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1. 发明授权

US07622263B2 Kit for immobilizing organic substance, organic substance-immobilized structure, and manufacturing methods therefor 失效
标题翻译：固定有机物，有机物固定结构的试剂盒及其制造方法
公开(公告)号：US07622263B2
公开(公告)日：2009-11-24
申请号：US10555383
申请日：2005-01-25
申请人： Kazuhiro Ban , Hidenori Shiotsuka , Takeshi Imamura
发明人： Kazuhiro Ban , Hidenori Shiotsuka , Takeshi Imamura
IPC分类号： G01N33/53 , G01N33/00 , C07K5/00
CPC分类号： G01N33/54353 , G01N33/551
摘要： To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic substance, particularly a biological substance is immobilized on the surface of a substrate, the organic substance, particularly the biological substance can be stably immobilized on the surface of the substrate through orientation of the organic substance, particularly the biological substance suitable for exerting physiological functions thereof. At least part of the substrate's surface is constructed of one or more substrates containing aluminum oxide. The immobilization of the organic substance to the surface of the substrate is carried out by binding at least part of the binding domain to the surface of the substrate through a binding domain containing a peptide having an affinity to aluminum oxide and composed of at least one or more amino acids, which is coupled with the organic substance.
摘要翻译：为了提供采用新型固定化技术的有机物质固定化结构及其制造方法，其中，当将有机物质，特别是生物物质固定在基材表面上时，有机物质，特别是生物物质可以通过有机物质，特别是适于发挥其生理功能的生物物质的取向，稳定地固定在基材的表面上。衬底表面的至少一部分由含有氧化铝的一个或多个衬底构成。有机物质固定到底物的表面是通过结合结构域与底物的表面结合而进行的，所述结合结构域含有与氧化铝具有亲和性的肽，并且由至少一个或多个更多的氨基酸，其与有机物质偶联。

2. 发明申请

US20090130776A1 BINDING PROTEIN MOLECULE 审中-公开
标题翻译：结合蛋白分子
公开(公告)号：US20090130776A1
公开(公告)日：2009-05-21
申请号：US11995911
申请日：2006-09-01
申请人： Takeshi Imamura , Hidenori Shiotsuka , Kazuhiro Ban , Takahisa Ibii
发明人： Takeshi Imamura , Hidenori Shiotsuka , Kazuhiro Ban , Takahisa Ibii
IPC分类号： G01N33/543 , C07K16/18 , B01J19/00
CPC分类号： C07K16/44 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C07K16/00 , C07K16/40 , C07K2317/565 , C07K2317/622 , C07K2317/626 , G01N33/543 , G01N33/54366 , G01N33/68 , G01N33/6845
摘要： A binding protein molecule, characterized in that it has a first domain having a binding site to an inhibitor of non-specific adsorption in which the domain comprises a part of the variable region of an antibody as the binding site and a second domain having a binding site to a target substance in which the domain comprises a part of the variable region of an antibody as the binding site, wherein the first and second domains are bound via a linker.
摘要翻译：一种结合蛋白质分子，其特征在于其具有与非特异性吸附抑制剂的结合位点的第一结构域，其中所述结构域包含作为结合位点的抗体的可变区的一部分和具有结合位点的第二结构域其中所述结构域包含作为结合位点的抗体的可变区的一部分的靶物质，其中所述第一和第二结构域经由接头结合。

3. 发明申请

US20080108132A1 Kit for Immobilizing Organic Substance, Organic Substance-Immobilized Structure, and Manufacturing Methods Therefor 失效
标题翻译：固定化有机物，有机物固定化结构用试剂盒及其制造方法
公开(公告)号：US20080108132A1
公开(公告)日：2008-05-08
申请号：US10555383
申请日：2005-01-25
申请人： Kazuhiro Ban , Hidenori Shiotsuka , Takeshi Imamura
发明人： Kazuhiro Ban , Hidenori Shiotsuka , Takeshi Imamura
IPC分类号： C12N15/63 , C07K7/08 , C07K7/64 , C07H21/04
CPC分类号： G01N33/54353 , G01N33/551
摘要： To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic substance, particularly a biological substance is immobilized on the surface of a substrate, the organic substance, particularly the biological substance can be stably immobilized on the surface of the substrate through orientation of the organic substance, particularly the biological substance suitable for exerting physiological functions thereof. At least part of the substrate's surface is constructed of one or more substrates containing aluminum oxide. The immobilization of the organic substance to the surface of the substrate is carried out by binding at least part of the binding domain to the surface of the substrate through a binding domain containing a peptide having an affinity to aluminum oxide and composed of at least one or more amino acids, which is coupled with the organic substance.
摘要翻译：为了提供采用新型固定化技术的有机物质固定化结构及其制造方法，其中，当将有机物质，特别是生物物质固定在基材表面上时，有机物质，特别是生物物质可以通过有机物质，特别是适于发挥其生理功能的生物物质的取向，稳定地固定在基材的表面上。衬底表面的至少一部分由含有氧化铝的一个或多个衬底构成。有机物质固定到底物的表面是通过结合结构域与底物的表面结合而进行的，所述结合结构域含有与氧化铝具有亲和性的肽，并且由至少一个或多个更多的氨基酸，其与有机物质偶联。

4. 发明授权

US08436535B2 Information acquisition method, information acquisition apparatus and disease diagnosis method 有权
标题翻译：信息采集方法，信息获取装置及疾病诊断方法
公开(公告)号：US08436535B2
公开(公告)日：2013-05-07
申请号：US12712131
申请日：2010-02-24
申请人： Hiroyuki Hashimoto , Katsuaki Kuge , Manabu Komatsu , Kumi Nakamura , Kazuhiro Ban , Takeshi Imamura , Shin Kobayashi , Tadashi Okamoto
发明人： Hiroyuki Hashimoto , Katsuaki Kuge , Manabu Komatsu , Kumi Nakamura , Kazuhiro Ban , Takeshi Imamura , Shin Kobayashi , Tadashi Okamoto
IPC分类号： H01J17/26
CPC分类号： G01N33/6848 , G01N33/4833
摘要： An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.
摘要翻译：一种用于获取关于目标对象的信息的信息获取方法，其包括使用促进所述目标对象的电离的物质促进所述目标对象的电离以使所述目标对象发射的步骤以及获取所述质量信息的步骤的飞行目标物体使用飞行时间二次离子质谱法。

5. 发明申请

US20100227308A1 INFORMATION ACQUISITION METHOD, INFORMATION ACQUISITION APPARATUS AND DISEASE DIAGNOSIS METHOD 有权
标题翻译：信息获取方法，信息获取装置和疾病诊断方法
公开(公告)号：US20100227308A1
公开(公告)日：2010-09-09
申请号：US12712131
申请日：2010-02-24
申请人： Hiroyuki Hashimoto , Katsuaki Kuge , Manabu Komatsu , Kumi Nakamura , Kazuhiro Ban , Takeshi Imamura , Shin Kobayashi , Tadashi Okamoto
发明人： Hiroyuki Hashimoto , Katsuaki Kuge , Manabu Komatsu , Kumi Nakamura , Kazuhiro Ban , Takeshi Imamura , Shin Kobayashi , Tadashi Okamoto
IPC分类号： C12Q1/00 , B01D59/44 , H01J49/40
CPC分类号： G01N33/6848 , G01N33/4833
摘要： An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.
摘要翻译：一种用于获取关于目标对象的信息的信息获取方法，其包括使用促进所述目标对象的电离的物质促进所述目标对象的电离以使所述目标对象发射的步骤以及获取所述质量信息的步骤的飞行目标物体使用飞行时间二次离子质谱法。

6. 发明授权

US07701138B2 Information acquisition method, information acquisition apparatus and disease diagnosis method 失效
标题翻译：信息采集方法，信息获取装置及疾病诊断方法
公开(公告)号：US07701138B2
公开(公告)日：2010-04-20
申请号：US11319233
申请日：2005-12-28
申请人： Hiroyuki Hashimoto , Katsuaki Kuge , Manabu Komatsu , Kumi Nakamura , Kazuhiro Ban , Takeshi Imamura , Shin Kobayashi , Tadashi Okamoto
发明人： Hiroyuki Hashimoto , Katsuaki Kuge , Manabu Komatsu , Kumi Nakamura , Kazuhiro Ban , Takeshi Imamura , Shin Kobayashi , Tadashi Okamoto
IPC分类号： H01J17/26
CPC分类号： G01N33/6848 , G01N33/4833
摘要： An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.
摘要翻译：一种用于获取关于目标对象的信息的信息获取方法，其包括使用促进所述目标对象的电离的物质促进所述目标对象的电离以使所述目标对象发射的步骤以及获取所述质量信息的步骤的飞行目标物体使用飞行时间二次离子质谱法。

7. 发明申请

US20060183235A1 Information acquisition method, information acquisition apparatus and disease diagnosis method 失效
公开(公告)号：US20060183235A1
公开(公告)日：2006-08-17
申请号：US11319233
申请日：2005-12-28
申请人： Hiroyuki Hashimoto , Katsuaki Kuge , Manabu Komatsu , Kumi Nakamura , Kazuhiro Ban , Takeshi Imamura , Shin Kobayashi , Tadashi Okamoto
发明人： Hiroyuki Hashimoto , Katsuaki Kuge , Manabu Komatsu , Kumi Nakamura , Kazuhiro Ban , Takeshi Imamura , Shin Kobayashi , Tadashi Okamoto
IPC分类号： G01N33/00
CPC分类号： G01N33/6848 , G01N33/4833
摘要： An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

8. 发明授权

US08962302B2 Biological tissue processing substrate for fixing proteins or protein degradation products in tissue for analysis 有权
标题翻译：用于将蛋白质或蛋白质降解产物固定在组织中用于分析的生物组织处理底物
公开(公告)号：US08962302B2
公开(公告)日：2015-02-24
申请号：US11592313
申请日：2006-11-03
申请人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
发明人： Kazuhiro Ban , Miki Ogawa , Norihiko Utsunomiya , Hiroyuki Hashimoto , Manabu Komatsu , Yohei Murayama
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/00 , C12Q1/34 , C12Q1/37 , C12Q1/02 , C12N11/14 , C12N11/02 , C12N11/04 , G01N33/68 , G01N33/50
CPC分类号： G01N33/6848 , G01N33/5082
摘要： A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.
摘要翻译：一种用于将蛋白质固定在生物组织中的生物组织处理底物或蛋白质的降解产物，所述底物包括：与生物组织形成接触表面的多孔体，多孔体在孔中保留用于获得蛋白质的酶或使来自生物组织的蛋白质的降解产物与由金属构成的构件接触，其中通过酶的作用获得的蛋白质或降解产物与金属接触。

9. 发明申请

US20080290268A1 INFORMATION OBTAINING METHOD 有权
标题翻译：信息获取方法
公开(公告)号：US20080290268A1
公开(公告)日：2008-11-27
申请号：US12120512
申请日：2008-05-14
申请人： Manabu Komatsu , Hiroyuki Hashimoto , Yohei Murayama , Kazuhiro Ban
发明人： Manabu Komatsu , Hiroyuki Hashimoto , Yohei Murayama , Kazuhiro Ban
IPC分类号： B01D59/44
CPC分类号： H01J49/145
摘要： An information obtaining method for obtaining information about a mass of a component of an analyte using a time of flight mass spectrometer and obtaining information about a distribution state of the component based on the obtained information about the mass includes the step of: (1) adding a self-reactive substance to the analyte on a base to facilitate ionization of the component; (2) irradiating the analyte with a primary beam in the presence of the self-reactive substance, thereby ionizing the components and allowing resulting ions to fly; (3) obtaining information about mass of the flying ions using the time of flight mass spectrometer; and (4) obtaining information about the distribution state of the component on the base based on the information about the mass.
摘要翻译：使用飞行时间质谱仪获取关于分析物的成分的质量的信息的信息获取方法，基于获得的关于质量的信息获得关于部件的分布状态的信息，包括以下步骤：（1）添加对基底上的分析物的自反应物质，以促进组分的离子化; （2）在存在自反应物质的情况下用主光束照射分析物，从而电离成分并允许所得离子飞行; （3）使用飞行时间质谱仪获取关于飞行离子质量的信息; 和（4）基于关于质量的信息获得关于组件在基础上的分布状态的信息。

10. 发明申请

US20080090267A1 METHOD FOR TREATING LIVING SAMPLES AND ANALYZING THE SAME 有权
标题翻译：用于处理生活样品和分析样品的方法
公开(公告)号：US20080090267A1
公开(公告)日：2008-04-17
申请号：US11867276
申请日：2007-10-04
申请人： Manabu Komatsu , Hiroyuki Hashimoto , Kazuhiro Ban , Yohei Murayama
发明人： Manabu Komatsu , Hiroyuki Hashimoto , Kazuhiro Ban , Yohei Murayama
IPC分类号： C12Q1/02
CPC分类号： G01N33/5082 , G01N35/1002 , G01N2035/1041
摘要： A method is provided by which a reagent is provided to a living sample, including contacting a thin-film containing a porous body with a living sample containing cells or tissues, and discharging a solution containing at least one or more reagents to a non-contact side of the thin-film by ink-jet to provide the solution to the specific area of the living sample through pores on the thin-film, wherein the smaller diameter of the pores on the porous body relative to the diameter of cells in the living sample enables the reagent to be provided to each individual cell separately. According to this method, the reagent and the reaction product can be fixed while maintaining positioning information of the target substance in the living sample, as a pretreatment for analyzing with high positioning accuracy the target substance in each individual cell in the living sample.
摘要翻译：提供了一种将试剂提供给活体样品的方法，包括使含有多孔体的薄膜与含有细胞或组织的活体样品接触，并将含有至少一种或多种试剂的溶液排出至非接触通过喷墨使薄膜的一侧通过薄膜上的孔提供到活体样品的特定区域的溶液，其中多孔体上的孔的直径相对于活体中细胞的直径较小样品使得可以分别向每个单独的细胞提供试剂。根据该方法，可以在维持活体样品中的目标物质的定位信息的同时固定试剂和反应产物，作为用于以高定位精度分析活体样品中各个细胞中的目标物质的预处理。

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