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1. 发明授权

US06216538B1 Particle handling apparatus for handling particles in fluid by acoustic radiation pressure 失效
标题翻译：用于通过声辐射压力处理流体中的颗粒的颗粒处理装置
公开(公告)号：US06216538B1
公开(公告)日：2001-04-17
申请号：US08742695
申请日：1996-11-04
申请人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
发明人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
IPC分类号： G01H1700
CPC分类号： B01D21/283 , G10K15/00
摘要： An ultrasonic manipulation apparatus has a plurality of ultrasonic wave oscillators arranged in two dimensions to trap, fix or move particles to an optional position in the solution or perform cell fusion by using a gradient force obtained by superposing one over another the gradient force fields generated by ultrasonic waves produced by a plurality of ultrasonic wave oscillators. The ultrasonic wave oscillators, functioning independently of one another, can emit ultrasonic waves with optional intensities and phases, and by using an external force produced by superposed gradient force fields generated by ultrasonic waves, particles are handled easily.
摘要翻译：超声波操作装置具有多个超声波振荡器，其被设置成二维排列，以将颗粒捕获，固定或移动到溶液中的可选位置，或者通过使用通过将颗粒叠加在另一个上而产生的梯度力场而获得的梯度力进行细胞融合由多个超声波振荡器产生的超声波。彼此独立起作用的超声波振荡器可以发射具有可选强度和相位的超声波，并且通过使用由超声波产生的叠加梯度力场产生的外力，可以容易地处理颗粒。

2. 发明申请

US20070161897A1 Ultrasonic treatment equipment 失效
标题翻译：超声波处理设备
公开(公告)号：US20070161897A1
公开(公告)日：2007-07-12
申请号：US10557237
申请日：2004-05-18
申请人： Kazuaki Sasaki , Takashi Azuma , Ken-ichi Kawabata , Shin-ichiro Umemura , Takashi Okai , Tetsuya Ishikawa
发明人： Kazuaki Sasaki , Takashi Azuma , Ken-ichi Kawabata , Shin-ichiro Umemura , Takashi Okai , Tetsuya Ishikawa
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/06 , A61B8/13 , A61B2090/378
摘要： Ultrasonic treatment equipment is provided which repeats therapeutic ultrasound exposure while measuring a degree of vessel constriction on a therapeutic ultrasound exposure basis. This equipment includes: a therapeutic ultrasonic transducer 2 which exposes a blood vessel of an affected part to a focused therapeutic ultrasonic wave for a specified period of exposure time; an imaging ultrasonic probe 3 which images an ultrasound tomographic image of the affected part; a display unit 24 which displays the ultrasound tomographic image; means 21 for detecting a blood flow signal from a signal received by the imaging ultrasonic probe and determining the blood flow velocity of the blood vessels of the affected part; means 21 for calculating a rate of change in blood flow velocity during the exposure to the therapeutic ultrasonic wave or before and after the exposure to the therapeutic ultrasonic wave; and means 23 for controlling exposure conditions of the therapeutic ultrasonic wave on the basis of the rate of change in blood flow velocity, and thereby controlling the therapeutic ultrasonic transducer.
摘要翻译：提供超声波处理设备，其在治疗超声暴露基础上测量血管收缩程度时重复治疗性超声波暴露。该设备包括：治疗超声波换能器2，其将受影响部分的血管暴露于聚焦的治疗超声波达指定的曝光时间; 成像超声波探头3，其对受影响部分的超声断层图像进行成像; 显示单元24，其显示超声断层图像; 用于从由成像超声波探头接收的信号中检测血流信号并确定受影响部分的血管的血流速度的装置21; 用于计算暴露于治疗超声波期间或暴露于治疗超声波之前和之后的血流速度变化率的装置21; 以及基于血流速度变化率来控制治疗超声波的暴露条件的装置23，由此控制治疗用超声波换能器。

3. 发明授权

US07699779B2 Ultrasonic treatment equipment 失效
标题翻译：超声波处理设备
公开(公告)号：US07699779B2
公开(公告)日：2010-04-20
申请号：US10557237
申请日：2004-05-18
申请人： Kazuaki Sasaki , Takashi Azuma , Ken-ichi Kawabata , Shin-ichiro Umemura , Takashi Okai , Tetsuya Ishikawa
发明人： Kazuaki Sasaki , Takashi Azuma , Ken-ichi Kawabata , Shin-ichiro Umemura , Takashi Okai , Tetsuya Ishikawa
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/06 , A61B8/13 , A61B2090/378
摘要： Ultrasonic treatment equipment is provided which repeats therapeutic ultrasound exposure while measuring a degree of vessel constriction on a therapeutic ultrasound exposure basis. This equipment includes: a therapeutic ultrasonic transducer 2 which exposes a blood vessel of an affected part to a focused therapeutic ultrasonic wave for a specified period of exposure time; an imaging ultrasonic probe 3 which images an ultrasound tomographic image of the affected part; a display unit 24 which displays the ultrasound tomographic image; means 21 for detecting a blood flow signal from a signal received by the imaging ultrasonic probe and determining the blood flow velocity of the blood vessels of the affected part; means 21 for calculating a rate of change in blood flow velocity during the exposure to the therapeutic ultrasonic wave or before and after the exposure to the therapeutic ultrasonic wave; and means 23 for controlling exposure conditions of the therapeutic ultrasonic wave on the basis of the rate of change in blood flow velocity, and thereby controlling the therapeutic ultrasonic transducer.
摘要翻译：提供超声波处理设备，其在治疗超声暴露基础上测量血管收缩程度时重复治疗性超声波暴露。该设备包括：治疗超声波换能器2，其将受影响部分的血管暴露于聚焦的治疗超声波达指定的曝光时间; 成像超声波探头3，其对受影响部分的超声断层图像进行成像; 显示单元24，其显示超声断层图像; 用于从由成像超声波探头接收的信号中检测血流信号并确定受影响部分的血管的血流速度的装置21; 用于计算暴露于治疗超声波期间或暴露于治疗超声波之前和之后的血流速度变化率的装置21; 以及基于血流速度变化率来控制治疗超声波的暴露条件的装置23，由此控制治疗用超声波换能器。

4. 发明申请

US20080019923A1 GAS BUBBLE-GENERATING AGENT 审中-公开
标题翻译：气体发泡剂
公开(公告)号：US20080019923A1
公开(公告)日：2008-01-24
申请号：US11778255
申请日：2007-07-16
申请人： Kenichi KAWABATA , Koji Hirata , Kazuaki Sasaki
发明人： Kenichi KAWABATA , Koji Hirata , Kazuaki Sasaki
IPC分类号： A61B8/00
CPC分类号： A61K41/0033 , A61B5/4839 , A61B8/481
摘要： This invention provides a gas bubble-generating agent that can be used as a contrast medium or a blocking agent in vivo. Such gas bubble-generating agent is produced by a method for producing a gas bubble-generating agent comprising the following steps of: (a) preparing a mixed solution of an amphiphilic substance, an amphiphilic substance comprising a water-soluble polymer chemically bound thereto, a hardly water-soluble substance having a boiling point of lower than 60° C. at atmospheric pressure, and a physiologically acceptable isotonic solution; (b) pressurizing the mixed solution; and (c) centrifuging the mixed solution after the step of pressurization, wherein a molar concentration of the amphiphilic substance in the mixed solution prepared in step (a) is 10 times or more higher than that of the amphiphilic substance comprising a water-soluble polymer chemically bound thereto.
摘要翻译：本发明提供了可用作造影剂或封闭剂的气泡产生剂。这种气泡生成剂是通过气泡发生剂的制造方法制造的，其特征在于，包括以下步骤：（a）制备两亲物质，包含化学键合的水溶性聚合物的两亲物质，在大气压下沸点低于60℃的几乎不溶于水的物质，以及生理上可接受的等渗溶液; （b）对混合溶液加压; 和（c）在加压步骤之后离心混合溶液，其中在步骤（a）中制备的混合溶液中的两亲物质的摩尔浓度比包含水溶性聚合物的两亲物质的摩尔浓度高10倍或更多化学结合。

5. 发明授权

US06572839B2 Sensitizer for tumor treatment 有权
标题翻译：敏化剂用于肿瘤治疗
公开(公告)号：US06572839B2
公开(公告)日：2003-06-03
申请号：US09801844
申请日：2001-03-09
申请人： Nami Sugita , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Isao Sakata
发明人： Nami Sugita , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Isao Sakata
IPC分类号： A61B800
CPC分类号： A61K31/353 , A61B8/4444 , A61N7/00 , C07D311/86
摘要： A sensitizer for tumor treatment has a structure such that a lipophilic group and a hydrophilic group are bound to one and the same carbon atom in a compound containing a xanthene dye structure. It is important that the lipophilic group and hydrophilic group are bound to one and the same carbon atom; if they are separated from each other, no sufficient effect is obtained. Thus, the sensitizer possesses both lipophilicity and hydrophilicity. This sensitizer has a function of promoting acoustic cavitation and a function of revealing an antitumor effect and is an agent highly accumulable in tumor tissues. Thus, this sensitizer is highly selective for tumor tissues and enables the treatment of malignant tumor using ultrasound.
摘要翻译：用于肿瘤治疗的敏化剂具有使亲油基团和亲水基团与含有呫吨染料结构的化合物中的同一个碳原子结合的结构。重要的是亲脂基团和亲水基团与同一个碳原子结合; 如果它们彼此分离，则不能获得足够的效果。因此，敏化剂具有亲油性和亲水性。这种敏化剂具有促进声孔的功能和显示抗肿瘤作用的功能，并且是在肿瘤组织中高度累积的药剂。因此，这种敏化剂对于肿瘤组织是高度选择性的并且能够使用超声治疗恶性肿瘤。

6. 发明授权

US08460191B2 Ultrasonic medical diagnostic device for imaging changes with time 有权
标题翻译：超声波医疗诊断装置随时间变化
公开(公告)号：US08460191B2
公开(公告)日：2013-06-11
申请号：US11914962
申请日：2006-05-18
申请人： Hideki Yoshikawa , Takashi Azuma , Kenichi Kawabata , Kazuaki Sasaki , Shinichiro Umemura
发明人： Hideki Yoshikawa , Takashi Azuma , Kenichi Kawabata , Kazuaki Sasaki , Shinichiro Umemura
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译：一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。

7. 发明授权

US07074427B2 Medicine, carrier for medicine, method of producing medicine, and method of tumor treatment 失效
公开(公告)号：US07074427B2
公开(公告)日：2006-07-11
申请号：US10198178
申请日：2002-07-19
申请人： Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki
发明人： Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki
IPC分类号： A61K9/48 , A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K41/0033
摘要： A medicinal preparation capable of lowering the threshold of cavitation and generating active oxygen species via acoustic cavitation caused by an ultrasound is provided. The preparation, which is to be used in combination with ultrasonic irradiation, comprises a shell within the internal space of which a gas is enclosed and which contains or retains a substance capable of generating active oxygen species upon ultrasonic irradiation of the shell.

8. 发明授权

US06511428B1 Ultrasonic medical treating device 失效
标题翻译：超声医疗处理装置
公开(公告)号：US06511428B1
公开(公告)日：2003-01-28
申请号：US09830423
申请日：2001-04-26
申请人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
发明人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
IPC分类号： A61B800
CPC分类号： A61N7/022 , A61B8/12 , A61B2017/00154 , A61B2017/00274 , A61B2018/00547 , A61B2090/378 , A61B2090/3782
摘要： An ultrasound therapy apparatus delivers focused ultrasound for therapeutical purposes which can be correctly targeted to a target region, and also, a positional shift from the target region under irradiation of ultrasound can be effectively avoided. An ultrasound transducer is inside an applicator with an imaging ultrasonic probe. Another ultrasound transducer monitors a position of a target and a positional shift is inside a catheter which is inserted into a urethral tube. An imaging system drives the ultrasound probe to display an ultrasound tomographic image of a region in the vicinity of a target region. The ultrasound transducer is driven in a pulse-shaped mode at the same frequency as the imaging ultrasound and also at such timing when the imaging ultrasound is reached. As a result, a point-shaped sound source image is superimposed and displayed on an ultrasound tomographic image.
摘要翻译：超声治疗装置将聚焦超声波提供给治疗目的，可以正确地瞄准目标区域，并且可以有效地避免从超声照射下的目标区域的位置偏移。超声波换能器在具有成像超声波探头的施加器内部。另一个超声波传感器监测目标的位置，位置偏移在插入尿道管内的导管内。成像系统驱动超声波探头以显示目标区域附近的区域的超声断层图像。超声波换能器以与成像超声相同的频率以及在达到成像超声的这种定时以脉冲模式驱动。结果，点状声源图像被叠加并显示在超声断层图像上。

9. 发明申请

US20100158816A1 GAS BUBBLE-GENERATING AGENT 审中-公开
标题翻译：气体发泡剂
公开(公告)号：US20100158816A1
公开(公告)日：2010-06-24
申请号：US12716891
申请日：2010-03-03
申请人： Kenichi Kawabata , Koji HIRATA , Kazuaki Sasaki
发明人： Kenichi Kawabata , Koji HIRATA , Kazuaki Sasaki
IPC分类号： A61B8/00
CPC分类号： A61K41/0033 , A61B5/4839 , A61B8/481
摘要： This invention provides a gas bubble-generating agent that can be used as a contrast medium or a blocking agent in vivo. Such gas bubble-generating agent is produced by a method for producing a gas bubble-generating agent comprising the following steps of: (a) preparing a mixed solution of an amphiphilic substance, an amphiphilic substance comprising a water-soluble polymer chemically bound thereto, a hardly water-soluble substance having a boiling point of lower than 60° C. at atmospheric pressure, and a physiologically acceptable isotonic solution; (b) pressurizing the mixed solution; and (c) centrifuging the mixed solution after the step of pressurization, wherein a molar concentration of the amphiphilic substance in the mixed solution prepared in step (a) is 10 times or more higher than that of the amphiphilic substance comprising a water-soluble polymer chemically bound thereto.
摘要翻译：本发明提供了可用作造影剂或封闭剂的气泡产生剂。这种气泡生成剂是通过气泡发生剂的制造方法制造的，其特征在于，包括以下步骤：（a）制备两亲物质，包含化学键合的水溶性聚合物的两亲物质，在大气压下沸点低于60℃的几乎不溶于水的物质，以及生理上可接受的等渗溶液; （b）对混合溶液加压; 和（c）在加压步骤之后离心混合溶液，其中在步骤（a）中制备的混合溶液中的两亲物质的摩尔浓度比包含水溶性聚合物的两亲物质的摩尔浓度高10倍或更多化学结合。

10. 发明申请

US20090048516A1 IMAGE DIAGNOSING DEVICE 有权
标题翻译：图像诊断装置
公开(公告)号：US20090048516A1
公开(公告)日：2009-02-19
申请号：US11914962
申请日：2006-05-18
申请人： Hideki Yoshikawa , Takashi Azuma , Kenichi Kawabata , Kazuaki Sasaki , Shinichiro Umemura
发明人： Hideki Yoshikawa , Takashi Azuma , Kenichi Kawabata , Kazuaki Sasaki , Shinichiro Umemura
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译：一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。

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