专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050038287A1 Preparation of Anilineboronic acids and derivatives thereof 有权
标题翻译：苯胺硼酸及其衍生物的制备
公开(公告)号：US20050038287A1
公开(公告)日：2005-02-17
申请号：US10846463
申请日：2004-05-14
申请人： Stefan Scherer , Andreas Meudt , Bernd Lehnemann , Alexei Kalinin , Victor Snieckus
发明人： Stefan Scherer , Andreas Meudt , Bernd Lehnemann , Alexei Kalinin , Victor Snieckus
IPC分类号： C07B61/00 , C07F5/02 , C07F5/04
CPC分类号： C07F5/025 , Y02P20/55
摘要： A process for preparing anilineboronic acid derivatives of the formula I, by converting an aniline (II) to a diprotected aniline (III) by introducing two protecting groups PG, metalating (III) and simultaneously or subsequently reacting with a boronic ester B(OR1,2,3)3 (IV) to a protected anilineboronic ester of the formula (V), which is converted, by detaching the protecting groups PG, to the anilineboronic esters of the formula (I) Step 1: Protection of the Aniline by Dibenzylation Step 2: Metalation of the Protected Aniline, Conversion to Boronic Acid Derivative Step 3: Detachment of the Protecting Group where R is for example, H, F, Cl, Br, I, a, C1-C20—,alkyl or -alkoxy radical, a C6-C12-aryl or -aryloxy radical, a heteroaryl or heteroaryloxy radical, a C3-C8-cycloalkyl radical; X is H, Cl, Br, I or F; R1, R2, R3 are each independently H, a C1-C20-alkyl group, and two R1-3 radicals together may optionally form a ring, or are each further B(OR)3 radicals.
摘要翻译：通过引入两个保护基PG，金属化（III）并同时或随后与硼酸酯B（OR 2）反应，将苯胺（II）转化为二保护苯胺（III），制备式I的苯胺硼酸衍生物的方法（Ⅳ）化合物与式（Ⅴ）的保护的苯胺硼酸酯反应，通过将保护基PG分离成式（I）的苯胺硼酸酯来转化步骤1：保护苯胺通过二苄基化步骤2：保护的苯胺的金属化，转化为硼酸衍生物步骤3：保护基团的脱离，其中R为例如H，F，Cl，Br，I，a，C 1 -C 20 - ，烷基或 - 烷氧基，C 6 -C 12 - 芳基或 - 芳氧基，杂芳基或杂芳氧基，C 3 -C 8 - 环烷基; X为H，Cl，Br，I或F; R 1，R 2，R 3各自独立地为H，C 1 -C 20 - 烷基和两个R 1-3基团可以任选地形成环，或者各自为B（OR ）3个自由基。

2. 发明申请

US20080269523A1 Preparation of Aminoaryl and Aminoheteroaryl Boronic Acids and Derivatives Thereof 审中-公开
标题翻译：氨基芳基和氨基杂芳基硼酸及其衍生物的制备
公开(公告)号：US20080269523A1
公开(公告)日：2008-10-30
申请号：US12108621
申请日：2008-04-24
申请人： Christoph J. Kressierer , Bernd Lehnemann , Jorg Jung
发明人： Christoph J. Kressierer , Bernd Lehnemann , Jorg Jung
IPC分类号： C07F5/04
CPC分类号： C07F5/025 , Y02P20/55
摘要： The invention relates to a method for preparation of aminoaryl- or aminoheteroarylboronic acids and esters and salts thereof in which an optionally substituted aminoaryl or aminoheteroaryl compound is protected at its nitrogen site via condensation with a carbonyl compound, subsequently metalated and converted with a suitable boron compound. Depending on the subsequent work-up and removal of the protective group, the corresponding boronic acid, the anhydride or the boronic acid ester thereof is obtained
摘要翻译：本发明涉及一种制备氨基芳基或氨基杂芳基硼酸及其酯和盐的方法，其中任选取代的氨基芳基或氨基杂芳基化合物在其氮位置通过与羰基化合物缩合而被保护，随后金属化并用合适的硼化合物。取决于随后的保护基的后续处理和除去，得到相应的硼酸，酸酐或其硼酸酯

3. 发明授权

US07196219B2 Preparation of Anilineboronic acids and derivatives thereof 有权
标题翻译：苯胺硼酸及其衍生物的制备
公开(公告)号：US07196219B2
公开(公告)日：2007-03-27
申请号：US10846463
申请日：2004-05-14
申请人： Stefan Scherer , Andreas Meudt , Bernd Lehnemann , Alexei Kalinin , Victor Snieckus
发明人： Stefan Scherer , Andreas Meudt , Bernd Lehnemann , Alexei Kalinin , Victor Snieckus
IPC分类号： C07F5/02 , C07F5/04
CPC分类号： C07F5/025 , Y02P20/55
摘要： A process for preparing anilineboronic acid derivative of the formula I, by converting an aniline to a diprotected aniline by introducing two protecting groups, metalating the diprotected aniline with a metalating agent and simultaneously or subsequently reacting with a boronic ester B(OR1,2,3)3 to form a protected anilineboronic ester, which is converted, by detaching the protecting groups, to the anilineboronic esters of the formula (I).
摘要翻译：一种制备式I的苯胺硼酸衍生物的方法，

4. 发明申请

US20060131762A1 Method for metal-organic production of organic intermediate products by means of aryl lithium-bases 审中-公开
标题翻译：通过芳基锂基金属有机生产有机中间产物的方法
公开(公告)号：US20060131762A1
公开(公告)日：2006-06-22
申请号：US10526237
申请日：2003-08-21
申请人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
IPC分类号： C07D333/22 , C07D213/63 , C07F1/02
CPC分类号： C07F5/025
摘要： The invention relates to a method for the production of substituted aromatic compounds by producing lithium arylene and by reacting it with suitable electrophiles. The method comprises the following steps (step 1); an aryl lithium compound ( auxiliary base”) is initially produced by reacting a halogen aromatic compound with lithium metal; said compound is subsequently (step 2) reacted for deprotonation of the aromatic substrate in order to form the corresponding lithium aromatic compound which is subsequently (step 3) reacted with a corresponding electrophile to form the desired substituted aromatic compound, see page 2 of the description.
摘要翻译：本发明涉及通过生产锂亚芳基并通过与合适的亲电体反应来制备取代的芳族化合物的方法。该方法包括以下步骤（步骤1）; 最初通过卤素芳族化合物与锂金属反应制备芳基锂化合物（辅助碱“）;随后（步骤2）使所述化合物反应进行芳族底物的去质子化，以形成相应的锂芳族化合物，随后（步骤3）与相应的亲电子试剂反应以形成所需的取代的芳族化合物，参见说明书的第2页。

5. 发明申请

US20050258553A1 Method for the organometallic production of organic intermediate products comprising carbon-heteroatom bonds achieved by the deprotonation of heteroatoms 审中-公开
标题翻译：通过杂原子脱质子实现的包含碳 - 杂原子键的有机中间产物的有机金属生产方法
公开(公告)号：US20050258553A1
公开(公告)日：2005-11-24
申请号：US10526327
申请日：2003-08-21
申请人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
IPC分类号： C07B41/00 , C07B43/00 , C07B61/00 , C07C249/16 , C07C251/86 , C07C269/04 , C07C271/28 , C07C281/04 , C07C303/40 , C07C311/53 , C07C319/14 , C07C321/14 , C07D307/42 , C07F9/02 , C07F1/02
CPC分类号： C07D307/42 , C07B41/00 , C07B43/00 , C07C249/16 , C07C269/04 , C07C303/40 , C07C319/14 , C07C321/14 , C07C311/53 , C07C271/28 , C07C251/86
摘要： The invention relates to a method for binding heteroatom-carbon bonds. According to said method, a lithium compound (II) is first generated by reacting aliphatic or aromatic halogen compounds (I) with lithium metal, said compound is then used for the deprotonation of the compounds (III) or (V). The lithium salts of formulas (IV) or (VI) obtained by said deprotonation are subsequently reacted with suitable carbon electrophiles (equation I), said process binding the heteroatom-carbon bond and forming the products (VIII) or (VIII), (equation I).
摘要翻译：本发明涉及一种结合杂原子 - 碳键的方法。根据所述方法，首先通过使脂族或芳族卤素化合物（I）与锂金属反应生成锂化合物（II），然后将所述化合物用于化合物（III）或（V）的去质子化。随后通过所述去质子化获得的式（Ⅳ）或（Ⅵ）的锂盐与合适的碳亲电子（式I）反应，所述方法结合杂原子 - 碳键并形成产物（Ⅷ）或（Ⅷ），一世）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式