

7. 发明申请

US20090148916A1 PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR 有权
标题翻译：生产HMG-CoA还原酶抑制剂的方法
公开(公告)号：US20090148916A1
公开(公告)日：2009-06-11
申请号：US12272448
申请日：2008-11-17
申请人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
发明人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C12P17/06 , C07H21/04 , C12N15/63 , C12N1/21 , C12P7/62
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
摘要翻译：本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟化的活性：其中R1表示氢原子，取代或未取代的烷基或碱金属并且R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码蛋白质的DNA; 和包含DNA的重组DNA。

8. 发明申请

US20060154348A1 Process for producing HMG-CoA reductase inhibitors 失效
标题翻译：生产HMG-CoA还原酶抑制剂的方法
公开(公告)号：US20060154348A1
公开(公告)日：2006-07-13
申请号：US11352308
申请日：2006-02-13
申请人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
发明人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C07H21/04 , C12P21/06 , C12P17/08 , C12P7/62 , C12N9/18 , C12N1/21 , C12N15/74
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
摘要翻译：本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟化的活性：其中R 1表示氢原子，取代的或未取代的烷基或碱金属，R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码蛋白质的DNA; 和包含DNA的重组DNA。

9. 发明授权

US07049111B1 Process for producing HMG-CoA reductase inhibitor 有权
标题翻译：生产HMG-CoA还原酶抑制剂的方法
公开(公告)号：US07049111B1
公开(公告)日：2006-05-23
申请号：US09869334
申请日：2000-01-28
申请人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
发明人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C12N9/02 , C12N15/00 , C12N5/00 , C12N1/20 , C12P7/22
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
摘要翻译：本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟化的活性：其中R 1表示氢原子，取代的或未取代的烷基或碱金属，R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码蛋白质的DNA; 和包含DNA的重组DNA。

10. 发明申请

US20100120126A1 MICROORGANISMS PRODUCING DIPEPTIDES AND PROCESS FOR PRODUCING DIPEPTIDE USING THE MICROORGANISMS 审中-公开
标题翻译：使用微生物生产皂苷的微生物和生产皂苷的方法
公开(公告)号：US20100120126A1
公开(公告)日：2010-05-13
申请号：US12615337
申请日：2009-11-10
申请人： Shin-ichi Hashimoto , Kazuhiko Tabata
发明人： Shin-ichi Hashimoto , Kazuhiko Tabata
IPC分类号： C12N1/21
CPC分类号： C12P21/02
摘要： Microorganisms in which the activities of one or more kinds of peptidases and one or more kinds of proteins having peptide-transporting activity are reduced or lost and which have the ability to produce a dipeptide. Also, microorganisms in which the activities of three or more kinds of peptidases are reduced or lost and which have the ability to produce a dipeptide, and a process for producing dipeptides using the microorganisms.
摘要翻译：其中一种或多种肽酶和一种或多种具有肽转运活性的蛋白质的活性减少或丧失并且具有产生二肽能力的微生物。此外，三种或更多种肽酶的活性减少或丧失并且具有产生二肽的能力的微生物以及使用微生物生产二肽的方法。

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