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1. 发明授权

US08962302B2 Biological tissue processing substrate for fixing proteins or protein degradation products in tissue for analysis 有权
标题翻译：用于将蛋白质或蛋白质降解产物固定在组织中用于分析的生物组织处理底物
公开(公告)号：US08962302B2
公开(公告)日：2015-02-24
申请号：US11592313
申请日：2006-11-03
申请人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
发明人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/00 , C12Q1/34 , C12Q1/37 , C12Q1/02 , C12N11/14 , C12N11/02 , C12N11/04 , G01N33/68 , G01N33/50
CPC分类号： G01N33/6848 , G01N33/5082
摘要： A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.
摘要翻译：一种用于将蛋白质固定在生物组织中的生物组织处理底物或蛋白质的降解产物，所述底物包括：与生物组织形成接触表面的多孔体，多孔体在孔中保留用于获得蛋白质的酶或使来自生物组织的蛋白质的降解产物与由金属构成的构件接触，其中通过酶的作用获得的蛋白质或降解产物与金属接触。

2. 发明申请

US20070105087A1 Biological tissue processing substrate, processing apparatus, processing method and processing kit 有权
标题翻译：生物组织加工基材，加工设备，加工方法和加工工具
公开(公告)号：US20070105087A1
公开(公告)日：2007-05-10
申请号：US11592313
申请日：2006-11-03
申请人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
发明人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
IPC分类号： C12Q1/00 , C12M3/00
CPC分类号： G01N33/6848 , G01N33/5082
摘要： A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.
摘要翻译：一种用于将蛋白质固定在生物组织中的生物组织处理底物或蛋白质的降解产物，所述底物包括：与生物组织形成接触表面的多孔体，多孔体在孔中保留用于获得蛋白质的酶或使来自生物组织的蛋白质的降解产物与由金属构成的构件接触，其中通过酶的作用获得的蛋白质或降解产物与金属接触。

3. 发明申请

US20060279738A1 Sensing element used in sensing device for sensing target substance in specimen by using plasmon resonance 失效
标题翻译：用于感测装置中的感测元件，用于通过使用等离子体共振来感测样品中的目标物质
公开(公告)号：US20060279738A1
公开(公告)日：2006-12-14
申请号：US11448070
申请日：2006-06-07
申请人： Miki Ogawa , Norihiko Utsunomiya
发明人： Miki Ogawa , Norihiko Utsunomiya
IPC分类号： G01N21/55
CPC分类号： G01N21/554
摘要： A method for producing a sensing element used in a sensing device for sensing a target substance in a specimen with the use of plasmon resonance includes the steps of: preparing a substrate having an electroconductive layer, forming an insulating layer on the electroconductive layer, selectively removing the insulating layer to make the electroconductive layer appear, and depositing a metal on the appearing electroconductive layer with an electrolytic plating method.
摘要翻译：一种在使用等离子体共振来检测样品中的目标物质的感测装置中使用的传感元件的制造方法，其特征在于，包括：制作具有导电层的基板，在导电层上形成绝缘层，选择性地除去出现导电层的绝缘层，并用电解电镀法在出现的导电层上沉积金属。

4. 发明申请

US20090009756A1 Recognition Chip for Target Substance, and Detection Method and Device for the Same 有权
标题翻译：目标物质识别芯片及其检测方法及装置
公开(公告)号：US20090009756A1
公开(公告)日：2009-01-08
申请号：US10571906
申请日：2005-03-02
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/01
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置，当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置基于在照射光时来自多个物体的光输出的总和的属性的变化。

5. 发明授权

US07403287B2 Sensing element used in sensing device for sensing target substance in specimen by using plasmon resonance 失效
标题翻译：用于感测装置中的感测元件，用于通过使用等离子体共振来感测样品中的目标物质
公开(公告)号：US07403287B2
公开(公告)日：2008-07-22
申请号：US11448070
申请日：2006-06-07
申请人： Miki Ogawa , Norihiko Utsunomiya
发明人： Miki Ogawa , Norihiko Utsunomiya
IPC分类号： G01N21/55
CPC分类号： G01N21/554
摘要： A method of producing a sensing element used in a detecting device for detecting a target substance in a specimen with the use of plasmon resonance. The method includes the steps of forming an insulating layer on a substrate, the surface of the substrate having an electroconductive layer including a first electroconductive material, forming a plurality of holes through the insulating layer to form an insulating pattern, filling up the holes with a second electroconductive material to form a metallic pattern, removing the insulating pattern, and removing a region other than the region sandwiched by the metallic pattern and the substrate in the electroconductive layer, using the metallic pattern as a mask.
摘要翻译：一种用于检测装置中用于使用等离子体共振来检测样品中的目标物质的感测元件的方法。该方法包括在衬底上形成绝缘层的步骤，衬底的表面具有包括第一导电材料的导电层，通过绝缘层形成多个孔以形成绝缘图案，用一个第二导电材料以形成金属图案，去除绝缘图案，并且使用金属图案作为掩模，除去导电层中被金属图案和基板夹持的区域以外的区域。

6. 发明授权

US08049896B2 Detecting element, detecting device, and method of producing the detecting element 有权
标题翻译：检测元件，检测装置及检测元件的制造方法
公开(公告)号：US08049896B2
公开(公告)日：2011-11-01
申请号：US12125543
申请日：2008-05-22
申请人： Miki Ogawa , Norihiko Utsunomiya
发明人： Miki Ogawa , Norihiko Utsunomiya
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/5025 , B01L3/50857 , G01N2021/258
摘要： A detecting element for detecting a target substance in a sample includes a substrate having a pore, in which a thickness direction of the substrate corresponds to a depth direction of the pore, and plurality of metal structures disposed in the pore. The plurality of metal structures have a ring shape.
摘要翻译：用于检测样品中的目标物质的检测元件包括具有孔的基板，其中基板的厚度方向对应于孔的深度方向，以及多个设置在孔中的金属结构。多个金属结构体具有环状。

7. 发明申请

US20110019195A1 RECOGNITION CHIP FOR TARGET SUBSTANCE, AND DETECTION METHOD AND DEVICE FOR THE SAME 有权
标题翻译：目标物质的识别芯片及其相关的检测方法和装置
公开(公告)号：US20110019195A1
公开(公告)日：2011-01-27
申请号：US12895776
申请日：2010-09-30
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/59
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置，当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置基于在照射光时来自多个物体的光输出的总和的属性的变化。

8. 发明授权

US08023109B2 Recognition chip for target substance, and detection method and device for the same 有权
标题翻译：目标物质识别芯片及其检测方法及装置
公开(公告)号：US08023109B2
公开(公告)日：2011-09-20
申请号：US12895776
申请日：2010-09-30
申请人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
发明人： Junta Yamamichi , Miki Ogawa , Yoichiro Handa , Takeshi Imamura , Norihiko Utsunomiya , Satoru Nishiuma
IPC分类号： G01N21/27 , G01N21/64
CPC分类号： G01N21/05 , G01N21/554 , G01N21/645 , G01N21/66 , G01N2021/0346
摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.
摘要翻译：一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置，当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置基于在照射光时来自多个物体的光输出的总和的属性的变化。

9. 发明申请

US20080297802A1 DETECTING ELEMENT, DETECTING DEVICE, AND METHOD OF PRODUCING THE DETECTING ELEMENT 有权
标题翻译：检测元件，检测装置以及检测元件的生产方法
公开(公告)号：US20080297802A1
公开(公告)日：2008-12-04
申请号：US12125543
申请日：2008-05-22
申请人： Miki Ogawa , Norihiko Utsunomiya
发明人： Miki Ogawa , Norihiko Utsunomiya
IPC分类号： G01N21/55 , G01N1/00
CPC分类号： G01N21/554 , B01L3/5025 , B01L3/50857 , G01N2021/258
摘要： A detecting element and a detecting device having high sensitivity, and a production method thereof are provided. The detecting element for detecting a target substance in a sample includes a substrate and a metal structure. The substrate has a pore in which the thickness direction of the substrate corresponds to the depth direction of the pore and in which part of the substrate forming the pore constitutes part of the outer surface of the substrate. The metal structure exists in the pore, and has a ring shape.
摘要翻译：提供了具有高灵敏度的检测元件和检测装置及其制造方法。用于检测样品中的目标物质的检测元件包括基板和金属结构。衬底具有孔，其中衬底的厚度方向对应于孔的深度方向，并且其中形成孔的衬底的一部分构成衬底的外表面的一部分。金属结构存在于孔中，具有环状。

10. 发明申请

US20090148346A1 SUBSTRATE WITH BINDING FUNCTIONAL GROUP 审中-公开
标题翻译：基座与绑定功能组
公开(公告)号：US20090148346A1
公开(公告)日：2009-06-11
申请号：US12065720
申请日：2006-10-03
申请人： Kazuhiro Ban , Kazumichi Nakahama , Miki Ogawa
发明人： Kazuhiro Ban , Kazumichi Nakahama , Miki Ogawa
IPC分类号： G01N21/00 , C08L33/02
CPC分类号： B82Y30/00 , B82Y15/00 , G01N33/54393
摘要： A structural member having a binding functional group on a substrate for binding a capturing molecule capable of capturing a target substance, characterized in that the substrate binds to one end of a polymer which includes at the other end those to which the binding functional group is bound and those to which a suppressing functional group for suppressing adsorption of biological molecules to the structural member and that the suppressing functional group is also bound to a side chain of the polymer.
摘要翻译：一种在底物上具有结合能捕获靶物质的捕获分子的结合官能团的结构部件，其特征在于，所述底物与聚合物的一端结合，所述聚合物的另一端包含结合官能团所结合的那些以及抑制生物分子吸附到结构构件上的抑制官能团，抑制官能团也与聚合物的侧链结合的那些。

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