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1. 发明申请

US20090061533A1 STRUCTURE, TARGET SUBSTANCE DETECTION ELEMENT AND TARGET SUBSTANCE DETECTION KIT 有权
标题翻译：结构，目标物质检测元件和目标物质检测试剂盒
公开(公告)号：US20090061533A1
公开(公告)日：2009-03-05
申请号：US12188166
申请日：2008-08-07
申请人： Masato Minami , Kazuhiro Ban
发明人： Masato Minami , Kazuhiro Ban
IPC分类号： G01N33/543 , B01J19/00 , C12M1/00
CPC分类号： G01N33/54353 , C08F292/00 , C08F2438/01
摘要： A target substance detection element that can effectively prevent the nonspecific adsorption of a target substance or impurities and detects the target substance with high sensitivity, a target substance detection kit, and a structure constituting the target substance detection element. The structure has a substrate, polymers present on the substrate surface, and first target substance capturing molecules bonded to the polymers. The polymer is composed of a polymer of a carboxybetaine monomer represented by General Formula (1) below. The first target substance capturing molecules are bonded to some of the carboxyl groups of the polymers. A compound represented by General Formula (2) is bonded to at least some of the carboxyl groups, from among the carboxyl groups of the polymers, that are not bonded to the first target substance capturing molecules.
摘要翻译：能够有效地防止目标物质或杂质的非特异性吸附的目标物质检测元件，高灵敏度地检测目标物质，目标物质检测试剂盒以及构成目标物质检测元件的结构。该结构具有底物，存在于基材表面上的聚合物和第一目标物质捕获与聚合物结合的分子。聚合物由以下通式（1）表示的羧基甜菜碱单体的聚合物组成。第一种靶物质捕获分子与聚合物的一些羧基键合。由通式（2）表示的化合物与不与第一目标物质捕获分子结合的聚合物的羧基中的至少一些羧基键合。

2. 发明申请

US20120283385A1 STRUCTURE, TARGET SUBSTANCE-DETECTING ELEMENT AND TARGET SUBSTANCE-DETECTING KIT 审中-公开
标题翻译：结构，目标物质检测元件和目标物质检测试剂盒
公开(公告)号：US20120283385A1
公开(公告)日：2012-11-08
申请号：US13536823
申请日：2012-06-28
申请人： Kazuhiro Ban , Masato Minami
发明人： Kazuhiro Ban , Masato Minami
IPC分类号： C08F130/02
CPC分类号： C09D133/26 , C08F220/60 , C08F230/02
摘要： According to the present invention, there can be provided a structure preventing the nonspecific adsorption, and a target substance-detecting element and a target substance-detecting kit. A first aspect of the present invention is a structure including: a substrate; and a membrane, present on the surface of the substrate, having a polymer of a monomer represented by the following General Formula (1) or (2): (wherein R represents H or CH3; x represents an integer of 2 to 5, and y represents an integer of 1 to 7, with the proviso that x+y=an integer of 3 to 10), and (wherein R1═H or CH3, and R2 represents O or NH; a represents an integer of 2 to 5, and b represents an integer of 1 to 7, with the proviso that a+b=an integer of 3 to 10.)
摘要翻译：根据本发明，可以提供防止非特异性吸附的结构，以及目标物质检测元件和目标物质检测试剂盒。本发明的第一方面是一种结构，包括：基板; 和存在于基材表面上的膜，其具有由以下通式（1）或（2）表示的单体的聚合物：（其中R表示H或CH3; x表示2〜5的整数，和 y表示1〜7的整数，条件是x + y = 3〜10的整数），（其中，R 1 = H或CH 3，R 2表示O或NH; a表示2〜5的整数， b表示1〜7的整数，条件是a + b = 3〜10的整数。）

3. 发明申请

US20110065212A1 GRAFT POLYMER-CONTAINING SUBSTRATE, METHOD FOR PRODUCING THE SAME, TARGET SUBSTANCE-DETECTING ELEMENT, AND TARGET SUBSTANCE DETECTION KIT 审中-公开
标题翻译：含聚合物基材，其生产方法，目标物质检测元件和目标物质检测试剂盒
公开(公告)号：US20110065212A1
公开(公告)日：2011-03-17
申请号：US12993390
申请日：2009-05-29
申请人： Kazuhiro Ban , Masato Minami , Mayuko Kishi
发明人： Kazuhiro Ban , Masato Minami , Mayuko Kishi
IPC分类号： G01N33/53 , C08L33/08
CPC分类号： G01N33/54353 , C08F2/38 , C08F8/06 , C08F292/00 , C08F2438/01 , G01N33/54393 , C08F222/1006
摘要： There is provided a graft polymer-containing substrate that reduces nonspecific adsorption of impurities onto a substrate surface and specifically captures a target substance. There is provided a graft polymer-containing substrate with a graft polymer formed on the surface thereof, characterized in that the graft polymer includes monomer units represented by the following general formulas (1) and (2): wherein R1, R2, and R3 represent one of a hydrogen atom and a methyl group, R4 represents a group including any of a carboxyl group, a succinimide group, an aldehyde group, an epoxy group, a bromo group, an amino group, and a maleimide group, X represents a hydrophilic crosslinking spacer having 15 or more atoms, and l, m, and n are an integer of 1 or greater.
摘要翻译：提供了含有接枝聚合物的底物，其将杂质的非特异性吸附减少到基底表面上并且特异地捕获目标物质。提供了在其表面形成有接枝聚合物的接枝聚合物的基材，其特征在于接枝聚合物包括由以下通式（1）和（2）表示的单体单元：其中R1，R2和R3表示氢原子和甲基中的一个，R 4表示包括羧基，琥珀酰亚胺基，醛基，环氧基，溴基，氨基和马来酰亚胺基中的任一个的基团，X表示亲水性具有15个以上原子的交联间隔物，l，m，n为1以上的整数。

4. 发明申请

US20090005495A1 STRUCTURE, TARGET SUBSTANCE-DETECTING ELEMENT AND TARGET SUBSTANCE-DETECTING KIT 有权
标题翻译：结构，目标物质检测元件和目标物质检测试剂盒
公开(公告)号：US20090005495A1
公开(公告)日：2009-01-01
申请号：US12145451
申请日：2008-06-24
申请人： Kazuhiro Ban , Masato Minami
发明人： Kazuhiro Ban , Masato Minami
IPC分类号： C08L43/02 , C08G69/08 , C08G69/42 , C08L33/26 , C08G73/00
CPC分类号： C09D133/26 , C08F220/60 , C08F230/02
摘要： According to the present invention, there can be provided a structure preventing the nonspecific adsorption, and a target substance-detecting element and a target substance-detecting kit. A first aspect of the present invention is a structure including: a substrate; and a membrane, present on the surface of the substrate, having a polymer of a monomer represented by the following General Formula (1) or (2): (wherein R represents H or CH3; x represents an integer of 2 to 5, and y represents an integer of 1 to 7, with the proviso that x+y=an integer of 3 to 10), and (wherein R1=H or CH3, and R2 represents O or NH; a represents an integer of 2 to 5, and b represents an integer of 1 to 7, with the proviso that a+b=an integer of 3 to 10.)
摘要翻译：根据本发明，可以提供防止非特异性吸附的结构，以及目标物质检测元件和目标物质检测试剂盒。本发明的第一方面是一种结构，包括：基板; 和存在于基材表面上的膜，其具有由以下通式（1）或（2）表示的单体的聚合物：（其中R表示H或CH3; x表示2〜5的整数，和 y表示1〜7的整数，条件是x + y = 3〜10的整数），（式中，R 1 = H或CH 3，R 2表示O或NH; a表示2〜5的整数， b表示1〜7的整数，条件是a + b = 3〜10的整数。）

5. 发明授权

US08232344B2 Structure, target substance-detecting element and target substance-detecting kit 有权
标题翻译：结构，靶物质检测元件和目标物质检测试剂盒
公开(公告)号：US08232344B2
公开(公告)日：2012-07-31
申请号：US12145451
申请日：2008-06-24
申请人： Kazuhiro Ban , Masato Minami
发明人： Kazuhiro Ban , Masato Minami
IPC分类号： C08L43/02 , C08L33/26 , C08G69/08 , C08G69/42
CPC分类号： C09D133/26 , C08F220/60 , C08F230/02
摘要： According to the present invention, there can be provided a structure preventing the nonspecific adsorption, and a target substance-detecting element and a target substance-detecting kit. A first aspect of the present invention is a structure including: a substrate; and a membrane, present on the surface of the substrate, having a polymer of a monomer represented by the following General Formula (1) or (2): (wherein R represents H or CH3; x represents an integer of 2 to 5, and y represents an integer of 1 to 7, with the proviso that x+y=an integer of 3 to 10), and (wherein R1═H or CH3, and R2 represents O or NH; a represents an integer of 2 to 5, and b represents an integer of 1 to 7, with the proviso that a+b=an integer of 3 to 10).
摘要翻译：根据本发明，可以提供防止非特异性吸附的结构，以及目标物质检测元件和目标物质检测试剂盒。本发明的第一方面是一种结构，包括：基板; 和存在于基材表面上的膜，其具有由以下通式（1）或（2）表示的单体的聚合物：（其中R表示H或CH3; x表示2〜5的整数，和 y表示1〜7的整数，条件是x + y = 3〜10的整数），（其中，R 1 = H或CH 3，R 2表示O或NH; a表示2〜5的整数， b表示1〜7的整数，条件是a + b = 3〜10的整数）。

6. 发明授权

US07943370B2 Structure, target substance detection element and target substance detection kit 有权
标题翻译：结构，靶物质检测元件和靶物质检测试剂盒
公开(公告)号：US07943370B2
公开(公告)日：2011-05-17
申请号：US12188166
申请日：2008-08-07
申请人： Masato Minami , Kazuhiro Ban
发明人： Masato Minami , Kazuhiro Ban
IPC分类号： C12M1/34 , C07C303/00 , C07C309/04 , A61K31/205
CPC分类号： G01N33/54353 , C08F292/00 , C08F2438/01
摘要： A target substance detection element that can effectively prevent the nonspecific adsorption of a target substance or impurities and detects the target substance with high sensitivity, a target substance detection kit, and a structure constituting the target substance detection element. The structure has a substrate, polymers present on the substrate surface, and first target substance capturing molecules bonded to the polymers. The polymer is composed of a polymer of a carboxybetaine monomer represented by General Formula (1) below. The first target substance capturing molecules are bonded to some of the carboxyl groups of the polymers. A compound represented by General Formula (2) is bonded to at least some of the carboxyl groups, from among the carboxyl groups of the polymers, that are not bonded to the first target substance capturing molecules.
摘要翻译：能够有效地防止目标物质或杂质的非特异性吸附的目标物质检测元件，高灵敏度地检测目标物质，目标物质检测试剂盒以及构成目标物质检测元件的结构。该结构具有底物，存在于基材表面上的聚合物和第一目标物质捕获与聚合物结合的分子。聚合物由以下通式（1）表示的羧基甜菜碱单体的聚合物组成。第一种靶物质捕获分子与聚合物的一些羧基键合。由通式（2）表示的化合物与不与第一目标物质捕获分子结合的聚合物的羧基中的至少一些羧基键合。

7. 发明申请

US20100292427A1 STRUCTURAL MEMBER AND METHOD OF PRODUCING THE STRUCTURAL MEMBER 审中-公开
标题翻译：结构构件和生产结构构件的方法
公开(公告)号：US20100292427A1
公开(公告)日：2010-11-18
申请号：US12671034
申请日：2008-08-05
申请人： Kazuhiro Ban , Masato Minami , Mayuko Kishi
发明人： Kazuhiro Ban , Masato Minami , Mayuko Kishi
IPC分类号： C08F136/20
CPC分类号： C09D4/00 , C08F2/38
摘要： The invention provides a structural member having an excellent ability to prevent the nonspecific adsorption of a biomolecule and a labeling substance to the surface of a substrate, and a method of producing the structural member. The structural member includes a substrate and a polymer present on a surface of the substrate, in which the polymer is formed from a polymer of a multi-vinyl monomer represented by the following general formula (I) or (II), and has a crosslinked structure: where R, R′, and R″ are independently a hydrogen atom or a methyl group, and X represents a hydrophilic functional group in which fifteen or more atoms are linked in series.
摘要翻译：本发明提供了具有优异的防止生物分子和标记物质对基材表面的非特异性吸附的能力的结构体及其制造方法。该结构构件包括基材和存在于基材表面上的聚合物，其中聚合物由下列通式（I）或（II）表示的多乙烯基单体的聚合物形成，并且具有交联结构：其中R，R'和R“独立地为氢原子或甲基，X表示其中十五个或更多原子串联连接的亲水官能团。

8. 发明授权

US08962302B2 Biological tissue processing substrate for fixing proteins or protein degradation products in tissue for analysis 有权
标题翻译：用于将蛋白质或蛋白质降解产物固定在组织中用于分析的生物组织处理底物
公开(公告)号：US08962302B2
公开(公告)日：2015-02-24
申请号：US11592313
申请日：2006-11-03
申请人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
发明人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/00 , C12Q1/34 , C12Q1/37 , C12Q1/02 , C12N11/14 , C12N11/02 , C12N11/04 , G01N33/68 , G01N33/50
CPC分类号： G01N33/6848 , G01N33/5082
摘要： A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.
摘要翻译：一种用于将蛋白质固定在生物组织中的生物组织处理底物或蛋白质的降解产物，所述底物包括：与生物组织形成接触表面的多孔体，多孔体在孔中保留用于获得蛋白质的酶或使来自生物组织的蛋白质的降解产物与由金属构成的构件接触，其中通过酶的作用获得的蛋白质或降解产物与金属接触。

9. 发明授权

US07622263B2 Kit for immobilizing organic substance, organic substance-immobilized structure, and manufacturing methods therefor 失效
标题翻译：固定有机物，有机物固定结构的试剂盒及其制造方法
公开(公告)号：US07622263B2
公开(公告)日：2009-11-24
申请号：US10555383
申请日：2005-01-25
申请人： Kazuhiro Ban , Hidenori Shiotsuka , Takeshi Imamura
发明人： Kazuhiro Ban , Hidenori Shiotsuka , Takeshi Imamura
IPC分类号： G01N33/53 , G01N33/00 , C07K5/00
CPC分类号： G01N33/54353 , G01N33/551
摘要： To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic substance, particularly a biological substance is immobilized on the surface of a substrate, the organic substance, particularly the biological substance can be stably immobilized on the surface of the substrate through orientation of the organic substance, particularly the biological substance suitable for exerting physiological functions thereof. At least part of the substrate's surface is constructed of one or more substrates containing aluminum oxide. The immobilization of the organic substance to the surface of the substrate is carried out by binding at least part of the binding domain to the surface of the substrate through a binding domain containing a peptide having an affinity to aluminum oxide and composed of at least one or more amino acids, which is coupled with the organic substance.
摘要翻译：为了提供采用新型固定化技术的有机物质固定化结构及其制造方法，其中，当将有机物质，特别是生物物质固定在基材表面上时，有机物质，特别是生物物质可以通过有机物质，特别是适于发挥其生理功能的生物物质的取向，稳定地固定在基材的表面上。衬底表面的至少一部分由含有氧化铝的一个或多个衬底构成。有机物质固定到底物的表面是通过结合结构域与底物的表面结合而进行的，所述结合结构域含有与氧化铝具有亲和性的肽，并且由至少一个或多个更多的氨基酸，其与有机物质偶联。

10. 发明申请

US20080290268A1 INFORMATION OBTAINING METHOD 有权
标题翻译：信息获取方法
公开(公告)号：US20080290268A1
公开(公告)日：2008-11-27
申请号：US12120512
申请日：2008-05-14
申请人： Manabu Komatsu , Hiroyuki Hashimoto , Yohei Murayama , Kazuhiro Ban
发明人： Manabu Komatsu , Hiroyuki Hashimoto , Yohei Murayama , Kazuhiro Ban
IPC分类号： B01D59/44
CPC分类号： H01J49/145
摘要： An information obtaining method for obtaining information about a mass of a component of an analyte using a time of flight mass spectrometer and obtaining information about a distribution state of the component based on the obtained information about the mass includes the step of: (1) adding a self-reactive substance to the analyte on a base to facilitate ionization of the component; (2) irradiating the analyte with a primary beam in the presence of the self-reactive substance, thereby ionizing the components and allowing resulting ions to fly; (3) obtaining information about mass of the flying ions using the time of flight mass spectrometer; and (4) obtaining information about the distribution state of the component on the base based on the information about the mass.
摘要翻译：使用飞行时间质谱仪获取关于分析物的成分的质量的信息的信息获取方法，基于获得的关于质量的信息获得关于部件的分布状态的信息，包括以下步骤：（1）添加对基底上的分析物的自反应物质，以促进组分的离子化; （2）在存在自反应物质的情况下用主光束照射分析物，从而电离成分并允许所得离子飞行; （3）使用飞行时间质谱仪获取关于飞行离子质量的信息; 和（4）基于关于质量的信息获得关于组件在基础上的分布状态的信息。

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