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1. 发明授权

US09144799B2 Modular microfluidic system for biological sample preparation 有权
标题翻译：用于生物样品制备的模块化微流体系统
公开(公告)号：US09144799B2
公开(公告)日：2015-09-29
申请号：US12943677
申请日：2010-11-10
申请人： Klint A. Rose , Raymond P. Mariella, Jr. , Christopher G. Bailey , Kevin Dean Ness
发明人： Klint A. Rose , Raymond P. Mariella, Jr. , Christopher G. Bailey , Kevin Dean Ness
IPC分类号： C12M1/33 , C12M3/08 , B01L3/00 , B03C5/02 , G01N35/00
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/027 , B01L2200/04 , B01L2300/0681 , B01L2400/0436 , B01L2400/0439 , B03C5/026 , B03C2201/26 , G01N2035/00326
摘要： A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.
摘要翻译：一种用于制备生物样品的可重构模块化微流体系统，包括用于自动化样品制备的一系列可重新配置模块，其适于选择性地包括a）微流体声学聚焦滤光器模块，b）介电电泳细菌滤膜模块，c）介电泳病毒过滤器模块， d）等速电泳核酸过滤器模块，e）裂解模块和f）基于等电泳的核酸过滤器。

2. 发明申请

US20110124098A1 Modular Microfluidic System for Biological Sample Preparation 有权
标题翻译：用于生物样品制备的模块化微流体系统
公开(公告)号：US20110124098A1
公开(公告)日：2011-05-26
申请号：US12943677
申请日：2010-11-10
申请人： Klint A. Rose , Raymond P. Mariella, JR. , Christopher G. Bailey , Kevin Dean Ness
发明人： Klint A. Rose , Raymond P. Mariella, JR. , Christopher G. Bailey , Kevin Dean Ness
IPC分类号： C12M1/12
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/027 , B01L2200/04 , B01L2300/0681 , B01L2400/0436 , B01L2400/0439 , B03C5/026 , B03C2201/26 , G01N2035/00326
摘要： A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.
摘要翻译：一种用于制备生物样品的可重构模块化微流体系统，包括用于自动化样品制备的一系列可重新配置模块，其适于选择性地包括a）微流体声学聚焦滤光器模块，b）介电电泳细菌滤膜模块，c）介电泳病毒过滤器模块， d）等速电泳核酸过滤器模块，e）裂解模块和f）基于等电泳的核酸过滤器。

3. 发明授权

US08524064B2 Three dimensional microelectrode system for dielectrophoresis 有权
标题翻译：用于介电电泳的三维微电极系统
公开(公告)号：US08524064B2
公开(公告)日：2013-09-03
申请号：US12843269
申请日：2010-07-26
申请人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, Jr.
发明人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, Jr.
IPC分类号： G01N27/26 , G01N27/453 , B03C5/02 , B01D57/02
CPC分类号： B03C5/005 , B01L2400/0424 , B03C5/026 , G01N27/447
摘要： A dielectrophoresis apparatus for separating particles from a sample, including an apparatus body; a dielectrophoresis channel in the apparatus body, the dielectrophoresis channel having a central axis, a bottom, a top, a first side, and a second side; a first mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the first mesa extending at an angle to the central axis of the dielectrophoresis channel; a first electrode extending along the first mesa; a second mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the second mesa extending at an angle to the central axis of the dielectrophoresis channel; a space between at least one of the first electrode and the second side or the second electrode and the second side; and a gap between the first electrode and the second electrode.
摘要翻译：一种用于从样品中分离颗粒的介电电泳装置，包括装置体; 所述设备主体中的介电电泳通道，所述介电电泳通道具有中心轴线，底部，顶部，第一侧面和第二侧面; 第一台面从底部突出到介电电泳通道中并且从第一侧穿过介电电泳通道延伸到第二侧，第一台面以与介电电泳通道的中心轴线成一定角度延伸; 沿第一台面延伸的第一电极; 第二台面从底部突出到介电电泳通道中，并从第一侧穿过介电电泳通道延伸到第二侧，第二台面以与介电电泳通道的中心轴成一定角度延伸; 第一电极和第二电极和第二电极和第二侧中的至少一个之间的空间; 以及第一电极和第二电极之间的间隙。

4. 发明申请

US20130306481A1 THREE DIMENSIONAL MICROELECTRODE SYSTEM FOR DIELECTROPHORESIS 有权
标题翻译：三维微电子系统用于电介质
公开(公告)号：US20130306481A1
公开(公告)日：2013-11-21
申请号：US13945768
申请日：2013-07-18
申请人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, JR.
发明人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, JR.
IPC分类号： B03C5/00
CPC分类号： B03C5/005 , B01L2400/0424 , B03C5/026 , G01N27/447
摘要： A dielectrophoresis apparatus for separating particles from a sample, including an apparatus body; a dielectrophoresis channel in the apparatus body, the dielectrophoresis channel having a central axis, a bottom, a top, a first side, and a second side; a first mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the first mesa extending at an angle to the central axis of the dielectrophoresis channel; a first electrode extending along the first mesa; a second mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the second mesa extending at an angle to the central axis of the dielectrophoresis channel; a space between at least one of the first electrode and the second side or the second electrode and the second side; and a gap between the first electrode and the second electrode.
摘要翻译：一种用于从样品中分离颗粒的介电电泳装置，包括装置体; 所述设备主体中的介电电泳通道，所述介电电泳通道具有中心轴线，底部，顶部，第一侧面和第二侧面; 第一台面从底部突出到介电电泳通道中并且从第一侧穿过介电电泳通道延伸到第二侧，第一台面以与介电电泳通道的中心轴线成一定角度延伸; 沿第一台面延伸的第一电极; 从底部突出到介电电泳通道的第二台面，并且从第一侧穿过介电电泳通道延伸到第二侧，第二台面以与介电电泳通道的中心轴线成一定角度延伸; 第一电极和第二电极和第二电极和第二侧中的至少一个之间的空间; 以及第一电极和第二电极之间的间隙。

5. 发明申请

US20110259745A1 Three Dimensional Microelectrode System For Dielectrophoresis 有权
标题翻译：用于电泳的三维微电极系统
公开(公告)号：US20110259745A1
公开(公告)日：2011-10-27
申请号：US12843269
申请日：2010-07-26
申请人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, JR.
发明人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, JR.
IPC分类号： B03C5/02
CPC分类号： B03C5/005 , B01L2400/0424 , B03C5/026 , G01N27/447
摘要： A dielectrophoresis apparatus for separating particles from a sample, including an apparatus body; a dielectrophoresis channel in the apparatus body, the dielectrophoresis channel having a central axis, a bottom, a top, a first side, and a second side; a first mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the first mesa extending at an angle to the central axis of the dielectrophoresis channel; a first electrode extending along the first mesa; a second mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the second mesa extending at an angle to the central axis of the dielectrophoresis channel; a space between at least one of the first electrode and the second side or the second electrode and the second side; and a gap between the first electrode and the second electrode.
摘要翻译：一种用于从样品中分离颗粒的介电电泳装置，包括装置体; 所述设备主体中的介电电泳通道，所述介电电泳通道具有中心轴线，底部，顶部，第一侧面和第二侧面; 第一台面从底部突出到介电电泳通道中并且从第一侧穿过介电电泳通道延伸到第二侧，第一台面以与介电电泳通道的中心轴线成一定角度延伸; 沿第一台面延伸的第一电极; 第二台面从底部突出到介电电泳通道中，并从第一侧穿过介电电泳通道延伸到第二侧，第二台面以与介电电泳通道的中心轴成一定角度延伸; 第一电极和第二电极和第二电极和第二侧中的至少一个之间的空间; 以及第一电极和第二电极之间的间隙。

6. 发明申请

US20100012497A1 FLOW CONTROL SYSTEMS 有权
标题翻译：流量控制系统
公开(公告)号：US20100012497A1
公开(公告)日：2010-01-21
申请号：US12567482
申请日：2009-09-25
申请人： David W. Neyer , Phillip H. Paul , Don Wesley Arnold , Christopher G. Bailey
发明人： David W. Neyer , Phillip H. Paul , Don Wesley Arnold , Christopher G. Bailey
IPC分类号： G01F1/64 , C25B9/04
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid (1204) whose flow rate is dependent on both hydrostatic pressures and electroosmotic flow can be used (a) directly as a working fluid in an operable device, for example a chromatograph, or (b) to displace a working fluid (1203) from a storage container (625) into an operable device (1301), or both (a) and (b). The driving fluid (1204) can be composed of one or more fluids. Part or all the driving fluid (1204) is passed through an electroosmotic device (100) so as to increase or decrease the flow rate induced by hydrostatic pressure.
摘要翻译：流量控制器，其使用静水压力和电渗流量的组合来控制流体的流动。其流量取决于流体静力压力和电渗流量的驱动流体（1204）可以（a）直接用作可操作装置（例如色谱仪）中的工作流体，或（b）将工作流体（1203））从存储容器（625）移动到可操作装置（1301）或（a）和（b）中。驱动流体（1204）可以由一种或多种流体组成。部分或全部驱动流体（1204）通过电渗装置（100），以增加或减少由静水压力引起的流速。

7. 发明授权

US07591197B2 Biobriefcase aerosol collector 失效
标题翻译： Biobriefcase气溶胶收集器
公开(公告)号：US07591197B2
公开(公告)日：2009-09-22
申请号：US11497918
申请日：2006-08-01
申请人： Perry M. Bell , Allen T. Christian , Christopher G. Bailey , Ladona Willis , Donald A. Masquelier , Shanavaz L. Nasarabadi
发明人： Perry M. Bell , Allen T. Christian , Christopher G. Bailey , Ladona Willis , Donald A. Masquelier , Shanavaz L. Nasarabadi
IPC分类号： G01N1/22
CPC分类号： G01N15/0606 , G01N1/2208 , G01N1/44 , G01N2015/0088 , G01N2015/0261
摘要： A system for sampling air and collecting particles entrained in the air that potentially include bioagents. The system comprises providing a receiving surface, directing a liquid to the receiving surface and producing a liquid surface. Collecting samples of the air and directing the samples of air so that the samples of air with particles entrained in the air impact the liquid surface. The particles potentially including bioagents become captured in the liquid. The air with particles entrained in the air impacts the liquid surface with sufficient velocity to entrain the particles into the liquid but cause minor turbulence. The liquid surface has a surface tension and the collector samples the air and directs the air to the liquid surface so that the air with particles entrained in the air impacts the liquid surface with sufficient velocity to entrain the particles into the liquid, but cause minor turbulence on the surface resulting in insignificant evaporation of the liquid.
摘要翻译：一种用于对空气进行取样并收集在空气中的颗粒的系统，其中可能包括生物标签。该系统包括提供接收表面，将液体引导到接收表面并产生液体表面。收集空气的样品并引导空气样品，使得夹带在空气中的颗粒的空气样品冲击液体表面。潜在地包括生物标记的颗粒被捕获在液体中。夹带在空气中的颗粒的空气以足够的速度冲击液体表面以将颗粒夹带入液体中，但是引起轻微的紊流。液体表面具有表面张力，并且收集器对空气进行采样并将空气引导到液体表面，使得夹带在空气中的颗粒的空气以足够的速度冲击液体表面以将颗粒夹带入液体中，但是引起轻微的紊流在表面上导致液体的微不足道的蒸发。

8. 发明授权

US08795493B2 Flow control systems 有权
标题翻译：流量控制系统
公开(公告)号：US08795493B2
公开(公告)日：2014-08-05
申请号：US12567482
申请日：2009-09-25
申请人： David W. Neyer , Phillip H. Paul , Don Wesley Arnold , Christopher G. Bailey
发明人： David W. Neyer , Phillip H. Paul , Don Wesley Arnold , Christopher G. Bailey
IPC分类号： G05D7/06
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid (1204) whose flow rate is dependent on both hydrostatic pressures and electroosmotic flow can be used (a) directly as a working fluid in an operable device, for example a chromatograph, or (b) to displace a working fluid (1203) from a storage container (625) into an operable device (1301), or both (a) and (b). The driving fluid (1204) can be composed of one or more fluids. Part or all the driving fluid (1204) is passed through an electroosmotic device (100) so as to increase or decrease the flow rate induced by hydrostatic pressure.
摘要翻译：流量控制器，其使用静水压力和电渗流量的组合来控制流体的流动。其流量取决于流体静力压力和电渗流量的驱动流体（1204）可以（a）直接用作可操作装置（例如色谱仪）中的工作流体，或（b）将工作流体（1203））从存储容器（625）移动到可操作装置（1301）或（a）和（b）中。驱动流体（1204）可以由一种或多种流体组成。部分或全部驱动流体（1204）通过电渗装置（100），以增加或减少由静水压力引起的流速。

9. 发明申请

US20110027874A1 Packed Bed for Nucleic Acid Capture and Amplification 审中-公开
标题翻译：用于核酸捕获和扩增的包装床
公开(公告)号：US20110027874A1
公开(公告)日：2011-02-03
申请号：US12899924
申请日：2010-10-07
申请人： Elizabeth K. Wheeler , Christopher G. Bailey , Allen T. Christian
发明人： Elizabeth K. Wheeler , Christopher G. Bailey , Allen T. Christian
IPC分类号： C12M1/00
CPC分类号： C12Q1/6834 , C12Q1/686 , C12Q2547/101 , C12Q2531/113 , C12Q2565/518
摘要： A system for nucleic acid capture and amplification comprising introducing a sample potentially containing the nucleic acid into a packed bed wherein the nucleic acid adheres to the packed bed, introducing an amplification mix into the packed bed, and thermal cycling the packed bed and the nucleic acid between denaturation and annealing temperatures for PCR amplification. One embodiment provides an apparatus for DNA capture and amplification comprising a tubing or housing having a cavity, bed media in the cavity, and a heater operatively connected to the tubing or housing.
摘要翻译：一种用于核酸捕获和扩增的系统，包括将可能含有核酸的样品引入填充床中，其中核酸粘附到填充床，将扩增混合物引入填充床中，以及热循环填充床和核酸在变性和退火温度之间进行PCR扩增。一个实施例提供了一种用于DNA捕获和扩增的装置，其包括具有空腔的管或壳体，空腔中的床介质和可操作地连接到管道或壳体的加热器。

10. 发明授权

US07695603B2 Electroosmotic flow controller 有权
标题翻译：电渗流量控制器
公开(公告)号：US07695603B2
公开(公告)日：2010-04-13
申请号：US11200369
申请日：2005-08-08
申请人： Phillip H. Paul , Don Wesley Arnold , Christopher G. Bailey
发明人： Phillip H. Paul , Don Wesley Arnold , Christopher G. Bailey
IPC分类号： G05D7/06
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： Electroosmotic flow controllers and methods of fluid flow control are described. The invention uses an electroosmotically generated flow component in conjunction with a pressure driven flow component to modulate fluid flow. The devices and methods of the invention may include salt bridges for making electrical connection between a power supply and a channel filled with a porous dielectric material and a fluid. Embodiments including flow controllers and flow splitters are described as is their use in a variety of fluid handling applications.
摘要翻译：描述了电渗流量控制器和流体流量控制的方法。本发明使用电动产生的流动部件与压力驱动流动部件结合以调节流体流动。本发明的装置和方法可以包括用于在电源和填充有多孔电介质材料的通道和流体之间进行电连接的盐桥。描述了包括流量控制器和分流器的实施例是它们在各种流体处理应用中的用途。

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