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1. 发明授权

US06962926B2 Antagonist of MCP-1 function, and compositions and methods of use thereof 失效
标题翻译： MCP-1功能的拮抗剂及其组合物及其使用方法
公开(公告)号：US06962926B2
公开(公告)日：2005-11-08
申请号：US10637746
申请日：2003-08-08
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Wenli Ma , Yukiharu Matsumoto , Kunihisa Baba , Hideaki Inagaki , Katsumasa Tanaka , Yoshiro Ishiwata , Shoji Yokochi , Masayuki Okamoto , Takashi Nakamura , Atsushi Miyachi , Mitsuaki Takeuchi , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Wenli Ma , Yukiharu Matsumoto , Kunihisa Baba , Hideaki Inagaki , Katsumasa Tanaka , Yoshiro Ishiwata , Shoji Yokochi , Masayuki Okamoto , Takashi Nakamura , Atsushi Miyachi , Mitsuaki Takeuchi , Kouji Matsushima
IPC分类号： A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , A61P29/00 , C07D471/04 , C07D498/04 , C07D519/00 , C61K31/5377
CPC分类号： A61K31/437 , A61K9/0019 , A61K9/2054 , A61K9/4866 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D231/56 , C07D471/04 , A61K2300/00
摘要： Compounds of formula A and formula B: and their pharmaceutically acceptable salts, compositions comprising them, methods for their use, and their use in the preparation of medicaments. The compounds are antagonists of MCP-1 function, and are useful in the prevention and treatment of chronic or acute inflammatory or autoimmune diseases, such as multiple sclerosis, and in the prevention and treatment of allergic hypersensitivity disorders.
摘要翻译：式A和式B化合物及其药学上可接受的盐，包含它们的组合物，其使用方法及其在制备药物中的用途。该化合物是MCP-1功能的拮抗剂，可用于预防和治疗慢性或急性炎性或自身免疫性疾病如多发性硬化，以及预防和治疗过敏性超敏反应性疾病。

2. 发明申请

US20130123460A1 PEPTIDE FOR IMPROVING BIOSTABILITY OF BIOACTIVE SUBSTANCE, AND BIOACTIVE SUBSTANCE HAVING IMPROVED BIOSTABILITY 审中-公开
标题翻译：用于改善生物活性物质的生物可利用性的肽，以及具有改善的生物活性的生物活性物质
公开(公告)号：US20130123460A1
公开(公告)日：2013-05-16
申请号：US13636498
申请日：2011-04-28
申请人： Masayuki Okamoto , Ryuhji Okamoto , Tomohiro Shigemori , Takayo Murase , Atsushi Miyachi , Mitsuaki Takeuchi , Miyuki Tamura , Hiroshi Kinoshita
发明人： Masayuki Okamoto , Ryuhji Okamoto , Tomohiro Shigemori , Takayo Murase , Atsushi Miyachi , Mitsuaki Takeuchi , Miyuki Tamura , Hiroshi Kinoshita
IPC分类号： C07K14/195 , C07K7/08 , C07K7/06
CPC分类号： C07K14/195 , A61K38/2278 , A61K38/26 , A61K38/31 , C07K7/06 , C07K7/08 , C07K14/31 , C07K14/315 , C07K14/605 , C07K2319/00 , C07K2319/31
摘要： The present invention aims at providing a peptide fragment capable of improving biostability of a bioactive substance while maintaining the activity of the bioactive substance, and a bioactive substance to which the peptide fragment is added. The present invention relates to a partial peptide of a GA module having 5 to 25 amino acids, including a partial sequence of a GA module (SEQ ID NO: 1) and the amino acid sequence Ile-Asp-Glu-Ile-Leu (SEQ ID NO: 2), and a bioactive complex in which the partial peptide of the GA module is bound to a bioactive substance. The bioactive substance includes GLP-1, GLP-2, GIP, VIP, somatostatin, amylin, ghrelin, derivatives thereof, and the like.
摘要翻译：本发明的目的在于提供能够提高生物活性物质生物活性的肽片段，同时保持生物活性物质的活性，以及加入肽片段的生物活性物质。本发明涉及具有5至25个氨基酸的GA模块的部分肽，包括GA模块（SEQ ID NO：1）和氨基酸序列Ile-Asp-Glu-Ile-Leu（SEQ ID NO：1）的部分序列 ID NO：2），以及GA模块的部分肽与生物活性物质结合的生物活性复合物。生物活性物质包括GLP-1，GLP-2，GIP，VIP，生长抑素，胰岛淀粉样多肽，生长素释放肽及其衍生物等。

3. 发明申请

US20120288710A1 PRESSURE-SENSITIVE ADHESIVE COMPOSITION AND PRESSURE-SENSITIVE ADHESIVE SHEET 审中-公开
标题翻译：压敏胶粘组合物和压敏粘合片
公开(公告)号：US20120288710A1
公开(公告)日：2012-11-15
申请号：US13521115
申请日：2010-01-07
申请人： Masayuki Okamoto , Masahito Niwa , Chie Kitano
发明人： Masayuki Okamoto , Masahito Niwa , Chie Kitano
IPC分类号： C09J177/02 , B05D3/02 , C08F2/46 , B32B27/30
CPC分类号： C09J139/04 , C09J7/385 , Y10T428/2891 , C08F2220/1858 , C08F226/06 , C08F2222/1013
摘要： An object of the present invention is to provide an acrylic pressure-sensitive adhesive composition capable of forming a pressure-sensitive adhesive, which has excellent adhesiveness to an adherend having surface polarity of every kind and can exhibit excellent repulsion resistance even in a moist heat environment, and a pressure-sensitive adhesive sheet using the composition. The pressure-sensitive adhesive composition provided by the present invention contains a copolymerization reaction product of a monomer mixture. The monomer mixture contains an alkyl (meth)acrylate having an alkyl group with a carbon number of from 4 to 20 and N-vinylcaprolactam. The total sum amount thereof is 95% by mass or more of the whole of monomer components. An amount of N-vinylcaprolactam is from 12 to 40% by mass.
摘要翻译：本发明的目的是提供一种能够形成粘合剂的丙烯酸类压敏粘合剂组合物，其对具有各种表面极性的被粘物具有优异的粘附性，并且即使在潮湿的热环境中也能表现出优异的抗斥性和使用该组合物的压敏粘合片。由本发明提供的压敏粘合剂组合物含有单体混合物的共聚反应产物。单体混合物含有碳数为4〜20的烷基（甲基）丙烯酸烷基酯和N-乙烯基己内酰胺。其总量为全部单体成分的95质量％以上。 N-乙烯基己内酰胺的量为12〜40质量％。

4. 发明申请

US20120266195A1 Similar Content Search Device And Computer-Readable Storage Medium 有权
标题翻译：类似的内容搜索设备和计算机可读存储介质
公开(公告)号：US20120266195A1
公开(公告)日：2012-10-18
申请号：US13423002
申请日：2012-03-16
申请人： Wataru NAKANO , Masaru Suzuki , Masayuki Okamoto , Tomohiro Yamasaki , Isao Mihara , Masahiro Sekine , Junya Takakura
发明人： Wataru NAKANO , Masaru Suzuki , Masayuki Okamoto , Tomohiro Yamasaki , Isao Mihara , Masahiro Sekine , Junya Takakura
IPC分类号： H04N21/482
CPC分类号： G06F17/30722
摘要： According to one embodiment, a phrase similarity is reduced when a common genre characteristic word Is included in a program of interest interested by a user and a similar phrase program including the same phrase. A genre similarity is increased when a common genre characteristic word is included in the program of interest and a similar genre program including the same genre as the program of interest. The similar phrase program is presented based on the phrase similarity, and the similar genre program is presented based on the genre similarity.
摘要翻译：根据一个实施例，当在由用户感兴趣的感兴趣的程序中包括公共类型特征词时，包括相同短语的类似短语程序时，词组相似性减小。当感兴趣的程序中包括常见的类型特征词并且包括与感兴趣的程序相同的类型的类似的类型程序时，类型相似性增加。基于短语相似性呈现类似的短语程序，并且基于类型相似性呈现类似的类型节目。

5. 发明申请

US20120036139A1 CONTENT RECOMMENDATION DEVICE, METHOD OF RECOMMENDING CONTENT, AND COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：内容推荐设备，推荐内容的方法和计算机程序产品
公开(公告)号：US20120036139A1
公开(公告)日：2012-02-09
申请号：US13241859
申请日：2011-09-23
申请人： Masayuki Okamoto , Masaru Suzuki , Daisuke Ajitomi , Masahiro Sekine , Yasukazu Higuchi
发明人： Masayuki Okamoto , Masaru Suzuki , Daisuke Ajitomi , Masahiro Sekine , Yasukazu Higuchi
IPC分类号： G06F17/30
CPC分类号： H04N7/17318 , H04N21/4722 , H04N21/4826 , H04N21/4828 , H04N21/8133
摘要： According to one embodiment, a content recommendation device includes a storage to store metadata; a display unit to display a plurality of pieces of content information corresponding to the contents; a selection unit to select first content information displayed on the display unit and second content information to be displayed after the first content information; an extraction unit to extract a keyword based on a co-occurrence relation between the metadata of the first and second content information; a generation unit to generate a search query based on the keyword; an acquisition unit to acquire third content information from an external database using the search query; a calculation unit configured to calculate similarity between the second and third content information by using the metadata of the second and third content information; and an arrangement control unit to arrange the third content information on the display unit based on the similarity.
摘要翻译：根据一个实施例，内容推荐设备包括存储元数据的存储器; 显示单元，用于显示与所述内容相对应的多条内容信息; 选择单元，用于选择在所述显示单元上显示的第一内容信息和在所述第一内容信息之后显示的第二内容信息; 提取单元，基于所述第一和第二内容信息的元数据之间的同现关系提取关键字; 基于关键字生成搜索查询的生成单元; 获取单元，用于使用所述搜索查询从外部数据库获取第三内容信息; 计算单元，被配置为通过使用第二和第三内容信息的元数据来计算第二和第三内容信息之间的相似度; 以及布置控制单元，用于基于相似度将第三内容信息布置在显示单元上。

6. 发明申请

US20110124833A1 MEDICAL PRESSURE-SENSITIVE ADHESIVE COMPOSITION 审中-公开
标题翻译：医用感应胶粘剂组合物
公开(公告)号：US20110124833A1
公开(公告)日：2011-05-26
申请号：US12945282
申请日：2010-11-12
申请人： Jun ISHIKURA , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Masayuki Okamoto , Masahito Niwa
发明人： Jun ISHIKURA , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Masayuki Okamoto , Masahito Niwa
IPC分类号： C09J133/26
CPC分类号： A61L15/58 , C08L33/26
摘要： There is provided a medical pressure-sensitive adhesive composition including an acrylic copolymer obtained by copolymerizing monomer components containing (a) at least one kind of a monomer of a (meth)acrylic acid alkyl ester and (b) at least one kind of a monomer of an N-hydroxyalkyl(meth)acrylamide, wherein: a content of the (meth)acrylic acid alkyl ester monomer (a) with respect to a total amount of the monomer components is 50 weight % to 99.9 weight % and a content of the N-hydroxyalkyl(meth)acrylamide monomer (b) with respect to the total amount is 0.1 weight % to 20 weight %; and the monomer components are substantially free of a monomer having a carboxyl group. The medical pressure-sensitive adhesive composition of the present invention is particularly suitable for applications such as medical patches and patch preparations.
摘要翻译：提供一种医用压敏粘合剂组合物，其包含通过共聚单体成分而获得的丙烯酸共聚物，所述单体成分含有（a）至少一种（甲基）丙烯酸烷基酯的单体和（b）至少一种单体的（甲基）丙烯酰胺的N-羟烷基酯，其中：（甲基）丙烯酸烷基酯单体（a）的含量相对于单体成分的总量为50重量％〜99.9重量％ N-羟烷基（甲基）丙烯酰胺单体（b）相对于总量为0.1重量％至20重量％并且单体组分基本上不含具有羧基的单体。本发明的医用压敏粘合剂组合物特别适用于医用贴剂和贴片制剂等。

7. 发明申请

US20090269946A1 CONNECTOR 审中-公开
标题翻译：连接器
公开(公告)号：US20090269946A1
公开(公告)日：2009-10-29
申请号：US12421518
申请日：2009-04-09
申请人： Masahiro Ono , Masayuki Okamoto
发明人： Masahiro Ono , Masayuki Okamoto
IPC分类号： H01R12/00
CPC分类号： H01R13/025 , H01R12/79 , H01R12/88
摘要： A connector to be surface mounted on a wiring board has a base having an opening to be inserted with a tip portion of a flexible printed circuit board at a front surface, and having a plurality of insertion holes passing from the front surface to a rear surface juxtaposed at a predetermined pitch, a connection terminal arranged in a projecting manner with a substantially T-shaped operating piece having at one end a movable contacting point that comes into pressure contact with joints juxtaposed at the tip portion of the flexible printed circuit board, the connection terminal having one end that becomes a fixed contacting point inserted to the insertion hole from the rear surface side, and an operating lever in which a cam portion is fitted into a turning recessed portion arranged at an upper side of the connection terminal to act as a turning supporting point, the cam portion driving an operation receiving portion positioned at the other end of the operating piece. A position regulation contacting portion that contacts a position regulating portion arranged at the upper side of the connection terminal when the operating lever is turned and a locking operation is completed is arranged at a lower surface of the operating lever.
摘要翻译：要表面安装在布线板上的连接器具有基部，该基部具有在前表面插入柔性印刷电路板的前端部的开口，并且具有从前表面到后表面的多个插入孔以预定间距并列设置的连接端子，其以大致T形的操作件突出地布置，其一端具有与柔性印刷电路板的尖端部分处并列的接头压力接触的可动接触点，连接端子，其一端成为从后表面侧插入到插入孔中的固定接触点;以及操作杆，其中凸轮部分配合到布置在连接端子的上侧的转向凹部中，以用作转动支撑点，所述凸轮部分驱动位于所述操作件的另一端的操作接收部。当操作杆转动并且锁定操作完成时，位置调节接触部分接触位于连接端子上侧的位置限制部分，并设置在操作杆的下表面。

8. 发明申请

US20090235614A1 TABLET FILLING DEVICE 失效
标题翻译：片剂填充装置
公开(公告)号：US20090235614A1
公开(公告)日：2009-09-24
申请号：US12066608
申请日：2006-09-11
申请人： Hiroyuki Yuyama , Naoki Koike , Takafumi Imai , Hirokazu Chihara , Katsunori Yoshina , Masayuki Okamoto , Yoshihiko Ide
发明人： Hiroyuki Yuyama , Naoki Koike , Takafumi Imai , Hirokazu Chihara , Katsunori Yoshina , Masayuki Okamoto , Yoshihiko Ide
IPC分类号： B65B65/00
CPC分类号： B65B5/103
摘要： A tablet filling device for supplying a vial container of desired size certainly with no mistake comprising a plurality of containing means containing vial containers by size, a mean for taking out a vial container from the containing means based on prescription data, means for carrying a vial container taken out by the container take out means, a means or providing a table to a vial container carried by the carrying means, a means for collecting a vial container in the middle of carriage by the carrying means, a means provided on the carrying passage of the carrying means and detecting the size of a carried vial container, and a control means for judging whether the size of a vial container selected based on the prescription data matches the size of a vial container detected by the container size detection means and collecting the carried vial container by the container collection means if they do not match each other.
摘要翻译：一种片剂填充装置，用于供应具有所需尺寸的小瓶容器，没有任何错误，包括多个容纳装置，容纳小容器的大小，根据处方数据从容纳装置取出小瓶容器的装置，用于携带小瓶的装置由容器取出的容器取出装置，装置或提供由携带装置携带的小瓶容器的装置，用于通过承载装置收集在托架中间的小瓶容器的装置，设置在承载通道上的装置以及检测携带的药瓶容器的尺寸的控制装置，以及用于判断基于处方数据选择的药瓶容器的尺寸是否与由容器尺寸检测装置检测的小瓶容器的尺寸相匹配并且收集如果容器收集装置不相配，则携带药瓶容器。

9. 发明申请

US20080319746A1 KEYWORD OUTPUTTING APPARATUS AND METHOD 有权
标题翻译：关键词输出装置及方法
公开(公告)号：US20080319746A1
公开(公告)日：2008-12-25
申请号：US12055030
申请日：2008-03-25
申请人： Masayuki Okamoto , Masaaki Kikuchi , Kazuyuki Goto
发明人： Masayuki Okamoto , Masaaki Kikuchi , Kazuyuki Goto
IPC分类号： G10L15/06
CPC分类号： G06F17/30719
摘要： A keyword analysis device obtains word vectors represented by the documents by analyzing keywords contained in each of documents input in a designated period. A topic cluster extraction device extracts topic clusters belonging to the same topic from a plurality of documents. A keyword extraction device extracts, as a characteristic keyword group, a predetermined number of keywords from the topic cluster in descending order of appearance frequency. A topic structurization determination device determines whether the topic can be structurized, by segmenting the topic cluster into subtopic clusters with reference to the number of documents, the variance of dates contained in the documents, or the C-value of keyword contained in the documents, as a determination criterion. And a keyword presentation device presents the characteristic keyword group in the subtopic cluster upon arranging the keyword group on the basis of the date information.
摘要翻译：关键字分析装置通过分析在指定期间输入的每个文档中包含的关键字来获得由文档表示的字向量。主题集群提取装置从多个文档中提取属于同一主题的主题集群。关键词提取装置以出现频率的降序从主题群中提取预定数量的关键词作为特征关键字组。主题结构化确定装置通过参考文档的数量，文档中包含的日期的差异或包含在文档中的关键字的C值来确定主题集合是否可以被结构化，将主题集合分成子主题集合，作为决定标准。并且，关键字呈现装置在基于日期信息安排关键字组时，在子主题集中呈现特征关键字组。

10. 发明申请

US20080243494A1 DIALOG DETECTING APPARATUS, DIALOG DETECTING METHOD, AND COMPUTER PROGRAM PRODUCT 有权
标题翻译：对话检测设备，对话检测方法和计算机程序产品
公开(公告)号：US20080243494A1
公开(公告)日：2008-10-02
申请号：US12046021
申请日：2008-03-11
申请人： Masayuki Okamoto , Naoki Iketani , Hideo Umeki , Sogo Tsuboi , Kenta Cho , Keisuke Nishimura , Masanori Hattori
发明人： Masayuki Okamoto , Naoki Iketani , Hideo Umeki , Sogo Tsuboi , Kenta Cho , Keisuke Nishimura , Masanori Hattori
IPC分类号： G10L11/06
CPC分类号： G10L15/22
摘要： A speech receiving unit receives a user ID, a speech obtained at a terminal, and an utterance duration, from the terminal. A proximity determining unit calculates a correlation value expressing a correlation between speeches received from plural terminals, compares the correlation value with a first threshold value, and determines that the plural terminals that receive the speeches whose correlation value is calculated are close to each other, when the correlation value is larger than the first threshold value. A dialog detecting unit determines whether a relationship between the utterance durations received from the plural terminals that are determined to be close to each other within an arbitrarily target period during which a dialog is to be detected fits a rule. When the relationship is determined to fit the rule, the dialog detecting unit detects dialog information containing the target period and the user ID.
摘要翻译：语音接收单元从终端接收用户ID，在终端获得的语音和话语持续时间。接近确定单元计算表示从多个终端接收的演讲之间的相关性的相关值，将相关值与第一阈值进行比较，并且确定接收相关值被计算的演讲的多个终端彼此接近，当相关值大于第一阈值。对话检测单元确定在检测对话期间的任意目标期间内判定为彼此接近的多个终端接收到的发声持续时间之间的关系是否适合规则。当确定该关系以适应规则时，对话检测单元检测包含目标周期和用户ID的对话信息。

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