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1. 发明申请

WO2005078470A2 MAGNETIC RESONANCE IMAGING METHOD 审中-公开
标题翻译：磁共振成像方法
公开(公告)号：WO2005078470A2
公开(公告)日：2005-08-25
申请号：PCT/IB2005/050458
申请日：2005-02-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , FUDERER, Miha , EGGERS, Holger
发明人： FUDERER, Miha , EGGERS, Holger
IPC分类号： G01R33/561
CPC分类号： G01R33/5611
摘要： A novel magnetic resonance imaging method and apparatus is described wherein an image is derived from sub-sampled magnetic resonance signals and on the basis of the spatial sensitivity profile of each receiving antenna. A sequence of RF-pulses and gradients is applied, which sequence corresponds to a set of trajectories containing at least one substantially non-linear trajectory in k-space, wherein the density of said trajectory set being substantially lower than the density corresponding to the object size. Each signal along said trajectory set is sampled at least at two different receiver antenna positions. The image is reconstructed by converting the data of said signals to a Cartesian grid by convolution with a gridding kernel, whereby the gridding kernel is specific for each antenna, differs between one region and another in k-space, and is a Fourier-transform of a pattern weighted for each antenna with respect to the Cartesian grid.
摘要翻译：描述了一种新颖的磁共振成像方法和装置，其中根据次采样的磁共振信号并基于每个接收天线的空间灵敏度分布导出图像。应用RF脉冲和梯度的序列，该序列对应于在k空间中包含至少一个基本非线性轨迹的一组轨迹，其中所述轨迹集的密度基本上低于对应于物体的密度尺寸。至少在两个不同的接收机天线位置对沿着所述轨迹组的每个信号进行采样。通过与网格内核卷积将所述信号的数据转换为笛卡尔网格来重建图像，由此网格核对于每个天线是特定的，在k空间中在一个区域和另一个区域之间是不同的，并且是傅立叶变换对于每个天线相对于笛卡尔网格加权的图案。

2. 发明申请

WO2011080693A1 WATER -FAT SEPARATION IN MRI USING PARTIAL ECHOES AT DIFFERENT ECHO TIMES 审中-公开
标题翻译：在不同的ECHO时期使用部分ECHO的MRI中的水分离
公开(公告)号：WO2011080693A1
公开(公告)日：2011-07-07
申请号：PCT/IB2010/056083
申请日：2010-12-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , FUDERER, Miha , EGGERS, Holger
发明人： FUDERER, Miha , EGGERS, Holger
IPC分类号： G01R33/54
CPC分类号： G01R33/4828
摘要： The invention relates to a method of imaging at least two chemical species using magnetic resonance imaging with signal separation for the at least two chemical species, the method comprising: acquiring dual partial echoes (204, 210, 406, 408, 502, 506, 10, 612) at different echo times, wherein the partial echoes at the respective echo times are located in opposite regions of k- space, processing the partial echoes for reconstruction of a first and second image data set, the first and second image data set comprising separate image data of the first and second chemical species.
摘要翻译：本发明涉及使用具有用于至少两种化学物质的信号分离的磁共振成像来成像至少两种化学物质的方法，所述方法包括：获取双重部分回波（204,210,406,408,502,506,10 ，612），其中在相应回波时间的部分回波位于k空间的相反区域中，处理用于重构第一和第二图像数据集的部分回波，第一和第二图像数据组包括分离第一和第二化学物质的图像数据。

3. 发明申请

WO2012038886A1 MAGNETIC RESONANCE IMAGING OF CHEMICAL SPECIES 审中-公开
标题翻译：化学物质的磁共振成像
公开(公告)号：WO2012038886A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/054107
申请日：2011-09-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , EGGERS, Holger
发明人： EGGERS, Holger
IPC分类号： A61B5/055 , G01R33/48
CPC分类号： G01R33/4818 , G01R33/4828
摘要： The invention relates to a method of imaging at least two chemical species using magnetic resonance imaging with signal separation for the two chemical species, the method comprising: - acquiring first and second echo data at different echo times resulting in a first and second acquired complex dataset, - modelling the first and second acquired dataset, said modelling comprising a spectral signal model of at least one of the chemical species, - identifying in the first and second acquired dataset the voxels for which the modelling yields a single, unambiguous mathematical solution for the signal separation, and - resolving the ambiguity for the voxels for which the modelling yields more than one mathematical solution, if any such voxels remain.
摘要翻译：本发明涉及使用两个化学物种的信号分离的磁共振成像来成像至少两种化学物质的方法，所述方法包括： - 以不同的回波时间获取第一和第二回波数据，得到第一和第二获得的复数数据集 - 对所述第一和第二获取的数据集进行建模，所述建模包括至少一个所述化学物质的光谱信号模型， - 在所述第一和第二获取的数据集中识别所述模型的体素，其为所述模型产生用于所述数据集的单一，明确的数学解信号分离，以及 - 解析体素的模糊度，其中模型产生多于一个数学解，如果有这样的体素保留。

4. 发明申请

WO2011080697A2 DYNAMIC NUCLEAR POLARIZATION APPARATUS 审中-公开
标题翻译：动态核极化装置
公开(公告)号：WO2011080697A2
公开(公告)日：2011-07-07
申请号：PCT/IB2010/056092
申请日：2010-12-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , LEUSSLER, Christoph , WIRTZ, Daniel , BOERNERT, Peter , KEUPP, Jochen , EGGERS, Holger , DAVID, Bernd , OVERWEG, Johannes, Adrianus , ECKART, Rainer
发明人： LEUSSLER, Christoph , WIRTZ, Daniel , BOERNERT, Peter , KEUPP, Jochen , EGGERS, Holger , DAVID, Bernd , OVERWEG, Johannes, Adrianus , ECKART, Rainer
IPC分类号： G01R33/28
CPC分类号： G01R33/62 , G01R33/282 , G01R33/5601 , G01R33/5605 , G01R33/5608 , G01R33/56366 , G01R33/56383
摘要： The invention relates to a dynamic nuclear polarization apparatus (116) for continuous provision of hyperpolarized samples (114) comprising dynamically nuclear polarized nuclear spins, the apparatus (116) comprising a polarization region (106) for polarization of said nuclear spins resulting in said hyperpolarized samples, wherein the apparatus (116) further comprises: a cryostat (102) for cooling the samples (114) in the polarization region (106), a magnet (100) for providing a magnetic field to the cooled samples in the polarization region (106), a radiation source (112) for concurrently to the magnetic field provision providing a nuclear polarizing radiation to the polarization region (106) for receiving the hyperpolarized samples, a sample transport system (104) for continuously receiving unpolarized samples (114), transporting the unpolarized samples to the polarization region (106) for nuclear spin polarization and providing the resulting hyperpolarized samples (114).
摘要翻译：本发明涉及用于连续提供包含动态核极化核自旋的超极化样本（114）的动态核极化装置（116），所述装置（116）包括用于所述核自旋的极化的偏振区域（106），导致所述超极化样品，其中所述设备（116）还包括：用于冷却所述偏振区域（106）中的样品（114）的低温恒温器（102），用于向所述偏振区域中的所述冷却样品提供磁场的磁体（100） 106），用于与磁场提供同时提供用于接收超极化样本的偏振区域（106）的核偏振辐射的辐射源（112），用于连续接收非偏振样本（114）的样本传输系统（104）将非偏振样品运送到用于核自旋极化的偏振区域（106），并提供所得到的超极化样品（114）。

5. 发明申请

WO2012143847A3 CONTRAST ENHANCED MAGNETIC RESONANCE ANGIOGRAPHY WITH CHEMICAL SHIFT ENCODING FOR FAT SUPPRESSION 审中-公开
公开(公告)号：WO2012143847A3
公开(公告)日：2012-10-26
申请号：PCT/IB2012/051902
申请日：2012-04-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GEERTS-OSSEVOORT, Liesbeth , KOOIJMAN, Hendrik , ALBERTS, Eveline , EGGERS, Holger
发明人： GEERTS-OSSEVOORT, Liesbeth , KOOIJMAN, Hendrik , ALBERTS, Eveline , EGGERS, Holger
IPC分类号： G01R33/54 , G01R33/561 , G01R33/56 , G01R33/563 , G01N24/08 , G01R33/48
摘要： The invention relates to a method of performing contrast enhanced first pass magnetic resonance angiography, the method comprising: acquiring (302) magnetic resonance datasets of a region of interest using a single- or multi-echo data acquisition technique, wherein the echo times of the one or multiple echoes are flexible, wherein at the time of the data acquisition the region of interest comprises fat, water and a contrast agent, processing (304) the datasets using a generalized Dixon water-fat separation technique to eliminate the signal originating from the fat from the background for reconstruction of an image data set.

6. 发明申请

WO2011161596A1 METHOD OF RECONSTRUCTING A MAGNETIC RESONANCE IMAGE OF AN OBJECT CONSIDERING HIGHER-ORDER DYNAMIC FIELDS 审中-公开
标题翻译：重构考虑高阶动态场景的物体的磁共振图像的方法
公开(公告)号：WO2011161596A1
公开(公告)日：2011-12-29
申请号：PCT/IB2011/052643
申请日：2011-06-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , EGGERS, Holger
发明人： EGGERS, Holger
IPC分类号： G01R33/565
CPC分类号： G01R33/48 , G01R33/28 , G01R33/56518 , G01R33/56563 , G01R33/56581
摘要： The invention relates to a method of acquiring a magnetic resonance image of an object employing spatial encoding by a gradient field, said gradient field comprising non-linear gradient field components, the method comprising: selecting (100) a limited set of spatially variant basis functions for describing the gradient field including the non-linear gradient field components by linear combinations of said basis functions, determining (102) the temporally variant weights of the basis functions for said linear combinations, acquiring (104) magnetic resonance data of the object (10), - embedding (106) the acquired magnetic resonance data into a multidimensional space, wherein the number of dimensions is given by the number of selected basis functions, transforming (110) the acquired magnetic resonance data in this multidimensional space from the measurement domain to the image domain, - calculating (112) the desired magnetic resonance image of the object (10) from this transformed multi-dimensional space by linear combinations along the surplus dimensions.
摘要翻译：本发明涉及一种利用梯度场采用空间编码获取对象的磁共振图像的方法，所述梯度场包括非线性梯度场分量，所述方法包括：选择（100）有限的一组空间变异基函数用于通过所述基函数的线性组合来描述包括非线性梯度场分量的梯度场，确定（102）所述线性组合的基函数的时间上不同的权重，获取（104）对象（10）的磁共振数据）， - 将所获得的磁共振数据嵌入（106）到多维空间中，其中所述维数由所选择的基函数的数量给出，将所述获取的所述磁共振数据从所述测量域变换（110）到所述多维空间中所述图像域， - 从所述变换的多维图像计算（112）所述对象（10）的期望磁共振图像，沿着剩余尺寸的线性组合的三维空间。

7. 发明申请

WO2013001415A1 MRI WITH SEPARATION OF DIFFERENT CHEMICAL SPECIES USING A SPECTRAL MODEL 审中-公开
标题翻译： MRI使用光谱模型分离不同的化学物种
公开(公告)号：WO2013001415A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053101
申请日：2012-06-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BOERNERT, Peter , EGGERS, Holger
发明人： BOERNERT, Peter , EGGERS, Holger
IPC分类号： G01R33/48
CPC分类号： G01R33/4828 , A61B5/055
摘要： The invention relates to a method of MR imaging of at least two chemical species having different MR spectra. The method comprises the steps of: generating MR signals of the chemical species by subjecting a portion of a body (10) to an imaging sequence of RF pulses and switched magnetic field gradients, which imaging sequence is determined by a set of imaging parameters (TR, α, TE); acquiring the MR signals; determining a spectral model of at least one of the chemical species, which spectral model is associated with the set of imaging parameters (TR, α, TE); separating signal contributions of the at least two chemical species to the acquired MR signals on the basis of the spectral model; and computing a MR image from the signal contributions of one of the chemical species. Moreover, the invention related to a MR device (1) and to a computer program for a MR device (1).
摘要翻译：本发明涉及至少两种具有不同MR谱的化学物质的MR成像方法。该方法包括以下步骤：通过对身体（10）的一部分进行RF脉冲和切换磁场梯度的成像序列来产生化学物质的MR信号，该成像序列由一组成像参数（TR ，a，TE）; 获取MR信号; 确定所述化学物质中的至少一个的光谱模型，所述光谱模型与所述一组成像参数（TR，a，TE）相关联; 基于光谱模型将所述至少两种化学物质的信号贡献分离成所获取的MR信号; 以及从所述化学物质之一的信号贡献计算MR图像。此外，本发明涉及一种MR装置（1）和一种用于MR装置（1）的计算机程序。

8. 发明申请

WO2011101786A1 MAGNETIC RESONANCE IMAGING OF CHEMICAL SPECIES WITH A SPECTRAL MODEL 审中-公开
标题翻译：具有光谱模型的化学物质的磁共振成像
公开(公告)号：WO2011101786A1
公开(公告)日：2011-08-25
申请号：PCT/IB2011/050639
申请日：2011-02-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , EGGERS, Holger
发明人： EGGERS, Holger
IPC分类号： G01R33/54 , G01R33/561
CPC分类号： G01R33/4828 , G01N24/08 , G01N24/088 , G01R33/5615
摘要： The invention relates to a method of imaging at least two chemical species using magnetic resonance imaging with signal separation for two chemical species resulting in separate signal datasets for these two chemical species, the method comprising: acquiring first and second echo data at different echo times resulting in a first and second acquired complex dataset, modelling the first and second acquired dataset by employing a spectral signal model of at least one of the chemical species, said modelling resulting in a first and second modelled complex dataset, said first and second modelled dataset comprising a first and second phase error and the separate signal datasets for the two chemical species, - determining from the first and second acquired dataset and the first and second modelled dataset the separate signal datasets for the two chemical species.
摘要翻译：本发明涉及使用两个化学物质的信号分离的磁共振成像对至少两种化学物质进行成像的方法，从而产生用于这两种化学物质的分离的信号数据集，所述方法包括：获得不同回波时间的第一和第二回波数据，得到在第一和第二获取的复杂数据集中，通过采用所述化学物种中的至少一个的光谱信号模型对所述第一和第二获取数据集进行建模，所述建模产生第一和第二建模复合数据集，所述第一和第二建模数据集包括第一和第二相位误差和两个化学物种的分离信号数据集， - 从第一和第二获取数据集以及第一和第二模拟数据集确定两种化学物种的分离信号数据集。

9. 发明申请

WO2010113048A1 TWO-POINT DIXON TECHNIQUE WITH FLEXIBLE CHOICE OF ECHO TIMES 审中-公开
标题翻译：两点狄克逊技术与ECHO时代的灵活选择
公开(公告)号：WO2010113048A1
公开(公告)日：2010-10-07
申请号：PCT/IB2010/050745
申请日：2010-02-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BRENDEL, Bernhard , EGGERS, Holger , DUIJNDAM, Adri, J.
发明人： BRENDEL, Bernhard , EGGERS, Holger , DUIJNDAM, Adri, J.
IPC分类号： G01R33/54
CPC分类号： G01R33/4828 , G01R33/56563
摘要： When distinguishing between fat and water in acquired MR data, a modified Dixon technique includes acquiring first and second signals Ii and I2, calculating first and second components B and S of the signals Iχ and I2, where one of the first and second components corresponds to fat and the other corresponds to water, deriving two differential phase error candidates from them, and selecting a phase error candidate based on the assumption of smoothness of the disturbing field inhomogeneity. The exact determination of the absolute values of the water and fat components is then made by solving three signal equations for two variables that respectively correspond to water and fat, and is performed using for example a least square minimization with a Newton method.
摘要翻译：在获取的MR数据中区分脂肪和水时，修改的Dixon技术包括获取第一和第二信号Ii和I2，计算信号I 1和I 2的第一和第二分量B和S。和I2，其中第一和第二分量中的一个对应于脂肪，而另一个对应于水，从它们中导出两个差分相位误差候选，并且基于干扰场不均匀性的平滑度的假设来选择相位误差候选。然后通过求解分别对应于水和脂肪的两个变量的三个信号方程，并且使用例如使用牛顿法的最小二乘法来进行水和脂肪成分的绝对值的确切确定。

10. 发明申请

WO2010150209A1 A HYPERPOLARIZED CONTRAST AGENT DISPENSER FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的超高对比度对比剂分配器
公开(公告)号：WO2010150209A1
公开(公告)日：2010-12-29
申请号：PCT/IB2010/052864
申请日：2010-06-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , LEUSSLER, Christoph , BOERNERT, Peter , WIRTZ, Daniel , DAVID, Bernd , EGGERS, Holger , KEUPP, Jochen , OVERWEG, Johannes, Adrianus , ECKART, Rainer
发明人： LEUSSLER, Christoph , BOERNERT, Peter , WIRTZ, Daniel , DAVID, Bernd , EGGERS, Holger , KEUPP, Jochen , OVERWEG, Johannes, Adrianus , ECKART, Rainer
IPC分类号： A61M16/10
CPC分类号： A61M16/10 , A61B5/055 , A61M16/14 , A61M2016/0015 , A61M2202/066
摘要： A dispenser (132), a magnetic resonance imaging system (100), and a method for using hyperpolarized contrast agent (304) during a magnetic resonance imaging examination. The dispenser comprises an attachment component (136) for a face piece (138). The face piece is adapted for receiving the surface of a subject (114) such that when the subject inhales hyperpolarized contrast agent enters the respiratory system of the subject. The dispenser further comprises a reservoir (300) adapted for receiving the hyperpolarized contrast agent. The dispenser further comprises a gas flow (406) tube connected to the attachment component and a vaporizer (406, 408, 412, 510, 602, 606) for vaporizing the hyperpolarized contrast agent in the gas flow tube into a hyperpolarized vapor. The dispenser further comprises a controller (402) for controlling when the vaporizer vaporizes the hyperpolarized contrast agent.
摘要翻译：分配器（132），磁共振成像系统（100）以及在磁共振成像检查期间使用超极化造影剂（304）的方法。分配器包括用于面件（138）的附接部件（136）。面部件适于接纳被检体（114）的表面，使得当受试者吸入超极化造影剂进入受试者的呼吸系统时。分配器还包括适于接收超极化造影剂的贮存器（300）。分配器还包括连接到附接部件的气流（406）管和用于将气体流管中的超极化造影剂蒸发成超极化蒸气的蒸发器（406,408,412,510,602,606）。分配器还包括控制器（402），用于控制蒸发器何时蒸发超极化造影剂。

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