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1. 发明授权

US5441488A Medical tool having lubricious surface in a wetted state and method for production thereof 失效
标题翻译：具有润湿状态的润滑表面的医疗工具及其制造方法
公开(公告)号：US5441488A
公开(公告)日：1995-08-15
申请号：US192574
申请日：1994-02-07
申请人： Kenichi Shimura , Naoki Ishii , Makoto Onishi
发明人： Kenichi Shimura , Naoki Ishii , Makoto Onishi
IPC分类号： A61L27/34 , A61L29/08 , A61L29/14 , A61L31/10 , A61M25/00 , A61M5/32
CPC分类号： A61M25/1027 , A61L27/34 , A61L29/085 , A61L29/14 , A61L31/10 , A61M2025/0046 , A61M2025/1088
摘要： This invention provides a medical tool the surface of which is enabled to acquire lasting lubricity (low friction) by assuming a state wetted with bodily fluid or aqueous solution. This surface is formed without requiring the coating work to be repeated. The medical tool is produced by coating a water-swellable polymer having in the molecular unit thereof a reactive functional group capable of being reacted with a proton-donating group, on the surface of a matric material possessing the proton-donating group, and also by coating a water-swellable polymer having in the molecular unit thereof a reactive group capable of being reacted with an acid anhydride group on the surface of a matric material possessing the acid anhydride group.
摘要翻译：本发明提供一种医疗工具，其表面能够通过假定用体液或水溶液润湿的状态来获得持久的润滑性（低摩擦）。该表面形成而不需要重复涂覆工作。该医疗用具是通过将具有能够与质子供体基团反应的反应性官能团的分子单元的水溶胀性聚合物涂布在具有质子供体基团的基质材料的表面上，涂布具有其分子单元的水溶胀性聚合物，该反应性基团能够与具有酸酐基团的基质材料的表面上的酸酐基反应。

2. 发明授权

US5670558A Medical instruments that exhibit surface lubricity when wetted 失效
标题翻译：润湿时表现出润滑性的医疗仪器
公开(公告)号：US5670558A
公开(公告)日：1997-09-23
申请号：US498796
申请日：1995-07-06
申请人： Makoto Onishi , Kenichi Shimura , Naoki Ishii
发明人： Makoto Onishi , Kenichi Shimura , Naoki Ishii
IPC分类号： A61L27/34 , A61L29/08 , A61L29/14 , A61L31/10 , A61L33/00 , A61M25/00 , A01N1/00 , A61F2/00 , A61M5/32
CPC分类号： A61M25/1027 , A61L27/34 , A61L29/085 , A61L29/14 , A61L29/145 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L2400/10 , A61M2025/0046 , A61M2025/1088
摘要： This invention provides a medical instrument having on a surface a layer (surface lubricating layer) that forms a hydrogel when wetted and that is composed of an insolubilized water-soluble or water-swellable polymer having a reactive functional group in the molecule. The surface having outstanding surface lubricity and, optionally, the ability to prevent the formation of thrombi.
摘要翻译：本发明提供了一种在表面上具有润湿时形成水凝胶的层（表面润滑层）的医疗器械，其由在分子中具有反应性官能团的不溶性水溶性或水可溶胀性聚合物构成。该表面具有优异的表面润滑性，并且可选地具有防止形成血栓的能力。

3. 发明授权

US5547576A Pathogenic substance removing material and a blood filter containing the material 失效
标题翻译：病原物除去物质和含有该物质的血液过滤器
公开(公告)号：US5547576A
公开(公告)日：1996-08-20
申请号：US85813
申请日：1993-07-06
申请人： Makoto Onishi , Takashi Ohwada , Ken Tatebe , Yoshitaka Ohmura , Kenichi Shimura
发明人： Makoto Onishi , Takashi Ohwada , Ken Tatebe , Yoshitaka Ohmura , Kenichi Shimura
IPC分类号： A61L2/00 , A61L2/02 , A61M1/36 , B01D39/16 , B01D67/00 , B01D63/00 , B01D69/12 , B01D71/60
CPC分类号： B01D67/0093 , A61L2/0017 , A61L2/022 , A61M1/3633 , B01D39/1623 , A61M2202/0415 , B01D2323/38
摘要： A material wherein a polyamine compound is immobilized on its base surface and a blood filter using this material. The material is provided in the form of a porous membrane having the maximum pore diameter of 0.1-50 .mu.m. The polyamine compound is at least one compound selected from the group consisting of (a) a polyamine compound which has primary and secondary amines in its molecule and a hydrophobic part between these amines, (b) a polyamine compound represented by the following formula (I); ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 represent hydrogen, aliphatic and aromatic hydrocarbons, and halogen, and n is 5 or more, and (c) a polyamine compound represented by the following formula (II); ##STR2## wherein R represents NH.sub.2 or aminoalkyl radical having 1 to 4 carbon atoms and n is 5 or more. The blood filter comprises a housing which has an inlet and outlet, and the material arranged inside the housing.
摘要翻译：其中多胺化合物固定在其基底表面上的材料和使用该材料的血液过滤器。该材料以最大孔径为0.1-50μm的多孔膜的形式提供。多胺化合物是选自（a）在其分子中具有伯胺和仲胺的多胺化合物和这些胺之间的疏水部分的至少一种化合物，（b）由下式（I）表示的多胺化合物）;存在氢，脂族和芳族烃和卤素，n为5以上，（c）由下式（II）表示的多胺化合物。（II）其中R表示NH 2或具有1至4个碳原子且n为5或更大的氨基烷基。血液过滤器包括具有入口和出口的壳体，以及布置在壳体内部的材料。

4. 发明授权

US5503631A Lubricious catheter balloon for vasodilation 失效
标题翻译：用于血管舒张的导管气囊
公开(公告)号：US5503631A
公开(公告)日：1996-04-02
申请号：US132873
申请日：1993-10-07
申请人： Makoto Onishi , Kenichi Shimura
发明人： Makoto Onishi , Kenichi Shimura
IPC分类号： A61M29/02 , A61M29/00
CPC分类号： A61M25/1027 , A61M25/104 , A61M2025/0004 , A61M2025/1088
摘要： A vasodilating catheter balloon characterized by the fact that the balloon portion thereof is provided with what serves concurrently as a lubricating portion and a non-lubricating portion.
摘要翻译：一种血管扩张导管气囊，其特征在于，其气囊部分设置有同时用作润滑部分和非润滑部分的事实。

5. 发明授权

US5202025A Porous membrane and method for preparing the same 失效
标题翻译：多孔膜及其制备方法
公开(公告)号：US5202025A
公开(公告)日：1993-04-13
申请号：US821844
申请日：1992-01-14
申请人： Makoto Onishi , Kenichi Shimura
发明人： Makoto Onishi , Kenichi Shimura
IPC分类号： B01D67/00
CPC分类号： B01D67/0093 , B01D67/0027 , B01D2323/38 , B01D2325/32 , B01D2325/36
摘要： In the method for preparing a porous membrane, a polymer having a low glass transition temperature is held on the surface of a porous membrane substrate and then drawing is conducted. Accordingly, the drawing at a high draw ratio can be conducted to which the substrate as such can not be subjected. As a result, not only an excellent porous membrane having an enlarged pore size and an increased void volume can be obtained but also it is possible to control the pore size and the void volume in wide ranges. Further, a hydrophilic polymer having a glass transition temperature of not more than 300 K is formed on the surface of pores of a porous membrane substrate by graft polymerization so as to bond the hydrophilic polymer on the substrate by a covalent bond. Therefore, it is possible to provide a porous membrane excellent in unbrittleness and inhibiting elution in an environmental liquid or the like.
摘要翻译：在制备多孔膜的方法中，将具有低玻璃化转变温度的聚合物保持在多孔膜基材的表面上，然后进行拉伸。因此，可以进行基板不能经受的高拉伸比的拉伸。结果，不仅可以获得具有扩大的孔径和增加的空隙体积的优异的多孔膜，而且可以在宽范围内控制孔径和空隙体积。此外，通过接枝聚合在多孔膜基材的孔的表面上形成玻璃化转变温度不超过300K的亲水性聚合物，以通过共价键将亲水性聚合物键合在基材上。因此，可以提供在环境液体等中不易脆性和抑制洗脱优异的多孔膜。

6. 发明授权

US5908656A Thermoformed medical device with lubricious modified polyethylene oxide layer 失效
标题翻译：具有润滑改性聚环氧乙烷层的热成型医疗器械
公开(公告)号：US5908656A
公开(公告)日：1999-06-01
申请号：US890965
申请日：1997-07-10
申请人： Kenji Ishikawa , Hideaki Kitou , Kenichi Shimura , Yasunobu Zushi , Naoki Ishii , Taku Aoike
发明人： Kenji Ishikawa , Hideaki Kitou , Kenichi Shimura , Yasunobu Zushi , Naoki Ishii , Taku Aoike
IPC分类号： A61L27/18 , A61L27/50 , A61L29/06 , A61L29/14 , A61L31/06 , A61L31/18 , B05D3/10 , B05D3/12
CPC分类号： A61L31/18 , A61L27/18 , A61L27/50 , A61L29/06 , A61L29/14 , A61L31/06
摘要： This invention provides a medical device in which its lubricity is continually maintained and its safety is guaranteed.Particularly, it provides a medical device in which lubricity is generated on at least a portion of its surface when the device is contacted with body fluids or exposed to physiological aqueous conditions, wherein the lubricity-generating portion is formed by thermoforming.
摘要翻译：本发明提供了一种医疗装置，其中其润滑性被持续保持并且其安全性得到保证。特别地，其提供了一种医疗装置，其中当该装置与体液接触或暴露于生理水分条件时，其表面的至少一部分产生润滑性，其中该润滑产生部分通过热成型形成。

7. 发明授权

US07477538B2 Magnetic random access memory 有权
标题翻译：磁性随机存取存储器
公开(公告)号：US07477538B2
公开(公告)日：2009-01-13
申请号：US10561213
申请日：2004-06-16
申请人： Kenichi Shimura , Kuniko Kikuta
发明人： Kenichi Shimura , Kuniko Kikuta
IPC分类号： G11C11/00
CPC分类号： H01L27/222 , G11C11/16
摘要： A technique for reducing influences of the bias magnetic field developed by yokes used for concentrating the magnetic field on magnetoresistance elements, on MRAM operations. An MRAM is composed of a plurality of magnetoresistance elements having magnetic anisotropy in a first direction; a wiring extended in a second direction different from the first direction, through which a write current flows for writing data into the magnetoresistance elements; and a yoke layer formed of ferromagnetic material, extended along the second direction, and covering at least a portion of a surface of the wiring. The plurality of magnetoresistance elements include a first magnetoresistance element, and a second magnetoresistance element of which the distance from an end of the yoke layer is further than that of the first magnetoresistance element. The first magnetoresistance element has a magnetic anisotropy stronger than that of the second magnetoresistance element.
摘要翻译：在MRAM操作中减小用于将磁场集中在磁阻元件上的磁轭产生的偏磁场的影响的技术。 MRAM由在第一方向上具有磁各向异性的多个磁阻元件构成; 沿与第一方向不同的第二方向延伸的布线，写入电流通过该布线将数据写入磁阻元件; 以及由铁磁材料形成的轭层，沿着第二方向延伸，并覆盖布线表面的至少一部分。多个磁阻元件包括第一磁阻元件和第二磁阻元件，其与轭层的端部的距离比第一磁阻元件的距离更远。第一磁阻元件具有比第二磁阻元件更强的磁各向异性。

8. 发明申请

US20060132987A1 Magnetic random access memory 有权
标题翻译：磁性随机存取存储器
公开(公告)号：US20060132987A1
公开(公告)日：2006-06-22
申请号：US10561213
申请日：2004-06-16
申请人： Kenichi Shimura , Kuniko Kikuta
发明人： Kenichi Shimura , Kuniko Kikuta
IPC分类号： G11B5/33
CPC分类号： H01L27/222 , G11C11/16
摘要： The present invention provides a technique for reducing influences of the bias magnetic field developed by yokes used for concentrating the magnetic field on magnetoresistance elements, on MRAM operations. An MRAM according to the present invention is composed of a plurality of magnetoresistance elements having magnetic anisotropy in a first direction; a wiring extended in a second direction different from the first direction, through which a write current is flown for writing data into the magnetoresistance elements; and a yoke layer formed of ferromagnetic material, extended along the second direction, and covering at least a portion of a surface of the wiring. The plurality of magnetoresistance elements include a first magnetoresistance element, and a second magnetoresistance element of which the distance from an end of the yoke layer is further than that of the first magnetoresistance element. The first magnetoresistance element has a magnetic anisotropy stronger than that of the second magnetoresistance element.
摘要翻译：本发明提供了一种用于减小用于磁场集中的磁轭产生的偏磁场对磁阻元件的影响的技术。根据本发明的MRAM由在第一方向上具有磁各向异性的多个磁阻元件构成; 沿与第一方向不同的第二方向延伸的布线，通过该布线写入电流以将数据写入磁阻元件; 以及由铁磁材料形成的轭层，沿着第二方向延伸，并覆盖布线表面的至少一部分。多个磁阻元件包括第一磁阻元件和第二磁阻元件，其与轭层的端部的距离比第一磁阻元件的距离更远。第一磁阻元件具有比第二磁阻元件更强的磁各向异性。

9. 发明授权

US06994824B2 Artificial cardiopulmonary circuit system 有权
标题翻译：人工心肺电路系统
公开(公告)号：US06994824B2
公开(公告)日：2006-02-07
申请号：US10180321
申请日：2002-06-27
申请人： Akira Mochizuki , Kenichi Shimura , Takao Anzai
发明人： Akira Mochizuki , Kenichi Shimura , Takao Anzai
IPC分类号： A61M1/14 , A61M37/00 , A61M1/34 , B01D39/00
CPC分类号： B01D67/0088 , A61M1/1625 , A61M1/1698 , B01D63/021
摘要： To provide an artificial cardiopulmonary circuit system having high heat resistance and excellent blood compatibility. The artificial cardiopulmonary circuit system includes a hollow fiber membrane oxygenator including a plurality of porous hollow fiber membranes for gas exchange having a blood contact part that contacts blood on one side thereof and a gas contact part that contacts a gas on the other side thereof, and a housing that contains the hollow fiber membranes therein. At least a portion of the blood contact part of the hollow fiber membrane oxygenator is coated with a polymer comprising a repeating unit represented by the following general formula (1) as a main structural component and having a viscosity at 65° C. of 5,000 poise (500 Pa·s) [Chemical Formula 4] (Wherein R1 is hydrogen or a methyl group, R2 is an alkylene group having 1 to 4 carbon atoms, and R3 is an alkyl group having 1 to 4 carbon atoms).
摘要翻译：提供具有高耐热性和优异血液相容性的人造心肺电路系统。人造心肺回路系统包括中空纤维膜氧合器，其包括多个用于气体交换的多孔中空纤维膜，其具有与其一侧接触血液的血液接触部分和与其另一侧接触气体的气体接触部分，以及其中包含中空纤维膜的壳体。中空纤维膜氧合器的血液接触部分的至少一部分涂覆有包含由以下通式（1）表示的重复单元作为主要结构组分并且在65℃下的粘度为5000泊的聚合物（500 Pa＆＃xb

10. 外观设计

USD726304S1 Medicament sprayer 有权
标题翻译：药剂喷雾器
公开(公告)号：USD726304S1
公开(公告)日：2015-04-07
申请号：US29431810
申请日：2012-09-11
申请人： Teruyuki Yatabe , Kenichi Shimura
设计人： Teruyuki Yatabe , Kenichi Shimura

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