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1. 发明申请

WO2011065677A3 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER 审中-公开
标题翻译：治疗癌症的药物组合物
公开(公告)号：WO2011065677A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007600
申请日：2010-11-01
申请人： KOREA RES INST OF BIOSCIENCE , WON MISUN , CHUNG KYUNG-SOOK , KIM YOUNG JOO , HONG HYE KYUNG , YEOM YOUNG IL , YUN CHAE OK , OH YU KYUNG , SONG KYUNG BIN , LEE HEE GU , SONG EUN YOUNG , KIM YOUNG HO , KIM MOON HEE , JUNG KYEONG-EUN
发明人： WON MISUN , CHUNG KYUNG-SOOK , KIM YOUNG JOO , HONG HYE KYUNG , YEOM YOUNG IL , YUN CHAE OK , OH YU KYUNG , SONG KYUNG BIN , LEE HEE GU , SONG EUN YOUNG , KIM YOUNG HO , KIM MOON HEE , JUNG KYEONG-EUN
IPC分类号： A61K31/7105 , A61K31/711 , A61P35/00
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/711 , A61K31/713 , C12N2310/531
摘要： The present invention provides a pharmaceutical composition for treating cancer, comprising at least one selected from deoxyribonucleic acids (DNA) for encoding small interfering RNA (siRNA) which complementarily binds to the base sequence of the transcript (mRNA transcript) of the FLJ25416 gene, represented by sequence number 3, sequence number 5, and sequence number 7 to inhibit the intracellular expression of the FLJ25416 gene, antisense RNA which inhibits expression of the FLJ25416 gene, and short hairpin RNA (shRNA) which inhibits expression of the FLJ25416 gene. As the siRNA, which is complementary to the base sequence of the transcript (mRNA transcript) of the FLJ25416 gene, the antisense RNA, and the shRNA, according to the present invention, inhibit expression of the FLJ25416 gene which is known to be expressed in cancer cells, and thus kill cancer cells, the composition of the present invention can be used as a novel anti-cancer agent.
摘要翻译：本发明提供用于治疗癌症的药物组合物，其包含选自用于编码与FLJ25416基因的转录物（mRNA转录物）的碱基序列互补结合的小干扰RNA（siRNA）的脱氧核糖核酸（DNA）中的至少一种，序列号3，序列号5和序列号7以抑制FLJ25416基因的细胞内表达，抑制FLJ25416基因表达的反义RNA和抑制FLJ25416基因表达的短发夹RNA（shRNA）。由于本发明的与FLJ25416基因，反义RNA和shRNA的转录物（mRNA转录物）的碱基序列互补的siRNA抑制已知表达癌细胞，从而杀死癌细胞，本发明的组合物可以用作新型的抗癌剂。

2. 发明申请

WO2009072831A3 NOVEL USE OF FLJ25416 GENE 审中-公开
标题翻译： FLJ25416基因的新用途
公开(公告)号：WO2009072831A3
公开(公告)日：2009-08-20
申请号：PCT/KR2008007196
申请日：2008-12-05
申请人： KOREA RES INST OF BIOSCIENCE , SAMCHULLY PHARM CO LTD , WON MISUN , CHUNG KYUNG-SOOK , KIM YOUNG-JOO , CHOI SHIN-JUNG , YEOM YOUNG IL , KIM SEON-YOUNG , SONG KYUNG BIN , LEE HEE GU , SONG EUN YOUNG , KIM YOUNG HO , CHUN HO KYUNG , YUN CHAE-OK , KIM MOON HEE , JUNG KYEONG-EUN , CHO SUN-JUNG
发明人： WON MISUN , CHUNG KYUNG-SOOK , KIM YOUNG-JOO , CHOI SHIN-JUNG , YEOM YOUNG IL , KIM SEON-YOUNG , SONG KYUNG BIN , LEE HEE GU , SONG EUN YOUNG , KIM YOUNG HO , CHUN HO KYUNG , YUN CHAE-OK , KIM MOON HEE , JUNG KYEONG-EUN , CHO SUN-JUNG
IPC分类号： A61K38/17 , A61P35/00
CPC分类号： G01N33/57484 , A61K31/7088 , A61K38/1709 , C12N15/1135 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2710/10343 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2500/04
摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.
摘要翻译：本发明提供了用于诊断癌症或筛选包含FLJ25416基因或针对由FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，所述组合物包含所述基因的抑制剂或由所述基因表达的蛋白质的抑制剂和药学上可接受的载体以及用于诊断癌症的试剂盒，其包含FLJ25416基因和由FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特定癌细胞中高水平表达，并诱导正常细胞增殖速率增加。该基因的表达被抑制，这导致对癌细胞生长的抑制作用。因此，FLJ25416基因可以用作诊断或治疗癌症的靶基因。

3. 发明申请

WO2010067969A3 NOVEL USE OF THE LOC284422 GENE 审中-公开
标题翻译： LOC284422基因的新用途
公开(公告)号：WO2010067969A3
公开(公告)日：2010-09-23
申请号：PCT/KR2009006832
申请日：2009-11-19
申请人： KOREA RES INST OF BIOSCIENCE , WON MISUN , CHUNG KYUNG-SOOK , CHO SUN-JUNG , CHOI SHIN-JUNG , YEOM YOUNG IL , KIM SEON-YOUNG , SONG KYUNG BIN , LEE HEE GU , SONG EUN YOUNG , KIM YOUNG HO , CHUN HO KYUNG , KIM MOON HEE , JUNG KYEONG-EUN , OH YU-KYOUNG
发明人： WON MISUN , CHUNG KYUNG-SOOK , CHO SUN-JUNG , CHOI SHIN-JUNG , YEOM YOUNG IL , KIM SEON-YOUNG , SONG KYUNG BIN , LEE HEE GU , SONG EUN YOUNG , KIM YOUNG HO , CHUN HO KYUNG , KIM MOON HEE , JUNG KYEONG-EUN , OH YU-KYOUNG
IPC分类号： C12N15/12 , C12N15/10 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4748 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , G01N33/57484 , G01N2500/00
摘要： The present invention provides a composition for cancer diagnosis or anti-cancer drug screening containing the LOC284422 gene or an antibody against the proteins expressed by LOC284422 gene, to a cancer treatment composition containing an inhibitor for said gene, an inhibitor for the proteins expressed by said gene, and a pharmaceutically acceptable carrier, and to a kit for cancer diagnosis containing the LOC284422 gene or one or more of the proteins expressed by the LOC284422 gene. The LOC284422 gene of the present invention is largely expressed in cancer cells, and increases the growth speed of normal cells. Therefore, the inhibition of the expression of this gene leads to the inhibition of the growth of cancer cells. Accordingly, the LOC284422 gene can be used as a target gene for the diagnosis of therapeutic agents for different types of cancer.
摘要翻译：本发明提供了含有LOC284422基因或针对由LOC284422基因表达的蛋白质的抗体的癌症诊断或抗癌药物筛选的组合物，其含有所述基因的抑制剂的癌症治疗组合物，所述蛋白质表达的蛋白质抑制剂基因和药学上可接受的载体，以及含有LOC284422基因或LOC284422基因表达的一种或多种蛋白质的癌症诊断试剂盒。本发明的LOC284422基因在癌细胞中大量表达，并且增加正常细胞的生长速度。因此，抑制该基因的表达导致癌细胞生长的抑制。因此，LOC284422基因可用作诊断不同类型癌症治疗剂的靶基因。

4. 发明申请

WO2009131366A3 CDCA5 AS A DIAGNOSIS MARKER AND THERAPEUTIC AGENT FOR GASTRIC CANCER OR COLORECTAL CANCER 审中-公开
标题翻译： CDCA5作为胃癌或色素沉着病的诊断标记和治疗药物
公开(公告)号：WO2009131366A3
公开(公告)日：2010-01-21
申请号：PCT/KR2009002085
申请日：2009-04-21
申请人： KOREA RES INST OF BIOSCIENCE , YEOM YOUNG IL , LEE HEE GU , YOON HYO RAN , KIM JAE WHA , SONG EUN YOUNG , KIM JONG TAE , KIM YOUNG HO , CHUN HO KYUNG , CHUNG KYUNG-SOOK , WON MISUN
发明人： YEOM YOUNG IL , LEE HEE GU , YOON HYO RAN , KIM JAE WHA , SONG EUN YOUNG , KIM JONG TAE , KIM YOUNG HO , CHUN HO KYUNG , CHUNG KYUNG-SOOK , WON MISUN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to bio marker CDCA5 (cell division cycle associated 5) which is specific to gastric cancer or colorectal cancer. More specifically, this invention concerns a composition for diagnosing gastric cancer or colorectal cancer which contains an agent measuring the expression level of CDCA 5, a kit containing the composition, a method for detecting the marker, and a method for screening a therapeutic agent of gastric cancer or colorectal cancer using the marker. In addition, this invention relates to a pharmaceutical composition for preventing and treating cancer, which contains a material inhibiting the expression or activation of CDCA5.
摘要翻译：本发明涉及对胃癌或结肠直肠癌特异性的生物标志物CDCA5（细胞分裂周期相关的5）。更具体地，本发明涉及用于诊断胃癌或结肠直肠癌的组合物，其包含测量CDCA 5的表达水平的试剂，含有该组合物的试剂盒，用于检测标记物的方法，以及筛选胃癌治疗剂的方法使用标记的癌症或结肠直肠癌。此外，本发明涉及用于预防和治疗癌症的药物组合物，其含有抑制CDCA5表达或活化的材料。

5. 发明公开

KR20100121949A Biomarkers indicative of colon cancer and metastasis and diagnosis and screening therapeutics using the same 无效
标题翻译：生物标志物指示结肠癌和METASTASIS和诊断和筛选治疗方法
公开(公告)号：KR20100121949A
公开(公告)日：2010-11-19
申请号：KR20090040902
申请日：2009-05-11
申请人： KOREA RES INST OF BIOSCIENCE
发明人： LEE HEE GU , SONG EUN YOUNG , YEOM YOUNG IL , KIM SEON YOUNG , KIM YOUNG HO , CHUN HO KYUNG , CHUNG KYUNG SOOK , WON MI SUN , PARK KYUNG CHAN , KIM NAM SOON , KIM YONG SUNG , KWON BYOUNG MOG
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/57419 , C12Q1/6837 , C12Q1/6844 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/53
摘要： PURPOSE: A biomarker for colon cancer and metastasis is provided to accurately diagnose and predict colon cancer or metastasis. CONSTITUTION: A kit for diagnosing or predicting colon cancer or metastasis comprises: a nucleotide sequence of FOSL1, MSLN, AQP9, CBX4, PDCD2L, HRASLS3, DUSP14, OLR1, SLC3A2, MYEOV, DNTTIP1, LEMD1, SERPINA3, EEF1D, REEP6, TREM1, ANKRD22, C19ORF59, CLEC5A, CTSL1, IRF9, ATL3, MARCO, OSCAR or FCN3 or antibody or aptamer which specifically binds to the proteins. The kit is an immunoassay kit. A method for screening a material for preventing or treating colon cancer or metastasis comprises: a step of contacting a sample to cells; a step of measuring expression level of the nucleotide sequence.
摘要翻译：目的：提供结肠癌和转移的生物标志物，以准确诊断和预测结肠癌或转移。构成：用于诊断或预测结肠癌或转移的试剂盒包括：FOSL1，MSLN，AQP9，CBX4，PDCD2L，HRASLS3，DUSP14，OLR1，SLC3A2，MYEOV，DNTTIP1，LEMD1，SERPINA3，EEF1D，REEP6，TREM1， ANKRD22，C19ORF59，CLEC5A，CTSL1，IRF9，ATL3，MARCO，OSCAR或FCN3或与蛋白质特异性结合的抗体或适体。该试剂盒是免疫测定试剂盒。筛选用于预防或治疗结肠癌或转移的材料的方法包括：使样品与细胞接触的步骤; 测量核苷酸序列的表达水平的步骤。

6. 发明专利

AU2003206179A1 An extract of acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug 未知
公开(公告)号：AU2003206179A1
公开(公告)日：2003-09-02
申请号：AU2003206179
申请日：2003-01-24
申请人： KOREA RES INST OF BIOSCIENCE
发明人： KIM YOUNG HO , KIM HANG SUB , LEE JEONG-HYUNG , NAM JEONG BUM , SOHN DONG HWAN , HONG YOUNG SOO , LEE JUNG JOON
IPC分类号： A61K36/25 , A23L1/00 , A61K20060101 , A61K31/715 , A61K36/254 , A61P1/16 , A61P43/00 , A61K35/78
摘要： The disclosure concerns an extract of Acanthopanax koreanum and its use. More particularly, it concerns the extract of Acanthopanax koreanum comprising 1) the extract of Acanthopanax koreanum extracted from water, 2) among the water extract, the extract of Acanthopanax koreanum only containing ethanol insoluble part obtained by precipitating ethanol, 3) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than range of 12,000~14,000, or 4) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than 100,000, which is respectively obtained from the root or stem of Acanthopanax koreanum. The extract of the present invention shows a high inhibitory activity against hepatitis and protects the liver, and thus, can be used for the treatment or prevention of hepatitis, or as a liver protective drug.

7. 发明公开

EP2352053A4 COUPLING METHOD AND STRUCTURE FOR COUPLING UNIT OF RIMLESS EYEGLASSES 审中-公开
标题翻译： KOPPELVERFAHREN UND STRUKTURFÜREINE KOPPELEINHEIT VON RANDLOSEN BRILLEN
公开(公告)号：EP2352053A4
公开(公告)日：2014-08-20
申请号：EP09823733
申请日：2009-03-16
申请人： KIM YOUNG HO
发明人： KIM YOUNG HO
IPC分类号： G02C1/02
CPC分类号： G02C1/02

8. 发明公开

EP2562583A4 STRUCTURE FOR CONNECTING TEMPLE TO EYEGLASS FRAME 审中-公开
标题翻译：结构用于连接手柄，镜头架
公开(公告)号：EP2562583A4
公开(公告)日：2014-01-29
申请号：EP11772224
申请日：2011-04-20
申请人： KIM YOUNG HO
发明人： KIM YOUNG HO
IPC分类号： G02C5/22 , G02C1/06 , G02C5/14 , G02C13/00
CPC分类号： G02C1/06 , G02C5/2209 , G02C5/2254 , G02C2200/04 , G02C2200/06 , G02C2200/12 , G02C2200/22
摘要： The present invention relates to a temple coupling structure for eyeglasses that provides a frame and temples made of titanium, especially, beta titanium having light weight, high hardness, and high frictional force, while the temples are being foldable. The temple coupling structure for eyeglasses includes: a frame made of a beta titanium plate and having lenses fitted thereinto, temples made of a beta titanium plate, and rotating means located between each temple and the frame in such a manner as to allow each temple to be elastically rotated and foldable.

9. 发明公开

EP3121642A4 EYEGLASS FRAME COUPLING STRUCTURE 有权
公开(公告)号：EP3121642A4
公开(公告)日：2017-11-15
申请号：EP15764757
申请日：2015-03-20
申请人： KIM YOUNG HO
发明人： KIM YOUNG HO
IPC分类号： G02C1/08
CPC分类号： G02C1/08
摘要： The present invention relates to an eyeglass frame coupling structure wherein one side of an eyeglass frame, to which a lens is fitted, can be separated into upper and lower parts in such a manner as to be fixedly coupled to each other by means of a screw, while the screw is being not exposed to the front of the eyeglass, thereby providing a good outer appearance and a simple and firm fixing structure capable of easily detachably attaching the lens to the eyeglass frame. The purpose of the present invention is to provide an eyeglass frame coupling structure wherein a fixing screw, which serves to couple or separate a connection portion of a metal eyeglass frame, is not exposed to the front of the eyeglass frame, and the connection portion of the eyeglass frame is separated even when the screw rotates to a small extent such that the screw does not escape from the connection portion of the eyeglass frame, thereby ensuring that a lens is easily fitted to or separated from the eyeglass frame and further guaranteeing that the lens is firmly fixed to the eyeglass frame. In order to accomplish the above purpose, the present invention provides an eyeglass frame coupling structure comprising: a receiving portion (11), a part of an eyeglass frame (10) to which lenses (1) are fitted being separably connected thereto, comprising a connection portion formed on the rear surface of one side of the connection portion of the eyeglass frame (10), a receiving groove (a) formed to be open towards the back, a fixing groove (b) formed on the bottom of the receiving groove (a), and an engaging groove (c) formed on a surface that forms the outer peripheral side wall of the receiving groove (a); a protruding portion (12) comprising a protrusion (d) formed on the rear surface of the other side of the connection portion of the eyeglass frame (10), which abuts the receiving portion (11), so as to be inserted into the receiving portion (11), an engaging step (e) formed to protrude from the outermost peripheral portion of the protrusion (d) to be inserted into the engaging groove (c), and a screw hole (f) formed in the middle of the protrusion (d) in the forward/backward direction so as to communicate with the fixing groove (b); and a fixing screw (13) screw-fastened to the screw hole (f) of the protruding portion (12) such that an end of the fixing screw (13) is inserted into the fixing groove (b) of the receiving portion (11), wherein the fixing screw (13) is not coupled to the receiving portion (11) in a screw fastening type, but is simply inserted into the fixing groove (b), such that coupling is made easy, fastening is completed by fastening the fixing screw (13) to a small extent, and the fixing screw (13) is not exposed to the front of the eyeglass frame (10), thereby providing an aesthetic appearance.

10. 发明公开

EP2832255A4 PUMP SAFETY DEVICE FOR VARIOUS CONTAINERS 审中-公开
标题翻译： PUMP安全装置各种容器
公开(公告)号：EP2832255A4
公开(公告)日：2015-10-28
申请号：EP12872659
申请日：2012-11-13
申请人： KIM YONG JUN , KIM YOUNG HO , KIM BO MI
发明人： KIM YONG JUN , KIM YOUNG HO , KIM BO MI
IPC分类号： A45D34/00 , A47K5/12 , B65D47/34 , B65D83/76
CPC分类号： A47K5/1205 , A45D34/04 , A45D2200/056 , B05B11/3008 , B05B11/3023 , B05B11/3043 , B05B11/3047 , B05B11/3059 , B05B11/3073

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