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1. 发明申请

US20100078854A1 Nanotemplate arbitrary-imprint lithography 有权
标题翻译：纳米模板任意刻印光刻
公开(公告)号：US20100078854A1
公开(公告)日：2010-04-01
申请号：US11542474
申请日：2006-10-03
申请人： Karl K. Berggren , Stefan Harrer , Giovanni A. Salvatore , Joel K. Yang
发明人： Karl K. Berggren , Stefan Harrer , Giovanni A. Salvatore , Joel K. Yang
IPC分类号： B29C59/02
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： In a method for imprinting a layer of material, a nanotemplate is impressed into a material layer, and the nanotemplate is maintained impressed in the material layer until a geometric trench corresponding to geometry of the nanotemplate is formed in the layer, and the nanotemplate is then removed from the material layer. A nanotemplate geometric trench is repeatedly formed in the material layer by nanotemplate impressions in the layer, until a final desired imprint pattern is produced in the layer. Each nanotemplate geometric trench is characterized by an extent that is a fraction of an extent of the final desired imprint pattern. The material layer is maintained in a condition for accepting nanotemplate impressions continuously throughout the nanotemplate impression repetition.
摘要翻译：在用于压印材料层的方法中，将纳米模板压入材料层中，并且将纳米模板保持印在材料层中，直到在层中形成对应于纳米模板的几何形状的几何沟槽，然后将纳米模板从材料层中移除。通过层中的纳米模板印模在材料层中重复地形成纳米模板几何沟槽，直到在该层中产生最终期望的压印图案。每个纳米模板几何沟槽的特征在于最终所需压印图案的程度的一部分。材料层保持在整个纳米模板印象重复中连续地接纳纳米模板印象的条件。

2. 发明授权

US08603381B2 Nanotemplate arbitrary-imprint lithography 有权
标题翻译：纳米模板任意刻印光刻
公开(公告)号：US08603381B2
公开(公告)日：2013-12-10
申请号：US11542474
申请日：2006-10-03
申请人： Karl K. Berggren , Stefan Harrer , Giovanni A. Salvatore , Joel K. Yang
发明人： Karl K. Berggren , Stefan Harrer , Giovanni A. Salvatore , Joel K. Yang
IPC分类号： B28B3/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： In a method for imprinting a layer of material, a nanotemplate is impressed into a material layer, and the nanotemplate is maintained impressed in the material layer until a geometric trench corresponding to geometry of the nanotemplate is formed in the layer, and the nanotemplate is then removed from the material layer. A nanotemplate geometric trench is repeatedly formed in the material layer by nanotemplate impressions in the layer, until a final desired imprint pattern is produced in the layer. Each nanotemplate geometric trench is characterized by an extent that is a fraction of an extent of the final desired imprint pattern. The material layer is maintained in a condition for accepting nanotemplate impressions continuously throughout the nanotemplate impression repetition.
摘要翻译：在用于压印材料层的方法中，将纳米模板压入材料层中，并且将纳米模板保持印在材料层中，直到在层中形成对应于纳米模板的几何形状的几何沟槽，然后将纳米模板从材料层中移除。通过层中的纳米模板印模在材料层中重复地形成纳米模板几何沟槽，直到在该层中产生最终期望的压印图案。每个纳米模板几何沟槽的特征在于最终所需压印图案的程度的一部分。材料层保持在整个纳米模板印象重复中连续地接纳纳米模板印象的条件。

3. 发明申请

US20140103582A1 Nano-Pipet Fabrication 审中-公开
标题翻译：纳米管制造
公开(公告)号：US20140103582A1
公开(公告)日：2014-04-17
申请号：US13651494
申请日：2012-10-15
申请人： Stefan Harrer , John A. Ott , Stanislav Polonsky
发明人： Stefan Harrer , John A. Ott , Stanislav Polonsky
IPC分类号： C03C23/00
CPC分类号： C03C23/005 , H01J2237/2002
摘要： A hollow high aspect ratio sample, such as a nano-test-tube, with a tip that is closed off is secured in a particle beam device, such as a transmission electron microscope. The tip is engaged with the particle beam of the particle beam device until a hole opens up on the tip, thereby turning the high aspect ratio sample into a nano-pipet. Alternatively, a nano-pipet having a hole that does not meet desired parameter values is secured in a particle beam device. The nano-pipet is engaged with the particle beam to attain the desired values of the hole parameters.
摘要翻译：具有封闭的尖端的诸如纳米试管的中空高宽比样品固定在诸如透射电子显微镜的粒子束装置中。尖端与粒子束装置的粒子束接合，直到在尖端上打开孔，从而将高纵横比样品转变为纳米移液管。或者，具有不符合期望参数值的孔的纳米移液管被确保在粒子束装置中。纳米移液管与颗粒束接合以获得所需的孔参数值。

4. 发明授权

US08623458B2 Methods of directed self-assembly, and layered structures formed therefrom 有权
标题翻译：定向自组装的方法和由其形成的分层结构
公开(公告)号：US08623458B2
公开(公告)日：2014-01-07
申请号：US12642018
申请日：2009-12-18
申请人： Joy Cheng , Matthew E. Colburn , Stefan Harrer , William D. Hinsberg , Steven J. Holmes , Ho-Cheol Kim , Daniel Paul Sanders
发明人： Joy Cheng , Matthew E. Colburn , Stefan Harrer , William D. Hinsberg , Steven J. Holmes , Ho-Cheol Kim , Daniel Paul Sanders
IPC分类号： B81C1/00 , C08J5/18 , C08J5/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： A layered structure comprising a self-assembled material is formed by a method that includes forming a photochemically, thermally and/or chemically treated patterned photoresist layer disposed on a first surface of a substrate. The treated patterned photoresist layer comprises a non-crosslinked treated photoresist. An orientation control material is cast on the treated patterned photoresist layer, forming a layer containing orientation control material bound to a second surface of the substrate. The treated photoresist and, optionally, any non-bound orientation control material are removed by a development process, resulting in a pre-pattern for self-assembly. A material capable of self-assembly is cast on the pre-pattern. The casted material is allowed to self-assemble with optional heating and/or annealing to produce the layered structure.
摘要翻译：包括自组装材料的层状结构通过包括形成设置在衬底的第一表面上的光化学，热和/或化学处理的图案化光致抗蚀剂层的方法形成。经处理的图案化光刻胶层包括非交联处理的光致抗蚀剂。将取向控制材料浇铸在经处理的图案化的光致抗蚀剂层上，形成包含与基材的第二表面结合的取向控制材料的层。经处理的光致抗蚀剂和任选的任何未结合的取向控制材料通过显影过程被去除，从而形成用于自组装的预图案。能够自组装的材料在预制图案上铸造。允许铸造材料通过任选的加热和/或退火自组装以产生分层结构。

5. 发明申请

US20140004300A1 Crossed slit structure for nanopores 审中-公开
标题翻译：用于纳米孔的交叉狭缝结构
公开(公告)号：US20140004300A1
公开(公告)日：2014-01-02
申请号：US13555251
申请日：2012-07-23
申请人： Jingwei Bai , Stefan Harrer , Stanislav Polonsky , Stephen M. Rossnagel
发明人： Jingwei Bai , Stefan Harrer , Stanislav Polonsky , Stephen M. Rossnagel
IPC分类号： B32B3/10
CPC分类号： B81C1/00087 , B81B2201/058 , H01L21/0337 , Y10T428/24322
摘要： For a cross slit structure that contains a nanopore, a layer is produced including a first spacer that penetrates through the layer. A subsequent layer over, and in direct contact with, the layer is also produced. The subsequent layer includes a second spacer penetrating through the subsequent layer. The first spacer and the second spacer are selectively etched away, creating a first slit and a second slit. Respective projections of these slits are crossing one another at an angle. At such a crossing an opening is formed which provides for fluid connectivity through the two layers.
摘要翻译：对于包含纳米孔的交叉狭缝结构，产生包括穿透层的第一间隔物的层。还产生了与层直接接触的后续层。随后的层包括贯穿后续层的第二间隔物。选择性地蚀刻掉第一间隔物和第二间隔物，形成第一狭缝和第二狭缝。这些狭缝的各个投影以一定角度相互交叉。在这样一个交叉口处，形成一个开口，其提供通过两层的流体连通性。

6. 发明申请

US20120193235A1 DNA MOTION CONTROL BASED ON NANOPORE WITH ORGANIC COATING FORMING TRANSIENT BONDING TO DNA 审中-公开
标题翻译：基于NANOPORE的DNA运动控制与有机涂层形成瞬态结合到DNA
公开(公告)号：US20120193235A1
公开(公告)日：2012-08-02
申请号：US13359743
申请日：2012-01-27
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
IPC分类号： G01N27/453
CPC分类号： G01N27/4473 , C12Q1/6869 , C12Q2523/303 , C12Q2565/631
摘要： A nanodevice includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an insulating layer. A nanopore is formed through the membrane, and an organic coating is provided on the insulating layer to form a transient bond to a DNA molecule in the nanopore. The transient bond is stronger than thermal motion, such that the transient bond can hold the DNA molecule against the thermal motion. When a voltage is applied across the membrane, the voltage will break the transient bond to move the DNA molecule through the nanopore in a controllable state.
摘要翻译：纳米器件包括填充有导电流体的储存器和分离储存器的膜。膜包括绝缘层。通过膜形成纳米孔，并且在绝缘层上提供有机涂层以与纳米孔中的DNA分子形成瞬时键合。瞬态键比热运动强，使得瞬态键可以保持DNA分子抵抗热运动。当跨膜施加电压时，电压将破坏瞬态键合，以在可控状态下将DNA分子移动通过纳米孔。

7. 发明申请

US20120193231A1 DNA SEQUENCING USING MULTIPLE METAL LAYER STRUCTURE WITH ORGANIC COATINGS FORMING TRANSIENT BONDING TO DNA BASES 审中-公开
标题翻译：使用多种金属层结构的DNA序列与有机涂层形成瞬态结合到DNA基础
公开(公告)号：US20120193231A1
公开(公告)日：2012-08-02
申请号：US13359750
申请日：2012-01-27
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2563/116 , C12Q2563/157 , C12Q2565/607 , C12Q2565/631
摘要： A nanodevice is provided. A reservoir is filled with an ionic fluid. A membrane separates the reservoir, and the membrane includes electrode layers separated by insulating layers in which the electrode layers have an organic coating. A nanopore is formed through the membrane, and the organic coating on the electrode layers forms transient bonds to a base of a molecule in the nanopore. When a first voltage is applied to the electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base.
摘要翻译：提供了一个纳米设备。储存器充满离子流体。膜分离储存器，并且膜包括由绝缘层分离的电极层，其中电极层具有有机涂层。通过膜形成纳米孔，并且电极层上的有机涂层与纳米孔中分子的碱基形成瞬态键。当第一电压施加到电极层时，通过纳米孔中的基底产生隧道电流，并且隧道电流通过形成到待测量的基极的瞬态键作为用于区分基极的电流签名传播。

8. 发明申请

US20110312176A1 FORMING AN ELECTRODE HAVING REDUCED CORROSION AND WATER DECOMPOSITION ON SURFACE USING AN ORGANIC PROTECTIVE LAYER 失效
标题翻译：使用有机保护层形成具有降低的腐蚀和表面水分解的电极
公开(公告)号：US20110312176A1
公开(公告)日：2011-12-22
申请号：US12820543
申请日：2010-06-22
申请人： Ali Afzali-Ardakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
发明人： Ali Afzali-Ardakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
IPC分类号： H01L21/283 , H01L21/441 , C23C28/00 , C30B23/02 , C23C14/34 , B05D3/14 , B05D5/12 , B05D3/06
CPC分类号： B82Y10/00 , H01L21/76834 , H01L29/0665 , H01L51/0093 , H01L51/0504 , H01L51/102
摘要： Accordingly, the present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A substrate which has a conductive layer disposed thereon is provided and the conductive layer has an oxide layer with an exposed surface. The exposed surface of the oxide layer contacts a solution of an organic surface active compound in an organic solvent to form a protective layer of the organic surface active compound over the oxide layer. The protective layer has a thickness of from about 0.5 nm to about 5 nm and ranges therebetween depending on a chemical structure of the surface active compound.
摘要翻译：因此，本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。提供了具有设置在其上的导电层的衬底，并且导电层具有具有暴露表面的氧化物层。氧化物层的暴露表面接触有机表面活性化合物在有机溶剂中的溶液，以在氧化物层上形成有机表面活性化合物的保护层。根据表面活性化合物的化学结构，保护层的厚度为约0.5nm至约5nm，并且其范围。

9. 发明授权

US10040682B2 Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores 有权
公开(公告)号：US10040682B2
公开(公告)日：2018-08-07
申请号：US13465280
申请日：2012-05-07
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： G01N27/40 , B82Y30/00 , B82Y40/00 , F03B11/02 , B82Y15/00 , G01N27/00
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N27/00 , Y10T137/8593
摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

10. 发明授权

US08641879B2 Charged entities as locomotive to control motion of polymers through a nanochannel 有权
公开(公告)号：US08641879B2
公开(公告)日：2014-02-04
申请号：US13611662
申请日：2012-09-12
申请人： Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , George F. Walker
发明人： Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , George F. Walker
IPC分类号： G01N27/26
CPC分类号： B82Y15/00 , C12Q1/6869 , C12Q2565/631
摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.

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