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    • 1. 发明授权
    • THE FINDING METHOD OF NEW DISEASE-ASSOCIATED GENES THROUGH ANALYSIS OF PROTEIN-PROTEIN INTERACTION NETWORK
    • 通过分析蛋白质 - 蛋白质相互作用网络的新疾病相关基因的发现方法
    • KR100692319B1
    • 2007-03-02
    • KR20060016120
    • 2006-02-20
    • KOREA RES INST OF BIOSCIENCE
    • KIM YOUNG JOOHWANG SO HYUNSON SEUNG WOOKIM SANG CHEOLJEONG HA WOONGYOON YOO SIKLEE DO HEON
    • C12Q1/68C12Q1/00
    • C12Q1/6811G06F19/18
    • A method for finding new disease-related genes is provided to select the genes related to the new disease through statistical and physical network analysis by generating protein-protein interaction network from well known disease genes and disease related literature information, gene expression information and protein interaction information. The method comprises the steps of: (a) selecting a candidate gene from document information data relating to disease-related genes; (b) identifying normality from test data of the disease-related genes' expression information provided by Online Mendelian In Man(OMIM) to select a candidate gene from significant data; (c) generating protein interaction network between the candidate genes selected from the steps(a) and (b) and protein from protein interaction information data which is Human protein reference database(HPRD); (d) analyzing nodes of the protein interaction network; and (e) making the analysis result to be scored to select disease-related genes.
    • 提供了一种寻找新的疾病相关基因的方法,通过统计和物理网络分析,通过从众所周知的疾病基因和疾病相关文献信息,基因表达信息和蛋白质相互作用产生蛋白质 - 蛋白质相互作用网络来选择与新疾病相关的基因 信息。 该方法包括以下步骤:(a)从涉及疾病相关基因的文献信息数据中选择候选基因; (b)从在线孟德尔人(OMIM)提供的疾病相关基因表达信息的测试数据中识别正常性,从重要数据中选择候选基因; (c)在选自步骤(a)和(b)的候选基因和蛋白质相互作用信息数据(即人蛋白质参考数据库(HPRD))之间产生蛋白质相互作用网络; (d)分析蛋白质相互作用网络的节点; 和(e)使分析结果进行评分以选择疾病相关基因。