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1. 发明授权

US5298518A Biphenylmethane derivative and pharmacological use 失效
标题翻译：联苯甲烷衍生物和药理用途
公开(公告)号：US5298518A
公开(公告)日：1994-03-29
申请号：US846950
申请日：1992-03-06
申请人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
发明人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
IPC分类号： C07D235/08 , C07D235/26 , C07D235/28 , C07D403/10 , C07D471/04 , C07D487/04 , A61K31/415 , C07D235/16 , C07D401/10
CPC分类号： C07D403/10 , C07D235/08 , C07D235/26 , C07D235/28 , C07D471/04 , C07D487/04
摘要： The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.
摘要翻译：具有式（I）的联苯甲烷衍生物可用于预防和治疗高血压和心脏衰竭。（*化学结构*）其中R1是氢，烷基，环烷基，卤代烷基，-S-R7，-SO2-R7，-C（三键）C-R7或 - （CH2）-OR7，R7 是氢，烷基，环烷基或卤代烷基，p为0或1，-A1 = A2-A3 = A4-为CH = CH-CH = CH-，-N = CH-CH = CH-，-CH = N-CH = CH-，-CH = CH-N = CH-，-CH = CH-CH = N-或-CH = N-CH = N-，R2和R3各自为氢，卤素，烷基，低级烷氧基，氨基甲酰基或氰基，R4是氢或低级烷基，R5是1H-四唑-5-基，羧基（-COOH）或羧酸酯，R6是氢，卤素，羟基或低级烷氧基或其药理学上可接受的盐。

2. 发明授权

US5506238A Biphenylmethane derivative and pharmacological use 失效
标题翻译：联苯甲烷衍生物和药理用途
公开(公告)号：US5506238A
公开(公告)日：1996-04-09
申请号：US877113
申请日：1992-05-01
申请人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
发明人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
IPC分类号： C07D235/08 , C07D235/26 , C07D235/28 , C07D403/10 , C07D471/04 , C07D487/04 , A61K31/435
CPC分类号： C07D403/10 , C07D235/08 , C07D235/26 , C07D235/28 , C07D471/04 , C07D487/04
摘要： The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1=A2--A3=A4-- is --CH=CH--CH=CH--, --N=CH--CH=CH--, --CH=N--CH=CH--, --CH=CH--N=CH--, --CH=CH--CH=N-- or --CH=N--CH=N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.
摘要翻译：具有式（I）的联苯甲烷衍生物可用于预防和治疗高血压和心脏衰竭。其中R 1是氢，烷基，环烷基，卤代烷基，-S-R 7，-SO 2 -R 7，-C 3位C-R 7或 - （CH 2）p-OR 7，R 7是氢，烷基，环烷基或卤代烷基，p为0或1，-A1 = A2-A3 = A4-为-CH = CH-CH = CH-，-N = CH-CH = CH-，-CH = N-CH = CH-，-CH = CH-N = CH-，-CH = CH-CH = N-或-CH = N-CH = N-，R2和R3各自为氢，卤素，低级烷基，烷氧基，氨基甲酰基或氰基，R4是氢或低级烷基，R5是1H-四唑-5-基，羧基（-COOH）或羧酸酯，R6是氢，卤素，羟基或低级烷氧基，或其药理学上可接受的盐。

3. 发明授权

US5328911A Biphenylmethane derivative and pharmacological use 失效
标题翻译：联苯甲烷衍生物和药理用途
公开(公告)号：US5328911A
公开(公告)日：1994-07-12
申请号：US583025
申请日：1990-09-13
申请人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
发明人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
IPC分类号： C07D235/08 , A61K31/00 , A61K31/415 , A61K31/4184 , A61K31/435 , A61K31/44 , A61K31/496 , A61K31/505 , A61P9/00 , A61P9/12 , A61P43/00 , C07D221/02 , C07D235/02 , C07D235/06 , C07D235/10 , C07D235/12 , C07D235/26 , C07D235/28 , C07D403/10 , C07D471/04 , C07D487/04
CPC分类号： C07D403/10 , C07D235/08 , C07D235/26 , C07D235/28 , C07D471/04 , C07D487/04
摘要： The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is --CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.
摘要翻译：具有式（I）的联苯甲烷衍生物可用于预防和治疗高血压和心脏衰竭。其中R 1是氢，烷基，环烷基，卤代烷基，-S-R 7，-SO 2 -R 7，-C 3位C-R 7或 - （CH 2）p-OR 7，R 7是氢，烷基，环烷基或卤代烷基，p为0或1，-A1 = A2-A3 = A4-为-CH = CH-CH = CH-，-N = CH-CH = CH-，-CH = N-CH = CH-，-CH = CH-N = CH-，-CH = CH-CH = N-或-CH = N-CH = N-，R2和R3各自为氢，卤素，低级烷基，烷氧基，氨基甲酰基或氰基，R4是氢或低级烷基，R5是1H-四唑-5-基，羧基（-COOH）或羧酸酯，R6是氢，卤素，羟基或低级烷氧基，或其药理学上可接受的盐。

4. 发明授权

US5082850A Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物及其含有阿拉木糖的治疗和预防剂
公开(公告)号：US5082850A
公开(公告)日：1992-01-21
申请号：US571313
申请日：1990-08-22
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , Y10S514/821
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.

5. 发明授权

US4996215A Piperidine derivative and pharmaceutical composition containing the same 失效
标题翻译：哌啶衍生物和含有其的药物组合物
公开(公告)号：US4996215A
公开(公告)日：1991-02-26
申请号：US408106
申请日：1989-09-15
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D473/08 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/50 , A61K31/505 , A61P9/06 , C07D207/08 , C07D211/22 , C07D211/28 , C07D211/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D473/10
CPC分类号： C07D401/04 , C07D211/28 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
摘要： A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R.sup.1 is a lower alkyl or a tolyl, R.sup.2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R.sup.3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH.sub.2 -- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, --CH.sub.2 COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## l being 1 or 2, --A--B, A being --(CH.sub.2).sub.n --, n being an integer of 1 to 5, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, --(CH.sub.2).sub.k --S--, k being an integer of 2 to 5, --(CH.sub.2).sub.p --CO--, p being an integer of 1 to 4, B being cyano, --NR.sub.4 R.sub.5, a heterocyclic ring or a condensed aromatic ring.

6. 发明授权

US5179095A Piperidine derivative and pharmaceutical composition containing the same 失效
标题翻译：哌啶衍生物和含有其的药物组合物
公开(公告)号：US5179095A
公开(公告)日：1993-01-12
申请号：US798963
申请日：1991-11-26
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/28 , C07D401/04 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
CPC分类号： C07D401/04 , C07D211/28 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
摘要： A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R.sup.1 is a lower alkyl or a tolyl, R.sup.2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R.sup.3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH.sup.2 -- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, CH.sup.2 COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## 1 being 1 or 2, --A--B, A being --(CH.sub.2).sub.n --, n being an integer of 1 to 5,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,--(CH.sub.2)k--S--, k being an integer of 2 to 5, --(CH.sub.2)p--CO--, p being an integer of 1 to 4, B being cyano, --NR.sub.4 R.sub.5, a heterocyclic ring or a condensed aromatic ring.
摘要翻译：新的哌啶化合物在治疗心律失常方面是药理学有效的，并由下式定义：其中R1是低级烷基或甲苯基，R2是氢，羟基，低级烷氧基或低级烷基，R3是氢低级烷基，低级烯基，环烷基或环烷基烷基，X为-CO-，-CH 2 - 或-CHOH-，g为1〜3的整数，h为1〜3的整数，Y为氢，低级烷基，低级烯基，氰基，CH 2 COOR，R为氢或低级烷基，环烷基，环烷基烷基，A为1或2，-AB，A为 - （CH 2）n - ，n为 1至5的整数，具有1至5个碳原子的直链亚烷基，其是衍生自直接与一个或多个碳原子键合的低级烷基，苯基或羟基的直链烷烃的二价基团通过除去与位于其两端的每个碳原子键合的氢原子构成所述烷烃，具有1至5个碳原子的直链亚烷基，其是通过除去与位于其两端的每个碳原子键合的氢原子，通过除去彼此相邻的碳原子之间形成的双键的直链烯烃的二价基团， - （CH 2）k S - ，k为 2〜5的整数， - （CH 2）p -CO-，p为1〜4的整数，B为氰基，-NR 4 R 5，杂环或稠合芳环。

7. 发明授权

US5246946A Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US5246946A
公开(公告)日：1993-09-21
申请号：US930727
申请日：1992-08-14
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
摘要翻译：哌啶化合物具有通用的结构，可用于治疗心律失常。（3）X是-S-，-SO-或-SO 2 - ，R 2（R 2），其中R 1是低级烷基，W是：是氢或 - （CH 2）n Y，n是1至5的整数，Y是芳基，吡啶基或取代的吡啶基，X'是-CO-或-CH（OH） - ，p是1〜 4，R 12是氢或低级烷基，Y'是 - （CH 2）mA，m是1或2，A是芳基，取代的芳基，吡啶基或取代的吡啶基，R 12和Y可以形成5-或6 环或具有一个或多个取代基的5或6元环，R 22是氢，卤素，低级烷基，低级烷氧基或羟基。

8. 发明授权

US4977165A Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US4977165A
公开(公告)日：1990-12-11
申请号：US234468
申请日：1988-08-19
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , Y10S514/821
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R.sup.1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO.sub.2 --, R.sup.2 is hydrogen or --(CH.sub.2).sub.n --Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R.sup.12 is hydrogen or a lower alkyl, Y' is --(CH.sub.2).sub.m --A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R.sup.12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR.sup.22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.

9. 发明授权

US4876262A Piperidine derivative and pharmaceutical composition containing the same 失效
标题翻译：哌啶衍生物和含有其的药物组合物
公开(公告)号：US4876262A
公开(公告)日：1989-10-24
申请号：US16035
申请日：1987-02-18
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D473/08 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/50 , A61K31/505 , A61P9/06 , C07D207/08 , C07D211/22 , C07D211/28 , C07D211/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D473/10
CPC分类号： C07D401/04 , C07D211/28 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
摘要： A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH2-- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, --CH2COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## 1 being 1 or 2, --A--B, A being --(CH2)n--, n being an integer of 1 to 5, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, --(CH2)k--S--, k being an integer of 2 to 5, --(CH2)p-CO--, p being an integer of 1 to 4, B being cyano, --NR4R5, a heterocyclic ring or a condensed aromatic ring.
摘要翻译：新的哌啶化合物在治疗心律失常方面是药理学有效的，并由下式定义：其中R1是低级烷基或甲苯基，R2是氢，羟基，低级烷氧基或低级烷基，R3是氢低级烷基，低级烯基，环烷基或环烷基烷基，X为-CO-，-CH 2 - 或-CHOH-，g为1〜3的整数，h为1〜3的整数，Y为氢，低级烷基，低级烯基，氰基，-CH 2 COOR，R为氢或低级烷基，环烷基，环烷基烷基，1为2或-AB，A为 - （CH 2）n - ，n 为1〜5的整数，碳原子数1〜5的直链亚烷基，是直链烷基，苯基或羟基的直链烷烃衍生自二价基团，直链烷烃直接与一个以上碳原子键合通过除去与位于其两端的每个碳原子键合的氢原子构成所述烷烃的原子，具有1至5个碳原子的直链亚烷基，其为通过除去与位于其两端的每个碳原子键合的氢原子，通过除去彼此相邻的碳原子之间形成的双键的直链烯烃的二价基团， - （CH 2）k S - ，k为 2〜5的整数， - （CH 2）p -CO-，p为1〜4的整数，B为氰基，-NR 4 R 5，杂环或稠合芳环。

10. 发明授权

US5162347A Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US5162347A
公开(公告)日：1992-11-10
申请号：US703208
申请日：1991-05-20
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
摘要翻译：哌啶化合物具有通用的结构，可用于治疗心律失常。（3）X是-S-，-SO-或-SO 2 - ，R 2（R 2），其中R 1是低级烷基，W是：是氢或 - （CH 2）n Y，n是1至5的整数，Y是芳基，吡啶基或取代的吡啶基，X'是-CO-或-CH（OH） - ，p是1〜 4，R 12是氢或低级烷基，Y'是 - （CH 2）mA，m是1或2，A是芳基，取代的芳基，吡啶基或取代的吡啶基，R 12和Y可以形成5-或6 环或具有一个或多个取代基的5或6元环，R 22是氢，卤素，低级烷基，低级烷氧基或羟基。

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