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1. 发明申请

US20070071810A1 Additive for tablets 审中-公开
标题翻译：片剂添加剂
公开(公告)号：US20070071810A1
公开(公告)日：2007-03-29
申请号：US10569582
申请日：2004-08-24
申请人： Kenichi Kudo , Mamoru Wada , Michihiro Sunako , Junichi Takahara , Takeshi Takaha , Kazutoshi Fujii , Takashi Kuriki
发明人： Kenichi Kudo , Mamoru Wada , Michihiro Sunako , Junichi Takahara , Takeshi Takaha , Kazutoshi Fujii , Takashi Kuriki
IPC分类号： A61K9/20 , A61K31/715 , A61K31/716
CPC分类号： A61K47/36 , A61K9/205 , A61K31/167
摘要： A disintegrant for tablets consisting of an α-1,4-glucan having a degree of polymerization of not less than 180 and less than 1230 and a dispersity (weight average molecular weight “Mw”/number average molecular weight “Mn”) of not more than 1.25 or a modified product thereof. A binder for tablets consisting of an α-1,4-glucan having a degree of polymerization of not less than 1230 and not more than 37000 and a dispersity of not more than 1.25, or a modified product thereof. A binding-disintegrating agent for tablets consisting of a low molecular weight α-1,4-glucan or a modified product thereof, and a high molecular weight α-1,4-glucan or a modified product thereof, wherein the low molecular weight α-1,4-glucan has a degree of polymerization of not less than 180 and less than 1230 and a dispersity of not more than 1.25, and wherein the high molecular weight α-1,4-glucan has a degree of polymerization of not less than 1230 and not less than 37000 and a dispersity of not more than 1.25.
摘要翻译：由聚合度不低于180且小于1230的α-1,4-葡聚糖和不分散性（重均分子量“Mw”/数均分子量“Mn”）组成的片剂的崩解剂大于1.25或其改性产物。用于由聚合度不小于1230且不大于37000，分散度不大于1.25的α-1,4-葡聚糖或其改性产物组成的片剂的粘合剂。一种由低分子量α-1,4-葡聚糖或其改性产物组成的片剂和高分子量α-1,4-葡聚糖或其改性产物的粘合崩解剂，其中低分子量α -1,4-葡聚糖的聚合度不低于180度且小于1230，分散度不大于1.25，其中高分子量的α-1,4-葡聚糖的聚合度不低于超过1230，不低于37000，分散度不超过1.25。

2. 发明申请

US20060134417A1 Molded object comprising alpha-1,4-glucans and/or modifications thereof and process for producing the same 有权
标题翻译：包含α-1,4-葡聚糖和/或其修饰物的成型物体及其制备方法
公开(公告)号：US20060134417A1
公开(公告)日：2006-06-22
申请号：US10563595
申请日：2004-07-09
申请人： Takeshi Takaha , Kazutoshi Fujii , Takashi Kuriki , Kenichi Kudo , Mamoru Wada , Michihiro Sunako , Junichi Takahara
发明人： Takeshi Takaha , Kazutoshi Fujii , Takashi Kuriki , Kenichi Kudo , Mamoru Wada , Michihiro Sunako , Junichi Takahara
IPC分类号： D02G3/00 , C08B37/00
CPC分类号： C08L5/00 , D01F9/00 , Y10T428/2978
摘要： The present invention discloses a molded article containing high molecular weight α-1,4-glucan and/or its modification, and low molecular weight α-1,4-glucan and/or its modification. The low molecular weight α-1,4-glucan has the degree of polymerization of greater than or equal to 180 and less than 620. And the high molecular weight α-1,4-glucan has the degree of polymerization of greater than or equal to 620 and less than 37000. The high molecular weight α-1,4-glucan may preferably have a molecular weight distribution of not greater than 1.25, and the low molecular weight α-1,4-glucan may preferably have a molecular weight distribution of not greater than 1.25. The present invention also discloses a process for preparing the molded article, wherein the process comprises the step of adding the low molecular weight α-1,4-glucan and/or its modification to a solution comprising the high molecular weight α-1,4-glucan and/or its modification to gel the solution.
摘要翻译：本发明公开了含有高分子量的α-1,4-葡聚糖和/或其改性的低分子量的α-1,4-葡聚糖和/或其改性的成型制品。低分子量的α-1,4-葡聚糖具有大于或等于180且小于620的聚合度。而高分子量的α-1,4-葡聚糖的聚合度大于或等于至620和小于37000.高分子量的α-1,4-葡聚糖可优选具有不大于1.25的分子量分布，低分子量的α-1,4-葡聚糖可优选具有分子量分布不大于1.25。本发明还公开了一种制备模塑制品的方法，其中该方法包括将低分子量的α-1,4-葡聚糖和/或其修饰物加入到包含高分子量α-1,4 葡聚糖和/或其修饰以凝胶化溶液。

3. 发明授权

US08013148B2 Molded object comprising α-1,4-glucans and/or modifications thereof and process for producing the same 有权
标题翻译：包含α-1,4-葡聚糖和/或其修饰物的成型物体及其制备方法
公开(公告)号：US08013148B2
公开(公告)日：2011-09-06
申请号：US10563595
申请日：2004-07-09
申请人： Takeshi Takaha , Kazutoshi Fujii , Takashi Kuriki , Kenichi Kudo , Mamoru Wada , Michihiro Sunako , Junichi Takahara
发明人： Takeshi Takaha , Kazutoshi Fujii , Takashi Kuriki , Kenichi Kudo , Mamoru Wada , Michihiro Sunako , Junichi Takahara
IPC分类号： C07H1/00 , C08B30/20
CPC分类号： C08L5/00 , D01F9/00 , Y10T428/2978
摘要： The present application discloses a molded article, and a process for preparing a molded article consisting essentially of (i) high molecular weight linear α-1,4-glucan and (ii) low molecular weight linear α-1,4-glucan, wherein the process comprises the step of: adding the low molecular weight linear α-1,4-glucan to a solution comprising the high molecular weight linear α-1,4-glucan to gel the solution, wherein the low molecular weight linear α-1,4-glucan has a degree of polymerization of greater than or equal to 180 and less than 620, and has a molecular weight distribution of not greater than 1.25 and, the high molecular weight linear α-1,4-glucan has a degree of polymerization of greater than or equal to 620 and less than 37000, and has a molecular weight distribution of not greater than 1.25.
摘要翻译：本申请公开了一种模制品，以及制备基本上由（i）高分子量线性α-1,4-葡聚糖和（ii）低分子量线性α-1,4-葡聚糖组成的模制品的方法，其中该方法包括以下步骤：将低分子量线性α-1,4-葡聚糖加入到包含高分子量线性α-1,4-葡聚糖的溶液中以使溶液凝胶化，其中低分子量线性α-1 ，4-葡聚糖具有大于或等于180且小于620的聚合度，并且分子量分布不大于1.25，高分子量线性α-1,4-葡聚糖的度聚合度大于或等于620且小于37000，并且分子量分布不大于1.25。

4. 发明申请

US20080153695A1 Adsorbent Containing Alpha-1,4-Glucan and Process for Producing the Same 审中-公开
标题翻译：含有α-1,4-葡聚糖的吸附剂及其制备方法
公开(公告)号：US20080153695A1
公开(公告)日：2008-06-26
申请号：US11883765
申请日：2006-02-06
申请人： Kayo Hosoya , Kazutoshi Fujii , Takeshi Takaha , Takashi Kuriki , Junichi Takahara , Michihiro Sunako , Akitomo Terada
发明人： Kayo Hosoya , Kazutoshi Fujii , Takeshi Takaha , Takashi Kuriki , Junichi Takahara , Michihiro Sunako , Akitomo Terada
IPC分类号： B01J20/22 , C08B37/00
CPC分类号： B01J20/24 , A61L9/01 , A61L9/014 , A61L9/16 , B01J20/262 , B01J2220/4825
摘要： The present invention provides a composition for adsorbing or trapping an undesired material, wherein the composition comprises a functional α-1,4-glucan as an active ingredient. Specifically, α-1,4-glucan is allowed to be functionalized to provide said composition for adsorbing or trapping an undesired material. There are provided a composition comprising a functional α-1,4-glucan, all or a part of which is in a form of V-type crystal or an amorphous form, as well as an article comprising the composition as a functional material.
摘要翻译：本发明提供了用于吸附或捕获不需要的物质的组合物，其中该组合物包含功能性的α-1,4-葡聚糖作为活性成分。具体地说，使α-1,4-葡聚糖官能化以提供用于吸附或捕获不期望的物质的所述组合物。提供了包含功能性α-1,4-葡聚糖的组合物，其全部或部分是V型晶体或非晶形式的形式，以及包含该组合物作为功能材料的制品。

5. 发明授权

US07229801B2 Production method and preparation method of glucans 有权
标题翻译：葡聚糖的制备方法和制备方法
公开(公告)号：US07229801B2
公开(公告)日：2007-06-12
申请号：US10475943
申请日：2002-05-27
申请人： Kazutoshi Fujii , Yoshinobu Terada , Michiyo Yanase , Koji Odan , Hiroki Takata , Takeshi Takaha , Takashi Kuriki , Shigetaka Okada
发明人： Kazutoshi Fujii , Yoshinobu Terada , Michiyo Yanase , Koji Odan , Hiroki Takata , Takeshi Takaha , Takashi Kuriki , Shigetaka Okada
IPC分类号： C12P19/60 , C12N9/10
CPC分类号： C08B37/0009 , C08B30/20 , C08B33/00 , C12P19/18
摘要： A first method for producing glucan comprises the step of allowing a reaction solution containing sucrose, a primer, inorganic phosphate or glucose-1-phosphate, sucrose phosphorylase, and glucan phosphorylase to react to produce glucans. The maximum value of the sucrose-phosphate ratio of the reaction solution from the start of the reaction to the end of the reaction is no more than about 17. A second method for producing glucan comprises the step of allowing a reaction solution containing sucrose, a primer, inorganic phosphate or glucose-1-phosphate, sucrose phosphorylase, and glucan phosphorylase to react to produce glucans. The reaction is conducted at a temperature of about 40 C to about 70 C.
摘要翻译：制备葡聚糖的第一种方法包括使含有蔗糖，底漆，无机磷酸盐或葡萄糖-1-磷酸，蔗糖磷酸化酶和葡聚糖磷酸化酶的反应溶液反应生成葡聚糖的步骤。从反应开始到反应结束的反应溶液的蔗糖磷酸酯比例的最大值不超过约17。第二种葡聚糖的制备方法包括以下步骤：使含有蔗糖的反应溶液，底物，无机磷酸盐或葡萄糖-1-磷酸盐，蔗糖磷酸化酶和葡聚糖磷酸化酶反应产生葡聚糖。反应在约40℃至约70℃的温度下进行。

6. 发明授权

US07968309B2 Method for improving the thermostability of sucrose phosphorylase (SP) 有权
标题翻译：提高蔗糖磷酸化酶（SP）热稳定性的方法
公开(公告)号：US07968309B2
公开(公告)日：2011-06-28
申请号：US10566224
申请日：2004-08-31
申请人： Kazutoshi Fujii , Masae Iiboshi , Michiyo Yanase , Hiroki Takata , Takeshi Takaha , Takashi Kuriki
发明人： Kazutoshi Fujii , Masae Iiboshi , Michiyo Yanase , Hiroki Takata , Takeshi Takaha , Takashi Kuriki
IPC分类号： C12Q1/48 , C12N9/12
CPC分类号： C12N9/1051
摘要： A sucrose phosphorylase (SP) having improved thermostability obtained by modifying a natural SP and a method for producing the SP having improved thermostability is provided. This SP having improved thermostability has an amino acid residue which is different from that of the natural sucrose phosphorylase, in at least one position selected from the group consisting of a position corresponding to position 14, a position corresponding to position 29 and a position corresponding to position 44 in motif sequence 1; a position corresponding to position 7, a position corresponding to position 19, a position corresponding to position 23 and a position corresponding to position 34 in motif sequence 2; and a position corresponding to position 19 in motif sequence 3, and wherein the enzyme activity of the SP having improved thermostability at 37° C., after heating the SP having improved thermostability in 20 mM Tris buffer (pH 7.0) at 55° C. for 20 minutes, is 20% or more of enzyme activity of the SP having improved thermostability at 37° C. before heating.
摘要翻译：提供了通过改善天然SP获得的具有改进的热稳定性的蔗糖磷酸化酶（SP）和具有改善的热稳定性的制备SP的方法。具有改善的热稳定性的SP具有与天然蔗糖磷酸化酶不同的氨基酸残基，在选自对应于位置14的位置，对应于位置29的位置和对应于基序序列1中的位置44; 对应于位置7的位置，对应于位置19的位置，对应于位置23的位置和对应于图案序列2中的位置34的位置; 和与基序序列3中的位置19相对应的位置，并且其中在55℃下加热在20mM Tris缓冲液（pH7.0）中具有改善的热稳定性的SP后，SP的酶活性在37℃下具有改善的热稳定性。 20分钟，在加热前在37℃下具有改善的热稳定性的SP的酶活性的20％或更多。

7. 发明申请

US20100047891A1 METHOD OF HEAT-STABILIZING alpha-GLUCAN PHOSPHORYLASE (GP) 有权
标题翻译：热稳定α葡萄糖磷酸酶（GP）的方法
公开(公告)号：US20100047891A1
公开(公告)日：2010-02-25
申请号：US12465135
申请日：2009-05-13
申请人： Michiyo Yanase , Hiroki Takata , Kazutoshi Fujii , Takeshi Takaha , Takashi Kuriki
发明人： Michiyo Yanase , Hiroki Takata , Kazutoshi Fujii , Takeshi Takaha , Takashi Kuriki
IPC分类号： C12N9/10
CPC分类号： C12N9/1051 , C12P19/02 , C12P19/04
摘要： An α-glucan phosphorylase having improved thermostability, which obtained by modifying natural α-glucan phosphorylase, and a method for producing this α-glucan phosphorylase having improved thermostability are provided. The natural α-glucan phosphorylase is derived from a plant, this α-glucan phosphorylase having improved thermostability has an amino acid residue which is different from that of the natural α-glucan phosphorylase in at least one position selected from the group consisting of a position corresponding to position 4 in a motif sequence 1L or 1H, a position corresponding to position 4 in a motif sequence 2, and a position corresponding to position 7 in a motif sequence 3L or 3H, and wherein the enzyme activity of α-glucan phosphorylase having improved thermostability at 37° C., after heating in a 20 mM citrate buffer (pH 6.7) at 60° C. for 10 minutes, is 20% or more of the enzyme activity of the α-glucan phosphorylase having improved thermostability at 37° C., before heating.
摘要翻译：提供通过改性天然α-葡聚糖磷酸化酶获得的具有改进的热稳定性的α-葡聚糖磷酸化酶，以及制备具有改善的热稳定性的该α-葡聚糖磷酸化酶的方法。天然α-葡聚糖磷酸化酶衍生自植物，具有改善的热稳定性的该α-葡聚糖磷酸化酶具有与天然α-葡聚糖磷酸化酶不同的氨基酸残基，所述氨基酸残基至少一个位置选自位置对应于基序序列1L或1H中的位置4，对应于基序序列2中的位置4的位置和对应于基序序列3L或3H中的位置7的位置，并且其中具有α-葡聚糖磷酸化酶的酶活性在60℃下在20mM柠檬酸盐缓冲液（pH7.7）中加热10分钟后，在37℃下改善的热稳定性为具有改善的热稳定性在37℃的α-葡聚糖磷酸化酶的酶活性的20％或更多 C.加热前。

8. 发明授权

US07569377B2 Method of heat-stabilizing α-glucan phosphorylase(GP) 失效
标题翻译：热稳定α-葡聚糖磷酸化酶（GP）的方法
公开(公告)号：US07569377B2
公开(公告)日：2009-08-04
申请号：US10560491
申请日：2004-06-15
申请人： Michiyo Yanase , Hiroki Takata , Kazutoshi Fujii , Takeshi Takaha , Takashi Kuriki
发明人： Michiyo Yanase , Hiroki Takata , Kazutoshi Fujii , Takeshi Takaha , Takashi Kuriki
IPC分类号： C12N9/12 , C07H21/04
CPC分类号： C12N9/1051 , C12P19/02 , C12P19/04
摘要： An α-glucan phosphorylase having improved thermostability, which obtained by modifying natural α-glucan phosphorylase, and a method for producing this α-glucan phosphorylase having improved thermostability are provided. The natural α-glucan phosphorylase is derived from a plant, this α-glucan phosphorylase having improved thermostability has an amino acid residue which is different from that of the natural α-glucan phosphorylase in at least one position selected from the group consisting of a position corresponding to position 4 in a motif sequence 1L or 1H, a position corresponding to position 4 in a motif sequence 2, and a position corresponding to position 7 in a motif sequence 3L or 3H, and wherein the enzyme activity of α-glucan phosphorylase having improved thermostability at 37° C., after heating in a 20 mM citrate buffer (pH 6.7) at 60° C. for 10 minutes, is 20% or more of the enzyme activity of the α-glucan phosphorylase having improved thermostability at 37° C., before heating.
摘要翻译：提供了通过改良天然α-葡聚糖磷酸化酶获得的具有改善的热稳定性的α-葡聚糖磷酸化酶，以及制备具有改善的热稳定性的该α-葡聚糖磷酸化酶的方法。天然α-葡聚糖磷酸化酶衍生自植物，具有改善的热稳定性的该α-葡聚糖磷酸化酶具有与天然α-葡聚糖磷酸化酶不同的氨基酸残基，所述氨基酸残基至少一个位置选自位置对应于基序序列1L或1H中的位置4，对应于基序序列2中的位置4的位置和对应于基序序列3L或3H中的位置7的位置，并且其中具有在60℃下在20mM柠檬酸盐缓冲液（pH7.7）中加热10分钟后，在37℃下改善的热稳定性是在37℃下具有改善的热稳定性的α-葡聚糖磷酸化酶的酶活性的20％或更多 C.加热前。

9. 发明授权

US07723090B2 Method of heat-stabilizing α-glucan phosphorylase (GP) 有权
标题翻译：热稳定α-葡聚糖磷酸化酶（GP）的方法
公开(公告)号：US07723090B2
公开(公告)日：2010-05-25
申请号：US12465135
申请日：2009-05-13
申请人： Michiyo Yanase , Hiroki Takata , Kazutoshi Fujii , Takeshi Takaha , Takashi Kuriki
发明人： Michiyo Yanase , Hiroki Takata , Kazutoshi Fujii , Takeshi Takaha , Takashi Kuriki
IPC分类号： C07H21/04 , C12N9/12
CPC分类号： C12N9/1051 , C12P19/02 , C12P19/04
摘要： An α-glucan phosphorylase having improved thermostability, which obtained by modifying natural α-glucan phosphorylase, and a method for producing this α-glucan phosphorylase having improved thermostability are provided. The natural α-glucan phosphorylase is derived from a plant, this α-glucan phosphorylase having improved thermostability has an amino acid residue which is different from that of the natural α-glucan phosphorylase in at least one position selected from the group consisting of a position corresponding to position 4 in a motif sequence 1L or 1H, a position corresponding to position 4 in a motif sequence 2, and a position corresponding to position 7 in a motif sequence 3L or 3H, and wherein the enzyme activity of α-glucan phosphorylase having improved thermostability at 37° C., after heating in a 20 mM citrate buffer (pH 6.7) at 60° C. for 10 minutes, is 20% or more of the enzyme activity of the α-glucan phosphorylase having improved thermostability at 37° C., before heating.
摘要翻译：提供通过改性天然α-葡聚糖磷酸化酶获得的具有改进的热稳定性的α-葡聚糖磷酸化酶，以及制备具有改善的热稳定性的该α-葡聚糖磷酸化酶的方法。天然α-葡聚糖磷酸化酶衍生自植物，具有改善的热稳定性的该α-葡聚糖磷酸化酶具有与天然α-葡聚糖磷酸化酶不同的氨基酸残基，所述氨基酸残基至少一个位置选自位置对应于基序序列1L或1H中的位置4，对应于基序序列2中的位置4的位置和对应于基序序列3L或3H中的位置7的位置，并且其中具有α-葡聚糖磷酸化酶的酶活性在60℃下在20mM柠檬酸盐缓冲液（pH7.7）中加热10分钟后，在37℃下改善的热稳定性为具有改善的热稳定性在37℃的α-葡聚糖磷酸化酶的酶活性的20％或更多 C.加热前。

10. 发明申请

US20080206822A1 Method for Improving the Thermostability of Sucrose Phosphorylase (Sp) 有权
标题翻译：提高蔗糖磷酸化酶（Sp）热稳定性的方法
公开(公告)号：US20080206822A1
公开(公告)日：2008-08-28
申请号：US10566224
申请日：2004-08-31
申请人： Kazutoshi Fujii , Masae Iiboshi , Michiyo Yanase , Hiroki Takata , Takeshi Takaha , Takashi Kuriki
发明人： Kazutoshi Fujii , Masae Iiboshi , Michiyo Yanase , Hiroki Takata , Takeshi Takaha , Takashi Kuriki
IPC分类号： C12P19/12 , C12N9/10 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C12N9/1051
摘要： A sucrose phosphorylase (SP) having improved thermostability obtained by modifying a natural SP and a method for producing the SP having improved thermostability is provided. This SP having improved thermostability has an amino acid residue which is different from that of the natural sucrose phosphorylase, in at least one position selected from the group consisting of a position corresponding to position 14, a position corresponding to position 29 and a position corresponding to position 44 in motif sequence 1; a position corresponding to position 7, a position corresponding to position 19, a position corresponding to position 23 and a position corresponding to position 34 in motif sequence 2; and a position corresponding to position 19 in motif sequence 3, and wherein the enzyme activity of the SP having improved thermostability at 37° C., after heating the SP having improved thermostability in 20 mM Tris buffer (pH 7.0) at 55° C. for 20 minutes, is 20% or more of enzyme activity of the SP having improved thermostability at 37° C. before heating.
摘要翻译：提供了通过改善天然SP获得的具有改进的热稳定性的蔗糖磷酸化酶（SP）和具有改善的热稳定性的制备SP的方法。具有改善的热稳定性的SP具有与天然蔗糖磷酸化酶不同的氨基酸残基，在选自对应于位置14的位置，对应于位置29的位置和对应于位置的位置的至少一个位置基序序列1中的位置44; 对应于位置7的位置，对应于位置19的位置，对应于位置23的位置和对应于图案序列2中的位置34的位置; 和与基序序列3中的位置19相对应的位置，并且其中在55℃下加热在20mM Tris缓冲液（pH7.0）中具有改善的热稳定性的SP后，SP的酶活性在37℃下具有改善的热稳定性。 20分钟，在加热前在37℃下具有改善的热稳定性的SP的酶活性的20％或更多。

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