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1. 发明授权

US4511738A Process for preparing phosphine oxides 失效
标题翻译：氧化膦的制备方法
公开(公告)号：US4511738A
公开(公告)日：1985-04-16
申请号：US456221
申请日：1983-01-07
申请人： Kanji Tokuyama , Yasuhiro Nishitani , Mamoru Tanaka , Wataru Nagata
发明人： Kanji Tokuyama , Yasuhiro Nishitani , Mamoru Tanaka , Wataru Nagata
IPC分类号： C07F9/11 , C07F9/53 , C07F9/54
CPC分类号： C07F9/53 , C07F9/11
摘要： A phosphine sulfide derivative is chlorinated and hydrolyzed with little pollution problem to give the corresponding phosphine oxide derivative.
摘要翻译：硫化膦衍生物被氯化和水解，几乎没有污染问题，得到相应的氧化膦衍生物。

2. 发明授权

US4705852A 1-oxadethia cephalosporin hydroxamic acid derivatives 失效
标题翻译： 1-oxadethia头孢菌素异羟肟酸衍生物
公开(公告)号：US4705852A
公开(公告)日：1987-11-10
申请号：US876976
申请日：1986-06-20
申请人： Wataru Nagata , Tsutomu Aoki , Yasuhiro Nishitani
发明人： Wataru Nagata , Tsutomu Aoki , Yasuhiro Nishitani
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/36 , C07D501/57 , C07D505/00 , C07D205/08 , A61K31/535
CPC分类号： C07D505/00 , Y02P20/55
摘要： An antibacterial cephalosporin hydroxamic acid derivative represented by the following formula (I), processes for its preparation, compositions containing the same as an active ingredient, and a method for killing bacteria by contacting with said compound. ##STR1## (wherein, R is acyl; R.sup.1 is hydrogen or methoxy; R.sup.2 is alkylene; R.sup.3 is hydrogen, aliphatic group or a hydroxy-protecting group; R.sup.4 is hydrogen or amino-protecting group; R.sup.5 is hydrogen, light metal atom or carboxy-protecting group; and X is oxygen, sulfur, or sulfinyl).

3. 发明授权

US4614797A Cephalosporin hydroxamic acids 失效
标题翻译：头孢菌素异羟肟酸
公开(公告)号：US4614797A
公开(公告)日：1986-09-30
申请号：US576404
申请日：1984-02-02
申请人： Wataru Nagata , Tsutomu Aoki , Yasuhiro Nishitani
发明人： Wataru Nagata , Tsutomu Aoki , Yasuhiro Nishitani
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/36 , C07D501/57 , C07D505/00
CPC分类号： C07D505/00 , Y02P20/55
摘要： An antibacterial cephalosporin hydroxamic acid derivative represented by the following formula (I), processes for its preparation, compositions containing the same as an active ingredient, and a method for killing bacteria by contacting with said compound. ##STR1## (wherein, R is acyl; R.sup.1 is hydrogen or methoxy; R.sup.2 is alkylene; R.sup.3 is hydrogen, aliphatic group or a hydroxy-protecting group; R.sup.4 is hydrogen or amino-protecting group; R.sup.5 is hydrogen, light metal atom or carboxy-protecting group; and X is oxygen, sulfur, or sulfinyl).
摘要翻译：由下式（I）表示的抗菌头孢菌素异羟肟酸衍生物，其制备方法，含有该活性成分的组合物，以及通过与所述化合物接触来杀死细菌的方法。（I）（I）（其中R为酰基; R 1为氢或甲氧基; R 2为亚烷基; R 3为氢，脂族基或羟基保护基; R 4为氢或氨基保护基; R 5为氢，金属原子或羧基保护基; X是氧，硫或亚磺酰基）。

4. 发明授权

US4159984A Reductive cleavage of oxazolidine compounds 失效
标题翻译：还原性裂解恶唑烷化合物
公开(公告)号：US4159984A
公开(公告)日：1979-07-03
申请号：US790618
申请日：1977-04-25
申请人： Mitsuru Yoshioka , Teruji Tsuji , Yasuhiro Nishitani , Wataru Nagata
发明人： Mitsuru Yoshioka , Teruji Tsuji , Yasuhiro Nishitani , Wataru Nagata
IPC分类号： C07D205/08 , C07D205/085 , C07D205/095 , C07D499/00 , C07D499/44 , C07D499/48 , C07D499/72 , C07D503/00 , C07D505/00
CPC分类号： C07D205/085 , C07D499/00 , C07D505/00
摘要： Compounds represented by the following formula prepared from 6-aminopenicillanic acid are key intermediates in a stereo-specific synthesis of 1-oxadethiacephalosporins, highly active antibiotics: ##STR1## [wherein COA and COB each is carboxy or protected carboxy;Cox is carboxy, protected carboxy, or a group of the formula --COCQ.dbd.N.sub.2 or --COCHQ--Z (in which Q is hydrogen, lower alkyl or aryl; and Z is hydrogen or a nucleophilic group);Hal is halogen;R is lower alkyl or aralkyl; andY is hydrogen or acyl].
摘要翻译：由6-氨基青霉烷酸制备的下列化合物所代表的化合物是立体特异性合成1-羟基乙硫菌素，高活性抗生素的关键中间体：其中COA和COB各自为羧基或被保护的羧基; COX是羧基，受保护的羧基或式-COCQ = N2或-COCHQ-Z（其中Q是氢，低级烷基或芳基; Z是氢或亲核基团）的基团; 卤素是卤素; R是低级烷基或芳烷基; 和Y是氢或酰基]。

5. 发明授权

US4592865A Azetidinone intermediates for cephalosporin analogs 失效
标题翻译：氮杂环丁酮中间体用于头孢菌素类似物
公开(公告)号：US4592865A
公开(公告)日：1986-06-03
申请号：US589670
申请日：1984-03-13
申请人： Masayuki Narisada , Hiroshi Onoue , Teruji Tsuji , Yasuhiro Nishitani , Mitsuru Yoshioka , Yoshio Hamashima , Wataru Nagata
发明人： Masayuki Narisada , Hiroshi Onoue , Teruji Tsuji , Yasuhiro Nishitani , Mitsuru Yoshioka , Yoshio Hamashima , Wataru Nagata
IPC分类号： C07D205/08 , C07D205/085 , C07D403/12 , C07D405/12 , C07D417/12 , C07D505/00 , C07F9/568 , C07D498/04
CPC分类号： C07F9/5683 , C07D205/085 , C07D505/00
摘要： Intermediates of the following formula are useful for the synthesis of 1-oxacephalosporins. Their preparation from penicillins and the transformation process to make 1-oxacephalosporins are disclosed. The compounds are of the formula: ##STR1## wherein A is amino or a selected acylamino;COB is carboxy or a selected protected-carboxy;X is halogen or the group ORin which R is a group represented by following formulas: ##STR2## wherein Nu is a selected nucleophilic group; R.sup.1 is a group of the following formula: ##STR3## in which Hal is halogen or alkylsulfonyloxy and R.sup.2 is alkyl or aryl; andY is hydrogen or methoxy; with the proviso that when R is propargyl or 2-oxopropyl andR.sup.1 is ##STR4## A is in the 3.alpha.-configuration and Y is 3.beta.-hydrogen or A is in the 3.beta.-configuration and Y is 3.alpha.-methoxy.
摘要翻译：下列配方的中间体可用于合成1-氧杂七环素。公开了它们从青霉素的制备和制备1-氧杂七环素的转化过程。化合物具有下式：其中A是氨基或选择的酰氨基; COB是羧基或选择的保护羧基; X是卤素或基团OR，其中R是由下式表示的基团：CH2CCH，CH2CCNu，CH2CHCH2，＆lt; IMAGE＆gt;＆gt;其中Nu是选择的亲核基团; R1是下式的基团：其中Hal是卤素或烷基磺酰氧基，R2是烷基或芳基的 Y为氢或甲氧基; 条件是当R为炔丙基或2-氧代丙基且R 1为A 3构型时，Y为3个β-氢，或A为3个β-构型，Y为3个α-甲氧基。

6. 发明授权

US4508909A Synthesis of hydroxyethyltetrazolethiol and etherified intermediates therefor 失效
标题翻译：合成羟乙基四唑硫醇及其醚化中间体
公开(公告)号：US4508909A
公开(公告)日：1985-04-02
申请号：US475410
申请日：1983-03-15
申请人： Wataru Nagata , Yasuhiro Nishitani , Hisao Sato
发明人： Wataru Nagata , Yasuhiro Nishitani , Hisao Sato
IPC分类号： C07C67/00 , C07C325/00 , C07C333/20 , C07D257/04
CPC分类号： C07D257/04 , Y02P20/55
摘要： By heating an N-(2-hydroxyethyl)dithiocarbamate ester protected at its hydroxy group as an ether in the presence of an azide, the corresponding 1-(protected hydroxyethyl)-1H-tetrazole-5-thiol is obtained, and then, if required, deprotecting the etheric protection to give an industrially useful chemical, 1-(2-hydroxyethyl)-1H-tetrazole-5-thiol.
摘要翻译：通过在叠氮化物存在下加热其羟基作为醚保护的N-（2-羟乙基）二硫代氨基甲酸酯酯，得到相应的1-（保护的羟乙基）-1H-四唑-5-硫醇，然后如果需要，脱保护以上的保护，得到工业上有用的化学品1-（2-羟乙基）-1H-四唑-5-硫醇。

7. 发明授权

US4529721A Vinylthioacetamido oxacephalosporin derivatives 失效
标题翻译：乙烯基硫代乙酰氨基氧杂环孢菌素衍生物
公开(公告)号：US4529721A
公开(公告)日：1985-07-16
申请号：US534147
申请日：1983-09-21
申请人： Wataru Nagata , Mitsuru Yoshioka , Yasuhiro Nishitani , Tsutomu Aoki , Toshiro Konoike , Tadatoshi Kubota
发明人： Wataru Nagata , Mitsuru Yoshioka , Yasuhiro Nishitani , Tsutomu Aoki , Toshiro Konoike , Tadatoshi Kubota
IPC分类号： A01N43/90 , C07D241/08 , C07D339/00 , C07D505/00 , C07D519/00 , C07F9/535 , A01N59/06 , C07D498/04
CPC分类号： C07F9/5352 , C07C309/00 , C07C323/00 , C07D241/08 , C07D339/00 , C07D505/00 , Y02P20/55
摘要： A compound of the formula: ##STR1## wherein u represents hydrogen, carboxamido, N-hydroxycarboxamido, carboxy, azido, an aryl, an acylamino, a protected carboxy or an N-alkoxycarboxamido, or, together with v, can represent --S-- or --CH.sub.2 S--; v represents hydrogen, halogen, cyano or an alkylthio, or, together with u, can represent --S-- or --CH.sub.2 S--, or, together with w, can represent --(CH.sub.2).sub.3 CO--; w represents hydrogen, carboamoyl, cyano, carboxy, an N-alkylcarbamoyl, an alkyl, an aryl, a protected carboxy or a heterocycle, or, together with v, can represents --(CH.sub.2).sub.3 CO--; x represents halogen, trifluoromethyl, an alkylthio or an arylthio; y represents hydrogen, a light metal or a carboxylic acid protecting group; and z represents an acyloxy or a heterocycle-thio, each of the above radicals represented by the symbols u, v, w, x, y and z being optionally substituted by halogen or a carbon-, nitrogen-, oxygen- or sulfur-containing functional group, a process for preparing the compound, a pharmaceutical composition containing the compound, and a therapeutical use of the compound.A compound of the formula: ##STR2## wherein u, v, w and x are as defined above, useful as a starting compound for preparing the compound (I) is also provided.
摘要翻译：下式的化合物：其中u表示氢，甲酰氨基，N-羟基羧甲酰氨基，羧基，叠氮基，芳基，酰氨基，被保护的羧基或N-烷氧基羧酰胺基，或与v一起可代表 -S-或-CH2S-; v表示氢，卤素，氰基或烷硫基，或与u一起可以表示-S-或-CH 2 S-，或者与w一起可以表示 - （CH 2）3 CO-; w表示氢，氨甲酰基，氰基，羧基，N-烷基氨基甲酰基，烷基，芳基，保护的羧基或杂环，或与v一起可以表示 - （CH 2）3 CO-; x表示卤素，三氟甲基，烷硫基或芳硫基; y表示氢，轻金属或羧酸保护基; 和z表示酰氧基或杂环硫基，由符号u，v，w，x，y和z表示的上述基团中的每一个任选被卤素或含碳，氮，氧或硫的官能团，制备该化合物的方法，含该化合物的药物组合物和该化合物的治疗用途。还提供了下式化合物：其中u，v，w和x如上定义，可用作制备化合物（I）的起始化合物。

8. 发明授权

US4143038A Cephalosporin analogues 失效
标题翻译： CEPHALOSPORIN ANALOGUES
公开(公告)号：US4143038A
公开(公告)日：1979-03-06
申请号：US846503
申请日：1977-10-26
申请人： Masayuki Narisada , Hiroshi Onoue , Teruji Tsuji , Yasuhiro Nishitani , Mitsuru Yoshioka , Yoshio Hamashima , Wataru Nagata
发明人： Masayuki Narisada , Hiroshi Onoue , Teruji Tsuji , Yasuhiro Nishitani , Mitsuru Yoshioka , Yoshio Hamashima , Wataru Nagata
IPC分类号： C07D205/085 , C07D505/00 , C07D205/00
CPC分类号： C07D205/085 , C07D505/00
摘要： Potent antibacterial cephalosporin analogues of the following formula in forms of free acids, pharmaceutically acceptable salts, or esters preparable from penicillins through azetidinone derivatives by way of a new process, and utilizable as active ingredients in bactericidal compositions for pharmaceutical and veterinary use: ##STR1## (wherein Acyl is selected from phenylacetyl, D-mandeloyl, .alpha.-phenylmalonyl, D-.alpha.-(3-methanesulfonyl-2-oxoimidazolidin-l-yl)carbonamido-.alpha.-phenylacetyl, and 2-thienylacetyl).

9. 发明申请

US20080110295A1 Transmission case 审中-公开
标题翻译：传动箱
公开(公告)号：US20080110295A1
公开(公告)日：2008-05-15
申请号：US11979923
申请日：2007-11-09
申请人： Toshihiko Aoki , Toshiyuki Miyoshi , Kazutoshi Omagari , Minoru Todo , Mikio Iwase , Yoshihiro Takigawa , Takayuki Kamei , Takashi Ando , Atsushi Honda , Kazutoshi Nozaki , Wataru Nagata
发明人： Toshihiko Aoki , Toshiyuki Miyoshi , Kazutoshi Omagari , Minoru Todo , Mikio Iwase , Yoshihiro Takigawa , Takayuki Kamei , Takashi Ando , Atsushi Honda , Kazutoshi Nozaki , Wataru Nagata
IPC分类号： F16H57/04 , B21B1/46
CPC分类号： F16H57/03 , F16H57/04 , F16H2057/02013 , F16H2057/02043 , F16H2057/02052 , F16H2057/02091 , Y10T29/49988 , Y10T74/2186
摘要： A transmission case includes a power transmission mechanism; a first case body and an adapter portion. The adapter portion includes a boss portion through which the output shaft is inserted, a first concave portion provided on an outer peripheral side of the boss portion and open rearward in the shaft direction, which is on the power output side of the power transmission mechanism, and a second concave portion open outward in a radial direction of the boss portion with the second concave portion separated in the shaft direction from the first concave portion by a separating wall.
摘要翻译：变速器壳体包括动力传递机构; 第一壳体和适配器部分。适配器部分包括：输出轴插入的凸台部分，设置在凸台部分的外周侧上的第一凹部，并且在动力传递机构的动力输出侧在轴向方向上向后方开放，以及第二凹部，其在所述凸台部的径向方向上向外开口，所述第二凹部沿着轴向与所述第一凹部分离，通过分隔壁。

10. 发明授权

US4570018A Fluorocyclopropanes 失效
标题翻译：氟环丙烷
公开(公告)号：US4570018A
公开(公告)日：1986-02-11
申请号：US610790
申请日：1984-05-16
申请人： Tsutomu Aoki , Hiromi Takahashi , Toshiro Konoike , Teruji Tsuji , Wataru Nagata
发明人： Tsutomu Aoki , Hiromi Takahashi , Toshiro Konoike , Teruji Tsuji , Wataru Nagata
IPC分类号： C07C23/04 , C07C43/192 , C07C43/313 , C07C43/32 , C07C69/653 , C07D505/00 , C07C87/34 , C07C149/26
CPC分类号： C07D505/00 , C07C323/00 , C07C323/30 , C07C43/192 , C07C43/313 , C07C43/32 , C07C2101/02
摘要： A novel chemical, fluorochlorocyclopropane (I) of the following formula: ##STR1## is prepared by the addition of fluorochlorocarbene to the corresponding olefin (II) of the following formula:CH.sub.2 .dbd.CR.sup.1 -R.sup.2The compound is a useful intermediate for synthesizing some chemicals, e.g., some cephalosporins.(wherein R.sup.1 is hydrogen, halogen, 1 to 8C alkylamino, alkoxy, or alkylthio andR.sup.2 is halogen, 1 to 8C alkylamino, alkoxy, or alkylthio).
摘要翻译：通过向相应的下式所示的烯烃（II）中加入氟氯碳烯制备下式的新型化学式氟氯环丙烷（I）：CH2 = CR1-R2该化合物是一种有用的中间体合成一些化学物质，例如一些头孢菌素。（其中R 1为氢，卤素，1至8烷基氨基，烷氧基或烷硫基，R 2为卤素，1至8烷基氨基，烷氧基或烷硫基）。

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