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1. 发明授权

US5506238A Biphenylmethane derivative and pharmacological use 失效
标题翻译：联苯甲烷衍生物和药理用途
公开(公告)号：US5506238A
公开(公告)日：1996-04-09
申请号：US877113
申请日：1992-05-01
申请人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
发明人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
IPC分类号： C07D235/08 , C07D235/26 , C07D235/28 , C07D403/10 , C07D471/04 , C07D487/04 , A61K31/435
CPC分类号： C07D403/10 , C07D235/08 , C07D235/26 , C07D235/28 , C07D471/04 , C07D487/04
摘要： The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1=A2--A3=A4-- is --CH=CH--CH=CH--, --N=CH--CH=CH--, --CH=N--CH=CH--, --CH=CH--N=CH--, --CH=CH--CH=N-- or --CH=N--CH=N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.
摘要翻译：具有式（I）的联苯甲烷衍生物可用于预防和治疗高血压和心脏衰竭。其中R 1是氢，烷基，环烷基，卤代烷基，-S-R 7，-SO 2 -R 7，-C 3位C-R 7或 - （CH 2）p-OR 7，R 7是氢，烷基，环烷基或卤代烷基，p为0或1，-A1 = A2-A3 = A4-为-CH = CH-CH = CH-，-N = CH-CH = CH-，-CH = N-CH = CH-，-CH = CH-N = CH-，-CH = CH-CH = N-或-CH = N-CH = N-，R2和R3各自为氢，卤素，低级烷基，烷氧基，氨基甲酰基或氰基，R4是氢或低级烷基，R5是1H-四唑-5-基，羧基（-COOH）或羧酸酯，R6是氢，卤素，羟基或低级烷氧基，或其药理学上可接受的盐。

2. 发明授权

US5328911A Biphenylmethane derivative and pharmacological use 失效
标题翻译：联苯甲烷衍生物和药理用途
公开(公告)号：US5328911A
公开(公告)日：1994-07-12
申请号：US583025
申请日：1990-09-13
申请人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
发明人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
IPC分类号： C07D235/08 , A61K31/00 , A61K31/415 , A61K31/4184 , A61K31/435 , A61K31/44 , A61K31/496 , A61K31/505 , A61P9/00 , A61P9/12 , A61P43/00 , C07D221/02 , C07D235/02 , C07D235/06 , C07D235/10 , C07D235/12 , C07D235/26 , C07D235/28 , C07D403/10 , C07D471/04 , C07D487/04
CPC分类号： C07D403/10 , C07D235/08 , C07D235/26 , C07D235/28 , C07D471/04 , C07D487/04
摘要： The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is --CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.
摘要翻译：具有式（I）的联苯甲烷衍生物可用于预防和治疗高血压和心脏衰竭。其中R 1是氢，烷基，环烷基，卤代烷基，-S-R 7，-SO 2 -R 7，-C 3位C-R 7或 - （CH 2）p-OR 7，R 7是氢，烷基，环烷基或卤代烷基，p为0或1，-A1 = A2-A3 = A4-为-CH = CH-CH = CH-，-N = CH-CH = CH-，-CH = N-CH = CH-，-CH = CH-N = CH-，-CH = CH-CH = N-或-CH = N-CH = N-，R2和R3各自为氢，卤素，低级烷基，烷氧基，氨基甲酰基或氰基，R4是氢或低级烷基，R5是1H-四唑-5-基，羧基（-COOH）或羧酸酯，R6是氢，卤素，羟基或低级烷氧基，或其药理学上可接受的盐。

3. 发明授权

US5298518A Biphenylmethane derivative and pharmacological use 失效
标题翻译：联苯甲烷衍生物和药理用途
公开(公告)号：US5298518A
公开(公告)日：1994-03-29
申请号：US846950
申请日：1992-03-06
申请人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
发明人： Kazutoshi Miyake , Masayuki Matsukura , Naoki Yoneda , Osamu Hiroshima , Nobuyuki Mori , Hiroki Ishihara , Takashi Musha , Toshiyuki Matsuoka , Sachiyuki Hamano , Norio Minami
IPC分类号： C07D235/08 , C07D235/26 , C07D235/28 , C07D403/10 , C07D471/04 , C07D487/04 , A61K31/415 , C07D235/16 , C07D401/10
CPC分类号： C07D403/10 , C07D235/08 , C07D235/26 , C07D235/28 , C07D471/04 , C07D487/04
摘要： The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.
摘要翻译：具有式（I）的联苯甲烷衍生物可用于预防和治疗高血压和心脏衰竭。（*化学结构*）其中R1是氢，烷基，环烷基，卤代烷基，-S-R7，-SO2-R7，-C（三键）C-R7或 - （CH2）-OR7，R7 是氢，烷基，环烷基或卤代烷基，p为0或1，-A1 = A2-A3 = A4-为CH = CH-CH = CH-，-N = CH-CH = CH-，-CH = N-CH = CH-，-CH = CH-N = CH-，-CH = CH-CH = N-或-CH = N-CH = N-，R2和R3各自为氢，卤素，烷基，低级烷氧基，氨基甲酰基或氰基，R4是氢或低级烷基，R5是1H-四唑-5-基，羧基（-COOH）或羧酸酯，R6是氢，卤素，羟基或低级烷氧基或其药理学上可接受的盐。

4. 发明授权

US5444083A Pyrrolidine compound and pharmaceutical use 失效
标题翻译：吡咯烷化合物和药物用途
公开(公告)号：US5444083A
公开(公告)日：1995-08-22
申请号：US468147
申请日：1990-01-22
申请人： Motosuke Yamanaka , Tomonori Hoshiko , Shinji Suda , Naoki Yoneda , Nobuyuki Mori , Mitsumasa Shino , Hiroki Ishihara , Mamoru Saito , Toshiyuki Matsuoka
发明人： Motosuke Yamanaka , Tomonori Hoshiko , Shinji Suda , Naoki Yoneda , Nobuyuki Mori , Mitsumasa Shino , Hiroki Ishihara , Mamoru Saito , Toshiyuki Matsuoka
IPC分类号： C07D207/06 , A61K31/40 , C07D207/08 , C07D207/10 , C07D207/12 , C07D207/14 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/06
CPC分类号： C07D207/08 , C07D207/12 , C07D207/14 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/06
摘要： A pyrrolidine compound having the following formula and a pharmacologically acceptable salt thereof is disclosed. It is useful in the pharmaceutical field. ##STR1## in which X is hydrogen, a halogen, or a lower alkyl, Y is --(CH2)n--, n being zero, 1 or 2, --S(O)p--, p being zero, 1 or 2, --O--, or --NH-- and R is phenyl, a substituent-having phenyl, naphtyl, a substituent-having naphthyl, a heteroaryl or a substituent-having heteroaryl.
摘要翻译：公开了具有下式的吡咯烷化合物及其药理学上可接受的盐。它在制药领域是有用的。其中X是氢，卤素或低级烷基，Y是 - （CH 2）n - ，n是0,1或2，-S（O）p - ，p是0,1或2， -O-或-NH-，R是苯基，具有取代基的苯基，萘基，具有取代基的萘基，杂芳基或具有取代基的杂芳基。

5. 发明授权

US06218392B1 Fused pyridazine compounds 失效
标题翻译：稠合哒嗪化合物
公开(公告)号：US06218392B1
公开(公告)日：2001-04-17
申请号：US09161946
申请日：1998-09-29
申请人： Nobuhisa Watanabe , Yasuhiro Kabasawa , Yasutaka Takase , Fumihiro Ozaki , Keiji Ishibashi , Kazuki Miyazaki , Masayuki Matsukura , Shigeru Souda , Kazutoshi Miyake , Hiroki Ishihara , Kohtaro Kodama , Hideyuki Adachi
发明人： Nobuhisa Watanabe , Yasuhiro Kabasawa , Yasutaka Takase , Fumihiro Ozaki , Keiji Ishibashi , Kazuki Miyazaki , Masayuki Matsukura , Shigeru Souda , Kazutoshi Miyake , Hiroki Ishihara , Kohtaro Kodama , Hideyuki Adachi
IPC分类号： A61K31502
CPC分类号： C07D231/12 , C07D233/56 , C07D237/34 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04
摘要： A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as “cGMP-PDE”). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma.
摘要翻译：由下述通式（I）表示的稠合哒嗪化合物或其对环状GMP磷酸二酯酶具有抑制活性的药理学上可接受的盐（以下称为“cGMP-PDE”），可用作预防和治疗剂 cGMP-PDE抑制作用有效的疾病，例如心绞痛，心肌梗死，慢性和急性心力衰竭，肺动脉高压，动脉硬化和支气管哮喘等缺血性心脏病。

6. 发明授权

US5849741A Fused pyridazine compounds 失效
标题翻译：稠合哒嗪化合物
公开(公告)号：US5849741A
公开(公告)日：1998-12-15
申请号：US619621
申请日：1996-04-09
申请人： Nobuhisa Watanabe , Yasuhiro Kabasawa , Yasutaka Takase , Fumihiro Ozaki , Keiji Ishibashi , Kazuki Miyazaki , Masayuki Matsukura , Shigeru Souda , Kazutoshi Miyake , Hiroki Ishihara , Kohtaro Kodama , Hideyuki Adachi
发明人： Nobuhisa Watanabe , Yasuhiro Kabasawa , Yasutaka Takase , Fumihiro Ozaki , Keiji Ishibashi , Kazuki Miyazaki , Masayuki Matsukura , Shigeru Souda , Kazutoshi Miyake , Hiroki Ishihara , Kohtaro Kodama , Hideyuki Adachi
IPC分类号： C07D237/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D521/00 , A01K31/50 , C07D237/30
CPC分类号： C07D231/12 , C07D233/56 , C07D237/34 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04
摘要： A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE"). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma. ##STR1##
摘要翻译： PCT No.PCT / JP95 / 01575 Sec。 371日期：1996年4月9日 102（e）日期1996年4月9日PCT提交1995年8月8日PCT公布。出版物WO96 / 05176 日期：1996年2月22日由下述通式（I）表示的稠合哒嗪化合物或其对环状GMP磷酸二酯酶具有抑制活性的药理学上可接受的盐（以下称为“cGMP-PDE”）。所述化合物可用作对于cGMP-PDE抑制作用有效的疾病的预防和治疗剂，例如心绞痛，心肌梗塞，慢性和急性心力衰竭，肺动脉高压，动脉硬化和支气管哮喘等缺血性心脏病。（一）

7. 发明授权

US06784192B2 Piperidine compound and pharmaceutical composition thereof 失效
标题翻译：新型哌啶化合物及其药物组合物。
公开(公告)号：US06784192B2
公开(公告)日：2004-08-31
申请号：US10181560
申请日：2002-07-19
申请人： Fumihiro Ozaki , Toshihiko Kaneko , Mutsuko Tabata , Yoshinori Takahashi , Kazuki Miyazaki , Junichi Kamata , Ichiro Yoshida , Masayuki Matsukura , Hiroyuki Suzuki , Takashi Yoshinaga , Hiroki Ishihara , Hiroshi Katoh , Kohei Sawada , Tatsuhiro Onogi , Kiyoaki Kobayashi , Miyuki Ohkubo
发明人： Fumihiro Ozaki , Toshihiko Kaneko , Mutsuko Tabata , Yoshinori Takahashi , Kazuki Miyazaki , Junichi Kamata , Ichiro Yoshida , Masayuki Matsukura , Hiroyuki Suzuki , Takashi Yoshinaga , Hiroki Ishihara , Hiroshi Katoh , Kohei Sawada , Tatsuhiro Onogi , Kiyoaki Kobayashi , Miyuki Ohkubo
IPC分类号： A61K31445
CPC分类号： C07D401/14 , C07D401/06 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention provides a novel compound having a superior Na+ channel inhibitory activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the ring A represents a ring represented by the formula: (wherein R1 represents a hydrogen atom etc.; and R2 represents indicates a hydrogen atom and the like) etc.; W represents an optionally substituted C1-6 alkylene group etc.; Z represents an optionally substituted C6-14 aromatic hydrocarbon cyclic group etc.; and l represents an integer from 0 to 6.
摘要翻译：本发明提供具有优异的Na +通道抑制活性的新型化合物。即，它提供由下式（I）表示的化合物，其盐或它们的水合物。在该式中，环A表示由下式表示的环：其中R 1表示氢原子等 R 2表示氢原子等）等; W表示任选取代的C 1-6亚烷基等; Z表示任选取代的C 6-14芳烃环基等。 l表示0〜6的整数。

8. 发明申请

US20050144975A1 Outdoor unit of refrigerator and electrical equipment box of outdoor unit 失效
标题翻译：户外单元冰箱和电气设备箱室外机
公开(公告)号：US20050144975A1
公开(公告)日：2005-07-07
申请号：US10503219
申请日：2003-10-27
申请人： Hiroshi Fuchikami , Hiroki Ishihara , Tadashi Sao , Toshiaki Mukaidani
发明人： Hiroshi Fuchikami , Hiroki Ishihara , Tadashi Sao , Toshiaki Mukaidani
IPC分类号： F24F1/00 , F24F13/20 , F25B39/04
CPC分类号： F24F1/50 , F24F1/20 , F24F1/22 , F24F1/46 , F24F2013/207
摘要： The present invention reduces the size of an outdoor refrigerator unit of the type that draws in air from a lateral face, exchanges heat with the air, and blows the air out of a top face while ensuring that the electrical equipment box has sufficient volume and suppressing the increase in the air flow resistance. The air conditioning system outdoor unit is of the type that draws in air from air inlets provided in the rear panel and a pair of side panels of a casing exchanges heat with the air, and blows the air out through an air outlet provided in a top panel. The outdoor unit is provided with an axial fan and an electrical equipment box arranged inside the casing. The electrical equipment box is arranged inside the casing and has a first box part that is provided below the axial fan and a second box part that is provided below the first box part and has a larger surface area in a plan view than the first box part.
摘要翻译：本发明减小了从侧面吸入空气的室外冰箱单元的尺寸，与空气交换热量，并且将空气吹出顶面，同时确保电气设备箱具有足够的体积并抑制气流阻力的增加。空调系统室外机的类型是从后面板上设置的空气入口吸入空气，一对壳体的侧面板与空气交换热量，并通过设置在顶部的空气出口吹出空气面板。室外机设置有设置在壳体内的轴流风扇和电气设备箱。所述电气设备箱布置在所述壳体的内部，并且具有设置在所述轴流风扇下方的第一箱部件和设置在所述第一箱体部下方并且在俯视图中比所述第一箱部件具有较大表面积的第二箱部件。

9. 发明授权

US5707998A Nitrogen-containing fused-heterocycle compounds 失效
标题翻译：含氮稠合杂环化合物
公开(公告)号：US5707998A
公开(公告)日：1998-01-13
申请号：US525739
申请日：1995-09-25
申请人： Yasutaka Takase , Nobuhisa Watanabe , Hideyuki Adachi , Kohtaro Kodama , Hiroki Ishihara , Takao Saeki , Shigeru Souda
发明人： Yasutaka Takase , Nobuhisa Watanabe , Hideyuki Adachi , Kohtaro Kodama , Hiroki Ishihara , Takao Saeki , Shigeru Souda
IPC分类号： C07D405/12 , C07D405/14 , C07D521/00 , C07D403/00 , A61K31/505 , C07D239/94 , C07D403/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14
摘要： The present invention relates to a nitrogen-containing heterocyclic compound exhibiting an inhibitory activity against cGMP-PDE. The compound represented by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1 represents a group represented by the formula: --NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 each represent hydrogen, lower alkyl or the like) or the like; R.sup.2 represents a group represented by the formula: ##STR2## (wherein R.sup.8 represents a carboxyl group which may be protected, or the like) or the like; and R.sup.3 represents a group represented by the formula: ##STR3## (wherein R.sup.6 and R.sup.7 each represent hydrogen, lower alkyl or the like) or the like.
摘要翻译： PCT No.PCT / JP94 / 00446 Sec。 371 1995年9月25日第 102（e）1995年9月25日PCT PCT 1994年3月18日PCT公布。公开号WO94 / 22855 日期：1994年10月13日本发明涉及对cGMP-PDE具有抑制活性的含氮杂环化合物。由式（I）表示的化合物或其药学上可接受的盐：其中R1表示由式-NR4R5表示的基团（其中R4和R5各自表示氢，低级烷基等）或类似; R2表示由下式表示的基团：其中R8表示可被保护的羧基等）等。并且R 3表示由下式表示的基团：其中R 6和R 7各自表示氢，低级烷基等）等。

10. 发明申请

US20190204767A1 SHEET CORRECTING DEVICE AND PRINTER 审中-公开
公开(公告)号：US20190204767A1
公开(公告)日：2019-07-04
申请号：US16181626
申请日：2018-11-06
申请人： Hiroki Ishihara , Genichiroh Kawamichi , Satoshi Aizawa , Kohki Asada
发明人： Hiroki Ishihara , Genichiroh Kawamichi , Satoshi Aizawa , Kohki Asada
IPC分类号： G03G15/20
CPC分类号： G03G15/2039
摘要： A sheet correcting device includes a plurality of curved surface members including curved surfaces, respectively, to deform a sheet along the curved surfaces, the plurality of curved surface members disposed along a conveyance direction of the sheet, a plurality of pressing members disposed facing the curved surfaces of the plurality of curved surface members, respectively, to press the sheet against the curved surfaces of the plurality of curved surface members, respectively, a sheet tensioner to apply tension to the sheet, and a heater to heat the sheet that is bent by the curved surfaces of the plurality of curved surface members.

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