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1. 发明授权

US07855056B2 Antibody against tumor specific antigen as target 失效
标题翻译：针对肿瘤特异性抗原的抗体作为靶标
公开(公告)号：US07855056B2
公开(公告)日：2010-12-21
申请号：US10548688
申请日：2004-03-09
申请人： Kimihisa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
发明人： Kimihisa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
IPC分类号： G01N33/53
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译：本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。

2. 发明申请

US20070166312A1 Antibody against tumor specific antigen as target 失效
标题翻译：针对肿瘤特异性抗原的抗体作为靶标
公开(公告)号：US20070166312A1
公开(公告)日：2007-07-19
申请号：US10548688
申请日：2004-03-09
申请人： Kimihisa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
发明人： Kimihisa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
IPC分类号： A61K39/395 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译：本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。

3. 发明申请

US20070025996A1 Oculospanin as a tumor specific antigen and methods and compositions utilizing same 审中-公开
标题翻译： Oculospanin作为肿瘤特异性抗原以及利用其的方法和组合物
公开(公告)号：US20070025996A1
公开(公告)日：2007-02-01
申请号：US11345651
申请日：2006-01-31
申请人： Kimihisa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
发明人： Kimihisa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30 , C40B40/10 , C40B30/06
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically
摘要翻译：本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有特异性抗体的药物组合物来检测癌症的方法

4. 发明授权

US07361340B2 Antibody against tumor specific antigen as target 失效
标题翻译：针对肿瘤特异性抗原的抗体作为靶标
公开(公告)号：US07361340B2
公开(公告)日：2008-04-22
申请号：US11223812
申请日：2005-09-09
申请人： Kimihasa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
发明人： Kimihasa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译：本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。

5. 发明申请

US20060127405A1 Antibody against tumor specific antigen as target 失效
标题翻译：针对肿瘤特异性抗原的抗体作为靶标
公开(公告)号：US20060127405A1
公开(公告)日：2006-06-15
申请号：US11223812
申请日：2005-09-09
申请人： Kimihasa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
发明人： Kimihasa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译：本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。

6. 发明授权

US07741447B2 Antibody against tumor specific antigen as target 失效
公开(公告)号：US07741447B2
公开(公告)日：2010-06-22
申请号：US11872479
申请日：2007-10-15
申请人： Kimihasa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
发明人： Kimihasa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.

7. 发明申请

US20080146785A1 ANTIBODY AGAINST TUMOR SPECIFIC ANTIGEN AS TARGET 失效
标题翻译：抗肿瘤抗体作为目标的抗体
公开(公告)号：US20080146785A1
公开(公告)日：2008-06-19
申请号：US11872479
申请日：2007-10-15
申请人： Kimihasa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
发明人： Kimihasa Ichikawa , Shu Takahashi , Toshinori Agatsuma , Keisuke Fukuchi , Takehiro Hirai
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译：本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。

8. 发明授权

US09342879B2 Method and apparatus for reviewing defect 有权
标题翻译：检查缺陷的方法和装置
公开(公告)号：US09342879B2
公开(公告)日：2016-05-17
申请号：US14347127
申请日：2012-07-06
申请人： Yohei Minekawa , Kenji Nakahira , Minoru Harada , Takehiro Hirai , Ryo Nakagaki
发明人： Yohei Minekawa , Kenji Nakahira , Minoru Harada , Takehiro Hirai , Ryo Nakagaki
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0004 , G06T7/001 , G06T2207/10061 , G06T2207/20016 , G06T2207/30148
摘要： A method for reviewing defect, comprising the steps of: as an image acquisition step, imaging a surface of a sample using arbitrary image acquisition condition selected from a plurality of image acquisition conditions and obtaining a defect image; as a defect position calculation step, proceeding the defect image obtained by the image acquisition step and calculating a defect position on the surface of the sample; as a defect detection accuracy calculation step, obtaining a defect detection accuracy of the defect position calculated by the defect position calculation step; and as a conclusion determination step, determinating whether the defect detection accuracy obtained by the defect detection accuracy calculation step meets a predetermined requirement or not; wherein until it is determined that the defect detection accuracy obtained by the defect detection accuracy calculation step meets a predetermined in the conclusion determination step, the image acquisition condition is selected from the plurality of image acquisition conditions once again and the image acquisition step, the defect position calculation step, the defect detection accuracy calculation step and the conclusion determination step are repeated.
摘要翻译：一种检查缺陷的方法，包括以下步骤：作为图像获取步骤，使用从多个图像获取条件中选择的任意图像获取条件对样本的表面进行成像并获得缺陷图像; 作为缺陷位置计算步骤，进行通过图像获取步骤获得的缺陷图像，并计算样本表面上的缺陷位置; 作为缺陷检测精度计算步骤，获得由缺陷位置计算步骤计算的缺陷位置的缺陷检测精度; 以及作为结论确定步骤，确定由缺陷检测精度计算步骤获得的缺陷检测精度是否满足预定要求; 其中直到确定由缺陷检测精度计算步骤获得的缺陷检测精度在结论确定步骤中达到预定值时，再次从多个图像获取条件中选择图像获取条件，并且图像获取步骤，缺陷位置计算步骤，重复缺陷检测精度计算步骤和结论确定步骤。

9. 发明授权

US09342878B2 Charged particle beam apparatus 有权
标题翻译：带电粒子束装置
公开(公告)号：US09342878B2
公开(公告)日：2016-05-17
申请号：US13991948
申请日：2011-10-24
申请人： Kohei Yamaguchi , Takehiro Hirai , Fumihiko Fukunaga
发明人： Kohei Yamaguchi , Takehiro Hirai , Fumihiko Fukunaga
IPC分类号： H04N9/47 , H04N7/18 , G06T7/00 , H01J37/22 , H01J37/28
CPC分类号： G06T7/0002 , G06T7/001 , G06T2200/24 , G06T2207/30148 , H01J37/222 , H01J37/28 , H01J2237/221 , H01J2237/24578 , H01J2237/24592 , H01J2237/2817
摘要： For inspection of a pattern such as a semiconductor device, it is useful to selectively detect a defect on the specific pattern in order to estimate the cause of the occurrence of the defect. An object of the invention is to provide a charged particle beam apparatus capable of setting, on the basis of the shape of the pattern on a sample, a region to be inspected. The invention is characterized in that the contour of the pattern on the sample is extracted using a template image obtained on the basis of an image of the sample, the region to be inspected is set on the basis of the contour of the pattern, a defect candidate is detected by comparing the image to be inspected with a comparative image, and the sample is inspected using a positional relationship between the region to be inspected and the defect candidate included in the region to be inspected.
摘要翻译：为了检查诸如半导体器件的图案，有选择地检测特定图案上的缺陷以估计缺陷发生的原因。本发明的目的是提供一种能够根据样品上的图案的形状来设定要检查的区域的带电粒子束装置。本发明的特征在于，使用基于样本的图像获得的模板图像来提取样本上的图案的轮廓，基于图案的轮廓设置待检查的区域，缺陷通过将待检查的图像与比较图像进行比较来检测候选物，并且使用待检查区域和包括在待检查区域中的缺陷候选物之间的位置关系来检查样品。

10. 发明授权

US09136189B2 Surface observation apparatus and surface observation method 有权
标题翻译：表面观察装置及表面观察法
公开(公告)号：US09136189B2
公开(公告)日：2015-09-15
申请号：US13318718
申请日：2010-05-25
申请人： Takehiro Hirai , Kenji Obara , Naoma Ban
发明人： Takehiro Hirai , Kenji Obara , Naoma Ban
IPC分类号： G06K9/00 , H01L21/66 , G06T7/00
CPC分类号： H01L22/20 , G06T7/001 , G06T2200/24 , G06T2207/10061 , G06T2207/30148 , H01L22/12 , H01L2924/0002 , H01L2924/00
摘要： A surface observation apparatus is achieved, which enables even a beginner to easily select an optimal evaluation indicator for each of various patterns to be evaluated without a trial and error approach. A plurality of images to be evaluated are input from an image processing unit (114) to an evaluation image input unit (113a) (in step 901). The input images to be evaluated are displayed on a display (115). A user rearranges the images in accordance with an evaluation criterion of the user while referencing the display (115), and defines an evaluation criterion (in step 902). Evaluation values are calculated for the input images (to be evaluated) using a plurality of evaluation indicators (in step 903). The evaluation values for each of the evaluation indicators are compared with the evaluation criterion defined by the user, and correlation coefficients are then calculated (in step 904). An evaluation indicator having the maximum absolute value of a correlation coefficient is automatically selected as an evaluation criterion that is closest to the evaluation criterion defined by the user (in step 905). The images are rearranged in order of correlation coefficient and a list of the images is displayed on the display (115) so that the images are arranged in order of evaluation value (in step 906).
摘要翻译：实现了表面观察装置，即使初学者也能够在不进行试错法的情况下容易地选择要评估的各种图案中的各种图案的最佳评价指标。将要评估的多个图像从图像处理单元（114）输入到评估图像输入单元（113a）（在步骤901中）。待评估的输入图像显示在显示器（115）上。用户根据用户的评价标准重新排列图像，同时参照显示器（115），并定义评估标准（步骤902）。使用多个评价指标对输入图像（待评价）计算评价值（步骤903）。将各评价指标的评价值与用户定义的评价标准进行比较，然后计算相关系数（步骤904）。自动选择具有相关系数的最大绝对值的评估指标作为最接近用户定义的评估标准的评估标准（在步骤905中）。按照相关系数的顺序重新排列图像，并且在显示器（115）上显示图像列表，使得以评估值的顺序排列图像（在步骤906中）。

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