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1. 发明授权

US09194861B2 Method of mixing fluids by coalescence of multiple emulsions 有权
标题翻译：通过多重乳液的聚结混合流体的方法
公开(公告)号：US09194861B2
公开(公告)日：2015-11-24
申请号：US12862542
申请日：2010-08-24
申请人： Benjamin J. Hindson , Billy W. Colston, Jr. , Kevin D. Ness , Donald A. Masquelier
发明人： Benjamin J. Hindson , Billy W. Colston, Jr. , Kevin D. Ness , Donald A. Masquelier
IPC分类号： G01N21/75 , G01N33/50 , C12Q1/68 , B01F13/00 , B01L3/00 , G01N35/08 , B01J19/00 , B01L7/00
CPC分类号： B01J19/0046 , B01F13/0071 , B01F13/0079 , B01J19/0093 , B01J2219/00286 , B01J2219/00418 , B01J2219/00495 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00873 , B01J2219/00894 , B01J2219/00903 , B01J2219/00957 , B01L3/502784 , B01L7/525 , B01L2200/0673 , B01L2200/16 , B01L2300/0867 , B01L2300/0883 , B01L2300/18 , B01L2400/0487 , B01L2400/0677 , C12Q1/6844 , C40B50/08 , C40B60/14 , G01N1/30 , G01N1/44 , G01N21/75 , G01N33/50 , G01N35/08 , C12Q2547/107
摘要： System, including methods, apparatus, compositions, and kits, for the mixing of small volumes of fluid by coalescence of multiple emulsions.
摘要翻译：系统，包括方法，装置，组合物和试剂盒，用于通过多个乳液的聚结来混合小体积的流体。

2. 发明申请

US20110212516A1 FLOW-BASED THERMOCYCLING SYSTEM WITH THERMOELECTRIC COOLER 有权
标题翻译：具有热电冷却器的基于流动的热循环系统
公开(公告)号：US20110212516A1
公开(公告)日：2011-09-01
申请号：US12890550
申请日：2010-09-24
申请人： Kevin D. Ness , Donald A. Masquelier , Billy W. Colston, JR. , Benjamin J. Hindson
发明人： Kevin D. Ness , Donald A. Masquelier , Billy W. Colston, JR. , Benjamin J. Hindson
IPC分类号： C12M1/00
CPC分类号： B01F3/0807 , B01F13/0062 , B01L3/0241 , B01L3/502784 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2300/0816 , B01L2300/0819 , B01L2300/087 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622
摘要： Thermocycling system, including methods and apparatus, for performing a flow-based reaction on a sample in fluid. The system may include a plurality of segments defining at least two temperature regions, and also may include a plurality of heating elements configured to maintain each temperature region at a different desired temperature. At least one of the heating elements may be a thermoelectric cooler operatively disposed to transfer heat to and/or from a temperature region The system further may include a fluid channel extending along a helical path that passes through the temperature regions multiple times such that fluid flowing in the channel is heated and cooled cyclically.
摘要翻译：热循环系统，包括用于对流体中的样品进行基于流的反应的方法和装置。该系统可以包括限定至少两个温度区域的多个段，并且还可以包括被配置为将每个温度区域保持在不同的期望温度的多个加热元件。加热元件中的至少一个可以是可操作地设置成将热传递到和/或从温度区域传递的热电冷却器。该系统还可以包括沿着螺旋路径延伸的流体通道，该螺旋路径多次通过温度区域，使得流体流动在通道中循环加热和冷却。

3. 发明申请

US20110053798A1 SYSTEM FOR MIXING FLUIDS BY COALESCENCE OF MULTIPLE EMULSIONS 有权
标题翻译：通过多种乳化剂混合使混合液体系统
公开(公告)号：US20110053798A1
公开(公告)日：2011-03-03
申请号：US12862542
申请日：2010-08-24
申请人： Benjamin J. Hindson , Billy W. Colston, JR. , Kevin D. Ness , Donald A. Masquelier
发明人： Benjamin J. Hindson , Billy W. Colston, JR. , Kevin D. Ness , Donald A. Masquelier
IPC分类号： C40B30/00 , C40B30/10 , C40B40/00 , C40B40/06
CPC分类号： B01J19/0046 , B01F13/0071 , B01F13/0079 , B01J19/0093 , B01J2219/00286 , B01J2219/00418 , B01J2219/00495 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00873 , B01J2219/00894 , B01J2219/00903 , B01J2219/00957 , B01L3/502784 , B01L7/525 , B01L2200/0673 , B01L2200/16 , B01L2300/0867 , B01L2300/0883 , B01L2300/18 , B01L2400/0487 , B01L2400/0677 , C12Q1/6844 , C40B50/08 , C40B60/14 , G01N1/30 , G01N1/44 , G01N21/75 , G01N33/50 , G01N35/08 , C12Q2547/107
摘要： System, including methods, apparatus, compositions, and kits, for the mixing of small volumes of fluid by coalescence of multiple emulsions.
摘要翻译：系统，包括方法，装置，组合物和试剂盒，用于通过多个乳液的聚结来混合小体积的流体。

4. 发明授权

US07591197B2 Biobriefcase aerosol collector 失效
标题翻译： Biobriefcase气溶胶收集器
公开(公告)号：US07591197B2
公开(公告)日：2009-09-22
申请号：US11497918
申请日：2006-08-01
申请人： Perry M. Bell , Allen T. Christian , Christopher G. Bailey , Ladona Willis , Donald A. Masquelier , Shanavaz L. Nasarabadi
发明人： Perry M. Bell , Allen T. Christian , Christopher G. Bailey , Ladona Willis , Donald A. Masquelier , Shanavaz L. Nasarabadi
IPC分类号： G01N1/22
CPC分类号： G01N15/0606 , G01N1/2208 , G01N1/44 , G01N2015/0088 , G01N2015/0261
摘要： A system for sampling air and collecting particles entrained in the air that potentially include bioagents. The system comprises providing a receiving surface, directing a liquid to the receiving surface and producing a liquid surface. Collecting samples of the air and directing the samples of air so that the samples of air with particles entrained in the air impact the liquid surface. The particles potentially including bioagents become captured in the liquid. The air with particles entrained in the air impacts the liquid surface with sufficient velocity to entrain the particles into the liquid but cause minor turbulence. The liquid surface has a surface tension and the collector samples the air and directs the air to the liquid surface so that the air with particles entrained in the air impacts the liquid surface with sufficient velocity to entrain the particles into the liquid, but cause minor turbulence on the surface resulting in insignificant evaporation of the liquid.
摘要翻译：一种用于对空气进行取样并收集在空气中的颗粒的系统，其中可能包括生物标签。该系统包括提供接收表面，将液体引导到接收表面并产生液体表面。收集空气的样品并引导空气样品，使得夹带在空气中的颗粒的空气样品冲击液体表面。潜在地包括生物标记的颗粒被捕获在液体中。夹带在空气中的颗粒的空气以足够的速度冲击液体表面以将颗粒夹带入液体中，但是引起轻微的紊流。液体表面具有表面张力，并且收集器对空气进行采样并将空气引导到液体表面，使得夹带在空气中的颗粒的空气以足够的速度冲击液体表面以将颗粒夹带入液体中，但是引起轻微的紊流在表面上导致液体的微不足道的蒸发。

5. 发明授权

US08633015B2 Flow-based thermocycling system with thermoelectric cooler 有权
标题翻译：基于流动的热电循环系统与热电冷却器
公开(公告)号：US08633015B2
公开(公告)日：2014-01-21
申请号：US12890550
申请日：2010-09-24
申请人： Kevin D. Ness , Donald A. Masquelier , Billy W. Colston, Jr. , Benjamin J. Hindson
发明人： Kevin D. Ness , Donald A. Masquelier , Billy W. Colston, Jr. , Benjamin J. Hindson
IPC分类号： C12M1/34
CPC分类号： B01F3/0807 , B01F13/0062 , B01L3/0241 , B01L3/502784 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2300/0816 , B01L2300/0819 , B01L2300/087 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622
摘要： Thermocycling system, including methods and apparatus, for performing a flow-based reaction on a sample in fluid. The system may include a plurality of segments defining at least two temperature regions, and also may include a plurality of heating elements configured to maintain each temperature region at a different desired temperature. At least one of the heating elements may be a thermoelectric cooler operatively disposed to transfer heat to and/or from a temperature region The system further may include a fluid channel extending along a helical path that passes through the temperature regions multiple times such that fluid flowing in the channel is heated and cooled cyclically.
摘要翻译：热循环系统，包括用于对流体中的样品进行基于流的反应的方法和装置。该系统可以包括限定至少两个温度区域的多个段，并且还可以包括被配置为将每个温度区域保持在不同的期望温度的多个加热元件。加热元件中的至少一个可以是可操作地设置成将热传递到和/或从温度区域传递的热电冷却器。该系统还可以包括沿着螺旋路径延伸的流体通道，该螺旋路径多次通过温度区域，使得流体流动在通道中循环加热和冷却。

6. 发明授权

US08582936B2 Separating and combining single-mode and multimode optical beams 有权
标题翻译：分离和组合单模和多模光束
公开(公告)号：US08582936B2
公开(公告)日：2013-11-12
申请号：US13071382
申请日：2011-03-24
申请人： Anthony J. Ruggiero , Donald A. Masquelier , Jeffery B. Cooke , Jeffery S. Kallman
发明人： Anthony J. Ruggiero , Donald A. Masquelier , Jeffery B. Cooke , Jeffery S. Kallman
IPC分类号： G02B6/26
CPC分类号： G02B6/2817
摘要： Techniques for combining initially separate single mode and multimode optical beams into a single “Dual Mode” fiber optic have been developed. Bi-directional propagation of two beams that are differentiated only by their mode profiles (i.e., wavefront conditions) is provided. The beams can be different wavelengths and or contain different modulation information but still share a common aperture. This method allows the use of conventional micro optics and hybrid photonic packaging techniques to produce small rugged packages suitable for use in industrial or military environments.
摘要翻译：已经开发了将初始分离的单模和多模光束组合成单个“双模”光纤的技术。提供了仅通过其模式分布区分的两个波束的双向传播（即波前条件）。光束可以是不同的波长并且或包含不同的调制信息，但仍然共享公共孔径。这种方法允许使用传统的微光学和混合光子封装技术来生产适用于工业或军事环境的小型坚固封装。

7. 发明申请

US20130084572A1 CALIBRATIONS AND CONTROLS FOR DROPLET-BASED ASSAYS 审中-公开
公开(公告)号：US20130084572A1
公开(公告)日：2013-04-04
申请号：US13251016
申请日：2011-09-30
申请人： Benjamin J. Hindson , Billy W. Colston, JR. , Kevin D. Ness , Donald A. Masquelier
发明人： Benjamin J. Hindson , Billy W. Colston, JR. , Kevin D. Ness , Donald A. Masquelier
IPC分类号： G01N21/75 , G01N21/64 , C12Q1/68
CPC分类号： G01N21/6428 , C12Q1/6851 , G01N2021/6441 , C12Q2545/101 , C12Q2563/159
摘要： System, including methods and apparatus, for performing droplet-based assays that are controlled and/or calibrated using signals detected from droplets.

8. 发明授权

US06520034B1 High air volume to low liquid volume aerosol collector 失效
标题翻译：高空气体积到低液体体积的气溶胶收集器
公开(公告)号：US06520034B1
公开(公告)日：2003-02-18
申请号：US10116375
申请日：2002-04-03
申请人： Donald A. Masquelier , Fred P. Milanovich , Klaus Willeke
发明人： Donald A. Masquelier , Fred P. Milanovich , Klaus Willeke
IPC分类号： G01N140
CPC分类号： G01N1/2273 , G01N1/2202 , G01N1/24 , G01N1/40 , G01N2001/1018 , G01N2001/2223 , G01N2001/2276 , G01N2015/0088
摘要： A high air volume to low liquid volume aerosol collector. A high volume flow of aerosol particles is drawn into an annular, centripetal slot in a collector which directs the aerosol flow into a small volume of liquid pool contained is a lower center section of the collector. The annular jet of air impinges into the liquid, imbedding initially airborne particles in the liquid. The liquid in the pool continuously circulates in the lower section of the collector by moving to the center line, then upwardly, and through assistance by a rotating deflector plate passes back into the liquid at the outer area adjacent the impinging air jet which passes upwardly through the liquid pool and through a hollow center of the collector, and is discharged via a side outlet opening. Any liquid droplets escaping with the effluent air are captured by a rotating mist eliminator and moved back toward the liquid pool. The collector includes a sensor assembly for determining, controlling, and maintaining the level of the liquid pool, and includes a lower centrally located valve assembly connected to a liquid reservoir and to an analyzer for analyzing the particles which are impinged into the liquid pool.
摘要翻译：高空气体积到低液体体积的气溶胶收集器。气溶胶颗粒的大体积流动被吸入收集器中的环形向心槽中，其将气溶胶流引导到容纳的小容积的液体池中，该容器是收集器的下部中心部分。环形空气射流冲击液体，最初嵌入液体中的空气中的颗粒。池中的液体通过移动到中心线，然后向上而在收集器的下部部分中连续地循环，并且通过旋转偏转板的辅助在靠近冲击空气射流的外部区域返回到液体中，该冲击空气射流向上通过液池并通过收集器的中空中心，并通过侧出口开口排出。用流出的空气排出的任何液滴都被旋转除雾器捕获并向液体池移回。收集器包括用于确定，控制和维持液池的液位的传感器组件，并且包括连接到液体储存器的下部中心定位的阀组件和用于分析撞击到液体池中的颗粒的分析器。

9. 发明授权

US09089844B2 System for forming emulsions 有权
标题翻译：乳液成型系统
公开(公告)号：US09089844B2
公开(公告)日：2015-07-28
申请号：US13287120
申请日：2011-11-01
申请人： Amy L. Hiddessen , Donald A. Masquelier , Kevin D. Ness , Benjamin J. Hindson , Anthony J. Makarewicz, Jr. , Erin R. Chia
发明人： Amy L. Hiddessen , Donald A. Masquelier , Kevin D. Ness , Benjamin J. Hindson , Anthony J. Makarewicz, Jr. , Erin R. Chia
IPC分类号： C12Q1/68 , B01L3/00 , G01N1/38 , B01F3/08 , B01F13/00 , B01F13/10 , G01N35/10
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F13/1022 , B01L3/502761 , B01L2200/0605 , B01L2200/0673 , B01L2300/0867 , B01L2400/0487 , G01N1/38 , G01N2035/1046 , Y10T137/0396 , Y10T137/8593
摘要： System, including methods, apparatus, and kits, for forming emulsions. The system may include an instrument and a microfluidic chip received by the instrument. The instrument may apply pressure to prospective emulsion phases held by the chip, to drive formation and collection of emulsions in the chip. In some embodiments, the instrument may stop applying pressure to the chip when a change in pressure meeting a predefined condition is detected by the instrument. The change may indicate that an endpoint of droplet generation has been reached.
摘要翻译：用于形成乳液的系统，包括方法，装置和试剂盒。该系统可以包括由仪器接收的仪器和微流体芯片。仪器可以对由芯片保持的预期乳液相施加压力，以驱动芯片中的乳液的形成和收集。在一些实施例中，当仪器检测到满足预定条件的压力变化时，仪器可能停止向芯片施加压力。该变化可能表明已达到液滴产生的终点。

10. 发明申请

US20120194805A1 DETECTION SYSTEM FOR DROPLET-BASED ASSAYS 有权
标题翻译：基于滴定法的检测检测系统
公开(公告)号：US20120194805A1
公开(公告)日：2012-08-02
申请号：US13341678
申请日：2011-12-30
申请人： Kevin D. Ness , Mark A. Arbore , Jerry E. Hurst , David L. Klein , Donald A. Masquelier
发明人： Kevin D. Ness , Mark A. Arbore , Jerry E. Hurst , David L. Klein , Donald A. Masquelier
IPC分类号： G01J1/00
CPC分类号： G01N21/6428 , B01L3/502784 , G01N15/1456 , G01N21/05 , G01N21/31 , G01N21/553 , G01N21/645 , G01N21/6486 , G01N2021/0346 , G01N2021/052 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/8564 , G01N2201/062 , G01N2201/0627 , G01N2201/0696
摘要： System, including methods and apparatus, for light detection and signal processing for droplet-based assays.
摘要翻译：用于基于液滴的测定的光检测和信号处理的系统，包括方法和装置。

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