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1. 发明申请

US20140189903A1 METHODS OF PREDICTING YIELD IN PLANTS AND APPLICATIONS OF USE THEREOF 有权
标题翻译：在植物中预测产量的方法及其应用
公开(公告)号：US20140189903A1
公开(公告)日：2014-07-03
申请号：US14002250
申请日：2012-03-07
申请人： Kateri Duncan , Jonathan Cohn , Lining Guo , Nalini Desai , Matthew Mitchell , Jacob Wulff
发明人： Kateri Duncan , Jonathan Cohn , Lining Guo , Nalini Desai , Matthew Mitchell , Jacob Wulff
IPC分类号： G01N33/50
CPC分类号： G01N33/5097 , A01C21/007 , A01H1/04 , G01N33/48 , G01N33/5038 , G06G7/75 , Y02A40/14
摘要： The present invention relates to the fields of agriculture, plant breeding or genetic engineering for plants with increased yield, crop forecasting and crop management. In particular, the methods herein describe novel methods of predicting a plant's yield through the measurement of specific metabolites either individually or in combination with one another in a specific plant reproductive tissue. The plant predictive methods described herein may be used to predict yield of plant populations as well as allow for more efficient crop management practices (e.g. amount and timing of chemical applications or amount of irrigation water applied to a field).
摘要翻译：本发明涉及具有增加的产量，作物预测和作物管理的植物的农业，植物育种或遗传工程领域。特别地，本文的方法描述了通过在特定植物生殖组织中单独或组合地测量特定代谢物来预测植物产量的新方法。本文描述的植物预测方法可以用于预测植物种群的产量，并且允许更有效的作物管理实践（例如化学应用的量和时间或施加到田地的灌溉水的量）。

2. 发明授权

US09310354B2 Methods of predicting crop yield using metabolic profiling 有权
标题翻译：使用代谢分析预测作物产量的方法
公开(公告)号：US09310354B2
公开(公告)日：2016-04-12
申请号：US14002250
申请日：2012-03-07
申请人： Kateri Duncan , Jonathan Cohn , Lining Guo , Nalini Desai , Matthew Mitchell , Jacob Wulff
发明人： Kateri Duncan , Jonathan Cohn , Lining Guo , Nalini Desai , Matthew Mitchell , Jacob Wulff
IPC分类号： G01N33/50 , A01H1/04 , G01N33/48 , G06G7/75 , A01C21/00
CPC分类号： G01N33/5097 , A01C21/007 , A01H1/04 , G01N33/48 , G01N33/5038 , G06G7/75 , Y02A40/14
摘要： The present invention relates to the fields of agriculture, plant breeding or genetic engineering for plants with increased yield, crop forecasting and crop management. In particular, the methods herein describe novel methods of predicting a plant's yield through the measurement of specific metabolites either individually or in combination with one another in a specific plant reproductive tissue. The plant predictive methods described herein may be used to predict yield of plant populations as well as allow for more efficient crop management practices (e.g. amount and timing of chemical applications or amount of irrigation water applied to a field).
摘要翻译：本发明涉及具有增加的产量，作物预测和作物管理的植物的农业，植物育种或遗传工程领域。特别地，本文的方法描述了通过在特定植物生殖组织中单独或组合地测量特定代谢物来预测植物产量的新方法。本文描述的植物预测方法可以用于预测植物种群的产量，并且允许更有效的作物管理实践（例如化学应用的量和时间或施加到田地的灌溉水的量）。

3. 发明授权

US06350934B1 Nucleic acid encoding delta-9 desaturase 失效
标题翻译：编码Δ-9去饱和酶的核酸
公开(公告)号：US06350934B1
公开(公告)日：2002-02-26
申请号：US08679645
申请日：1996-07-12
申请人： Michael G. Zwick , Brent E. Edington , James A. McSwiggen , Patricia Ann Owens Merlo , Lining Guo , Thomas A. Skokut , Scott A. Young , Otto Folkerts , Donald J. Merlo
发明人： Michael G. Zwick , Brent E. Edington , James A. McSwiggen , Patricia Ann Owens Merlo , Lining Guo , Thomas A. Skokut , Scott A. Young , Otto Folkerts , Donald J. Merlo
IPC分类号： C12N504
CPC分类号： C12N15/113 , C12N9/0083 , C12N9/1051 , C12N15/8216 , C12N15/8218 , C12N15/8243 , C12N15/8245 , C12N15/8247 , C12N15/8255 , C12N2310/12 , C12N2310/121 , C12N2310/122
摘要： The present invention relates to nucleic acid molecules encoding delta 9 desaturase gene, and expression vectors, plant cells, and transgenic plants expressing delta 9 desaturase nucleic acid. The nucleic acid molecules of the present invention can be used, for example, to decrease delta 9 desaturase activity in plant cells, resulting in decreased unsaturated fatty acid production.
摘要翻译：本发明涉及编码Δ9去饱和酶基因的核酸分子和表达载体，植物细胞和表达Δ9去饱和酶核酸的转基因植物。本发明的核酸分子可以用于例如降低植物细胞中δ9去饱和酶的活性，导致不饱和脂肪酸的产生降低。

4. 发明授权

US06331664B1 Acyl-ACP thioesterase nucleic acids from maize and methods of altering palmitic acid levels in transgenic plants therewith 失效
标题翻译：来自玉米的酰基-ACP硫酯酶核酸和改变转基因植物中的棕榈酸水平的方法
公开(公告)号：US06331664B1
公开(公告)日：2001-12-18
申请号：US09064411
申请日：1998-04-22
申请人： Beth Rubin-Wilson , Lining Guo , Tom Skokut , Scott Young , Otto Folkerts , Katherine Armstrong , Neil M. Cowen
发明人： Beth Rubin-Wilson , Lining Guo , Tom Skokut , Scott Young , Otto Folkerts , Katherine Armstrong , Neil M. Cowen
IPC分类号： A01H500
CPC分类号： C12N15/8247 , C12N9/16
摘要： Genes encoding maize oleoyl-ACP and palmitoyl-ACP thioesterase enzymes have been isolated from maize. These genes, when expressed in a plant, can be used to create transgenic plants having altered palmitic acid oil profiles.
摘要翻译：从玉米中分离出编码玉米油酰基-ACP和棕榈酰-ACP硫酯酶的基因。当在植物中表达时，这些基因可用于产生具有改变的棕榈酸油分布的转基因植物。

5. 发明授权

US07709623B2 Xenorhabdus TC proteins and genes for pest control 有权
标题翻译： Xenorhabdus TC蛋白和病虫害防治基因
公开(公告)号：US07709623B2
公开(公告)日：2010-05-04
申请号：US12422749
申请日：2009-04-13
申请人： Scott B. Bintrim , Jon C. Mitchell , Ignacio M. Larrinua , Patricia C. Apel-Birkhold , Susan B. Green , Barry W. Schafer , Scott A. Bevan , Scott A. Young , Lining Guo
发明人： Scott B. Bintrim , Jon C. Mitchell , Ignacio M. Larrinua , Patricia C. Apel-Birkhold , Susan B. Green , Barry W. Schafer , Scott A. Bevan , Scott A. Young , Lining Guo
IPC分类号： C07H21/04 , C12N1/20 , C07K14/00 , C12N5/10
CPC分类号： C12N15/8286 , Y02A40/162
摘要： The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.
摘要翻译：本发明涉及新型异戊酰梭菌毒素复合物（TC）蛋白质和编码这些蛋白质的基因。更具体地，本发明涉及从Xenorhabdus菌株Xwi获得的TC基因和蛋白质。本发明还提供可从Xwi菌株获得的外切蛋白酶。该外切蛋白酶可以使用本领域已知的方法来控制昆虫。

6. 发明申请

US20060156434A1 Xenorhabdus TC proteins and genes for pest control 有权
公开(公告)号：US20060156434A1
公开(公告)日：2006-07-13
申请号：US11375551
申请日：2006-03-14
申请人： Scott Bintrim , Jon Mitchell , Ignacio Larrinua , Patricia Apel-Birkhold , Susan Green , Barry Schafer , Scott Bevan , Scott Young , Lining Guo
发明人： Scott Bintrim , Jon Mitchell , Ignacio Larrinua , Patricia Apel-Birkhold , Susan Green , Barry Schafer , Scott Bevan , Scott Young , Lining Guo
IPC分类号： A01H1/00 , C07H21/04 , C12N15/82 , C12N5/04 , C07K14/195 , C07K14/415
CPC分类号： C12N15/8286 , Y02A40/162
摘要： The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.

7. 发明申请

US20050130118A1 Methods for identifying inhibitors of chlorophyll synthase 审中-公开
标题翻译：鉴定叶绿素合酶抑制剂的方法
公开(公告)号：US20050130118A1
公开(公告)日：2005-06-16
申请号：US10737014
申请日：2003-12-16
申请人： Abubakr Aslamkhan , Lining Guo , Rao Mulpuri , Neil Hoffman , Susanne Kjemtrup , Jocelyn Kearney , Cory Christensen , Keith Davis , Adel Zayed , Robert Ascenzi , Douglas Boyes
发明人： Abubakr Aslamkhan , Lining Guo , Rao Mulpuri , Neil Hoffman , Susanne Kjemtrup , Jocelyn Kearney , Cory Christensen , Keith Davis , Adel Zayed , Robert Ascenzi , Douglas Boyes
IPC分类号： C12Q1/00 , G01N33/573
CPC分类号： G01N33/573
摘要： The present inventors have discovered that antisense suppression of a chlorophyll synthase (CS) gene results in plants exhibiting one or more of chlorosis, reduced growth, and altered development. Thus, the present inventors have discovered that the protein encoded by the CS gene is essential for normal plant growth and development, and is useful as a target for the identification of compounds as antibiotics and herbicides, especially herbicides. The present invention is directed to methods for identifying inhibitors of a CS enzyme by incubating a CS polypeptide with a chlorophyllide and a phopholipid substrate in the presence and absence of a test compound under conditions suitable for the CS enzyme activity, adding a solution to the incubation reactions comprising a water immiscible organic solvent, a water-soluble alcohol, and a water-soluble dye that absorbs in the range of one or both the excitation and emission wavelength ranges of the chlorophyllide substrate, and measuring the fluorescence of the incubation reactions at from about 650 to 750 nm, using from about 425 to 445 nm as excitation wavelength, wherein a decrease in the fluorescence in the presence of the test compound indicates that the compound is a CS inhibitor.
摘要翻译：本发明人已经发现，叶绿素合酶（CS）基因的反义抑制导致植物表现出一种或多种褪绿，生长减少和改变发育。因此，本发明人已经发现，由CS基因编码的蛋白质对于正常的植物生长和发育是必需的，并且可用作鉴定作为抗生素和除草剂，特别是除草剂的化合物的靶标。本发明涉及通过在适合于CS酶活性的条件下，在存在和不存在测试化合物的情况下，将CS多肽与叶绿素和磷脂底物一起温育来鉴定CS酶抑制剂的方法，向培养基中加入溶液包括与水不溶混的有机溶剂，水溶性醇和在所述叶绿素底物的激发和发射波长范围中的一个或两个的范围内吸收的水溶性染料的反应，以及测量从约650至750nm，使用约425至445nm作为激发波长，其中在测试化合物存在下荧光的降低表明该化合物是CS抑制剂。

8. 发明授权

US06528484B1 Insecticidal protein toxins from Photorhabdus 失效
公开(公告)号：US06528484B1
公开(公告)日：2003-03-04
申请号：US08851567
申请日：1997-05-05
申请人： Jerald C. Ensign , David J. Bowen , James Petell , Raymond Fatig , Sue Schoonover , Richard H. ffrench-Constant , Thomas A. Rocheleau , Michael B. Blackburn , Timothy D. Hey , Donald J. Merlo , Gregory L. Orr , Jean L. Roberts , James A. Strickland , Lining Guo , Todd A. Ciche , Kitisri Sukhapinda
发明人： Jerald C. Ensign , David J. Bowen , James Petell , Raymond Fatig , Sue Schoonover , Richard H. ffrench-Constant , Thomas A. Rocheleau , Michael B. Blackburn , Timothy D. Hey , Donald J. Merlo , Gregory L. Orr , Jean L. Roberts , James A. Strickland , Lining Guo , Todd A. Ciche , Kitisri Sukhapinda
IPC分类号： A01N3718
CPC分类号： C07K14/24 , A01N63/02 , C07K14/195 , C12N9/52 , C12N15/8286 , Y02A40/162
摘要： Proteins from the genus Photorhabdus are toxic to insects upon exposure. Photorhabdus luminescens (formerly Xenorhabdus luminescens) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus Heterorhabditis. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.

9. 发明授权

US08658351B2 Determining liver toxicity of an agent using metabolite biomarkers 有权
标题翻译：使用代谢物生物标志物测定药物的肝脏毒性
公开(公告)号：US08658351B2
公开(公告)日：2014-02-25
申请号：US13148082
申请日：2010-02-05
申请人： Michael Milburn , Lining Guo , Jacob Edward Wulff , Kay A. Lawton
发明人： Michael Milburn , Lining Guo , Jacob Edward Wulff , Kay A. Lawton
IPC分类号： C12Q1/00
CPC分类号： G01N33/5014 , G01N33/5067 , G01N33/5088
摘要： The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2′-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant.
摘要翻译：本发明提供用于肝毒性的各种生物标志物和使用生物标志物的各种方法本发明范围内的一些生物标志物是胆酸，甘油脱氧胆酸，甘氨胆酸，牛磺酸，3-羟基-2-乙基丙酸酯，4-咪唑乙酸酯，酪胺，邻氨基苯甲酸酯， 2'-脱氧胞苷，N-乙酰天冬氨酸（NAA），β-羟基己酸酯和肌氨酸（N-甲基甘氨酸）使用生物标志物的方法包括将第一肝细胞培养物暴露于测试试剂，并比较其中一种或多种在第一肝细胞培养物中获得的更多生物标志物在没有测试剂的第二肝细胞培养物中获得的一种或多种生物标志物的水平，其中第一肝细胞培养物中的一种或多种生物标志物的差异水平与第二次肝细胞培养物中的水平相比肝细胞培养表明试验剂是肝毒性剂。

10. 发明申请

US20110300571A1 Determination of the Liver Toxicity of an Agent 有权
标题翻译：药物肝脏毒性的测定
公开(公告)号：US20110300571A1
公开(公告)日：2011-12-08
申请号：US13148082
申请日：2010-02-05
申请人： Michael Milburn , Lining Guo , Jacob Edward Wulff , Kay A. Lawton
发明人： Michael Milburn , Lining Guo , Jacob Edward Wulff , Kay A. Lawton
IPC分类号： C12Q1/02 , G01N27/00
CPC分类号： G01N33/5014 , G01N33/5067 , G01N33/5088
摘要： The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2′-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant.
摘要翻译：本发明提供用于肝毒性的各种生物标志物和使用生物标志物的各种方法本发明范围内的一些生物标志物是胆酸，甘油脱氧胆酸，甘氨胆酸，牛磺酸，3-羟基-2-乙基丙酸酯，4-咪唑乙酸酯，酪胺，邻氨基苯甲酸酯， 2'-脱氧胞苷，N-乙酰天冬氨酸（NAA），β-羟基己酸酯和肌氨酸（N-甲基甘氨酸）使用生物标志物的方法包括将第一肝细胞培养物暴露于测试试剂，并比较其中一种或多种在第一肝细胞培养物中获得的更多生物标志物在没有测试剂的第二肝细胞培养物中获得的一种或多种生物标志物的水平，其中第一肝细胞培养物中的一种或多种生物标志物的差异水平与第二次肝细胞培养物中的水平相比肝细胞培养表明试验剂是肝毒性剂。

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