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1. 发明申请

WO2012080900A1 METHOD AND DEVICE FOR ANALYSING A REGION OF INTEREST IN AN OBJECT USING X-RAYS 审中-公开
标题翻译：用于分析使用X-RAYS的对象中的兴趣区域的方法和装置
公开(公告)号：WO2012080900A1
公开(公告)日：2012-06-21
申请号：PCT/IB2011/055463
申请日：2011-12-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , CARLSEN, Ingwer-Curt , KOEHLER, Thomas , MARTENS, Gerhard , RÖSSL, Ewald , WIEMKER, Rafael
发明人： CARLSEN, Ingwer-Curt , KOEHLER, Thomas , MARTENS, Gerhard , RÖSSL, Ewald , WIEMKER, Rafael
IPC分类号： G01N23/04 , G01N23/20
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3 -dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.
摘要翻译：提出了一种用于分析对象中的感兴趣区域的方法和装置。该方法包括：（a）通过差分相位X射线成像系统提供测量数据，以及（b）分析感兴趣区域中物体的特征。其中，测量数据包括2维或3维像素集合，其中对于每个像素，测量数据包括彼此空间对准的三种类型的图像数据，包括（i）表示图像数据A的吸收，（ii）差分表示图像数据D的相位对比度和（iii）表示图像数据C的相干性。分析步骤基于每个像素，包括在表示图像数据A的吸收中包括的信息中的至少两个信息和差分中包含的信息表示图像数据D的相位对比度和表示图像数据C的相干性中包含的信息。

2. 发明申请

WO2012077014A1 METHOD OF PROVIDING A DISPLAYABLE PIXEL DATA SET FROM MEASUREMENT DATA PROVIDED BY A DIFFERENTIAL PHASE CONTRAST X-RAY IMAGING SYSTEM 审中-公开
标题翻译：通过差分相位X射线成像系统提供的测量数据提供可显示像素数据的方法
公开(公告)号：WO2012077014A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/055305
申请日：2011-11-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WIEMKER, Rafael , CARLSEN, Ingwer-Curt , RÖSSL, Ewald , MARTENS, Gerhard , KOEHLER, Thomas
发明人： WIEMKER, Rafael , CARLSEN, Ingwer-Curt , RÖSSL, Ewald , MARTENS, Gerhard , KOEHLER, Thomas
IPC分类号： G06T11/00
CPC分类号： G06T11/001 , G06T2207/10116
摘要： A method for providing a displayable pixel data set (11) from measurement data (3) provided by a differential phase-contrast X-ray imaging system (1) and a device (7) adapted to perform such method are proposed. The measurement data (3) comprise three types of measurement information: an absorption representing image data set A, a differential phase-contrast representing image data set D and a coherence representing image data set C. Each of the image data sets A, D and C comprises a 2-dimensional or 3-dimensional set of pixels (5) and the three image data sets are spatially aligned with each other. In the method for providing a displayable pixel data set, a colour value corresponding to a position in a 3- dimensional colour space (9) is attributed to each pixel (13) in the displayable pixel data set (11), wherein each of three coordinates HSI of the position in the 3-dimensional colour space (9) is determined based on data values A ij , D ij , C ij of a corresponding pixel (5) in a respective one of the image data sets A, D, C. For example, the coordinates within the colour space (9) may be indicated by an intensity I, a saturation S and a hue H thereby allowing a very intuitive representation of the complex DPCI measurement data to a human observer.
摘要翻译：提出了一种从由差分相位对比度X射线成像系统（1）提供的测量数据（3）和适于执行该方法的装置（7）提供可显示像素数据组（11）的方法。测量数据（3）包括三种类型的测量信息：表示图像数据组A的吸收，表示图像数据组D的差分相位对照和表示图像数据组C的相干。每个图像数据组A，D和 C包括2维或3维像素集合（5），并且三个图像数据集在空间上彼此对准。在提供可显示像素数据集的方法中，与可显示像素数据集合（11）中的每个像素（13）相对应的与三维颜色空间（9）中的位置相对应的颜色值，其中三个基于图像数据组A，D，C的相应一个中的对应像素（5）的数据值A ij，D ij，C ij确定三维颜色空间（9）中的位置的坐标HSI 例如，颜色空间（9）内的坐标可以由强度I，饱和度S和色调H来表示，从而允许对人类观察者的复杂DPCI测量数据的非常直观的表示。

3. 发明申请

WO2010109368A1 DIFFERENTIAL PHASE-CONTRAST IMAGING WITH CIRCULAR GRATINGS 审中-公开
标题翻译：具有圆形光栅的差分相位对比成像
公开(公告)号：WO2010109368A1
公开(公告)日：2010-09-30
申请号：PCT/IB2010/051098
申请日：2010-03-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , ROESSL, Ewald , KOEHLER, Thomas , MARTENS, Gerhard
发明人： ROESSL, Ewald , KOEHLER, Thomas , MARTENS, Gerhard
IPC分类号： A61B6/03 , G01N23/04 , G21K7/00
CPC分类号： G21K7/00 , A61B6/4291 , A61B6/484 , A61B6/502
摘要： The invention relates to an X-ray differential phase-contrast imaging system which has three circular gratings. The circular gratings are aligned with the optical axis of the radiation beam and a phase stepping is performed along the optical axis with the focal spot, the phase grating and/or the absorber grating. The signal measured is the phase-gradient in radial direction away from the optical axis.
摘要翻译：本发明涉及一种具有三个圆形光栅的X射线差分相位对比成像系统。圆形光栅与辐射束的光轴对准，并且沿着光轴与焦斑，相位光栅和/或吸收光栅一起执行相位步进。测量的信号是远离光轴的径向相位梯度。

4. 发明申请

WO2012104751A1 DETECTION VALUES PROCESSING APPARATUS 审中-公开
标题翻译：检测值加工设备
公开(公告)号：WO2012104751A1
公开(公告)日：2012-08-09
申请号：PCT/IB2012/050344
申请日：2012-01-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , PROKSA, Roland , MARTENS, Gerhard
发明人： PROKSA, Roland , MARTENS, Gerhard
IPC分类号： G01N23/04 , G01N23/087 , A61B6/03
CPC分类号： G01N23/04 , A61B6/032 , A61B6/06 , A61B6/4042 , A61B6/4241 , A61B6/5205 , A61B6/5258 , G01N23/046 , G01N2223/419 , G06T11/003
摘要： The invention relates to a detection values processing apparatus. Energy- dependent detection values are provided, which are indicative of polychromatic radiation (4) after having traversed an examination zone (5). The radiation is filtered by a filter (15) which comprises K-edge filter material. A component decomposition technique is applied to the detection values for determining K-edge attenuation values being first component attenuation values, which are indicative of an attenuation caused by the K-edge filter material, and additional component attenuation values, which are indicative of an attenuation caused by additional components of the examination zone, wherein an image of the examination zone is reconstructed from the additional component attenuation values. An image can therefore be reconstructed, which is not adversely affected by the filter, because the K-edge attenuation values are not used for reconstructing the image. This can improve the quality of the reconstructed image.
摘要翻译：本发明涉及一种检测值处理装置。提供依赖于能量的检测值，这些检测值表示穿过检查区域（5）后的多色辐射（4）。辐射由包括K边缘过滤材料的过滤器（15）过滤。分量分解技术被应用于用于确定作为表示由K边缘滤波器材料引起的衰减的第一分量衰减值的K边缘衰减值的检测值以及指示衰减的附加分量衰减值由检查区域的附加组件引起，其中从附加分量衰减值重建检查区域的图像。因此，由于K边缘衰减值不用于重建图像，因此可以重构图像，其不受滤波器的不利影响。这可以提高重建图像的质量。

5. 发明申请

WO2004098649A3 APPARATUS AND METHOD FOR EXAMINING AN OBJECT BY MEANS OF ELASTICALLY SCATTERED X-RAY RADIATION AND CONTRAST AGENT 审中-公开
公开(公告)号：WO2004098649A3
公开(公告)日：2004-11-18
申请号：PCT/IB2004/050579
申请日：2004-05-04
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , SCHLOMKA, Jens-Peter , HARDING, Geoffrey , MARTENS, Gerhard
发明人： SCHLOMKA, Jens-Peter , HARDING, Geoffrey , MARTENS, Gerhard
IPC分类号： A61K49/04
摘要： The invention relates to A contrast agent for application to an examination area of an object that is to be examined, in particular a patient, for an X-ray examination of the examination area by means of X-ray radiation, characterized that the contrast agent comprises scattering particles to form elastically scattered X-rays. By means of the scattering particles, the examination area can be made visible in the detected signal compared to surrounding areas. Furthermore, the invention relates to a method of examining an object, in particular a patient, by means of elastically scattered X-ray radiation as claimed in claim 9, a method of producing a contrast agent as claimed in claim 12, and an apparatus for examining an object by means of elastically scattered x-ray radiation as claimed in claim 15.

6. 发明申请

WO2004078043A1 METHOD AND IMAGING SYSTEM FOR IMAGING THE SPATIAL DISTRIBUTION OF AN X-RAY FLUORESCENCE MARKER 审中-公开
标题翻译：用于成像X射线荧光标记的空间分布的方法和成像系统
公开(公告)号：WO2004078043A1
公开(公告)日：2004-09-16
申请号：PCT/IB2004/000543
申请日：2004-03-02
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , HARDING, Geoffrey , SCHLOMKA, Jens-Peter , MARTENS, Gerhard
发明人： HARDING, Geoffrey , SCHLOMKA, Jens-Peter , MARTENS, Gerhard
IPC分类号： A61B6/00
CPC分类号： A61B6/485 , A61B6/00 , A61B6/4092 , G01N23/223 , G01N2223/076
摘要： The invention describes a method of generating metabolic images of an investigation region (3) of a body (1) by irradiating an X-ray fluorescence marker in that region and detecting the resulting X-ray fluorescence with a fluorescence detector (30). A fan beam (12) is used as a source of primary X-radiation, thus allowing the scanning of a whole body slice (3) in one step. The fluorescence image may be directly measured, e.g. by mapping voxels (104) of the investigation region onto pixels (134) of the detector (130) with the help of a pinhole collimator (132), or it may be reconstructed by procedures of computed tomography. Moreover, a morphological image may be generated by simultaneously recording X-ray transmission through the body (1).
摘要翻译：本发明描述了通过在该区域中照射X射线荧光标记物并用荧光检测器（30）检测所得到的X射线荧光来产生身体（1）的调查区域（3）的代谢图像的方法。风扇光束（12）被用作初级X辐射源，从而允许在一个步骤中扫描全身切片（3）。可以直接测量荧光图像，例如，通过借助于针孔准直器（132）将调查区域的体素（104）映射到检测器（130）的像素（134）上，或者可以通过计算机断层摄影的程序来重构。此外，可以通过同时记录穿过身体（1）的X射线透射来产生形态学图像。

7. 发明申请

WO2005083406A1 DEVICE AND METHOD FOR MAPPING THE DISTRIBUTION OF AN X-RAY FLUORESCENCE MARKER 审中-公开
标题翻译：用于映射X射线荧光标记分布的装置和方法
公开(公告)号：WO2005083406A1
公开(公告)日：2005-09-09
申请号：PCT/IB2005/050535
申请日：2005-02-11
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , HARDING, Geoffrey , MARTENS, Gerhard , BARSCHDORF, Hans , SCHWEIZER, Bernd
发明人： HARDING, Geoffrey , MARTENS, Gerhard , BARSCHDORF, Hans , SCHWEIZER, Bernd
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , G01N2223/076 , G01N2223/0766
摘要： The invention relates to a method and a device for determining the distribution of an X-ray fluorescence (XRF) marker (16) in a body volume (14). The body volume (14) is irradiated with a beam of rays (12) from an X-ray source (10) with a first ray component with a quantum energy just above and a second ray component with a quantum energy just below the K-edge of the XRF marker (16). Secondary radiation emitted from the body volume (14) is detected in a location-resolved way by a detector (30). To separate the X-ray fluorescence components in the secondary radiation from background radiation, the body volume is irradiated for a second time with a beam of rays from which the first ray component has been substantially removed by a filter (22) made from the material of the XRF marker.
摘要翻译：本发明涉及一种用于确定身体体积（14）中的X射线荧光（XRF）标记物（16）的分布的方法和装置。用来自X射线源（10）的射线束（12）照射具有刚好在上面的量子能的第一射线分量的体积（14），并且具有刚好低于K值的量子能量的第二射线分量，边缘的XRF标记（16）。通过检测器（30）以位置分辨的方式检测从体积（14）发射的次级辐射。为了将二次辐射中的X射线荧光成分从背景辐射中分离出来，用第一射线成分基本上被该材料制成的过滤器（22）除去的射线束照射体积第二次的XRF标记。

8. 发明公开

EP2410921A1 DIFFERENTIAL PHASE-CONTRAST IMAGING WITH CIRCULAR GRATINGS 审中-公开
标题翻译：差异相同的苦参蛋白苦参
公开(公告)号：EP2410921A1
公开(公告)日：2012-02-01
申请号：EP10710906.8
申请日：2010-03-15
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： ROESSL, Ewald , KOEHLER, Thomas , MARTENS, Gerhard
IPC分类号： A61B6/03 , G01N23/04 , G21K7/00
CPC分类号： G21K7/00 , A61B6/4291 , A61B6/484 , A61B6/502
摘要： The invention relates to an X-ray differential phase-contrast imaging system which has three circular gratings. The circular gratings are aligned with the optical axis of the radiation beam and a phase stepping is performed along the optical axis with the focal spot, the phase grating and/or the absorber grating. The signal measured is the phase-gradient in radial direction away from the optical axis.
摘要翻译： X射线差分相位对比成像系统具有三个圆形光栅。圆形光栅与辐射束的光轴对准，并且沿着光轴与焦点，相位光栅和/或吸收器光栅执行相位步进。测量的信号是远离光轴的径向相位梯度。

9. 发明公开

EP2509503A1 APPARATUS FOR PHASE-CONTRAST IMAGING COMPRISING A DISPLACEABLE X-RAY DETECTOR ELEMENT AND METHOD 失效转让
标题翻译：设备技术采用了侧滑射线探测器元件和方法相衬成像
公开(公告)号：EP2509503A1
公开(公告)日：2012-10-17
申请号：EP10807374.3
申请日：2010-12-03
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： ROESSL, Ewald , ENGEL, Klaus J. , VOGTMEIER, Gereon , GELLER, Dieter , MARTENS, Gerhard , KOEHLER, Thomas , SCHUSSER, Sebastian, Siegmund
IPC分类号： A61B6/00 , G01N23/04
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4021 , A61B6/4092 , A61B6/4291 , A61B6/484
摘要： The present invention relates to X-ray image acquisition technology in general. Employing phase-contrast imaging for X-ray image acquisition may significantly enhance the quality and information content of images acquired. However, phase- contrast information may only be obtainable in a small detector region, possibly being too small for a sufficient field of view for specialized X-ray imaging applications. Accordingly, an apparatus for phase-contrast imaging is provided that may allow the acquisition of an enlarged field of view. According to the present invention an apparatus (1) for phase-contrast imaging is provided, comprising an X-ray source (2), an X-ray detector (12) element having a detector size, a beam splitter grating (8) and an analyzer grating (10). An object (6) is arrangeable between the X-ray source (2) and the X-ray detector (12). The beam splitter grating (8) and the analyzer grating (10) are arrangeable between the X-ray source (2) and the X-ray detector (12). X-ray source (2), the beam splitter grating (8), the analyzer grating (10) and the X-ray detector (12) are operatively coupled such that a phase-contrast image of the object (6) is obtainable. The apparatus (1) is adapted for acquiring a phase-contrast image having a field of view larger than the detector size. The X-ray detector element (12) is displaceable and by the displacement of the X-ray detector (12) a phase-contrast image of the field of view is obtainable.
摘要翻译：一种X射线图像采集装置用人相衬成像的视场放大包括X射线源到具有检测器尺寸，分束器光栅和上分析器光栅的X射线检测器元件。一个目的是在X射线源和检测器之间可布置。分束器光栅和分析器光栅是在X射线源和检测器之间可布置。的X射线源，所述射束分裂器光栅，所述分析器光栅和X射线检测器可操作地耦合检查没有所述对象的相位对比图像可获得A. 该装置是配置为获取具有的视野比检测器尺寸大的一个领域，相位对比图像。 X射线检测器元件是可移动的，其中，由X射线检测器的位移，所述视场放大的相位对比图像可获得A.

10. 发明公开

EP2652487A1 METHOD AND DEVICE FOR ANALYSING A REGION OF INTEREST IN AN OBJECT USING X-RAYS 有权
标题翻译：方法和装置相关区域中的对象分析利用X射线
公开(公告)号：EP2652487A1
公开(公告)日：2013-10-23
申请号：EP11805207.5
申请日：2011-12-05
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH
发明人： CARLSEN, Ingwer-Curt , KOEHLER, Thomas , MARTENS, Gerhard , RÖSSL, Ewald , WIEMKER, Rafael
IPC分类号： G01N23/04 , G01N23/20
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3-dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.
摘要翻译：的方法和用于分析的对象中感兴趣区域的装置被提议。该方法包括：（A）由微分相位对比X射线成像系统中提供的测量数据，以及（b）分析在所述感兴趣区域中的对象的特性。在其中，所述测量数据包括二维或三维集合worin为所述测量数据包括三种类型的海誓山盟空间对齐的图像数据的每个像素的像素的，包括：（i）吸收表示图像数据A，（ⅱ）差动相位对比表示图像数据D，和（iii）相干性表示图像数据C的分析步骤是基于针对每个像素，对至少两个在吸收由信息的组合表示图像数据A和信息的鉴别包括相位对比表示代表图像数据C.在相干包括图像数据D和信息

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