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1. 发明申请

US20050027235A1 Radiofrequency arthrosopic ablation device 有权
标题翻译：射频关节置换术
公开(公告)号：US20050027235A1
公开(公告)日：2005-02-03
申请号：US10490979
申请日：2003-02-12
申请人： Katherine Knudsen , Duane Marion , Hugh Sharkey
发明人： Katherine Knudsen , Duane Marion , Hugh Sharkey
IPC分类号： A61B18/12 , A61B18/14 , A61N1/30
CPC分类号： A61B18/148 , A61B2018/00101 , A61B2018/162 , A61B2218/002
摘要： A surgical device includes an elongated shaft having first and second electrically isolated electrodes coupled to the shaft such that an exposed portion of the second electrode is disposed around only part of a circumference of the elongated shaft, and includes a portion that is spaced proximally from the first electrode. Another surgical device also includes an elongated shaft having first and second electrically isolated electrodes coupled to the shaft, wherein the shaft includes a first side, and exposed surfaces of the first and second electrodes are side-facing toward the first side. Various embodiments of a “cool back” are provided, allowing arthroscopic surgery on a first side of a device without tissue effects on a back side of the device.
摘要翻译：手术装置包括细长轴，其具有联接到所述轴的第一和第二电隔离电极，使得所述第二电极的暴露部分仅围绕所述细长轴的圆周的一部分设置，并且包括与所述细长轴的近侧间隔开的部分第一电极。另一种手术装置还包括细长轴，其具有联接到所述轴的第一和第二电隔离电极，其中所述轴包括第一侧，并且所述第一和第二电极的暴露表面朝向所述第一侧面朝向。提供“冷却回”的各种实施例，允许在装置的第一侧上进行关节镜手术，而不会在装置的背面产生组织影响。

2. 发明申请

US20080051859A1 METHOD FOR TREATING INTERVERTEBRAL DISCS 有权
标题翻译：治疗椎间盘突出症的方法
公开(公告)号：US20080051859A1
公开(公告)日：2008-02-28
申请号：US11929644
申请日：2007-10-30
申请人： Hugh Sharkey , John Ashley , Joel Saal , Jeffrey Saal , Le Le
发明人： Hugh Sharkey , John Ashley , Joel Saal , Jeffrey Saal , Le Le
IPC分类号： A61F7/00 , A61B18/14 , A61F7/12
CPC分类号： A61B17/1671 , A61B10/02 , A61B17/00491 , A61B17/29 , A61B17/320016 , A61B17/320068 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B17/7061 , A61B17/8836 , A61B18/00 , A61B18/08 , A61B18/082 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00577 , A61B2018/00595 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1425 , A61B2018/1435 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0084 , A61M25/0133 , A61M25/0144 , A61M25/0147 , A61M25/0155 , A61M25/0158 , A61M25/09 , A61N1/06 , A61N1/40 , A61N1/403
摘要： A method of treating an intervertebral disc includes inserting an introducer into an intervertebral disc, inserting a catheter through the introducer and into the intervertebral disc, advancing a distal region of the catheter through a nucleus pulposus of the intervertebral disc to an annular wall of an annulus fibrosus, delivering energy to material of the intervertebral disc using an electrode disposed at the distal region of the catheter, and removing the material with the delivered energy, wherein removing material with the delivered energy reduces pressure in the intervertebral disc.
摘要翻译：治疗椎间盘的方法包括将导引器插入椎间盘，将导管穿过导引器插入椎间盘中，将导管的远侧区域推进通过椎间盘的髓核到环形的环形壁纤维，使用设置在导管的远端区域的电极向椎间盘的材料输送能量，并且用所输送的能量去除材料，其中用所输送的能量去除材料减少了椎间盘中的压力。

3. 发明申请

US20060229491A1 Method for treating myocardial rupture 审中-公开
标题翻译：治疗心肌破裂的方法
公开(公告)号：US20060229491A1
公开(公告)日：2006-10-12
申请号：US11199633
申请日：2005-08-09
申请人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
发明人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
IPC分类号： A61F2/00 , A61M1/10
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/00898 , A61B2017/00942 , A61B2017/12095
摘要： A method and device for the treatment of a patient with heart disease and particularly a heart chamber having a myocardial rupture or characteristics of an incipient myocardial rupture. The heart chamber is partitioned so as to isolate a non-productive portion having a rupture or a region of an incipient rupture from a productive portion. The heart chamber is preferably partitioned with a reinforced membrane which has a pressure receiving surface that defines part of the productive portion of the heart chamber. The peripheral base of the reinforced membrane may have an eccentric configuration.
摘要翻译：用于治疗患有心脏病的患者的方法和装置，特别是具有心肌破裂或初始心肌破裂特征的心室。将心脏腔室分隔开以分离具有破裂的非生产性部分或从生产部分开始的初始区域。心室优选用加强膜分隔，该增强膜具有限定心室的生产部分的一部分的压力接收表面。增强膜的周边基底可以具有偏心构造。

4. 发明申请

US20050203503A1 Infusion array ablation apparatus 审中-公开
标题翻译：输液阵列消融装置
公开(公告)号：US20050203503A1
公开(公告)日：2005-09-15
申请号：US11034503
申请日：2005-01-12
申请人： Stuart Edwards , James Baker , Hugh Sharkey , Ronald Lax
发明人： Stuart Edwards , James Baker , Hugh Sharkey , Ronald Lax
IPC分类号： A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61B18/18 , A61B18/22 , A61M3/02 , A61M25/00 , A61N1/40 , A61N5/04 , C22C1/04 , C22C14/00 , C22F1/18
摘要： An infusion array ablation apparatus includes an elongated delivery device having a lumen and an infusion array positionable in the lumen. The infusion array includes an RF electrode and at least a first and a second infusion member. Each infusion member has a tissue piercing distal portion and an infusion lumen. At least one of the first or second infusion members is positionable in the elongated delivery device in a compacted state and deployable from the elongated delivery device with curvature in a deployed state. Also, at least one of the first or second infusion members exhibits a changing direction of travel when advanced from the elongated delivery device to a selected tissue site. At least one infusion port is coupled to one of the elongated delivery device, the infusion array, the first infusion member or the second infusion member.
摘要翻译：输液阵列消融装置包括细长递送装置，其具有可定位在内腔中的内腔和输液排列。输注阵列包括RF电极和至少第一和第二输注构件。每个输注构件具有组织穿刺远端部分和输注腔。第一或第二输注构件中的至少一个可以处于压实状态的细长输送装置中定位并且可以从伸长的输送装置以部署状态的曲率展开。此外，第一或第二输注构件中的至少一个表现出当从细长递送装置前进到选定的组织部位时改变的行进方向。至少一个输注端口连接到细长递送装置，输注阵列，第一输注构件或第二输注构件中的一个。

5. 发明申请

US20050154252A1 Ventricular partitioning device 有权
标题翻译：心室分配装置
公开(公告)号：US20050154252A1
公开(公告)日：2005-07-14
申请号：US10754182
申请日：2004-01-09
申请人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovanecevic
发明人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovanecevic
IPC分类号： A61B17/12 , A61F2/00 , A61F2/24
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B2017/12095 , A61F2/2487
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber and a support or spacing member extending between the reinforced membrane and the wall of the patient's heart chamber. The support or spacing member has a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者的心室分离成生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有加强的可扩张的膜，其分离心室的生产和非生产部分以及在增强膜和患者心室的壁之间延伸的支撑或间隔构件。支撑或间隔构件具有非创伤性远端以接合心室壁。

6. 发明授权

US06726685B2 Intervertebral disc device employing looped probe 有权
公开(公告)号：US06726685B2
公开(公告)日：2004-04-27
申请号：US09876833
申请日：2001-06-06
申请人： Kevin To , Le T. Le , Andy Uchida , Hugh Sharkey , John Ashley
发明人： Kevin To , Le T. Le , Andy Uchida , Hugh Sharkey , John Ashley
IPC分类号： H61B1818
CPC分类号： A61B18/1492 , A61B2017/00261 , A61B2017/003 , A61B2018/0044 , A61B2018/1407
摘要： An intervertebral disc device is provided comprising a probe capable of being extended from a distal end of an introducer that is percutaneously delivered into an interior of an intervertebral disc, the probe forming a loop when extended from the distal end of the introducer, the loop having first and second proximal ends external to the introducer which are brought together adjacent the introducer distal end to form the loop by the proximal ends being either attached to or entering the distal end of the introducer; and a proximal handle for externally causing the probe to be extended from the distal end of the introducer and externally guiding the probe within an intervertebral disc.

7. 发明授权

US06632222B1 Tissue ablation apparatus 失效
标题翻译：组织消融装置
公开(公告)号：US06632222B1
公开(公告)日：2003-10-14
申请号：US09512985
申请日：2000-02-24
申请人： Stuart D. Edwards , James Baker , Hugh Sharkey , Ronald G. Lax
发明人： Stuart D. Edwards , James Baker , Hugh Sharkey , Ronald G. Lax
IPC分类号： A61B1818
CPC分类号： A61B18/1477 , A61B18/1206 , A61B18/14 , A61B18/1402 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00026 , A61B2017/00084 , A61B2017/00101 , A61B2018/00011 , A61B2018/00023 , A61B2018/00196 , A61B2018/00273 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00761 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1472 , A61B2018/162 , A61B2018/1861 , A61B2218/002 , A61M1/0084 , A61M3/0279 , A61M25/007 , A61N1/403 , B22F2999/00 , C22C1/0491 , C22C14/00 , C22F1/183 , B22F3/1216 , C22C33/0285
摘要： A tissue ablation apparatus comprises a first elongated delivery device including a lumen and an obturator with a tissue piercing distal end. The obturator is positionable in the lumen of the first elongated delivery device. A second elongated delivery device is positionable in the lumen of the first elongated delivery device. An energy delivery device is positionable in the second elongated delivery device. The energy delivery device includes at least a first and a second RF electrode each with a tissue piercing distal portion. The first and second RF electrodes are positionable in the second elongated delivery device in a compacted state and deployable from the second elongated delivery device with curvature in a deployed state. The first and second RF electrodes exhibit a changing direction of travel when advanced from the second elongated delivery device to a selected tissue site. At least one infusion port is coupled to one of the first elongated delivery device, the second elongated delivery device, the energy delivery device, the first RF electrode or the second RF electrode. An electrode advancement member is coupled to the first and second RF electrodes. The advancement member is configured to advance the RF electrode out of the elongated delivery device.
摘要翻译：组织消融装置包括第一细长递送装置，其包括内腔和具有组织穿刺远端的闭孔器。闭塞器可定位在第一细长递送装置的内腔中。第二细长递送装置可定位在第一细长递送装置的内腔中。能量输送装置可定位在第二细长递送装置中。能量输送装置至少包括第一和第二RF电极，每个具有组织刺穿的远端部分。第一和第二RF电极可以处于致密状态的第二细长递送装置中定位，并且可以从布置状态的曲率从第二细长递送装置展开。第一和第二RF电极表现出从第二细长递送装置前进到所选择的组织部位时改变的行进方向。至少一个输注端口连接到第一细长输送装置，第二细长输送装置，能量输送装置，第一RF电极或第二RF电极之一。电极前进构件耦合到第一和第二RF电极。推进构件被配置为将RF电极推出细长的输送装置。

8. 发明授权

US06632221B1 Method of creating a lesion in tissue with infusion 失效
标题翻译：用输液在组织中产生病变的方法
公开(公告)号：US06632221B1
公开(公告)日：2003-10-14
申请号：US09512744
申请日：2000-02-24
申请人： Stuart D. Edwards , James Baker , Hugh Sharkey , Ronald G. Lax
发明人： Stuart D. Edwards , James Baker , Hugh Sharkey , Ronald G. Lax
IPC分类号： A61B1818
CPC分类号： A61B18/1477 , A61B18/1206 , A61B18/14 , A61B18/1402 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00026 , A61B2017/00084 , A61B2017/00101 , A61B2018/00011 , A61B2018/00023 , A61B2018/00196 , A61B2018/00273 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00761 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1472 , A61B2018/162 , A61B2018/1861 , A61B2218/002 , A61M3/0279 , A61M25/007 , A61N1/403 , A61N5/04 , B22F2999/00 , C22C1/0491 , C22C14/00 , C22F1/183 , B22F3/1216 , C22C33/0285
摘要： A method of creating a lesion in tissue with infusion includes providing an apparatus comprising a first elongated delivery device with a lumen, an obturator with a second elongated delivery device and an energy delivery device positional in a lumen of the first elongated delivery device. The energy device includes at least a first and a second RF electrode each with a tissue piercing distal portion, the first and second RF electrodes being deployable from the first elongated delivery device with curvature in a deployed state. The energy delivery device includes an infusion lumen and at least one infusion port. The obturator and second delivery device are introduced to a selected tissue site. The obturator is removed from a lumen of the second delivery device and the first delivery device and energy delivery device are introduced into the lumen of the second delivery device. The first and second RF electrodes are advanced from the first delivery device to at least partially surround a target tissue site. The target tissue site is at least partially infused with an infusion fluid. Energy is delivered from the energy delivery device to the target tissue site and cell necrosis is created at the target tissue site.
摘要翻译：在输注组织中产生病变的方法包括提供一种包括具有内腔的第一细长递送装置，带有第二细长递送装置的闭孔器和位于第一细长输送装置的内腔中的能量输送装置的装置。能量装置包括至少第一和第二RF电极，每个RF组件具有组织穿透的远端部分，第一和第二RF电极可从部分状态的曲率从第一细长输送装置展开。能量输送装置包括输液腔和至少一个输注口。将闭塞器和第二递送装置引入选定的组织部位。封闭器从第二输送装置的内腔移除，第一输送装置和能量输送装置被引入第二输送装置的内腔。第一和第二RF电极从第一递送装置前进至至少部分地围绕目标组织部位。目标组织部位至少部分地用输注液注入。能量从能量输送装置输送到目标组织部位，并在目标组织部位产生细胞坏死。

9. 发明申请

US20080091252A1 METHOD FOR TREATING INTERVERTEBRAL DISC 有权
公开(公告)号：US20080091252A1
公开(公告)日：2008-04-17
申请号：US11872437
申请日：2007-10-15
申请人： Hugh Sharkey , John Ashley , Joel Saal , Jeffrey Saal , Le Le
发明人： Hugh Sharkey , John Ashley , Joel Saal , Jeffrey Saal , Le Le
IPC分类号： A61F7/00 , A61B18/18
CPC分类号： A61B17/1671 , A61B10/02 , A61B17/00491 , A61B17/29 , A61B17/320016 , A61B17/320068 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B17/7061 , A61B17/8836 , A61B18/00 , A61B18/08 , A61B18/082 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00577 , A61B2018/00595 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1425 , A61B2018/1435 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0084 , A61M25/0133 , A61M25/0144 , A61M25/0147 , A61M25/0155 , A61M25/0158 , A61M25/09 , A61N1/06 , A61N1/40 , A61N1/403
摘要： A device is described that may be positioned at a location in an intervertebral disc for diagnosis or treatment of the disc. Treatment may include, for example, applying energy or removing material, and may decrease intradiscal pressure. Radiofrequency energy may be applied. A percutaneous method of repairing a fissure in the annulus pulposus comprises placing an energy source adjacent to the fissure and providing sufficient energy to the fissure to raise the temperature to at least about 45-70° C. and for a sufficient time to cause the collagen to weld. An intervertebral fissure also can be treated by placing a catheter with a lumen adjacent to the fissure and injecting sealant into the fissure via the catheter, thereby sealing the fissure. An intervertebral fissure additionally can be treated by providing a catheter having a distal end, a proximal end, a longitudinal axis, and an intradiscal section at the catheter's distal end on which there is at least one functional element. The next step is applying a force longitudinally to the proximal of the catheter which is sufficient to advance the intradiscal section through the nucleus pulposus and around an inner wall of an annulus fibrosus, but which force is insufficient to puncture the annulus fibrosus. Next the functional element is positioned at a selected location of the disc by advancing or retracting the catheter and optionally twisting the proximal end of the catheter. Then the functional unit treats the annular fissure. Optionally, there is an additional step of adding a substance to seal the fissure. An externally guidable intervertebral disc apparatus also is disclosed.

10. 发明申请

US20070213815A1 System for improving cardiac function 有权
公开(公告)号：US20070213815A1
公开(公告)日：2007-09-13
申请号：US11801075
申请日：2007-05-07
申请人： Alexander Khairkhahan , Hugh Sharkey , Serjan Nikolic
发明人： Alexander Khairkhahan , Hugh Sharkey , Serjan Nikolic
IPC分类号： A61M1/10
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12095
摘要： A system for improving cardiac function is provided. A foldable and expandable frame having at least one anchoring formation is attached to an elongate manipulator and placed in a catheter tube while folded. The tube is inserted into a left ventricle of a heart where the frame is ejected from the tube and expands in the left ventricle. Movements of the elongate manipulator cause the anchor to penetrate the heart muscle and the elongate manipulator to release the frame. The installed frame minimizes the effects of an akinetic portion of the heart forming an aneurysmic bulge.

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