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1. 发明授权

US08338649B2 Method for the production of aromatic carbonyl compounds 失效
标题翻译：芳香族羰基化合物的制备方法
公开(公告)号：US08338649B2
公开(公告)日：2012-12-25
申请号：US12733445
申请日：2008-09-02
申请人： Klaus Forstinger , Thomas Sommer , Daniel Decker , Andreas Martin , Angela Köckritz , Michael Kant , Alexander Hofmann
发明人： Klaus Forstinger , Thomas Sommer , Daniel Decker , Andreas Martin , Angela Köckritz , Michael Kant , Alexander Hofmann
IPC分类号： C07C45/28
CPC分类号： C07B41/06 , C07C45/28 , C07C47/55
摘要： The invention relates to a method for the production of an aromatic carbonyl compound by the oxidation of a methyl group or methylene group bonded to the aromatic group in which the aromatic substance is reacted in the presence of an oxidizing agent and a sulphoxide, a sulphoxide being selected for the oxidation of a specific aromatic substance whose ionization potential, in terms of magnitude, differs from the ionization potential of the aromatic substance to be oxidized by a maximum of ±0.25 eV.
摘要翻译：本发明涉及一种芳族羰基化合物的制备方法，该方法是通过氧化连接到芳香族基团上的甲基或亚甲基，其中芳族物质在氧化剂和亚砜存在下反应，亚砜为选择用于氧化特定芳族物质，其电离电位（以量级计）与待氧化的芳族物质的电离电位不同，最大为±0.25eV。

2. 发明申请

US20100312017A1 METHOD FOR THE PRODUCTION OF AROMATIC CARBONYL COMPOUNDS 失效
标题翻译：生产芳香碳化合物的方法
公开(公告)号：US20100312017A1
公开(公告)日：2010-12-09
申请号：US12733445
申请日：2008-09-02
申请人： Klaus Forstinger , Thomas Sommer , Daniel Decker , Andreas Martin , Angela Köckritz , Michael Kant , Alexander Hofmann
发明人： Klaus Forstinger , Thomas Sommer , Daniel Decker , Andreas Martin , Angela Köckritz , Michael Kant , Alexander Hofmann
IPC分类号： C07C45/28
CPC分类号： C07B41/06 , C07C45/28 , C07C47/55
摘要： The invention relates to a method for the production of an aromatic carbonyl compound by the oxidation of a methyl group or methylene group bonded to the aromatic group in which the aromatic substance is reacted in the presence of an oxidising agent and a sulphoxide, a sulphoxide being selected for the oxidation of a specific aromatic substance whose ionisation potential, in terms of magnitude, differs from the ionisation potential of the aromatic substance to be oxidised by a maximum of ±0.25 eV.
摘要翻译：本发明涉及一种芳族羰基化合物的制备方法，该方法是通过氧化与芳族基团结合的甲基或亚甲基，其中芳族物质在氧化剂和亚砜存在下反应，亚砜为选择用于氧化特定芳族物质，其电离电位（以量级计）与待氧化的芳族物质的电离电位不同于最大±0.25eV。

3. 发明申请

US20070078282A1 Process for reductively aminating ketones and aldehydes with aqueous amines and catalysts suitable therefor 失效
标题翻译：用含胺胺和合适的催化剂还原胺化酮和醛的方法
公开(公告)号：US20070078282A1
公开(公告)日：2007-04-05
申请号：US11526337
申请日：2006-09-25
申请人： Daniel Schramm , Daniel Decker , Klaus Forstinger , Klemens Flick
发明人： Daniel Schramm , Daniel Decker , Klaus Forstinger , Klemens Flick
IPC分类号： C07C209/26
CPC分类号： C07C209/26 , C07C211/27 , C07C211/29
摘要： A process for preparing amines of the general formula (I) R1R2CHNR3R4 (I) in which R1, R2, R3 and R4 are each independently hydrogen, straight-chain or branched, halogenated or halogen-free C1-C12-alkyl, C3-C12-cycloalkyl, C6-C10-aryl or C7-C11-aralkyl, by catalytic, hydrogenating amination of carbonyl compounds of the general formula (II) R1—C(═O)—R2 (II)with nitrogen compounds of the general formula (III) HNR3R4 (III)in the presence of bifunctional catalyst systems comprising a.) a hydrogenation-active catalyst component comprising one or more metals of transition group 8 of the Periodic Table and b.) one or more solid, acidic cocatalysts, wherein the hydrogenating amination is carried out in the presence of aqueous ammonia or aqueous amine of the formula (III) and at least one organic solvent miscible with ammonia or the aqueous amine of the formula (III).
摘要翻译：制备通式（I）的胺的方法<？in-line-formula description =“In-line Formulas”end =“lead”？> R＆lt; 2＆lt; 2＆gt; （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R ^{R 1 -C（-O）-R 与通式（III）的氮化合物< 公式描述=“内联公式”end =“lead”？> HNR <3> 4（III）<？in-line-formula description =“In- 在包含a）包含一种或多种元素周期表第8族金属的氢化活性催化剂组分和b）一种或多种固体，酸性的双官能催化剂体系的存在下，式“末端=”尾“ 助催化剂，其中所述氢化胺化在式（III）的氨水或胺水溶液的存在下进行，和至少一种可与氨或式（III）的胺水溶液混合的至少一种有机溶剂。}

4. 发明授权

US07323599B2 Process for reductively aminating ketones and aldehydes with aqueous amines and catalysts suitable therefor 失效
标题翻译：用含胺胺和合适的催化剂还原胺化酮和醛的方法
公开(公告)号：US07323599B2
公开(公告)日：2008-01-29
申请号：US11526337
申请日：2006-09-25
申请人： Daniel Schramm , Daniel Decker , Klaus Forstinger , Klemens Flick
发明人： Daniel Schramm , Daniel Decker , Klaus Forstinger , Klemens Flick
IPC分类号： C07C209/00
CPC分类号： C07C209/26 , C07C211/27 , C07C211/29
摘要： A process for preparing amines of the general formula (I) R1R2CHNR3R4 (I) in which R1, R2, R3 and R4 are each independently hydrogen, straight-chain or branched, halogenated or halogen-free C1-C12-alkyl, C3-C12-cycloalkyl, C6-C10-aryl or C7-C11-aralkyl, by catalytic, hydrogenating amination of carbonyl compounds of the general formula (II) R1—C(═O)—R2 (II) with nitrogen compounds of the general formula (III) HNR3R4 (III) in the presence of bifunctional catalyst systems comprising a.) a hydrogenation-active catalyst component comprising one or more metals of transition group 8 of the Periodic Table and b.) one or more solid, acidic cocatalysts, wherein the hydrogenating amination is carried out in the presence of aqueous ammonia or aqueous amine of the formula (III) and at least one organic solvent miscible with ammonia or the aqueous amine of the formula (III).
摘要翻译：制备通式（I）的胺的方法<？in-line-formula description =“In-line Formulas”end =“lead”？> R＆lt; 2＆lt; 2＆gt; （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R ^{R 1 -C（-O）-R 2 与式（III）的氮化合物相同的式（III）中，式（II）<？in-line-formula description =“In-line formula”end =“tail” 公式“end =”lead“？> HNR <3> 4（III）<？in-line-formula description =”In-line Formul 在包含a）包含一种或多种元素周期表第8族金属的氢化活性催化剂组分和b）一种或多种固体，酸性助催化剂的双官能催化剂体系存在下，ae“end =”tail“ 其中所述氢化胺化在式（III）的氨水或胺水溶液的存在下进行，和至少一种与氨或式（III）的胺水溶液混合的至少一种有机溶剂。}

5. 发明授权

US5227535A Process for the preparation of 2-nitro-5-fluoro- or -5-chlorophenol 失效
标题翻译： 2-硝基-5-氟或5-氯苯酚的制备方法
公开(公告)号：US5227535A
公开(公告)日：1993-07-13
申请号：US957674
申请日：1992-10-07
申请人： Ralf Pfirmann , Theodor Papenfuhs , Klaus Forstinger
发明人： Ralf Pfirmann , Theodor Papenfuhs , Klaus Forstinger
IPC分类号： C07C201/12 , C07C205/26
CPC分类号： C07C201/12
摘要： The present invention relates to a process for the preparation of isomerically pure 2-nitro-5-fluoro- or -5-chlorophenol, by reacting 2,4-difluoronitrobenzene or 2,4-dichloronitrobenzene with aqueous alkali metal or alkaline earth metal hydroxide solution or suspension in the absence of organic solvents or other solubility promoting substances at temperatures from about 20.degree. C. to about 190.degree. C., adjusting the pH of the reaction mixture to about 1 to about 6 by the addition of acid, steam distilling the resultant product and isolating it from the distillate after cooling.
摘要翻译：本发明涉及通过2,4-二氟硝基苯或2,4-二氯硝基苯与碱金属或碱土金属氢氧化物水溶液的反应来制备异构纯的2-硝基-5-氟 - 或-5-氯苯酚的方法或在约20℃至约190℃的温度下不存在有机溶剂或其它促溶解物质的悬浮液，通过加入酸将反应混合物的pH调节至约1至约6，蒸馏蒸馏冷却后将其与馏出物分离。

6. 发明申请

US20060131762A1 Method for metal-organic production of organic intermediate products by means of aryl lithium-bases 审中-公开
标题翻译：通过芳基锂基金属有机生产有机中间产物的方法
公开(公告)号：US20060131762A1
公开(公告)日：2006-06-22
申请号：US10526237
申请日：2003-08-21
申请人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
IPC分类号： C07D333/22 , C07D213/63 , C07F1/02
CPC分类号： C07F5/025
摘要： The invention relates to a method for the production of substituted aromatic compounds by producing lithium arylene and by reacting it with suitable electrophiles. The method comprises the following steps (step 1); an aryl lithium compound ( auxiliary base”) is initially produced by reacting a halogen aromatic compound with lithium metal; said compound is subsequently (step 2) reacted for deprotonation of the aromatic substrate in order to form the corresponding lithium aromatic compound which is subsequently (step 3) reacted with a corresponding electrophile to form the desired substituted aromatic compound, see page 2 of the description.
摘要翻译：本发明涉及通过生产锂亚芳基并通过与合适的亲电体反应来制备取代的芳族化合物的方法。该方法包括以下步骤（步骤1）; 最初通过卤素芳族化合物与锂金属反应制备芳基锂化合物（辅助碱“）;随后（步骤2）使所述化合物反应进行芳族底物的去质子化，以形成相应的锂芳族化合物，随后（步骤3）与相应的亲电子试剂反应以形成所需的取代的芳族化合物，参见说明书的第2页。

7. 发明授权

US5594145A Process for the preparation of 2(3H)-benzothiazolones 失效
标题翻译：制备2（3H） - 苯并噻唑酮的方法
公开(公告)号：US5594145A
公开(公告)日：1997-01-14
申请号：US232748
申请日：1994-04-25
申请人： Klaus Forstinger , Heinrich Volk , Werner Wykypiel
发明人： Klaus Forstinger , Heinrich Volk , Werner Wykypiel
IPC分类号： C07D277/68
CPC分类号： C07D277/68
摘要： The process for the preparation of 2(3H)-benzothiazolones which are optionally substituted on the benzene ring by reacting a 2-aminobenzothiazole which is optionally substituted on the benzene ring with a diazotization agent in the presence of aqueous hydrochloric acid, if appropriate with addition of a chloride, to give a diazonium chloride, reacting the diazonium chloride directly to give a 2-chlorobenzothiazole, which is optionally substituted on the benzene ring, and hydrolyzing the 2-chlorobenzothiazole, without intermediate isolation, at 120.degree.-200.degree. C. under reaction pressure.
摘要翻译：制备任选在苯环上取代的2（3H） - 苯并噻唑酮的方法，如果合适，加入盐酸盐酸盐，在苯环上任选取代的2-氨基苯并噻唑与重氮化试剂反应的氯化物，得到重氮氯化物，直接使重氮化钾反应，得到在苯环上任意取代的2-氯苯并噻唑，并在120℃-200℃下水解2-氯苯并噻唑，无需中间分离。在反应压力下。

8. 发明申请

US20070185353A1 Method for producing alkylene glycol diethers 审中-公开
标题翻译：亚烷基二醇二醚的制备方法
公开(公告)号：US20070185353A1
公开(公告)日：2007-08-09
申请号：US10590187
申请日：2005-02-08
申请人： Alexander Snell , Achim Stankowiak , Gabriele Oberendfellner , Hieng Kim , Klaus Forstinger , Christian Wille
发明人： Alexander Snell , Achim Stankowiak , Gabriele Oberendfellner , Hieng Kim , Klaus Forstinger , Christian Wille
IPC分类号： C07C41/01
CPC分类号： C07C41/02 , C07C43/10 , C07C43/11
摘要： The invention relates to a method for producing alkylene glycol diethers by reacting a linear or cyclic ether with an alkylene oxide in the presence of a Lewis acid. The invention is characterized in that the reaction is continuously carried out in a micro reactor.
摘要翻译：本发明涉及在路易斯酸存在下使直链或环状醚与烯化氧反应制备亚烷基二醇二醚的方法。本发明的特征在于反应在微反应器中连续进行。

9. 发明申请

US20060142588A1 Acetoacetylation of alcohols, thiols and amines in a microreactor 审中-公开
标题翻译：在微反应器中醇，硫醇和胺的乙酰乙酰化
公开(公告)号：US20060142588A1
公开(公告)日：2006-06-29
申请号：US10544076
申请日：2003-12-13
申请人： Uwe Nickel , Detlef Wehle , Leonhard Unverdorben , Klaus Forstinger , Hieng Kim
发明人： Uwe Nickel , Detlef Wehle , Leonhard Unverdorben , Klaus Forstinger , Hieng Kim
IPC分类号： C07D235/22 , C07C69/76 , C07C309/29
CPC分类号： C07D235/26 , C07C67/46 , C07C231/04 , C07C303/22 , C07C303/32 , C07C69/72 , C07C309/51
摘要： The invention relates to a method for the production of β-keto-carboxylic acid derivatives of formula (I) or the salts thereof, where X═NR′, O or S, R, R′, R1-R4 independently ═H, alkyl, alkenyl, aryl or heteroaryl, by reaction of a diketene of formula (II) with a compound comprising an active hydrogen of formula ROH, NHRR′ or RSH, characterised in that the reaction is continuously carried out in a microreactor.
摘要翻译：本发明涉及制备式（I）的β-酮 - 羧酸衍生物或其盐的方法，其中X-NR'，O或S，R，R'，R 1 通过式（II）的二烯酮与包含式ROH，NHRR'或RSH的活性氢的化合物的反应，独立地是-H，烷基，烯基，芳基或杂芳基，-R 因为反应在微反应器中连续进行。

10. 发明授权

US5516932A Halogenated cinnamic acids and esters thereof, processes for the preparation thereof and halogenated aryldiazonium salts 失效
标题翻译：卤化肉桂酸及其酯，其制备方法和卤代芳基重氮盐
公开(公告)号：US5516932A
公开(公告)日：1996-05-14
申请号：US178089
申请日：1994-01-06
申请人： Matthias Beller , Hartmut Fischer , Laurent Weisse , Klaus Forstinger , Ralf Pfirmann , Heinz Strutz
发明人： Matthias Beller , Hartmut Fischer , Laurent Weisse , Klaus Forstinger , Ralf Pfirmann , Heinz Strutz
IPC分类号： B01J23/44 , C07B61/00 , C07C57/60 , C07C67/333 , C07C67/343 , C07C69/65 , C07C245/20 , C07C69/76
CPC分类号： C07C245/20 , C07C57/60 , C07C67/343 , C07C69/65
摘要： The present invention relates to compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are hydrogen or an alkyl radical having 1 to 18 carbon atoms and optionally containing oxygen, nitrogen or halogen, the radicals X, Y and Z are identical and are a fluorine, bromine or iodine atom or if two of the radicals X, Y or Z are identical or all of the radicals X, Y, Z are different from each other, X, Y and Z are a fluorine, chlorine, bromine or iodine atom. The invention further relates to a process for the preparation of the compounds, by reacting an aryldiazonium salt of the formula ##STR2## in which the radicals X, Y and Z are identical and are a fluorine, bromine or iodine atom or, if two of the radicals X, Y and Z are identical or all of the radicals X, Y, Z are different from each other, X, Y and Z are a fluorine, chlorine, bromine or iodine atom and A.sup.(-) is an anion of an acid having a pK.sub.a
摘要翻译：本发明涉及式（I）的化合物，其中R 1和R 2相同或不同并且是氢或具有1至18个碳原子并且任选地含有氧，氮或卤素的烷基，基团X， Y和Z相同并且是氟，溴或碘原子，或者如果基团X，Y或Z中的两个相同或基团X，Y，Z的全部彼此不同，则X，Y和Z是氟，氯，溴或碘原子。本发明还涉及通过使基团X，Y和Z相同且为氟，溴或碘原子的式（II）的芳基重氮盐与式如果基团X，Y和Z中的两个相同或全部基团X，Y，Z彼此不同，X，Y和Z是氟，氯，溴或碘原子，并且A（ - ）是具有pKa <7的酸的阴离子与式（III）的化合物反应，其中R 1和R 2相同或不同，并且是氢或具有1至18个碳原子的烷基，并且任选地含有氧，氮或卤素，在含钯催化剂的存在下，如果合适，加入碱，和式（II）的芳基重氮盐。

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