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1. 发明授权

US10669350B2 Antigen-binding constructs that bind to and inhibit catalase and/or superoxide dismutase as well as pharmaceutical compositions containing them for tumor therapy 审中-公开
公开(公告)号：US10669350B2
公开(公告)日：2020-06-02
申请号：US15543215
申请日：2016-02-01
申请人： Georg Bauer , Manfred Motz
发明人： Georg Bauer , Manfred Motz
IPC分类号： C07K16/40 , C07K16/30 , A61K31/337 , A61K39/395 , A61K45/06 , A61K39/00
摘要： The invention relates to single domain VHH fragments which specifically bind to and inhibit superoxide dismutase and/or bind to and inhibit catalase and/or bind to and inhibit superoxide dismutase and catalase, in particular for the use in the therapy of tumor diseases.

2. 发明申请

US20180002445A1 ANTIGEN-BINDING CONSTRUCTS THAT BIND TO AND INHIBIT CATALASE AND/OR SUPEROXIDE DISMUTASE AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR TUMOR THERAPY 审中-公开
公开(公告)号：US20180002445A1
公开(公告)日：2018-01-04
申请号：US15543215
申请日：2016-02-01
申请人： Georg BAUER , Manfred MOTZ
发明人： Georg BAUER , Manfred MOTZ
IPC分类号： C07K16/40 , A61K31/337 , A61K39/395 , A61K45/06 , A61K39/00
摘要： The invention relates to single domain VHH fragments which specifically bind to and inhibit superoxide dismutase and/or bind to and inhibit catalase and/or bind to and inhibit superoxide dismutase and catalase, in particular for the use in the therapy of tumor diseases.

3. 发明申请

US20090098528A1 Method for determining early HCV seroconversion 审中-公开
标题翻译：确定早期HCV血清学转换的方法
公开(公告)号：US20090098528A1
公开(公告)日：2009-04-16
申请号：US11974030
申请日：2007-10-11
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutscheck
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutscheck
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译：本发明涉及由免疫学试验中由丙型肝炎病毒的氨基酸1207±10至1488±10和小于20个外来氨基酸组成的多肽，以及该多肽作为抗原的用途。

4. 发明申请

US20060057563A1 Peptides derived from capsid antigens of the Epstein-Barr virus and the use thereof 有权
公开(公告)号：US20060057563A1
公开(公告)日：2006-03-16
申请号：US11192070
申请日：2005-07-29
申请人： Manfred Motz , Georg Bauer , Erwin Soutschek
发明人： Manfred Motz , Georg Bauer , Erwin Soutschek
IPC分类号： C12Q1/70 , C07H21/04 , C07K14/05
CPC分类号： G01N33/56994
摘要： In the area of virus diagnosis, in particular Epstein-Barr virus (EBV) diagnosis, methods for the detection of EBV and agents suitable for this purpose are provided, including peptides which are derived from p18-VCA and permit discrimination between acute and past EBV infection.

5. 发明授权

US06183755B2 Active proteins from Borrelia burgdorferi 失效
标题翻译：来自博氏疏螺旋体的活性蛋白
公开(公告)号：US06183755B2
公开(公告)日：2001-02-06
申请号：US09196293
申请日：1998-11-19
申请人： Manfred Motz , Erwin Soutscheck , Renate Fuchs , Bettina Wilske , Vera Preac-Mursic
发明人： Manfred Motz , Erwin Soutscheck , Renate Fuchs , Bettina Wilske , Vera Preac-Mursic
IPC分类号： A61K3902
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , C07K14/20 , G01N33/56911 , Y02A50/401 , Y02A50/57 , Y10S436/804 , Y10S530/825
摘要： Various immunologically active proteins from Borrelia burgdorferi have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a B. burgdorferi gene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The Borrelia burgdorferi-specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).
摘要翻译：通过遗传操作在微生物中制备了来自博氏疏螺旋体的各种免疫活性蛋白质。为此，使用合适的筛选方法从布氏疏螺旋体基因库中选择特异性DNA序列，或者通过使用选择的杂交探针的DNA扩增直接制备，并置于诱导型启动子的控制下，例如， lac启动子。由于对表达的抗原的有效纯化方法的描述，可以以合适的方式提供蛋白质是可能的。这些蛋白质可用于制备特异性敏感的诊断测定试剂盒。免疫活性蛋白质的特异性组合使得精确的诊断成为可能。此外，已经产生了单克隆抗体，并且用作用于在测试样品中或培养后直接检测病原体的试剂。疏螺旋体异常特异性DNA序列可用于直接检测患者样品中的病原体（例如通过PCR反应）。

6. 发明授权

US6136527A Polypeptides derived from proteins of the hepatitis C virus, test kits containing these polypeptides and vaccines against infections of hepatitis C viruses 失效
标题翻译：衍生自丙型肝炎病毒蛋白质的多肽，含有这些多肽的试剂盒和针对丙型肝炎病毒感染的疫苗
公开(公告)号：US6136527A
公开(公告)日：2000-10-24
申请号：US78271
申请日：1993-10-15
申请人： Klaus Fuchs , Manfred Motz , Michael Roggendorf , Erwin Soutschek
发明人： Klaus Fuchs , Manfred Motz , Michael Roggendorf , Erwin Soutschek
IPC分类号： A61K39/29 , A61K39/00 , A61P31/12 , C07H21/04 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/705 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/51 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/53 , G01N33/576
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222
摘要： The cloning and sequencing of different polypeptides from the genome of a hepatitis C virus is disclosed. The polypeptides are prepared as non-fusion proteins in good yield. The polypeptide originating from the structure protein (core) is soluble under physiological conditions. Since the polypeptides have no foreign protein portions, they are preferably used in test kits and as vaccine.
摘要翻译： PCT No.PCT / DE91 / 01020 Sec。 371日期：1993年10月15日 102（e）日期1993年10月15日PCT 1991年12月20日PCT PCT。出版物WO92 / 11370 日期1992年7月9日公开了来自丙型肝炎病毒基因组的不同多肽的克隆和测序。多肽以良好的产率制备为非融合蛋白。来自结构蛋白（核心）的多肽在生理条件下是可溶的。由于多肽不含外来蛋白质部分，因此优选用于测试试剂盒和疫苗中。

7. 发明授权

US07083792B2 Immunologically active proteins from Borrelia burgdorferi 失效
公开(公告)号：US07083792B2
公开(公告)日：2006-08-01
申请号：US10762665
申请日：2004-01-22
申请人： Renate Fuchs , Bettina Wilske , Vera Preac-Mursic , Manfred Motz , Erwin Soutscheck
发明人： Renate Fuchs , Bettina Wilske , Vera Preac-Mursic , Manfred Motz , Erwin Soutscheck
IPC分类号： A61K39/00 , A61K39/02 , C07K1/00 , C07K14/00
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , C07K14/20 , G01N33/56911 , Y02A50/401 , Y02A50/57 , Y10S436/804 , Y10S530/825
摘要： Various immunologically active proteins from Borrelia burgdorferi have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a B. burgdorferi gene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The Borrelia burgdorferi-specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).

8. 发明申请

US20050095584A1 Method for determining early HCV seroconversion 审中-公开
标题翻译：确定早期HCV血清学转换的方法
公开(公告)号：US20050095584A1
公开(公告)日：2005-05-05
申请号：US10802891
申请日：2004-03-17
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： G01N33/53 , A61K38/00 , A61K39/29 , A61P1/16 , A61P31/12 , A61P31/14 , C07H21/04 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/40 , C12N15/51 , C12P21/02 , C12P21/04 , C12R1/19 , G01N33/532 , G01N33/537 , G01N33/569 , G01N33/576 , G01N33/68 , C12Q1/70 , C12N15/86 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译：本发明涉及由免疫学试验中由丙型肝炎病毒的氨基酸1207±10至1488±10和小于20个外来氨基酸组成的多肽和该多肽作为抗原的用途。

9. 发明授权

US06306579B1 Recombinant antigen from the NS3 region of the hepatitis C virus 失效
标题翻译：来自丙型肝炎病毒NS3区域的重组抗原
公开(公告)号：US06306579B1
公开(公告)日：2001-10-23
申请号：US08892704
申请日：1997-07-15
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译：本发明涉及一种多肽，其由丙型肝炎病毒的氨基酸1207 10至1488 10和少于20个外来氨基酸组成，并且在免疫测试中使用该多肽作为抗原

10. 发明授权

US06270960B1 Recombinant antigen from the NS3 region of the hepatitis C virus 有权
公开(公告)号：US06270960B1
公开(公告)日：2001-08-07
申请号：US09592197
申请日：2000-06-12
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

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