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1. 发明授权

US07223419B2 Production process for polymeric micelle charged therein with drug and polymeric micelle composition 有权
标题翻译：用药物和聚合物胶束组合物填充聚合物胶束的生产方法
公开(公告)号：US07223419B2
公开(公告)日：2007-05-29
申请号：US10666384
申请日：2003-09-22
申请人： Masayuki Yokoyama , Eiichi Honzawa , Yasuaki Ogawa
发明人： Masayuki Yokoyama , Eiichi Honzawa , Yasuaki Ogawa
IPC分类号： A61K9/14
CPC分类号： A61K9/1075
摘要： Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.
摘要翻译：提供稳定且具有高药物含量的聚合胶束的生产方法和含有这种聚合胶束的组合物。公开了一种聚合物胶束的制备方法，包括以下步骤：将药物和特定共聚物溶解在水不混溶的有机溶剂中以制备溶液，将所得溶液与水混合以形成O / W型乳液，然后从溶液中缓慢挥发有机溶剂，以及在其中装入难溶于水的药物的聚合胶束组合物，其可以通过上述制备方法获得。

2. 发明申请

US20060153930A1 Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle 审中-公开
标题翻译：含药缓释微粒，其制造方法和含有微粒的制剂
公开(公告)号：US20060153930A1
公开(公告)日：2006-07-13
申请号：US10559512
申请日：2004-06-11
申请人： Yutaka Mizushima , Yasuaki Ogawa , Junzo Tanaka , Toshiyuki Ikoma
发明人： Yutaka Mizushima , Yasuaki Ogawa , Junzo Tanaka , Toshiyuki Ikoma
IPC分类号： A61K33/42
CPC分类号： A61K31/00 , A61K9/1611 , A61K33/30 , A61K33/42 , A61K45/06 , A61K2300/00
摘要： Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound. The drug-containing sustained release microparticles can be produced by dispersing under agitation microparticles of a porous apatite derivative in an aqueous solution containing a drug so that the aqueous solution infiltrates into the porous apatite derivative; optionally adding an aqueous solution containing a water-soluble bivalent metal compound that may infiltrate into the porous apatite derivative; further adding additives such as a stabilizer to the mixture; and effecting lyophilization or vacuum drying.
摘要翻译：适用于各种类型药物的持续释放微粒，或能够在三天或更长时间内持续释放药物并且能够抑制初始爆发释放的药物持续释放微粒; 其制造方法; 并且公开了含有微粒的制剂。含药物的缓释微粒包含除人生长激素以外的药物和多孔磷灰石衍生物，任选地包含水溶性二价金属化合物。含药缓释微粒可以通过将多孔磷灰石衍生物的微粒分散在含有药物的水溶液中分散而制成，使得水溶液渗透到多孔磷灰石衍生物中; 任选地加入含有可渗透到多孔磷灰石衍生物中的水溶性二价金属化合物的水溶液; 进一步向混合物中加入稳定剂等添加剂; 并进行冻干或真空干燥。

3. 发明授权

US5094854A Liposome composition useful for hypertheria therapy 失效
标题翻译：脂质体组合物可用于治疗高血压
公开(公告)号：US5094854A
公开(公告)日：1992-03-10
申请号：US607647
申请日：1990-10-31
申请人： Yasuaki Ogawa , Katsumi Iga , Yasutaka Igari
发明人： Yasuaki Ogawa , Katsumi Iga , Yasutaka Igari
IPC分类号： A61K9/127 , A61K9/133
CPC分类号： A61K9/1277 , A61K9/127 , A61K9/1272 , Y10S514/963 , Y10T428/2984
摘要： This invention relates to the liposome compositions which are characterized in that the phase transition temperature of the membrane is in the range of 40.degree. to 45.degree. C. and the osmotic pressure of a drug-containing solution to be entrapped in liposomes is 1.2 to 2.5 times higher than that of body fluid of warm-blooded animals. The compositions are useful for treatment of solid tumors in hyperthermia therapy.

4. 发明授权

US4954298A Method for producing microcapsule 失效
标题翻译：微胶囊生产方法
公开(公告)号：US4954298A
公开(公告)日：1990-09-04
申请号：US249198
申请日：1988-09-23
申请人： Masaki Yamamoto , Shigeyuki Takada , Yasuaki Ogawa
发明人： Masaki Yamamoto , Shigeyuki Takada , Yasuaki Ogawa
IPC分类号： A61K9/56 , A61K9/16 , A61K9/50 , A61K9/52 , A61K9/58 , A61K9/62 , B01J13/02 , B01J13/12
CPC分类号： A61K9/5031 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/1694 , B01J13/02 , Y10S514/80 , Y10S514/885 , Y10S514/963 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： Microcapsules are advantageously produced with high take-up of a water-soluble drug by preparing a W/O emulsion composed of a water-soluble drug-containing solution as the inner aqueous phase and a polymer-containing solution as the oil phase, dispersing said emulsion in an aqueous phase and subjecting the resulting W/O/W emulsion to an in-water drying, wherein the viscosity of the W/O emulsion used in preparing the W/O/W emulsion is adjusted to about 150 to about 10,000 centipoises.
摘要翻译：通过制备由作为内部水相的水溶性药物溶液和作为油相的含有聚合物的溶液组成的W / O乳液，有利地生产水溶性药物的高吸收性的微胶囊，将所述在水相中的乳液，并将所得W / O / W乳液进行水中干燥，其中用于制备W / O / W乳液的W / O乳液的粘度调节至约150至约10,000厘泊。

5. 发明授权

US4283389A Novel antibiotic, BN-183B substance 失效
标题翻译：新型抗生素，BN-183B物质
公开(公告)号：US4283389A
公开(公告)日：1981-08-11
申请号：US105442
申请日：1979-12-19
申请人： Norio Ezaki , Shinji Miyadoh , Yasuaki Ogawa , Takashi Hisamatsu , Harumi Fukuyashu , Yujiro Yamada
发明人： Norio Ezaki , Shinji Miyadoh , Yasuaki Ogawa , Takashi Hisamatsu , Harumi Fukuyashu , Yujiro Yamada
IPC分类号： C07G11/00 , A61K35/74 , A61P31/00 , A61P31/04 , C12P1/04 , C12R1/38 , A61K35/00
CPC分类号： C12P1/04
摘要： A novel antibiotic designated BN-183B substance is disclosed which is produced by cultivating a strain of the genus Pseudomonas. The antibiotic has a strong action against Gram-positive and Gram-negative bacteria.
摘要翻译：公开了一种称为BN-183B物质的新型抗生素，其通过培养假单胞菌属的菌株产生。抗生素对革兰氏阳性和革兰氏阴性菌具有很强的作用。

6. 发明授权

US4103083A Novel antibiotics derivatives and process for preparing the same 失效
标题翻译：新型抗生素衍生物及其制备方法
公开(公告)号：US4103083A
公开(公告)日：1978-07-25
申请号：US751877
申请日：1976-12-17
申请人： Yasuaki Ogawa , Yasumitsu Kondo , Takashi Shomura , Takashi Tsuruoka , Shigeharu Inouye , Taro Niida
发明人： Yasuaki Ogawa , Yasumitsu Kondo , Takashi Shomura , Takashi Tsuruoka , Shigeharu Inouye , Taro Niida
IPC分类号： C07D501/20 , C07D501/57
CPC分类号： C07D501/57 , Y10S435/886
摘要： Novel antibiotics derivatives 7-(5-acylamido-5-carboxyvaleramido)-3-(.alpha.-methoxy-p-acyloxycinnamoyloxymethyl)-7-methoxy-3-cephem-4-carboxylic acids and the salts thereof which are useful as antibiotics and intermediates for the preparation of cephamycin derivatives, a process for preparing the same, and a process for recovering the cephamycin derivatives effectively and stably from the fermentation broth in the form of an N-acyl derivative.
摘要翻译：新型抗生素衍生物7-（5-酰氨基-5-羧基戊酰氨基）-3-（α-甲氧基 - 对酰氧基肉桂酰氧基甲基）-7-甲氧基-3-头孢烯-4-羧酸及其盐，可用作抗生素和中间体用于制备头孢霉素衍生物，其制备方法，以及以N-酰基衍生物的形式从发酵液中有效稳定地回收头孢霉素衍生物的方法。

7. 发明授权

US4010155A Antibiotic SF-1623 substance 失效
标题翻译：抗生素SF-1623物质
公开(公告)号：US4010155A
公开(公告)日：1977-03-01
申请号：US526731
申请日：1974-11-25
申请人： Shigeharu Inouye , Takashi Shomura , Michio Kojima , Yasuaki Ogawa , Hiroshi Watanabe , Yasumitsu Kondo , Kazuo Saito, deceased , Yujiro Yamada , Taro Niida
发明人： Shigeharu Inouye , Takashi Shomura , Michio Kojima , Yasuaki Ogawa , Hiroshi Watanabe , Yasumitsu Kondo , Kazuo Saito, deceased , Yujiro Yamada , Taro Niida
IPC分类号： A61K35/74 , C07D501/36 , C07D501/57 , C12P1/06 , C12P35/08 , C12D9/00
CPC分类号： C12P35/08 , Y10S435/803 , Y10S435/893 , Y10S435/929
摘要： A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the form of its an alkali metal salt may be recovered from the culture when the cultivation is effected under aerobic conditions in the presence of an alkali metal thiosulfate.
摘要翻译：现在通过培育已知种类的链霉菌Streptomyces chartreusis的新菌株ATCC 21999，产生一种被指定为对革兰氏阴性细菌有用的抗菌活性的SF-1623物质的新抗生素。当在有氧条件下在碱金属硫代硫酸盐存在下进行培养时，可以从培养物中回收其碱金属盐形式的SF-1623物质。

8. 发明申请

US20100322902A1 DRUG-CONTAINING SUSTAINED RELEASE MICROPARTICLE, PROCESS FOR PRODUCING THE SAME AND PREPARATION CONTAINING THE MICROPARTICLE 失效
标题翻译：包含持续释放微生物的药物，其生产方法和含有微生物的制剂
公开(公告)号：US20100322902A1
公开(公告)日：2010-12-23
申请号：US12837810
申请日：2010-09-02
申请人： Yutaka Mizushima , Yasuaki Ogawa , Junzo Tanaka , Toshiyuki Ikoma
发明人： Yutaka Mizushima , Yasuaki Ogawa , Junzo Tanaka , Toshiyuki Ikoma
IPC分类号： A61K38/21 , A61K47/02 , A61K31/573
CPC分类号： A61K31/00 , A61K9/1611 , A61K33/30 , A61K33/42 , A61K45/06 , A61K2300/00
摘要： Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound. The drug-containing sustained release microparticles can be produced by dispersing under agitation microparticles of a porous apatite derivative in an aqueous solution containing a drug so that the aqueous solution infiltrates into the porous apatite derivative; optionally adding an aqueous solution containing a water-soluble bivalent metal compound that may infiltrate into the porous apatite derivative; further adding additives such as a stabilizer to the mixture; and effecting lyophilization or vacuum drying.
摘要翻译：适用于各种类型药物的持续释放微粒，或能够在三天或更长时间内持续释放药物并且能够抑制初始爆发释放的药物持续释放微粒; 其制造方法; 并且公开了含有微粒的制剂。含药物的缓释微粒包含除人生长激素以外的药物和多孔磷灰石衍生物，任选地包含水溶性二价金属化合物。含药缓释微粒可以通过将多孔磷灰石衍生物的微粒分散在含有药物的水溶液中分散而制成，使得水溶液渗透到多孔磷灰石衍生物中; 任选地加入含有可渗透到多孔磷灰石衍生物中的水溶性二价金属化合物的水溶液; 进一步向混合物中加入稳定剂等添加剂; 并进行冻干或真空干燥。

9. 发明申请

US20070259047A1 Protein Sustained-Release Microparticle Preparation for Injection and Process for Producing the Same 审中-公开
标题翻译：用于注射的蛋白质持续释放微粒制备及其制备方法
公开(公告)号：US20070259047A1
公开(公告)日：2007-11-08
申请号：US10588834
申请日：2005-01-27
申请人： Yasuaki Ogawa , Yoko Miyamoto , Jun Niimi , Takao Fujii
发明人： Yasuaki Ogawa , Yoko Miyamoto , Jun Niimi , Takao Fujii
IPC分类号： A61K9/14 , A61K38/00
CPC分类号： A61K9/0019 , A61K9/5031 , A61K38/212 , A61K38/27 , A61K38/28 , A61K47/02 , A61K47/34
摘要： To provide protein drug sustained-release microparticle preparations for injection that in the production thereof, minimize the use of organic solvents and avoid the simultaneous use of an organic solvent immiscible with water and an aqueous solution and that with respect to the obtained product, simultaneously have in vivo disappearing and sustained-release capabilities, slowly release the contained protein drug at a substantially constant rate over a period of three days or more and realize a drug content of 5% or more, excelling in dispersibility and needle passability; and to provide a process for producing the same. The protein drug sustained-release microparticle preparations for injection comprise a porous apatite or derivative thereof containing a protein drug and, provided thereon by coating or adhesion, an in vivo disappearing polymer.
摘要翻译：为了提供用于注射的蛋白质药物持续释放微粒制剂，在其生产中，使有机溶剂的使用最小化，并避免同时使用与水和水溶液不混溶的有机溶剂，并且相对于获得的产品，同时具有体内消失和持续释放能力，在三天以上的时间内以基本恒定的速度缓慢释放所含的蛋白质药物，实现5％以上的药物含量，分散性和针通过性优异; 并提供其制造方法。用于注射的蛋白质药物缓释微粒制剂包含含有蛋白质药物的多孔磷灰石或其衍生物，并通过涂覆或粘附在其上提供体内消失的聚合物。

10. 发明授权

US07048947B2 Sustained-release preparation 有权
标题翻译：缓释制剂
公开(公告)号：US07048947B2
公开(公告)日：2006-05-23
申请号：US10127558
申请日：2002-04-23
申请人： Shigeru Kamei , Yasutaka Igari , Yasuaki Ogawa
发明人： Shigeru Kamei , Yasutaka Igari , Yasuaki Ogawa
IPC分类号： A61K9/14 , C07K7/23
CPC分类号： C07K7/23 , A61K9/1647 , A61K38/00 , A61K38/09
摘要： A sustained-release preparation which comprises a physiologically active peptide of general formula wherein X represents an acyl group; R1, R2 and R4 each represents an aromatic cyclic group; R3 represents a D-amino acid residue or a group of the formula wherein R3′ is a heterocyclic group; R5 represents a group of the formula —(CH2)n—R5′ wherein n is 2 or 3, and R5′ is an amino group which may optionally be substituted, an aromatic cyclic group or an O-glycosyl group; R6 represents a group of the formula —(CH2)n—R6′ wherein n is 2 or 3, and R6′ is an amino group which may optionally be substituted; R7 represents a D-amino acid residue or an azaglycyl residue; and Q represents hydrogen or a lower alkyl group, or a salt thereof and a biodegradable polymer having a terminal carboxyl group. The sustained-release preparation shows a constant release of the peptide over a long time and is substantially free from an initial burst.
摘要翻译：一种持续释放制剂，其包含通式的生理活性肽，其中X表示酰基; R 1，R 2和R 4各自表示芳族环状基团; R 3表示D-氨基酸残基或下式的基团其中R 3'是杂环基; R 5表示下式的基团 - （CH 2）n - n -R 5其中n为2 或3，并且R 5'是可任选被取代的氨基，芳族环状基团或O-糖基基团; R 6表示下式的基团 - （CH 2）n - 其中n为2 或3，并且R 6'是可任选被取代的氨基; R 7表示D-氨基酸残基或azaglycyl残基; Q表示氢或低级烷基，或其盐和具有末端羧基的生物降解性聚合物。持续释放制剂显示长时间的肽的恒定释放并且基本上没有初始爆发。

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