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1. 发明申请

WO2012080900A1 METHOD AND DEVICE FOR ANALYSING A REGION OF INTEREST IN AN OBJECT USING X-RAYS 审中-公开
标题翻译：用于分析使用X-RAYS的对象中的兴趣区域的方法和装置
公开(公告)号：WO2012080900A1
公开(公告)日：2012-06-21
申请号：PCT/IB2011/055463
申请日：2011-12-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , CARLSEN, Ingwer-Curt , KOEHLER, Thomas , MARTENS, Gerhard , RÖSSL, Ewald , WIEMKER, Rafael
发明人： CARLSEN, Ingwer-Curt , KOEHLER, Thomas , MARTENS, Gerhard , RÖSSL, Ewald , WIEMKER, Rafael
IPC分类号： G01N23/04 , G01N23/20
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3 -dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.
摘要翻译：提出了一种用于分析对象中的感兴趣区域的方法和装置。该方法包括：（a）通过差分相位X射线成像系统提供测量数据，以及（b）分析感兴趣区域中物体的特征。其中，测量数据包括2维或3维像素集合，其中对于每个像素，测量数据包括彼此空间对准的三种类型的图像数据，包括（i）表示图像数据A的吸收，（ii）差分表示图像数据D的相位对比度和（iii）表示图像数据C的相干性。分析步骤基于每个像素，包括在表示图像数据A的吸收中包括的信息中的至少两个信息和差分中包含的信息表示图像数据D的相位对比度和表示图像数据C的相干性中包含的信息。

2. 发明申请

WO2012077014A1 METHOD OF PROVIDING A DISPLAYABLE PIXEL DATA SET FROM MEASUREMENT DATA PROVIDED BY A DIFFERENTIAL PHASE CONTRAST X-RAY IMAGING SYSTEM 审中-公开
标题翻译：通过差分相位X射线成像系统提供的测量数据提供可显示像素数据的方法
公开(公告)号：WO2012077014A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/055305
申请日：2011-11-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WIEMKER, Rafael , CARLSEN, Ingwer-Curt , RÖSSL, Ewald , MARTENS, Gerhard , KOEHLER, Thomas
发明人： WIEMKER, Rafael , CARLSEN, Ingwer-Curt , RÖSSL, Ewald , MARTENS, Gerhard , KOEHLER, Thomas
IPC分类号： G06T11/00
CPC分类号： G06T11/001 , G06T2207/10116
摘要： A method for providing a displayable pixel data set (11) from measurement data (3) provided by a differential phase-contrast X-ray imaging system (1) and a device (7) adapted to perform such method are proposed. The measurement data (3) comprise three types of measurement information: an absorption representing image data set A, a differential phase-contrast representing image data set D and a coherence representing image data set C. Each of the image data sets A, D and C comprises a 2-dimensional or 3-dimensional set of pixels (5) and the three image data sets are spatially aligned with each other. In the method for providing a displayable pixel data set, a colour value corresponding to a position in a 3- dimensional colour space (9) is attributed to each pixel (13) in the displayable pixel data set (11), wherein each of three coordinates HSI of the position in the 3-dimensional colour space (9) is determined based on data values A ij , D ij , C ij of a corresponding pixel (5) in a respective one of the image data sets A, D, C. For example, the coordinates within the colour space (9) may be indicated by an intensity I, a saturation S and a hue H thereby allowing a very intuitive representation of the complex DPCI measurement data to a human observer.
摘要翻译：提出了一种从由差分相位对比度X射线成像系统（1）提供的测量数据（3）和适于执行该方法的装置（7）提供可显示像素数据组（11）的方法。测量数据（3）包括三种类型的测量信息：表示图像数据组A的吸收，表示图像数据组D的差分相位对照和表示图像数据组C的相干。每个图像数据组A，D和 C包括2维或3维像素集合（5），并且三个图像数据集在空间上彼此对准。在提供可显示像素数据集的方法中，与可显示像素数据集合（11）中的每个像素（13）相对应的与三维颜色空间（9）中的位置相对应的颜色值，其中三个基于图像数据组A，D，C的相应一个中的对应像素（5）的数据值A ij，D ij，C ij确定三维颜色空间（9）中的位置的坐标HSI 例如，颜色空间（9）内的坐标可以由强度I，饱和度S和色调H来表示，从而允许对人类观察者的复杂DPCI测量数据的非常直观的表示。

3. 发明申请

WO2013001471A3 DISPLAYING A PLURALITY OF REGISTERED IMAGES 审中-公开
公开(公告)号：WO2013001471A3
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053259
申请日：2012-06-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
发明人： BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
IPC分类号： G06T7/00 , G06T19/20
摘要： A system for displaying a plurality of registered images is disclosed. A first viewport unit (1) displays a representation of a first image dataset (4) in a first viewport (201). A second viewport unit (2) displays a representation of a second image dataset (5) in a second viewport (202). A position indication unit (7) enables a user to indicate a position in the first dataset (4) displayed in the first viewport (201), to obtain a user-indicated position. A corresponding position determining unit (8) determines a position in the second image dataset (5) corresponding to the user-indicated position, to obtain a corresponding position in the second image dataset (5), based on correspondence information (9) mapping positions in the first image dataset (4) to corresponding positions in the second image dataset (5). The second viewport unit (2) displays an indication of the corresponding position in the second viewport (202).

4. 发明申请

WO2012156862A1 GENERATING A SLICING SCHEME FOR SLICING A SPECIMEN 审中-公开
标题翻译：生成一个样本的SLI方案
公开(公告)号：WO2012156862A1
公开(公告)日：2012-11-22
申请号：PCT/IB2012/052276
申请日：2012-05-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , MEETZ, Kirsten , BERGTHOLDT, Martin , BUELOW, Thomas , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
发明人： MEETZ, Kirsten , BERGTHOLDT, Martin , BUELOW, Thomas , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
IPC分类号： G01N1/06 , A61B10/00 , G06F9/30
CPC分类号： G01N1/31 , A61B10/0041 , G01N1/06 , G01N2001/2873 , G06T7/0012
摘要： A system for generating a slicing scheme for slicing a specimen is disclosed. A parameter unit (1) is arranged for determining at least one parameter of a lesion in a specimen, based on an image dataset (14) representing at least part of the specimen. A slicing scheme unit (2) is arranged for determining a slicing scheme (15) for pathologic examination of the specimen, based on the at least one parameter. A specimen preparation unit (3) is arranged for determining a slicing preparation protocol, based on the image dataset, wherein the slicing preparation protocol comprises a representation of preparation steps relating to the specimen. A segmentation unit (5) is arranged for segmenting the lesion in the image dataset (14), wherein the parameter unit (1) is arranged for determining the at least one parameter, based on the segmented lesion.
摘要翻译：公开了一种用于产生用于切片试样的切片方案的系统。基于表示至少部分样本的图像数据集（14），配置参数单元（1），用于确定样本中病变的至少一个参数。基于所述至少一个参数，设置切片方案单元（2），用于确定用于所述样本的病理检查的切片方案（15）。一种样本制备单元（3），用于基于图像数据集来确定切片制备方案，其中切片制备方案包括与试样有关的准备步骤的表示。分割单元（5）被布置用于分割图像数据集（14）中的病变，其中参数单元（1）被布置用于基于分割的病变确定至少一个参数。

5. 发明申请

WO2012176100A1 SYSTEM AND METHOD FOR PROCESSING A MEDICAL IMAGE 审中-公开
标题翻译：用于处理医学图像的系统和方法
公开(公告)号：WO2012176100A1
公开(公告)日：2012-12-27
申请号：PCT/IB2012/053007
申请日：2012-06-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
发明人： BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
IPC分类号： G06T7/00
CPC分类号： G06F3/04845 , G06F3/0485 , G06T7/10 , G06T2207/20092 , G06T2207/20112
摘要： A system (100) for processing a medical image (102), the system being arranged for establishing a region of interest 104 in the medical image, and the system comprising segmentation means (120) for applying a plurality of different segmentation methods (124) to the region of interest for obtaining an associated plurality of segmentation results (122), visualization means (140) for simultaneously displaying the plurality of segmentation results to a user, and a user input (160) for receiving from the user a selection command (162) indicative of a selection of one of the plurality of segmentation results for establishing an associated one of the plurality of different segmentation methods as a selected segmentation method (164).
摘要翻译：一种用于处理医学图像（102）的系统（100），所述系统被布置成用于在医学图像中建立感兴趣区域104，并且所述系统包括用于应用多个不同分割方法（124）的分割装置（120）到用于获得相关联的多个分割结果（122）的感兴趣区域，用于将多个分割结果同时显示给用户的可视化装置（140）和用户输入（160），用于从用户接收选择命令 162），其指示所述多个分割结果之一的选择，用于建立所述多个不同分割方法中的相关联的分割方法作为选择的分割方法（164）。

6. 发明申请

WO2012069990A1 IMAGE PROCESSING APPARATUS 审中-公开
标题翻译：图像处理设备
公开(公告)号：WO2012069990A1
公开(公告)日：2012-05-31
申请号：PCT/IB2011/055232
申请日：2011-11-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WIEMKER, Rafael , BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt
发明人： WIEMKER, Rafael , BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt
IPC分类号： G06T11/00
CPC分类号： G06T11/60 , G06T11/00
摘要： Image processing apparatus (100) for creating an overlaid presentation of a first input image (101) and a second input image (102) in an output image (108), the first input image comprising input values, the output image comprising vectors of output values, the vectors of output values representing colors of the output image, and the apparatus comprising an input (110) for obtaining the first input image and the second input image, a rendering unit (140) configured for rendering the first input image in the output image by using a first mapping function for representing the input values in the vectors of output values, a predictor (120) configured for predicting the second input image from the first input image for obtaining a predicted second input image (104), a residual calculator (130) configured for calculating a residual image (106) from the second input image and the predicted second input image, the residual image comprising residual values representing prediction errors of the predicted second input image, and the rendering unit being further configured for rendering the residual image in the output image by using a second mapping function for representing the residual values in the vectors of output values, the second mapping function being different from the first mapping function for distinguishing the residual image from the first input image.
摘要翻译：用于在输出图像（108）中创建第一输入图像（101）和第二输入图像（102）的叠加呈现的图像处理装置（100），所述第一输入图像包括输入值，所述输出图像包括输出矢量值，表示输出图像的颜色的输出值的矢量，以及包括用于获得第一输入图像和第二输入图像的输入（110）的装置，被配置为将第一输入图像呈现在通过使用用于表示输出值的向量中的输入值的第一映射函数来输出图像;预测器（120），被配置为从第一输入图像预测第二输入图像以获得预测的第二输入图像（104），剩余计算器（130），被配置为从所述第二输入图像和所述预测的第二输入图像计算残差图像（106），所述残差图像包括表示所述第二输入图像的预测误差的残差值预测的第二输入图像，并且再现单元还被配置为通过使用用于表示输出值的向量中的残差的第二映射函数来渲染输出图像中的残差图像，第二映射函数不同于第一映射函数用于区分残留图像与第一输入图像。

7. 发明申请

WO2007054864A1 A METHOD, A SYSTEM AND A COMPUTER PROGRAM FOR VOLUMETRIC REGISTRATION 审中-公开
标题翻译：一种用于体积注册的方法，系统和计算机程序
公开(公告)号：WO2007054864A1
公开(公告)日：2007-05-18
申请号：PCT/IB2006/054078
申请日：2006-11-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , CARLSEN, Ingwer-Curt , NETSCH, Thomas , BYSTROV, Daniel
发明人： CARLSEN, Ingwer-Curt , NETSCH, Thomas , BYSTROV, Daniel
IPC分类号： G06T3/00 , G06T7/00
CPC分类号： G06T3/0081 , G06T7/35 , G06T7/38 , G06T2207/30004
摘要： The invention relates to a method for volumetric registration of a floating image with a reference image. At step 2' a floating image and a reference image are accessed. At step 4 and at step 6 a transformation function T and a similarity function (S) are accessed. The method according to the invention uses a-priori knowledge, notably a restricted parameter set, which is accessed at step 3. Preferably, the restricted parameter set is obtained by performing a suitable volumetric registration of a set of training images. The training set preferably comprises a sequence of floating images and reference images for each clinical application. Likewise, the training set may be composed of images of a patient group representing a certain group of disease, age, gender, race, etc. The invention further relates to a system and a computer program for enabling volumetric registration.
摘要翻译：本发明涉及一种浮动图像与参考图像的体积配准的方法。在步骤2'中，访问浮动图像和参考图像。在步骤4和步骤6，访问变换函数T和相似度函数（S）。根据本发明的方法使用在步骤3访问的先验知识，特别是限制参数集合。优选地，通过执行一组训练图像的合适的体积登记来获得受限参数集。训练集优选地包括用于每个临床应用的浮动图像和参考图像的序列。类似地，训练集可以由代表某一组疾病，年龄，性别，种族等的患者群体的图像组成。本发明还涉及用于启用体积登记的系统和计算机程序。

8. 发明申请

WO2007072451A2 ADAPTIVE POINT-BASED ELASTIC IMAGE REGISTRATION 审中-公开
标题翻译：自适应点弹性图像注册
公开(公告)号：WO2007072451A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054991
申请日：2006-12-21
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , FRANZ, Astrid , CARLSEN, Ingwer-Curt
发明人： FRANZ, Astrid , CARLSEN, Ingwer-Curt
IPC分类号： G06T7/00
CPC分类号： G06K9/6211 , G06K9/32 , G06T7/33
摘要： A point-based elastic registration method for registering a first image and a second image. A number of prominent feature are identified within the first image using a SIFT algorithm (S1). Then, a single control point is placed (S2) with the source image region at the most prominent SIFT feature and optimal parameter settings in respect thereof are determined (S3) for performing elastic deformation (S4) in respect of the first image so as to optimise a similarity measure. Additional control points are then added (S6) one-by-one at the next most prominent SIFT features, and the elastic deformation process repeated each time (S8) in respect of the new control point set, until a predetermined stopping criterion is met, e.g. the resultant improvement in the similarity measure no longer exceeds some predetermined threshold value. Thus, a high speed, high quality registration method is provided without having to specify the number of control points initially.
摘要翻译：一种用于登记第一图像和第二图像的基于点的弹性登记方法。使用SIFT算法在第一图像内识别出许多突出特征（S1）。然后，放置单个控制点（S2），源图像区域处于最突出的SIFT特征，并且确定相对于第一图像执行弹性变形（S4）的最佳参数设置（S3），以便优化相似性度量。然后在下一个最突出的SIFT特征中逐个添加附加的控制点（S6），并且相对于新的控制点集合每次重复（S8）弹性变形过程，直到满足预定的停止标准，例如所得到的相似性度量的改善不再超过某个预定阈值。因此，提供高速，高质量的登记方法，而不必首先指定控制点的数量。

9. 发明申请

WO2007054907A1 ADAPTIVE POINT-BASED ELASTIC IMAGE REGISTRATION 审中-公开
标题翻译：自适应点弹性图像注册
公开(公告)号：WO2007054907A1
公开(公告)日：2007-05-18
申请号：PCT/IB2006/054183
申请日：2006-11-09
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , FRANZ, Astrid , CARLSEN, Ingwer-Curt , RENISCH, Steffen , WISCHMANN, Hans
发明人： FRANZ, Astrid , CARLSEN, Ingwer-Curt , RENISCH, Steffen , WISCHMANN, Hans
IPC分类号： G06T3/00
CPC分类号： G06T3/0081
摘要： A point-based elastic registration method for registering a first image and a second image. Initially, a single control point is randomly placed (S2) with the source image region and optimal parameter settings in respect thereof are determined (S3) for performing elastic deformation (S4) in respect of the first image so as to optimise a similarity measure. Additional control points are then added (S6) one-by-one, and the elastic deformation process repeated each time (S8) in respect of the new control point set, until a predetermined stopping criterion is met, e.g. the resultant improvement in the similarity measure no longer exceeds some predetermined threshold value. Thus, a high speed, high quality registration method is provided without having to specify the number of control points initially.
摘要翻译：一种用于登记第一图像和第二图像的基于点的弹性登记方法。首先，单个控制点与源图像区域随机放置（S2），并且确定相对于第一图像执行弹性变形（S4）的最佳参数设置（S3），以便优化相似性度量。然后逐个添加附加的控制点（S6），并且相对于新的控制点集合每次重复弹性变形过程（S8），直到达到预定的停止标准为止。所得到的相似性度量的改善不再超过某个预定阈值。因此，提供高速，高质量的登记方法，而不必首先指定控制点的数量。

10. 发明申请

WO2010109350A2 PET/CT BASED THERAPY MONITORING SYSTEM SUPPORTED BY A CLINICAL GUIDELINE NAVIGATOR 审中-公开
标题翻译：基于PET / CT的临床指南导航器支持的治疗监测系统
公开(公告)号：WO2010109350A2
公开(公告)日：2010-09-30
申请号：PCT/IB2010/050638
申请日：2010-02-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , OPFER, Roland , BOROCZKY, Lilla , CARLSEN, Ingwer-Curt , DUTTA, Pradyumna , RENISCH, Steffen , SABCZYNSKI, Joerg , TULIPANO, Paola, Karina
发明人： OPFER, Roland , BOROCZKY, Lilla , CARLSEN, Ingwer-Curt , DUTTA, Pradyumna , RENISCH, Steffen , SABCZYNSKI, Joerg , TULIPANO, Paola, Karina
IPC分类号： A61B6/03 , G01T1/29 , G06F19/00
CPC分类号： G16H10/60 , A61B6/037 , A61B6/508 , G06F19/00 , G06F19/321 , G06Q50/24
摘要： An oncology monitoring system comprises: an image analysis module (42, 44) configured to perform an oncological monitoring operation based on images of a subject, for example acquired by positron emission tomography (PET) and computed tomography (CT); and a clinical guideline support module (10). The clinical guideline support module is configured to: display a graphical flow diagram (GFD) of a clinical therapy protocol for treating the subject comprising graphical blocks (B0, B1, B2, B3, B4, B5, B21, B211, B22, B221, B222, B223, B23, B231, B232) representing therapeutic or monitoring operations of the clinical therapy protocol including at least one monitoring operation performed by the image analysis module; annotate a graphical block of the graphical flow diagram with subject-specific information pertaining to a therapeutic or monitoring operation represented by the graphical block; and display an annotation (POP) of a graphical block (B211) responsive to selection of the graphical block by a user.
摘要翻译：肿瘤学监测系统包括：图像分析模块（42,44），其被配置为基于例如由正电子发射断层摄影（PET）和计算机断层摄影术获取的对象的图像来执行肿瘤学监测操作（CT）; 和临床指南支持模块（10）。临床指南支持模块被配置为：显示用于治疗患者的临床治疗方案的图形流程图（GFD），其包括图形块（B0，B1，B2，B3，B4，B5，B21，B211，B22，B221， B222，B223，B23，B231，B232）表示临床治疗方案的治疗或监测操作，包括由图像分析模块执行的至少一个监测操作; 利用与由图形块表示的治疗或监视操作有关的特定于受试者的信息来注释图形流程图的图形块; 并且响应于用户对图形块的选择而显示图形块的注释（POP）（B211）。

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