专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4202886A Antibiotic SF-1942 substance and process for production of the same 失效
标题翻译：抗生素SF-1942物质及其制备方法相同
公开(公告)号：US4202886A
公开(公告)日：1980-05-13
申请号：US902137
申请日：1978-05-02
申请人： Kazunori Ohba , Takashi Shomura , Yasuaki Ogawa , Takashi Tsuruoka , Hiroshi Watanabe , Takashi Hisamatsu , Shingo Uchida , Michio Kojima , Shigeharu Inouye
发明人： Kazunori Ohba , Takashi Shomura , Yasuaki Ogawa , Takashi Tsuruoka , Hiroshi Watanabe , Takashi Hisamatsu , Shingo Uchida , Michio Kojima , Shigeharu Inouye
IPC分类号： C07G11/00 , A61K35/74 , A61P31/00 , A61P31/04 , A61P35/00 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06
摘要： An antibiotic SF-1942 substance produced by cultivating an SF-1942 substance producing strain of the genus Streptomyces in a nutrient medium under aerobic conditions to produce and accumulate the SF-1942 substance in the nutrient medium and isolating the SF-1942 substance from the fermentation broth followed by purification and a process for the production of the antibiotic SF-1942 substance. The SF-1942 substance is effective as an antimicrobial agent and an antitumor agent against Sarcoma 180 tumor cells in mice.
摘要翻译：通过在营养培养基中在需氧条件下培养产生链霉菌属的SF-1942物质的菌株而产生的抗生素SF-1942物质，以在营养培养基中产生并积累SF-1942物质并从发酵中分离出SF-1942物质肉汤，然后进行纯化和生产抗生素SF-1942物质的方法。 SF-1942物质作为抗微生物剂和抗小鼠肉瘤180肿瘤细胞的抗肿瘤剂是有效的。

2. 发明授权

US4010155A Antibiotic SF-1623 substance 失效
标题翻译：抗生素SF-1623物质
公开(公告)号：US4010155A
公开(公告)日：1977-03-01
申请号：US526731
申请日：1974-11-25
申请人： Shigeharu Inouye , Takashi Shomura , Michio Kojima , Yasuaki Ogawa , Hiroshi Watanabe , Yasumitsu Kondo , Kazuo Saito, deceased , Yujiro Yamada , Taro Niida
发明人： Shigeharu Inouye , Takashi Shomura , Michio Kojima , Yasuaki Ogawa , Hiroshi Watanabe , Yasumitsu Kondo , Kazuo Saito, deceased , Yujiro Yamada , Taro Niida
IPC分类号： A61K35/74 , C07D501/36 , C07D501/57 , C12P1/06 , C12P35/08 , C12D9/00
CPC分类号： C12P35/08 , Y10S435/803 , Y10S435/893 , Y10S435/929
摘要： A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the form of its an alkali metal salt may be recovered from the culture when the cultivation is effected under aerobic conditions in the presence of an alkali metal thiosulfate.
摘要翻译：现在通过培育已知种类的链霉菌Streptomyces chartreusis的新菌株ATCC 21999，产生一种被指定为对革兰氏阴性细菌有用的抗菌活性的SF-1623物质的新抗生素。当在有氧条件下在碱金属硫代硫酸盐存在下进行培养时，可以从培养物中回收其碱金属盐形式的SF-1623物质。

3. 发明授权

US4076588A Antibiotic SF-1623 substance and the production thereof 失效
标题翻译：抗生素SF-1623物质及其生产
公开(公告)号：US4076588A
公开(公告)日：1978-02-28
申请号：US703589
申请日：1976-07-08
申请人： Shigeharu Inouye , Takashi Shomura , Michio Kojima , Yasuaki Ogawa , Hiroshi Watanabe , Yasumitsu Kondo , Kazuo Saito, deceased , Yujiro Yamada , Taro Niida
发明人： Shigeharu Inouye , Takashi Shomura , Michio Kojima , Yasuaki Ogawa , Hiroshi Watanabe , Yasumitsu Kondo , Kazuo Saito, deceased , Yujiro Yamada , Taro Niida
IPC分类号： A61K35/74 , C07D501/36 , C07D501/57 , C12P1/06 , C12P35/08 , C12D9/14
CPC分类号： C12P35/08 , Y10S435/803 , Y10S435/893 , Y10S435/929
摘要： A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the form of its an alkali metal salt may be recovered from the culture when the cultivation is effected under aerobic conditions in the presence of an alkali metal thiosulfate.
摘要翻译：现在通过培育已知种类的链霉菌Streptomyces chartreusis的新菌株ATCC 21999，产生一种被指定为对革兰氏阴性细菌有用的抗菌活性的SF-1623物质的新抗生素。当在有氧条件下在碱金属硫代硫酸盐存在下进行培养时，可以从培养物中回收其碱金属盐形式的SF-1623物质。

4. 发明授权

US3974035A Process for preparing a cephamycin type antibiotic substance 失效
标题翻译：制备头孢霉素型抗生素的方法
公开(公告)号：US3974035A
公开(公告)日：1976-08-10
申请号：US552281
申请日：1975-02-24
申请人： Takashi Shomura , Hiroshi Watanabe , Yasuaki Ogawa , Kazunori Ohba , Yasumitsu Kondo , Michio Kojima , Shigeharu Inoje , Taro Niida
发明人： Takashi Shomura , Hiroshi Watanabe , Yasuaki Ogawa , Kazunori Ohba , Yasumitsu Kondo , Michio Kojima , Shigeharu Inoje , Taro Niida
IPC分类号： A61K31/545 , A61P31/04 , C12P35/08 , C12D9/14
CPC分类号： C12P35/08 , Y10S435/893
摘要： This invention relates to a process for preparing a cephamycin type antibiotic substance which comprises cultivating a microorganism belonging to the genus Streptomyces under aerobic conditions and a primary object of this invention is to provide a process for preparing the said product on a simple and industrial scale.
摘要翻译：本发明涉及一种制备头孢霉素型抗生素物质的方法，该方法包括在需氧条件下培养属于链霉菌属的微生物，本发明的主要目的是提供以简单和工业规模制备所述产品的方法。

5. 发明授权

US4220639A Antibiotics SF-2050 and SF-2050B substances and production and use thereof 失效
标题翻译：抗生素SF-2050和SF-2050B物质及其生产和使用
公开(公告)号：US4220639A
公开(公告)日：1980-09-02
申请号：US006873
申请日：1979-01-26
申请人： Kazunori Ohba , Chuhei Nojiri , Yasuaki Ogawa , Jiro Itoh , Kunikazu Totsugawa , Norio Ezaki , Takashi Shomura , Tomizo Niwa , Shigeharu Inouye , Yujiro Yamada
发明人： Kazunori Ohba , Chuhei Nojiri , Yasuaki Ogawa , Jiro Itoh , Kunikazu Totsugawa , Norio Ezaki , Takashi Shomura , Tomizo Niwa , Shigeharu Inouye , Yujiro Yamada
IPC分类号： C12N9/99 , C12P1/06 , C12D9/14 , A61K35/00
CPC分类号： C12N9/99 , C12P1/06 , Y10S435/886
摘要： New antibiotics, SF-2050 substance and SF-2050B substance are produced by cultivating a microorganism Streptomyces sp. SF-2050 now deposited under FERM-P 4358 and under ATCC. 31450 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and useful as an antibacterial agent. These antibiotics have an activity inhibitory to .beta.-lactamase.
摘要翻译：新型抗生素SF-2050物质和SF-2050B物质是通过培养微生物Streptomyces sp。 SF-2050现在以FERM-P 4358和ATCC保藏。 31450在有氧条件下在液体培养基中，这些抗生素可以从发酵液中分离并用作抗菌剂。这些抗生素具有抑制β-内酰胺酶的活性。

6. 发明授权

US4103083A Novel antibiotics derivatives and process for preparing the same 失效
标题翻译：新型抗生素衍生物及其制备方法
公开(公告)号：US4103083A
公开(公告)日：1978-07-25
申请号：US751877
申请日：1976-12-17
申请人： Yasuaki Ogawa , Yasumitsu Kondo , Takashi Shomura , Takashi Tsuruoka , Shigeharu Inouye , Taro Niida
发明人： Yasuaki Ogawa , Yasumitsu Kondo , Takashi Shomura , Takashi Tsuruoka , Shigeharu Inouye , Taro Niida
IPC分类号： C07D501/20 , C07D501/57
CPC分类号： C07D501/57 , Y10S435/886
摘要： Novel antibiotics derivatives 7-(5-acylamido-5-carboxyvaleramido)-3-(.alpha.-methoxy-p-acyloxycinnamoyloxymethyl)-7-methoxy-3-cephem-4-carboxylic acids and the salts thereof which are useful as antibiotics and intermediates for the preparation of cephamycin derivatives, a process for preparing the same, and a process for recovering the cephamycin derivatives effectively and stably from the fermentation broth in the form of an N-acyl derivative.
摘要翻译：新型抗生素衍生物7-（5-酰氨基-5-羧基戊酰氨基）-3-（α-甲氧基 - 对酰氧基肉桂酰氧基甲基）-7-甲氧基-3-头孢烯-4-羧酸及其盐，可用作抗生素和中间体用于制备头孢霉素衍生物，其制备方法，以及以N-酰基衍生物的形式从发酵液中有效稳定地回收头孢霉素衍生物的方法。

7. 发明授权

US3975235A Process for the production of cephamycin type antibiotic substances 失效
标题翻译：生产头孢霉素类抗生素物质的方法
公开(公告)号：US3975235A
公开(公告)日：1976-08-17
申请号：US552282
申请日：1975-02-24
申请人： Tomizo Niwa , Hitoshi Goi , Takashi Shomura , Yasuaki Ogawa , Shigeharu Inouye , Kazuo Saito, deceased , Taro Niida
发明人： Tomizo Niwa , Hitoshi Goi , Takashi Shomura , Yasuaki Ogawa , Shigeharu Inouye , Kazuo Saito, deceased , Taro Niida
IPC分类号： C07D501/04 , C07D501/57 , C12P35/08 , C12D9/00
CPC分类号： C12P35/08 , Y10S435/916 , Y10S435/931 , Y10S435/933
摘要： Novel 7-(5-amino-5-carboxyvaleramido)-7-methoxy-3-hydroxymethyl-3-cephem-4-carboxylic acid derivatives. Such derivatives are prepared by subjecting cephamycin type compounds to the action of esterase enzyme of mold fungi.
摘要翻译：新的7-（5-氨基-5-羧基戊酰氨基）-7-甲氧基-3-羟甲基-3-头孢烯-4-羧酸衍生物。这种衍生物通过使头霉素类化合物对霉菌的酯酶的作用进行制备。

8. 发明授权

US4283389A Novel antibiotic, BN-183B substance 失效
标题翻译：新型抗生素，BN-183B物质
公开(公告)号：US4283389A
公开(公告)日：1981-08-11
申请号：US105442
申请日：1979-12-19
申请人： Norio Ezaki , Shinji Miyadoh , Yasuaki Ogawa , Takashi Hisamatsu , Harumi Fukuyashu , Yujiro Yamada
发明人： Norio Ezaki , Shinji Miyadoh , Yasuaki Ogawa , Takashi Hisamatsu , Harumi Fukuyashu , Yujiro Yamada
IPC分类号： C07G11/00 , A61K35/74 , A61P31/00 , A61P31/04 , C12P1/04 , C12R1/38 , A61K35/00
CPC分类号： C12P1/04
摘要： A novel antibiotic designated BN-183B substance is disclosed which is produced by cultivating a strain of the genus Pseudomonas. The antibiotic has a strong action against Gram-positive and Gram-negative bacteria.
摘要翻译：公开了一种称为BN-183B物质的新型抗生素，其通过培养假单胞菌属的菌株产生。抗生素对革兰氏阳性和革兰氏阴性菌具有很强的作用。

9. 发明授权

US07223419B2 Production process for polymeric micelle charged therein with drug and polymeric micelle composition 有权
标题翻译：用药物和聚合物胶束组合物填充聚合物胶束的生产方法
公开(公告)号：US07223419B2
公开(公告)日：2007-05-29
申请号：US10666384
申请日：2003-09-22
申请人： Masayuki Yokoyama , Eiichi Honzawa , Yasuaki Ogawa
发明人： Masayuki Yokoyama , Eiichi Honzawa , Yasuaki Ogawa
IPC分类号： A61K9/14
CPC分类号： A61K9/1075
摘要： Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.
摘要翻译：提供稳定且具有高药物含量的聚合胶束的生产方法和含有这种聚合胶束的组合物。公开了一种聚合物胶束的制备方法，包括以下步骤：将药物和特定共聚物溶解在水不混溶的有机溶剂中以制备溶液，将所得溶液与水混合以形成O / W型乳液，然后从溶液中缓慢挥发有机溶剂，以及在其中装入难溶于水的药物的聚合胶束组合物，其可以通过上述制备方法获得。

10. 发明申请

US20060153930A1 Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle 审中-公开
标题翻译：含药缓释微粒，其制造方法和含有微粒的制剂
公开(公告)号：US20060153930A1
公开(公告)日：2006-07-13
申请号：US10559512
申请日：2004-06-11
申请人： Yutaka Mizushima , Yasuaki Ogawa , Junzo Tanaka , Toshiyuki Ikoma
发明人： Yutaka Mizushima , Yasuaki Ogawa , Junzo Tanaka , Toshiyuki Ikoma
IPC分类号： A61K33/42
CPC分类号： A61K31/00 , A61K9/1611 , A61K33/30 , A61K33/42 , A61K45/06 , A61K2300/00
摘要： Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound. The drug-containing sustained release microparticles can be produced by dispersing under agitation microparticles of a porous apatite derivative in an aqueous solution containing a drug so that the aqueous solution infiltrates into the porous apatite derivative; optionally adding an aqueous solution containing a water-soluble bivalent metal compound that may infiltrate into the porous apatite derivative; further adding additives such as a stabilizer to the mixture; and effecting lyophilization or vacuum drying.
摘要翻译：适用于各种类型药物的持续释放微粒，或能够在三天或更长时间内持续释放药物并且能够抑制初始爆发释放的药物持续释放微粒; 其制造方法; 并且公开了含有微粒的制剂。含药物的缓释微粒包含除人生长激素以外的药物和多孔磷灰石衍生物，任选地包含水溶性二价金属化合物。含药缓释微粒可以通过将多孔磷灰石衍生物的微粒分散在含有药物的水溶液中分散而制成，使得水溶液渗透到多孔磷灰石衍生物中; 任选地加入含有可渗透到多孔磷灰石衍生物中的水溶性二价金属化合物的水溶液; 进一步向混合物中加入稳定剂等添加剂; 并进行冻干或真空干燥。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式