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1. 发明申请

US20050131336A1 Electrode structure 审中-公开
标题翻译：电极结构
公开(公告)号：US20050131336A1
公开(公告)日：2005-06-16
申请号：US10501948
申请日：2003-01-23
申请人： Kenji Mori , Hiroyuki Maeda , Yoshihiro Nishi , Tetsuya Arimoto , Naruhito Higo , Shuji Sato , Tatsuya Ogawa , Saori Takahashi , Yasushi Fuchita
发明人： Kenji Mori , Hiroyuki Maeda , Yoshihiro Nishi , Tetsuya Arimoto , Naruhito Higo , Shuji Sato , Tatsuya Ogawa , Saori Takahashi , Yasushi Fuchita
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0492 , A61N1/0412 , A61N1/0428 , A61N1/0496
摘要： An electrode structure is provided which is capable of efficiently using a material that can be a non-polarized electrode component, allowing the material to fully demonstrate the effect as the non-polarized electrode and maintaining the performance. This electrode structure comprises an insulating base (13), a polarized component layer (first layer) (12) laminated on the insulating base so as not to penetrate the insulating base, the polarized component layer comprising a conductive paste or metallic foil which is predominantly made of a component that can be a polarized electrode, and a non-polarized component layer (second layer) (11) provided on the polarized component layer, the non-polarized component layer comprising a conductive paste which is predominantly made of a component that can be a non-polarized electrode.
摘要翻译：提供一种电极结构，其能够有效地使用可以是非极化电极组分的材料，从而允许材料充分显示作为非极化电极的作用并保持性能。该电极结构包括绝缘基底（13），层叠在绝缘基底上的极化部件层（第一层）（12），以便不穿透绝缘基底，所述偏振构件层包括导电膏或金属箔，其主要是由可以是极化电极的部件和设置在偏振部件层上的非偏振部件层（第二层）（11）构成，非极化部件层包括主要由以下部件构成的导电膏可以是非极化电极。

2. 发明申请

US20050085887A1 Electrode structural body 审中-公开
标题翻译：电极结构体
公开(公告)号：US20050085887A1
公开(公告)日：2005-04-21
申请号：US10505158
申请日：2003-02-19
申请人： Kenji Mori , Hiroyuki Maeda , Tatsuya Ogawa , Saori Takahashi , Yoshihiro Nishi , Tetsuya Arimoto , Naruhito Higo , Shuji Sato , Yasushi Fuchita
发明人： Kenji Mori , Hiroyuki Maeda , Tatsuya Ogawa , Saori Takahashi , Yoshihiro Nishi , Tetsuya Arimoto , Naruhito Higo , Shuji Sato , Yasushi Fuchita
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0424 , A61N1/044
摘要： There is provided an electrode structure in which cracks are hardly generated in the bending processed portions, in particular, in the electrode layer and the insulating layer. The electrode structure comprises a support (3) having bending processed portions (4), an electrode layer (1) formed on the support so as to pass over the bending processed portions (4), and an insulating layer (2) formed on the electrode layer (1) passing over the bending processed portions (4). The glass transition temperature of the dielectric material forming the insulating layer (2) is made to be 25° C. or below. The electrode layer (1) includes at least one material belonging to the group consisting of silver, silver chloride and carbon, and in particular, a terminal portion (5) of the electrode layer (1) passing over the bending processed portions (4) is formed of a paste containing carbon as the main component.
摘要翻译：提供了一种在弯曲加工部分，特别是在电极层和绝缘层中几乎不产生裂纹的电极结构。电极结构包括具有弯曲加工部分（4）的支撑件（3），形成在支撑件上以便穿过弯曲加工部分（4）的电极层（1），以及形成在经过弯曲处理部分（4）的电极层（1）。形成绝缘层（2）的电介质材料的玻璃化转变温度为25℃以下。电极层（1）包括属于由银，氯化银和碳组成的组中的至少一种材料，特别是通过弯曲加工部分（4）的电极层（1）的端子部分（5）由以碳为主要成分的糊状物形成。

3. 发明申请

US20050113738A1 Iontophoresis electrode device 审中-公开
标题翻译：离子电渗电极装置
公开(公告)号：US20050113738A1
公开(公告)日：2005-05-26
申请号：US10500537
申请日：2003-01-09
申请人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Takuji Oikawa , Shuji Sato , Naruhito Higo , Hiroyuki Maeda , Kenji Mori
发明人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Takuji Oikawa , Shuji Sato , Naruhito Higo , Hiroyuki Maeda , Kenji Mori
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： There is provided an electrode device for iontophoresis capable of retaining a drug in a gel state with a force just enough so as not to disturb the treatment. In order to retain the gel (70), a sheet member (50) composed of a nonwoven fabric is laminated on a base film (20) including an electrode layer (30) so as to be integrated with the base film (20). The sheet member (50) has a property for allowing the gel (70) to permeate therein. Owing to this feature, the gel (70) loaded on the sheet member (50) is retained thereon with at least a part of the gel (70) permeated therein.
摘要翻译：提供了一种用于离子电渗疗法的电极装置，其能够以刚好足够的力将药物保持在凝胶状态，以免扰乱治疗。为了保持凝胶（70），将由非织造织物构成的片材（50）层叠在包含电极层（30）的基膜（20）上以与基膜（20）一体化。片材（50）具有使凝胶（70）渗透到其中的性质。由于这个特征，装载在片材（50）上的凝胶（70）保留在其上，凝胶（70）的至少一部分渗入其中。

4. 发明授权

US07502654B2 Electrode device having recessed part 失效
标题翻译：具有凹部的电极装置
公开(公告)号：US07502654B2
公开(公告)日：2009-03-10
申请号：US10517535
申请日：2003-06-11
申请人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
发明人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
IPC分类号： A61N1/00
CPC分类号： A61N1/0492 , A61B2562/187 , A61N1/0424 , A61N1/044 , A61N1/0448
摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed.An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).
摘要翻译：本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。电极装置（10）具有在外部凸缘部（110f）的不同于通过模制形成的凹部（60）的一部分中向上方突出的突起（70）。突出部70配置成包围凹部60的外周。当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中发生翘曲（沿周向的翘曲）。因此，突起（70）也可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，防止电极层（30）断开。

5. 发明申请

US20060206186A1 Electrode device having recessed part 失效
标题翻译：具有凹部的电极装置
公开(公告)号：US20060206186A1
公开(公告)日：2006-09-14
申请号：US10517535
申请日：2003-06-11
申请人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
发明人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
IPC分类号： A61N1/04
CPC分类号： A61N1/0492 , A61B2562/187 , A61N1/0424 , A61N1/044 , A61N1/0448
摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed. An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).
摘要翻译：本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。电极装置（10）具有突出部（70），该突起部（70）在除了通过模制形成的凹部（60）之外的向外的凸缘部分（110f）的一部分中向上突出。突出部70配置成包围凹部60的外周。当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中的翘曲（沿着周向的翘曲）发生。因此，突起（70）还可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，并防止电极层（30）断开。

6. 发明授权

US06587717B1 Iontophoresis device and method of assembling the same 失效
标题翻译：离子渗透装置及其组装方法
公开(公告)号：US06587717B1
公开(公告)日：2003-07-01
申请号：US09581261
申请日：2000-06-28
申请人： Mitsuru Kuribayashi , Hiroyuki Maeda , Nobuhiro Koga , Naruhito Higo
发明人： Mitsuru Kuribayashi , Hiroyuki Maeda , Nobuhiro Koga , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/0448
摘要： The present invention relates to an iontophoresis device, which can ensure the long-term stability of a drug and makes the operations for assemblage upon application easy as well as a method of assembling the device. A backing layer (4) is provided with a drug-dissolving portion (11) on a donor electrode-printed portion (6) thereof and a drug support (14) removably contacts with the drug-dissolving portion. A liner (12) is disposed on the backing layer on the skin (40) side and this is peeled off upon practical use. An opening (15) is formed on the liner (12) and an opening (5) is formed on an electrode portion (Ib). When assembling the device, these openings coincide with each other to thus easily and precisely dispose the drug support (14) on the drug-dissolving portion (11).
摘要翻译：离子电渗疗法装置技术领域本发明涉及一种离子电渗疗法装置，能够确保药物的长期稳定性，容易进行装配操作以及组装装置的方法。背衬层（4）在其供体电极印刷部分（6）上设有药物溶解部分（11），药物载体（14）可与药物溶解部分可拆卸地接触。衬垫（12）设置在皮肤（40）侧的背衬层上，并且在实际使用时将其剥离。在衬套（12）上形成开口（15），在电极部分（1b）上形成开口（5）。当组装装置时，这些开口彼此重合，从而容易且精确地将药物载体（14）放置在药物溶解部分（11）上。

7. 发明授权

US06510341B1 Iontophoresis device and drug unit 失效
公开(公告)号：US06510341B1
公开(公告)日：2003-01-21
申请号：US09581262
申请日：2000-06-28
申请人： Mitsuru Kuribayashi , Hiroyuki Maeda , Nobuhiro Koga , Naruhito Higo
发明人： Mitsuru Kuribayashi , Hiroyuki Maeda , Nobuhiro Koga , Naruhito Higo
IPC分类号： A61B1720
CPC分类号： A61N1/0448
摘要： Herein disclosed is an iontophoresis device suitable for effective use of a drug supported on a drug support. A donor electrode-printed portion (6) and a reference electrode-printed portion (7) are arranged on a backing layer (4). The backing layer is provided with, at the periphery, an adhesive film (3) for fixing a pharmaceutical preparation to an application site. The both electrode-printed portions (6), (7) are electrically connected to a current-generating portion (Ia) through a conductive snap connector (Id). The drug support (14) is removably joined with a conductive layer (11) formed on the electrode on the side of the donor electrode-printed portion (6). The drug support (14) is subjected to a drug diffusion-inhibitory treatment (30).

8. 发明授权

US06597947B1 Iontophoresis device 有权
标题翻译：离子渗透装置
公开(公告)号：US06597947B1
公开(公告)日：2003-07-22
申请号：US09958599
申请日：2001-10-12
申请人： Kazutaka Inoue , Hirotoshi Adachi , Hiroyuki Maeda , Naruhito Higo
发明人： Kazutaka Inoue , Hirotoshi Adachi , Hiroyuki Maeda , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： The present invention provides an iontophoresis device allowing effective and continuous absorption for a long period. The iontophoresis device comprises the first electrode structure (100a) and the second electrode structure (110a) each having a hydrophilic conductive layer (102a, 112a) containing active ingredient and an electrode member (101a, 111a), and a power supply (120a) having polarity inverting means for switching over a current direction between the two electrode structures, wherein at least one of the first and the second electrode structures contains chloride ions and before administration, a chloride-ion content (P mg) is within a range satisfying the following equation: 1.0×(I×T×0.022)≦P wherein T represents a polarity inverting time (min) until polarity is inverted after energization in a certain direction and I represents an average current (mA).
摘要翻译：本发明提供一种允许长时间有效且持续吸收的离子电渗装置。离子电渗装置包括：第一电极结构（100a）和第二电极结构（110a），每个第一电极结构具有含有活性成分的亲水性导电层（102a，112a）和电极部件（101a，111a）;以及电源（120a）具有用于切换两个电极结构之间的电流方向的极性反转装置，其中第一和第二电极结构中的至少一个包含氯离子并且在给药之前，氯离子含量（P mg）在满足以下等式：其中T表示在一定方向通电之后极性反转的极性反转时间（min），I表示平均电流（mA）。

9. 发明授权

US06915159B1 Electrode structure for iontophoresis device and method of producing the same 失效
标题翻译：离子电渗装置的电极结构及其制造方法
公开(公告)号：US06915159B1
公开(公告)日：2005-07-05
申请号：US09807832
申请日：2000-05-10
申请人： Mitsuru Kuribayashi , Hiroyuki Maeda , Nobuhiro Koga , Naruhito Higo
发明人： Mitsuru Kuribayashi , Hiroyuki Maeda , Nobuhiro Koga , Naruhito Higo
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0448
摘要： The invention is to provide an electrode structure of an iontophoresis device and a method of producing the same, excellent in an economical property, an operational property, stability and safety. The electrode structure for the iontophoresis device comprises a backing having a substrate film (1) having a molding portion, an anode side and a cathode side electrode layers (14), (15) formed passing the outer circumferential portion from the inner bottom of the molding portion, and an insulating layer 3 formed in the outer circumferential portion of the molding portion. The molding portion of the backing has a dent portion and an anode side and a cathode side conductive layers (12), (13) are separately installed therein. A cover member (8) is installed to seal between these conductive layers (12), (13) and the insulating layer (3). An adhesive sheet (10) for attachment to the skin is provided to the rear face of the substrate film (1) and a liner (16) for the adhesive sheet is provided on the cover member (8).
摘要翻译：本发明提供离子电渗装置的电极结构及其制造方法，经济性，操作性，稳定性，安全性优异。用于离子电渗装置的电极结构包括：背衬，具有具有模制部分的基底膜（1），阳极侧和阴极侧电极层（14），（15），其形成为穿过外周部分从内壁模制部分和形成在模制部分的外圆周部分中的绝缘层3。背衬的模制部分具有凹部和阳极侧，并且阴极侧导电层（12），（13）分别安装在其中。盖构件（8）被安装以密封在这些导电层（12），（13）和绝缘层（3）之间。在基材膜（1）的背面设有用于附着于皮肤的粘合片（10），在盖部件（8）上设置粘接片用衬垫（16）。

10. 发明授权

US06654635B1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US06654635B1
公开(公告)日：2003-11-25
申请号：US09622050
申请日：2000-08-24
申请人： Nobuhiro Koga , Hiroyuki Maeda , Mitsuru Kuribayashi , Naruhito Higo
发明人： Nobuhiro Koga , Hiroyuki Maeda , Mitsuru Kuribayashi , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/303
摘要： An iontophoresis device, which can ensure the long-term stability of drugs and which can be easily assembled when used, is provided. A donor electrode-printed portion (6) is placed on one side of a backing layer (4), and a reference electrode-printed portion (7) is placed on the other side. Both printed parts are connected to a current generating part (Ia) through a connector (Id). A drug support film (14) is joined to a drug-dissolving portion (11), and a cup-like shaped protective cover (12), which covers the drug support film (14), is removed before the device is used. The exposed drug support film (14) is attached to the skin of a user, and the device is driven by turning on a power supply of the current-generating portion (Ia).
摘要翻译：一种离子电渗疗法装置，其可以确保药物的长期稳定性，并且在使用时可以容易地组装。供体电极印刷部分（6）放置在背衬层（4）的一侧上，另一侧放置参考电极印刷部分（7）。两个印刷部分通过连接器（Id）连接到电流产生部分（Ia）。将药物保护膜（14）与药物溶解部（11）接合，在使用该装置之前，除去覆盖药物保护膜（14）的杯状保护罩（12）。暴露的药物支撑膜（14）附接到使用者的皮肤，并且通过接通电流产生部分（1a）的电源来驱动该装置。

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