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    • 2. 发明申请
    • CANCER DIAGNOSIS KIT AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER
    • 癌症诊断试剂盒和药物组合物预防或治疗癌症
    • WO2012011778A3
    • 2012-05-24
    • PCT/KR2011005433
    • 2011-07-22
    • KOREA RES INST OF BIOSCIENCECHUNG KYUNG SOOKWON MI SUNAHN JI WONKIM YOUNG JOOSONG EUN YOUNGYEOM YOUNG ILLEE HEE GU
    • CHUNG KYUNG SOOKWON MI SUNAHN JI WONKIM YOUNG JOOSONG EUN YOUNGYEOM YOUNG ILLEE HEE GU
    • C12Q1/68A61K48/00C12N15/12G01N33/574
    • C12Q1/6886C12Q2600/106C12Q2600/158G01N33/574
    • The present invention relates to a composition for cancer diagnosis having a formulation for measuring the expression level of Chromosome 10 open reading frame 81 (C10orf81) gene mRNA or protein thereof, a kit for cancer diagnosis having the composition, a method for providing information on cancer diagnosis including a step for measuring the expression level of C10orf81 gene mRNA or the expression level of protein coded by the gene, and a method for screening pharmaceutical compositions for the prevention or the treatment of cancer including an expression inhibitor for the C10orf81 gene or an activity inhibitor for the protein thereof, and therapeutic agents for cancer. The present invention enables an accurate diagnosis of cancer by providing genes specific to stomach cancer, liver cancer, colorectal cancer, lung cancer, or prostate cancer, and diagnostic markers for determining the metastasis and prognosis of the cancer, and can be useful in the diagnosis and prognosis management of cancer. Also, the present invention enables the development of new bio-medicines having fewer side effects and customized anticancer drugs by providing a cancer-specific therapeutic agent capable of inhibiting the gene.
    • 本发明涉及用于癌症诊断的组合物,其具有用于测量染色体10开放阅读框81(C10orf81)基因mRNA或其蛋白质的表达水平的制剂,具有该组成的癌症诊断用试剂盒,提供癌症信息的方法 诊断包括测量C10orf81基因mRNA的表达水平的步骤或由该基因编码的蛋白质的表达水平的步骤,以及用于筛选用于预防或治疗癌症的药物组合物的方法,包括用于C10orf81基因的表达抑制剂或活性 其蛋白质的抑制剂和癌症治疗剂。 本发明能够通过提供对胃癌,肝癌,结肠直肠癌,肺癌或前列腺癌特异性的基因和用于确定癌症的转移和预后的诊断标记物来准确诊断癌症,并且可用于诊断 和癌症的预后管理。 此外,通过提供能够抑制该基因的癌症特异性治疗剂,本发明能够开发副作用较少的新生物药物和定制的抗癌药物。
    • 3. 发明申请
    • KIT FOR DIAGNOSING COLORECTAL CANCER AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF COLORECTAL CANCER
    • 用于诊断颜色性癌症和药物组合物的工具包,用于预防或治疗色素性癌症
    • WO2012011777A2
    • 2012-01-26
    • PCT/KR2011005431
    • 2011-07-22
    • KOREA RES INST OF BIOSCIENCECHUNG KYUNG SOOKWON MI SUNKIM YOUNG JOOSONG EUN YOUNGAHN JI WONYEOM YOUNG ILLEE HEE GUJANG YEO-JIN
    • CHUNG KYUNG SOOKWON MI SUNKIM YOUNG JOOSONG EUN YOUNGAHN JI WONYEOM YOUNG ILLEE HEE GUJANG YEO-JIN
    • C12Q1/68A61P35/00C12N15/12G01N33/574
    • G01N33/57419C12Q1/6886C12Q2600/106C12Q2600/158
    • The present invention relates to: a composition for diagnosing colorectal cancer containing a formulation for measuring the expression level of a chromosome 1 open reading frame 135 (C1orf135) gene mRNA or the protein thereof; a kit for diagnosing colorectal cancer containing the composition; a method for providing information on diagnosis of colorectal cancer, the method comprising a step for measuring the expression level of a C1orf135 gene mRNA or the expression level of the protein coded by the gene; a pharmaceutical composition for the prevention or the treatment of colorectal cancer, the composition comprising an expression inhibitor for a C1orf135 gene or an activity inhibitor for the protein thereof; and a method for screening a therapeutic agent for colorectal cancer. The present invention enables the accurate diagnosis of colorectal cancer by providing a gene specific to colorectal cancer, and a diagnostic marker for determining the metastasis and prognosis of colorectal cancer, and can be useful in the diagnosis and prognosis management of colorectal cancer. Also, the present invention enables the development of new bio-medicines having fewer side effects and customized anticancer drugs by providing a colorectal cancer-specific therapeutic agent capable of inhibiting the gene.
    • 本发明涉及:用于诊断结肠直肠癌的组合物,其含有用于测量染色体1开放阅读框135(C1orf135)基因mRNA或其蛋白质的表达水平的制剂; 用于诊断含有该组合物的结肠直肠癌的试剂盒; 提供关于结肠直肠癌诊断的信息的方法,所述方法包括测定C1orf135基因mRNA的表达水平或由所述基因编码的蛋白质的表达水平的步骤。 用于预防或治疗结肠直肠癌的药物组合物,所述组合物包含C1orf135基因的表达抑制剂或其蛋白质的活性抑制剂; 以及筛选结直肠癌治疗剂的方法。 本发明能够通过提供对结肠直肠癌特异性的基因和用于确定结肠直肠癌的转移和预后的诊断标记物来准确诊断结肠直肠癌,并且可用于结肠直肠癌的诊断和预后管理。 此外,通过提供能够抑制该基因的结肠直肠癌特异性治疗剂,本发明使得能够开发具有较少副作用的新生物药物和定制的抗癌药物。
    • 5. 发明授权
    • THE FINDING METHOD OF NEW DISEASE-ASSOCIATED GENES THROUGH ANALYSIS OF PROTEIN-PROTEIN INTERACTION NETWORK
    • 通过分析蛋白质 - 蛋白质相互作用网络的新疾病相关基因的发现方法
    • KR100692319B1
    • 2007-03-02
    • KR20060016120
    • 2006-02-20
    • KOREA RES INST OF BIOSCIENCE
    • KIM YOUNG JOOHWANG SO HYUNSON SEUNG WOOKIM SANG CHEOLJEONG HA WOONGYOON YOO SIKLEE DO HEON
    • C12Q1/68C12Q1/00
    • C12Q1/6811G06F19/18
    • A method for finding new disease-related genes is provided to select the genes related to the new disease through statistical and physical network analysis by generating protein-protein interaction network from well known disease genes and disease related literature information, gene expression information and protein interaction information. The method comprises the steps of: (a) selecting a candidate gene from document information data relating to disease-related genes; (b) identifying normality from test data of the disease-related genes' expression information provided by Online Mendelian In Man(OMIM) to select a candidate gene from significant data; (c) generating protein interaction network between the candidate genes selected from the steps(a) and (b) and protein from protein interaction information data which is Human protein reference database(HPRD); (d) analyzing nodes of the protein interaction network; and (e) making the analysis result to be scored to select disease-related genes.
    • 提供了一种寻找新的疾病相关基因的方法,通过统计和物理网络分析,通过从众所周知的疾病基因和疾病相关文献信息,基因表达信息和蛋白质相互作用产生蛋白质 - 蛋白质相互作用网络来选择与新疾病相关的基因 信息。 该方法包括以下步骤:(a)从涉及疾病相关基因的文献信息数据中选择候选基因; (b)从在线孟德尔人(OMIM)提供的疾病相关基因表达信息的测试数据中识别正常性,从重要数据中选择候选基因; (c)在选自步骤(a)和(b)的候选基因和蛋白质相互作用信息数据(即人蛋白质参考数据库(HPRD))之间产生蛋白质相互作用网络; (d)分析蛋白质相互作用网络的节点; 和(e)使分析结果进行评分以选择疾病相关基因。
    • 8. 发明授权
    • 연속 합성거더교용 프리스트레스트 콘크리트 거더를 이용한 연속 합성거더교의 시공 방법
    • 用于连续复合钢丝绳桥梁的预制混凝土梁及其构造方法
    • KR101578637B1
    • 2015-12-17
    • KR20150077785
    • 2015-06-02
    • KIM YOUNG JOO
    • KIM YOUNG JOO
    • E01D2/00E01D21/00
    • 본발명은연속합성거더교용프리스트레스트콘크리트거더및 이를이용한연속합성거더교의시공방법에관한것으로서, 더욱상세하게는프리캐스트 PSC 거더들을교대및 교각등의하부구조위에설치하고바닥판을시공하기전에교각상의연속부에서거더를현장타설콘크리트로이음하고텐던을사용하여연속화를하는거더연속화시공방법에있어서연속화된거더의정모멘트작용부와부모멘트작용부의텐던을다르게구성하여구조적으로매우효율적이며긴장작업도용이하고다경간연속교에도적합한연속합성거더교용프리스트레스트콘크리트거더및 이를이용한연속합성거더교의시공방법에관한것이다. 본발명은, 프리캐스트프리스트레스트콘크리트거더들을교대및 교각등의하부구조위에설치하고바닥판을시공하기전에교각상의거더연속부에서거더를현장타설콘크리트로이음하고텐던을사용하여연속화를하는거더연속화시공방법에있어서, 연속거더의양단부에배치되는측경간용거더와상기측경간용거더의사이에배치되는중앙경간용거더를포함(중앙경간용거더는거더의수가 3개이상인경우에만포함)하며연속합성거더교에사용되는프리스트레스트콘크리트거더에있어서, 거더연속화이후에연속거더에작용하는사하중들에의한작용휨모멘트의부호가변하는변곡점주변(측경간용거더의본체에는교대로부터먼 단부쪽에위치하고, 중앙경간용거더본체에는양 단부쪽에하나씩한 쌍이존재함)에형성되는중간정착부를포함하며, 일방향으로길게제작되는철근콘크리트재질의본체; 상기본체의양단부에각각마련되는제1정착구와, 상기한 쌍의제1정착구를연결하며어느하나의제1정착구로부터본체의중앙까지는점차적으로아래로내려가다가본체의중앙부로부터다른하나의제1정착구까지는점차적으로위로올라가는곡선형상으로배치되는제1쉬스관과, 상기제1쉬스관에삽입되며인장력이가해진상태로양단부가상기한 쌍의제1정착구에각각정착되는제1텐던을포함하는제1프리스트레싱유닛; 상기측경간용거더본체의경우중간정착부로부터먼쪽의단부와상기중간정착부의에각각마련되고, 상기중앙경간용거더본체의경우상기한 쌍의중간정착부에각각마련되는제2정착구와, 상기한 쌍의제2정착구를연결하며곡선형상으로배치되는제2쉬스관과, 상기제2쉬스관에삽입되며인장력이가해진상태로양단부가상기한 쌍의제2정착구에각각정착되는제2텐던을포함하는제2프리스트레싱유닛; 서로인접한한 쌍의본체의서로접하는단부와가까이위치한한 쌍의중간정착부에각각마련되는제3정착구와, 상기한 쌍의제3정착구를연결하며곡선형상으로배치되되양단부의일정길이만큼은상기제2텐던과겹치도록배치되는제3쉬스관과, 상기제3쉬스관에삽입되며인장력이가해진상태로양단부가상기한 쌍의제3정착구에각각정착되는제3텐던을포함하는제3프리스트레싱유닛;을포함하는것을특징으로하는연속합성거더교용프리스트레스트콘크리트거더를제공한다.
    • 本发明涉及一种使用连续复合梁桥的预应力混凝土梁的连续复合梁桥的施工方法,更具体地说,涉及一种使用连续复合梁预应力混凝土梁的连续复合梁桥的施工方法 桥梁,其能够通过在下部结构(例如桥台和码头)上安装预制PSC梁并使用现浇混凝土将梁连接到码头的延续部分,使用腱延伸 底板结构。 因此,本发明通过使用彼此不同的正矩施加部分和连续梁的负矩施加部分的腱来提高结构效率,促进张力作用,并且适用于多跨连续桥梁 。
    • 10. 发明授权
    • COMPOSITION OF CEMENT MORTAR FOR REINFORCING OF SECTION AND METHOD OF USING THEREOF
    • 用于加固部分的水泥浆的组合物及其使用方法
    • KR100913255B1
    • 2009-08-24
    • KR20090042097
    • 2009-05-14
    • KIM YOUNG JOOKNIX CORPTAE KYUNG DEV CO LTD
    • KIM YOUNG JOO
    • C04B24/04C04B16/04C04B16/06C04B24/38
    • C04B28/06C04B2111/723C04B7/02C04B14/06C04B20/0048C04B22/00C04B22/04C04B24/24C04B38/02C04B2103/40C04B2103/65
    • The cement mortar composition for the cross section enforcement is provided to improve the mechanical and chemical strength corresponding to the impairing factor. The cement mortar composition comprises the Portland cement of 20~40 wt%, the inorganic expander of 3~10 wt%, the alumina cement of 5~30 wt%, the silica of 35~60 wt%, the zirconium(Zr) of 3~8 wt%, the fiber of 0.2~2.5 wt%, the polymer of 0.5~5.0 wt%, the reactivity control liquid of 0.3~2.0 wt%, the water repellent of 0.1~1.0 wt% and the surfactant of 0.3~2.0 wt%. The surfactant is one selected from the melamine system, the naphthalene system, and the carboxyl system. The fiber is selected from the nylon, polypropylene acryl, acryl amide, cellulose, PVA, and the steel. The reactivity control liquid is selected from the citric acid, sodium gluconate, tartaric acid, fluoride, methyl cellulose, ethylcellulose and the boric acid.
    • 提供了用于横截面实施的水泥砂浆组合物,以改善与损伤因素相对应的机械和化学强度。 水泥砂浆组成包括20〜40重量%的波特兰水泥,3〜10重量%的无机膨胀剂,5〜30重量%的氧化铝水泥,35〜60重量%的二氧化硅,锆(Zr) 3〜8重量%,纤维为0.2〜2.5重量%,聚合物为0.5〜5.0重量%,反应性控制液为0.3〜2.0重量%,防水性为0.1〜1.0重量%,表面活性剂为0.3〜 2.0重量%。 表面活性剂选自三聚氰胺体系,萘体系和羧基体系。 纤维选自尼龙,聚丙烯丙烯酸,丙烯酰胺,纤维素,PVA和钢。 反应性控制液体选自柠檬酸,葡萄糖酸钠,酒石酸,氟化物,甲基纤维素,乙基纤维素和硼酸。