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1. 发明授权

US06216538B1 Particle handling apparatus for handling particles in fluid by acoustic radiation pressure 失效
标题翻译：用于通过声辐射压力处理流体中的颗粒的颗粒处理装置
公开(公告)号：US06216538B1
公开(公告)日：2001-04-17
申请号：US08742695
申请日：1996-11-04
申请人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
发明人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
IPC分类号： G01H1700
CPC分类号： B01D21/283 , G10K15/00
摘要： An ultrasonic manipulation apparatus has a plurality of ultrasonic wave oscillators arranged in two dimensions to trap, fix or move particles to an optional position in the solution or perform cell fusion by using a gradient force obtained by superposing one over another the gradient force fields generated by ultrasonic waves produced by a plurality of ultrasonic wave oscillators. The ultrasonic wave oscillators, functioning independently of one another, can emit ultrasonic waves with optional intensities and phases, and by using an external force produced by superposed gradient force fields generated by ultrasonic waves, particles are handled easily.
摘要翻译：超声波操作装置具有多个超声波振荡器，其被设置成二维排列，以将颗粒捕获，固定或移动到溶液中的可选位置，或者通过使用通过将颗粒叠加在另一个上而产生的梯度力场而获得的梯度力进行细胞融合由多个超声波振荡器产生的超声波。彼此独立起作用的超声波振荡器可以发射具有可选强度和相位的超声波，并且通过使用由超声波产生的叠加梯度力场产生的外力，可以容易地处理颗粒。

2. 发明授权

US5523058A Ultrasonic irradiation apparatus and processing apparatus based thereon 失效
标题翻译：超声波照射装置及其处理装置
公开(公告)号：US5523058A
公开(公告)日：1996-06-04
申请号：US240733
申请日：1994-05-12
申请人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
发明人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
IPC分类号： A61B17/22 , A61N7/00 , A61N7/02 , B01F11/02 , A61B8/00 , B06B1/00
CPC分类号： A61N7/02 , A61B17/22004 , A61N2007/006 , A61N2007/0078 , A61N2007/0095
摘要： By providing an ultrasonic irradiation apparatus for generating acoustic cavitation efficiently, it is intended to realize an ultrasonic therapeutic apparatus for generating the action of cavitation on a living body suitable for medical treatment of malignant tumors and medical treatment of thrombi and calculi, an ultrasonic diagnostic apparatus for generating cavitation for emphasizing an ultrasonic echo image such as a blood flow and utilizing the reflection capability of the cavitation, an ultrasonic chemical reaction accelerating apparatus, an ultrasonic cleaning apparatus or an ultrasonic sterilizing apparatus. Irradiation focus/code signals for defining irradiated acoustic fields of a fundamental wave and a second harmonic wave as well as focus positions/acoustic pressure distribution forms of the respective waves are applied from an irradiation unit main control circuit to drive phase generating circuits. Generated drive phases are applied to drive signal generating circuits, generated drive signals are applied to element drive circuits and a group of fundamental frequency elements and a group of second harmonic elements are driven. The drive phases are controlled such that the fundamental wave and second harmonic wave are superimposed on each other in a medium near a focal point, thus generating acoustic caviation locally and efficiently.
摘要翻译： PCT No.PCT / JP93 / 01310 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1993年9月14日PCT公布。公开号WO94 / 06380 日期为1994年3月31日。通过提供用于有效产生声孔的超声波照射装置，旨在实现用于产生适于恶性肿瘤治疗的生物体上的空化作用的超声波治疗装置和血栓的治疗和结石，用于产生用于强调超声波回波图像如血流并利用空化反射能力的超声波诊断装置，超声波化学反应加速装置，超声波清洗装置或超声波消毒装置。用于定义基波和二次谐波的辐射声场以及各波的聚焦位置/声压分布形式的照射焦点/码信号从照射单元主控制电路施加到驱动相位产生电路。产生的驱动相位被施加到驱动信号发生电路，所产生的驱动信号被施加到元件驱动电路，并且一组基频元件和一组二次谐波元件被驱动。控制驱动相位使得基波和二次谐波在焦点附近的介质中彼此叠加，从而局部且有效地产生声空化。

3. 发明申请

US20080311046A1 Ultrasound Contrast Agent 有权
标题翻译：超声对比剂
公开(公告)号：US20080311046A1
公开(公告)日：2008-12-18
申请号：US11658591
申请日：2005-08-04
申请人： Kenichi Kawabata , Nami Sugita , Shin-ichiro Umemura
发明人： Kenichi Kawabata , Nami Sugita , Shin-ichiro Umemura
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： An ultrasound contrast agent composed of at least one kind of low-boiling water-insoluble substance (with a boiling point lower than 37° C.) and at least one kind of high-boiling water-insoluble substance (with a boiling point higher than 37° C.). The former vaporizes to absorb ultrasonic energy upon application of ultrasound, thereby causing the latter to vaporize secondarily, with the resulting bubbles producing an echo image. It is less liable to bumping and hence safe.
摘要翻译：由至少一种低沸点水不溶性物质（沸点低于37℃）和至少一种高沸点水不溶性物质（沸点高于 37℃）。前者在施加超声波时蒸发以吸收超声能量，从而使后者二次蒸发，产生的回波图像产生气泡。它不太容易碰撞，因此安全。

4. 发明授权

US08323620B2 Ultrasound contrast agent 有权
标题翻译：超声造影剂
公开(公告)号：US08323620B2
公开(公告)日：2012-12-04
申请号：US11658591
申请日：2005-08-04
申请人： Kenichi Kawabata , Nami Sugita , Shin-ichiro Umemura
发明人： Kenichi Kawabata , Nami Sugita , Shin-ichiro Umemura
IPC分类号： A61B8/00
CPC分类号： A61K49/223
摘要： An ultrasound contrast agent composed of at least one kind of low-boiling water-insoluble substance (with a boiling point lower than 37° C.) and at least one kind of high-boiling water-insoluble substance (with a boiling point higher than 37° C.). The former vaporizes to absorb ultrasonic energy upon application of ultrasound, thereby causing the latter to vaporize secondarily, with the resulting bubbles producing an echo image. It is less liable to bumping and hence safe.
摘要翻译：由至少一种低沸点水不溶性物质（沸点低于37℃）和至少一种高沸点水不溶性物质（沸点高于 37℃）。前者在施加超声波时蒸发以吸收超声能量，从而使后者二次蒸发，产生的回波图像产生气泡。它不太容易碰撞，因此安全。

5. 发明授权

US06572839B2 Sensitizer for tumor treatment 有权
标题翻译：敏化剂用于肿瘤治疗
公开(公告)号：US06572839B2
公开(公告)日：2003-06-03
申请号：US09801844
申请日：2001-03-09
申请人： Nami Sugita , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Isao Sakata
发明人： Nami Sugita , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Isao Sakata
IPC分类号： A61B800
CPC分类号： A61K31/353 , A61B8/4444 , A61N7/00 , C07D311/86
摘要： A sensitizer for tumor treatment has a structure such that a lipophilic group and a hydrophilic group are bound to one and the same carbon atom in a compound containing a xanthene dye structure. It is important that the lipophilic group and hydrophilic group are bound to one and the same carbon atom; if they are separated from each other, no sufficient effect is obtained. Thus, the sensitizer possesses both lipophilicity and hydrophilicity. This sensitizer has a function of promoting acoustic cavitation and a function of revealing an antitumor effect and is an agent highly accumulable in tumor tissues. Thus, this sensitizer is highly selective for tumor tissues and enables the treatment of malignant tumor using ultrasound.
摘要翻译：用于肿瘤治疗的敏化剂具有使亲油基团和亲水基团与含有呫吨染料结构的化合物中的同一个碳原子结合的结构。重要的是亲脂基团和亲水基团与同一个碳原子结合; 如果它们彼此分离，则不能获得足够的效果。因此，敏化剂具有亲油性和亲水性。这种敏化剂具有促进声孔的功能和显示抗肿瘤作用的功能，并且是在肿瘤组织中高度累积的药剂。因此，这种敏化剂对于肿瘤组织是高度选择性的并且能够使用超声治疗恶性肿瘤。

6. 发明授权

US08460191B2 Ultrasonic medical diagnostic device for imaging changes with time 有权
标题翻译：超声波医疗诊断装置随时间变化
公开(公告)号：US08460191B2
公开(公告)日：2013-06-11
申请号：US11914962
申请日：2006-05-18
申请人： Hideki Yoshikawa , Takashi Azuma , Kenichi Kawabata , Kazuaki Sasaki , Shinichiro Umemura
发明人： Hideki Yoshikawa , Takashi Azuma , Kenichi Kawabata , Kazuaki Sasaki , Shinichiro Umemura
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译：一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。

7. 发明授权

US07074427B2 Medicine, carrier for medicine, method of producing medicine, and method of tumor treatment 失效
公开(公告)号：US07074427B2
公开(公告)日：2006-07-11
申请号：US10198178
申请日：2002-07-19
申请人： Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki
发明人： Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki
IPC分类号： A61K9/48 , A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K41/0033
摘要： A medicinal preparation capable of lowering the threshold of cavitation and generating active oxygen species via acoustic cavitation caused by an ultrasound is provided. The preparation, which is to be used in combination with ultrasonic irradiation, comprises a shell within the internal space of which a gas is enclosed and which contains or retains a substance capable of generating active oxygen species upon ultrasonic irradiation of the shell.

8. 发明授权

US06511428B1 Ultrasonic medical treating device 失效
标题翻译：超声医疗处理装置
公开(公告)号：US06511428B1
公开(公告)日：2003-01-28
申请号：US09830423
申请日：2001-04-26
申请人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
发明人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
IPC分类号： A61B800
CPC分类号： A61N7/022 , A61B8/12 , A61B2017/00154 , A61B2017/00274 , A61B2018/00547 , A61B2090/378 , A61B2090/3782
摘要： An ultrasound therapy apparatus delivers focused ultrasound for therapeutical purposes which can be correctly targeted to a target region, and also, a positional shift from the target region under irradiation of ultrasound can be effectively avoided. An ultrasound transducer is inside an applicator with an imaging ultrasonic probe. Another ultrasound transducer monitors a position of a target and a positional shift is inside a catheter which is inserted into a urethral tube. An imaging system drives the ultrasound probe to display an ultrasound tomographic image of a region in the vicinity of a target region. The ultrasound transducer is driven in a pulse-shaped mode at the same frequency as the imaging ultrasound and also at such timing when the imaging ultrasound is reached. As a result, a point-shaped sound source image is superimposed and displayed on an ultrasound tomographic image.
摘要翻译：超声治疗装置将聚焦超声波提供给治疗目的，可以正确地瞄准目标区域，并且可以有效地避免从超声照射下的目标区域的位置偏移。超声波换能器在具有成像超声波探头的施加器内部。另一个超声波传感器监测目标的位置，位置偏移在插入尿道管内的导管内。成像系统驱动超声波探头以显示目标区域附近的区域的超声断层图像。超声波换能器以与成像超声相同的频率以及在达到成像超声的这种定时以脉冲模式驱动。结果，点状声源图像被叠加并显示在超声断层图像上。

9. 发明申请

US20100158816A1 GAS BUBBLE-GENERATING AGENT 审中-公开
标题翻译：气体发泡剂
公开(公告)号：US20100158816A1
公开(公告)日：2010-06-24
申请号：US12716891
申请日：2010-03-03
申请人： Kenichi Kawabata , Koji HIRATA , Kazuaki Sasaki
发明人： Kenichi Kawabata , Koji HIRATA , Kazuaki Sasaki
IPC分类号： A61B8/00
CPC分类号： A61K41/0033 , A61B5/4839 , A61B8/481
摘要： This invention provides a gas bubble-generating agent that can be used as a contrast medium or a blocking agent in vivo. Such gas bubble-generating agent is produced by a method for producing a gas bubble-generating agent comprising the following steps of: (a) preparing a mixed solution of an amphiphilic substance, an amphiphilic substance comprising a water-soluble polymer chemically bound thereto, a hardly water-soluble substance having a boiling point of lower than 60° C. at atmospheric pressure, and a physiologically acceptable isotonic solution; (b) pressurizing the mixed solution; and (c) centrifuging the mixed solution after the step of pressurization, wherein a molar concentration of the amphiphilic substance in the mixed solution prepared in step (a) is 10 times or more higher than that of the amphiphilic substance comprising a water-soluble polymer chemically bound thereto.
摘要翻译：本发明提供了可用作造影剂或封闭剂的气泡产生剂。这种气泡生成剂是通过气泡发生剂的制造方法制造的，其特征在于，包括以下步骤：（a）制备两亲物质，包含化学键合的水溶性聚合物的两亲物质，在大气压下沸点低于60℃的几乎不溶于水的物质，以及生理上可接受的等渗溶液; （b）对混合溶液加压; 和（c）在加压步骤之后离心混合溶液，其中在步骤（a）中制备的混合溶液中的两亲物质的摩尔浓度比包含水溶性聚合物的两亲物质的摩尔浓度高10倍或更多化学结合。

10. 发明申请

US20090048516A1 IMAGE DIAGNOSING DEVICE 有权
标题翻译：图像诊断装置
公开(公告)号：US20090048516A1
公开(公告)日：2009-02-19
申请号：US11914962
申请日：2006-05-18
申请人： Hideki Yoshikawa , Takashi Azuma , Kenichi Kawabata , Kazuaki Sasaki , Shinichiro Umemura
发明人： Hideki Yoshikawa , Takashi Azuma , Kenichi Kawabata , Kazuaki Sasaki , Shinichiro Umemura
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译：一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。

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