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1. 发明授权

US5530118A Benzenesulfonamide derivatives 失效
标题翻译：苯磺酰胺衍生物
公开(公告)号：US5530118A
公开(公告)日：1996-06-25
申请号：US161817
申请日：1993-12-06
申请人： Hitoshi Oinuma , Takashi Hasegawa , Tadanobu Takamura , Kenichi Nomoto , Yoshiharu Daiku , Toshihiko Naito , Sachiyuki Hamano
发明人： Hitoshi Oinuma , Takashi Hasegawa , Tadanobu Takamura , Kenichi Nomoto , Yoshiharu Daiku , Toshihiko Naito , Sachiyuki Hamano
IPC分类号： A61K31/63 , A61P7/02 , A61P9/10 , C07C309/88 , C07C311/00 , C07C311/46 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/19 , C07D211/00 , C07D211/58 , C07D213/00 , C07D213/42 , C07D213/56 , C07D215/40 , C07D223/12 , C07D233/60 , C07D239/69 , C07D243/08 , C07D277/44 , C07D277/52 , C07D295/135 , C07D295/16 , C07D295/26 , C07D401/06 , C07D417/12 , C07D453/02 , C07D487/08 , C07D521/00 , C07D205/08
CPC分类号： C07D213/42 , C07C309/88 , C07C311/46 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/19 , C07D211/58 , C07D213/56 , C07D215/40 , C07D223/12 , C07D231/12 , C07D233/56 , C07D239/69 , C07D249/08 , C07D277/52 , C07D295/135 , C07D295/26 , C07D401/06 , C07D417/12 , C07D453/02 , C07C2101/14 , C07C2101/18 , C07C2102/08 , C07C2102/10 , C07C2103/66
摘要： A novel benzenesulfonamide derivative represented by the formula: ##STR1## has an inhibitory activity against phospholipase A.sub.2, so that it is effective in the treatment of diseases for which such an activity is efficacious.
摘要翻译：由下式表示的新型苯磺酰胺衍生物：＆lt; IMAGE＆gt;对磷脂酶A2具有抑制活性，因此在治疗这种活性有效的疾病方面是有效的。

2. 发明授权

US5082850A Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物及其含有阿拉木糖的治疗和预防剂
公开(公告)号：US5082850A
公开(公告)日：1992-01-21
申请号：US571313
申请日：1990-08-22
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , Y10S514/821
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.

3. 发明授权

US4996215A Piperidine derivative and pharmaceutical composition containing the same 失效
标题翻译：哌啶衍生物和含有其的药物组合物
公开(公告)号：US4996215A
公开(公告)日：1991-02-26
申请号：US408106
申请日：1989-09-15
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D473/08 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/50 , A61K31/505 , A61P9/06 , C07D207/08 , C07D211/22 , C07D211/28 , C07D211/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D473/10
CPC分类号： C07D401/04 , C07D211/28 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
摘要： A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R.sup.1 is a lower alkyl or a tolyl, R.sup.2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R.sup.3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH.sub.2 -- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, --CH.sub.2 COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## l being 1 or 2, --A--B, A being --(CH.sub.2).sub.n --, n being an integer of 1 to 5, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, --(CH.sub.2).sub.k --S--, k being an integer of 2 to 5, --(CH.sub.2).sub.p --CO--, p being an integer of 1 to 4, B being cyano, --NR.sub.4 R.sub.5, a heterocyclic ring or a condensed aromatic ring.

4. 发明授权

US5246946A Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US5246946A
公开(公告)日：1993-09-21
申请号：US930727
申请日：1992-08-14
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
摘要翻译：哌啶化合物具有通用的结构，可用于治疗心律失常。（3）X是-S-，-SO-或-SO 2 - ，R 2（R 2），其中R 1是低级烷基，W是：是氢或 - （CH 2）n Y，n是1至5的整数，Y是芳基，吡啶基或取代的吡啶基，X'是-CO-或-CH（OH） - ，p是1〜 4，R 12是氢或低级烷基，Y'是 - （CH 2）mA，m是1或2，A是芳基，取代的芳基，吡啶基或取代的吡啶基，R 12和Y可以形成5-或6 环或具有一个或多个取代基的5或6元环，R 22是氢，卤素，低级烷基，低级烷氧基或羟基。

5. 发明授权

US4876262A Piperidine derivative and pharmaceutical composition containing the same 失效
标题翻译：哌啶衍生物和含有其的药物组合物
公开(公告)号：US4876262A
公开(公告)日：1989-10-24
申请号：US16035
申请日：1987-02-18
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D473/08 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/50 , A61K31/505 , A61P9/06 , C07D207/08 , C07D211/22 , C07D211/28 , C07D211/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D473/10
CPC分类号： C07D401/04 , C07D211/28 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
摘要： A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH2-- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, --CH2COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## 1 being 1 or 2, --A--B, A being --(CH2)n--, n being an integer of 1 to 5, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, --(CH2)k--S--, k being an integer of 2 to 5, --(CH2)p-CO--, p being an integer of 1 to 4, B being cyano, --NR4R5, a heterocyclic ring or a condensed aromatic ring.
摘要翻译：新的哌啶化合物在治疗心律失常方面是药理学有效的，并由下式定义：其中R1是低级烷基或甲苯基，R2是氢，羟基，低级烷氧基或低级烷基，R3是氢低级烷基，低级烯基，环烷基或环烷基烷基，X为-CO-，-CH 2 - 或-CHOH-，g为1〜3的整数，h为1〜3的整数，Y为氢，低级烷基，低级烯基，氰基，-CH 2 COOR，R为氢或低级烷基，环烷基，环烷基烷基，1为2或-AB，A为 - （CH 2）n - ，n 为1〜5的整数，碳原子数1〜5的直链亚烷基，是直链烷基，苯基或羟基的直链烷烃衍生自二价基团，直链烷烃直接与一个以上碳原子键合通过除去与位于其两端的每个碳原子键合的氢原子构成所述烷烃的原子，具有1至5个碳原子的直链亚烷基，其为通过除去与位于其两端的每个碳原子键合的氢原子，通过除去彼此相邻的碳原子之间形成的双键的直链烯烃的二价基团， - （CH 2）k S - ，k为 2〜5的整数， - （CH 2）p -CO-，p为1〜4的整数，B为氰基，-NR 4 R 5，杂环或稠合芳环。

6. 发明授权

US4564617A Theophylline and theobromine derivatives 失效
标题翻译：茶碱和可可碱衍生物
公开(公告)号：US4564617A
公开(公告)日：1986-01-14
申请号：US484044
申请日：1983-04-11
申请人： Hachiro Sugimoto , Takaharu Nakamura , Sachiyuki Hamazo , Yoshiharu Daiku
发明人： Hachiro Sugimoto , Takaharu Nakamura , Sachiyuki Hamazo , Yoshiharu Daiku
IPC分类号： C07D473/08 , C07D473/10 , A61K31/52
CPC分类号： C07D473/10 , C07D473/08 , Y10S514/826 , Y10S514/929
摘要： A novel compound has the following formula: ##STR1## in which R.sub.1 and R.sub.2 are methyl or a group having the formula: ##STR2## provided that one of R.sub.1 and R.sub.2 is methyl and the other is said group, wherein R stands for a hydrogen atom or a lower alkyl group, Z stands for a group ##STR3## in which X.sub.1 and X.sub.2, which may be the same or different, stand for a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, or a pyridyl group or a group ##STR4## in which Y.sub.1 and Y.sub.2, which may be the same or different stand for a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom, X stands for a nitrogen or carbon atom, and n is an integer of from 2 to 10, provided that when R.sub.2 is the group having the formula II, X is not carbon and Z is not pyridyl.
摘要翻译：一种新型化合物具有下式：其中R 1和R 2为甲基或具有下式的基团的化合物：其中R1和R2之一为甲基，另一个为所述基团，其中R代表氢原子或低级烷基，Z代表基团“IMAGE”，其中X1和X2可以相同或不同，代表氢原子，低级烷基，低级烷氧基，三氟甲基或卤素原子，或吡啶基或其中Y 1和Y 2可以相同或不同，代表氢原子，低级烷基，低级烷氧基，三氟甲基基团或卤素原子，X表示氮原子或碳原子，n表示2〜10的整数，条件是当R 2为式II的基团时，X不为碳，Z为非吡啶基。

7. 发明授权

US5606073A Diazole-propenoic acid compounds 失效
标题翻译：二唑 - 丙烯酸化合物
公开(公告)号：US5606073A
公开(公告)日：1997-02-25
申请号：US419941
申请日：1995-04-11
申请人： Masayuki Matsukura , Keizoh Satoh , Naoki Yoneda , Makoto Kaino , Kazutoshi Miyake , Yoshiharu Daiku , Naoya Kishi , Fusayo Yoshida , Kenichi Nomoto , Toshiaki Ogawa , Tadanobu Takamura , Koichi Nose , Mikio Tomimatsu , Masanori Mizuno , Shigeto Negi , Shigeru Souda
发明人： Masayuki Matsukura , Keizoh Satoh , Naoki Yoneda , Makoto Kaino , Kazutoshi Miyake , Yoshiharu Daiku , Naoya Kishi , Fusayo Yoshida , Kenichi Nomoto , Toshiaki Ogawa , Tadanobu Takamura , Koichi Nose , Mikio Tomimatsu , Masanori Mizuno , Shigeto Negi , Shigeru Souda
IPC分类号： C07D213/38 , C07D213/61 , C07D231/12 , C07D233/54 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14
CPC分类号： C07D231/12 , C07D213/38 , C07D213/61 , C07D233/64 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14
摘要： Propenoic acid derivatives of the formula: ##STR1## where R.sup.15 and R.sup.17 are aryl or heteroalkyl groups and R.sup.16 and R.sup.18 are hydrogen, a lower alkyl or the like are intermediates used to prepare pharmaceutically active diazole propenoic acid compounds.
摘要翻译：下式的丙烯酸衍生物：其中R 15和R 17是芳基或杂烷基，R 16和R 18是氢，低级烷基等是用于制备药物活性二唑丙烯酸的中间体酸化合物。

8. 发明授权

US5281626A Benzenesulfonamide derivatives 失效
标题翻译：苯磺酰胺衍生物
公开(公告)号：US5281626A
公开(公告)日：1994-01-25
申请号：US768515
申请日：1991-09-26
申请人： Hitoshi Oinuma , Takashi Hasegawa , Tadanobu Takamura , Kenichi Nomoto , Yoshiharu Daiku , Toshihiko Naito , Sachiyuki Hamano
发明人： Hitoshi Oinuma , Takashi Hasegawa , Tadanobu Takamura , Kenichi Nomoto , Yoshiharu Daiku , Toshihiko Naito , Sachiyuki Hamano
IPC分类号： A61K31/63 , A61P7/02 , A61P9/10 , C07C309/88 , C07C311/00 , C07C311/46 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/19 , C07D211/00 , C07D211/58 , C07D213/00 , C07D213/42 , C07D213/56 , C07D215/40 , C07D223/12 , C07D233/60 , C07D239/69 , C07D243/08 , C07D277/44 , C07D277/52 , C07D295/135 , C07D295/16 , C07D295/26 , C07D401/06 , C07D417/12 , C07D453/02 , C07D487/08 , C07D521/00 , A61K31/18
CPC分类号： C07D213/42 , C07C309/88 , C07C311/46 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/19 , C07D211/58 , C07D213/56 , C07D215/40 , C07D223/12 , C07D231/12 , C07D233/56 , C07D239/69 , C07D249/08 , C07D277/52 , C07D295/135 , C07D295/26 , C07D401/06 , C07D417/12 , C07D453/02 , C07C2101/14 , C07C2101/18 , C07C2102/08 , C07C2102/10 , C07C2103/66
摘要： A novel benzenesulfonamide derivative represented by the formula: ##STR1## has an inhibitory activity against phospholipase A.sub.2, so that it is effective in the treatment of diseases for which such an activity is efficacious.
摘要翻译： PCT No.PCT / JP91 / 00149 Sec。 371日期1991年9月26日 102（e）1991年9月26日PCT 1991年2月7日PCT PCT。公开号WO91 / 12237 日期：1991年8月22日。由式（* CHEMICAL STRUCTURE *）表示的新型苯磺酰胺衍生物对磷脂酶A2具有抑制活性，因此在治疗这种活性有效的疾病方面是有效的。

9. 发明授权

US5663414A Benzenesulfonamide derivatives 失效
标题翻译：苯磺酰胺衍生物
公开(公告)号：US5663414A
公开(公告)日：1997-09-02
申请号：US581257
申请日：1995-12-29
申请人： Hitoshi Oinuma , Takashi Hasegawa , Tadanobu Takamura , Kenichi Nomoto , Yoshiharu Daiku , Toshihiko Naito , Sachiyuki Hamano
发明人： Hitoshi Oinuma , Takashi Hasegawa , Tadanobu Takamura , Kenichi Nomoto , Yoshiharu Daiku , Toshihiko Naito , Sachiyuki Hamano
IPC分类号： A61K31/63 , A61P7/02 , A61P9/10 , C07C309/88 , C07C311/00 , C07C311/46 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/19 , C07D211/00 , C07D211/58 , C07D213/00 , C07D213/42 , C07D213/56 , C07D215/40 , C07D223/12 , C07D233/60 , C07D239/69 , C07D243/08 , C07D277/44 , C07D277/52 , C07D295/135 , C07D295/16 , C07D295/26 , C07D401/06 , C07D417/12 , C07D453/02 , C07D487/08 , C07D521/00 , C07C311/16
CPC分类号： C07D213/42 , C07C309/88 , C07C311/46 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/19 , C07D211/58 , C07D213/56 , C07D215/40 , C07D223/12 , C07D231/12 , C07D233/56 , C07D239/69 , C07D249/08 , C07D277/52 , C07D295/135 , C07D295/26 , C07D401/06 , C07D417/12 , C07D453/02 , C07C2101/14 , C07C2101/18 , C07C2102/08 , C07C2102/10 , C07C2103/66
摘要： A novel benzenesulfonamide derivative represented by the formula: ##STR1## has an inhibitory activity against phospholipase A.sub.2, so that it is effective in the treatment of diseases for which such an activity is efficacious.
摘要翻译：由下式表示的新型苯磺酰胺衍生物：＆lt; IMAGE＆gt;对磷脂酶A2具有抑制活性，因此在治疗这种活性有效的疾病方面是有效的。

10. 发明授权

US5162347A Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US5162347A
公开(公告)日：1992-11-10
申请号：US703208
申请日：1991-05-20
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
摘要翻译：哌啶化合物具有通用的结构，可用于治疗心律失常。（3）X是-S-，-SO-或-SO 2 - ，R 2（R 2），其中R 1是低级烷基，W是：是氢或 - （CH 2）n Y，n是1至5的整数，Y是芳基，吡啶基或取代的吡啶基，X'是-CO-或-CH（OH） - ，p是1〜 4，R 12是氢或低级烷基，Y'是 - （CH 2）mA，m是1或2，A是芳基，取代的芳基，吡啶基或取代的吡啶基，R 12和Y可以形成5-或6 环或具有一个或多个取代基的5或6元环，R 22是氢，卤素，低级烷基，低级烷氧基或羟基。

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