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1. 发明申请

WO2010150209A1 A HYPERPOLARIZED CONTRAST AGENT DISPENSER FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的超高对比度对比剂分配器
公开(公告)号：WO2010150209A1
公开(公告)日：2010-12-29
申请号：PCT/IB2010/052864
申请日：2010-06-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , LEUSSLER, Christoph , BOERNERT, Peter , WIRTZ, Daniel , DAVID, Bernd , EGGERS, Holger , KEUPP, Jochen , OVERWEG, Johannes, Adrianus , ECKART, Rainer
发明人： LEUSSLER, Christoph , BOERNERT, Peter , WIRTZ, Daniel , DAVID, Bernd , EGGERS, Holger , KEUPP, Jochen , OVERWEG, Johannes, Adrianus , ECKART, Rainer
IPC分类号： A61M16/10
CPC分类号： A61M16/10 , A61B5/055 , A61M16/14 , A61M2016/0015 , A61M2202/066
摘要： A dispenser (132), a magnetic resonance imaging system (100), and a method for using hyperpolarized contrast agent (304) during a magnetic resonance imaging examination. The dispenser comprises an attachment component (136) for a face piece (138). The face piece is adapted for receiving the surface of a subject (114) such that when the subject inhales hyperpolarized contrast agent enters the respiratory system of the subject. The dispenser further comprises a reservoir (300) adapted for receiving the hyperpolarized contrast agent. The dispenser further comprises a gas flow (406) tube connected to the attachment component and a vaporizer (406, 408, 412, 510, 602, 606) for vaporizing the hyperpolarized contrast agent in the gas flow tube into a hyperpolarized vapor. The dispenser further comprises a controller (402) for controlling when the vaporizer vaporizes the hyperpolarized contrast agent.
摘要翻译：分配器（132），磁共振成像系统（100）以及在磁共振成像检查期间使用超极化造影剂（304）的方法。分配器包括用于面件（138）的附接部件（136）。面部件适于接纳被检体（114）的表面，使得当受试者吸入超极化造影剂进入受试者的呼吸系统时。分配器还包括适于接收超极化造影剂的贮存器（300）。分配器还包括连接到附接部件的气流（406）管和用于将气体流管中的超极化造影剂蒸发成超极化蒸气的蒸发器（406,408,412,510,602,606）。分配器还包括控制器（402），用于控制蒸发器何时蒸发超极化造影剂。

2. 发明申请

WO2003001556A1 X-RAY SOURCE PROVIDED WITH A LIQUID METAL TARGET 审中-公开
标题翻译： X射线源由液体金属靶提供
公开(公告)号：WO2003001556A1
公开(公告)日：2003-01-03
申请号：PCT/IB2002/002374
申请日：2002-06-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS CORPORATE INTELLECTUAL PROPERTY GMBH , HARDING, Geoffrey , DAVID, Bernd , ECKART, Rainer, W. , SCHLOMKA, Jens, P.
发明人： HARDING, Geoffrey , DAVID, Bernd , ECKART, Rainer, W. , SCHLOMKA, Jens, P.
IPC分类号： H01J35/08
CPC分类号： H01J35/08 , H01J2235/082
摘要： The invention relates to an X-ray source which is provided with a liquid metal target (3) which flows through a system of ducts (6) and is conducted through a duct section (8) whose flow cross-section is reduced relative to that of the system of ducts. The X-ray source is characterized notably in that there is provided a pressure source (12, 13; 14; 16) for acting on the liquid metal target (3) in such a manner that in the operating condition of the X-ray source the pressure in the liquid metal target (3) at the area of the reduced flow cross-section equals essentially a selectable reference value (Ps) or remains essentially in a pressure range between selectable limit values (Ps1, Ps2) of the pressure. A comparatively small thickness of a window which is transparent to an electron beam can thus be realized in conjunction with a comparatively high flow speed, that is, without having to accept the risk of cavitations. The invention also relates to an X-ray apparatus provided with an X-ray source of this kind.
摘要翻译：本发明涉及一种具有液体金属靶（3）的X射线源，该液体金属靶（3）流过管道（6）的系统，并通过导管部分（8）传导，该管道部分（8）的流动横截面相对于的管道系统。 X射线源的特征在于，提供了一个用于作用在液态金属靶（3）上的压力源（12,13; 14; 16），使得在X射线源的运行状态在流动截面减小的区域中的液态金属靶（3）中的压力基本上等于可选择的参考值（Ps），或者基本上保持在压力的可选极限值（Ps1，Ps2）之间的压力范围内。因此，与电子束透明的窗口相对较小的厚度可以结合较高的流速来实现，即不必接受空化的风险。本发明还涉及具备这种X射线源的X射线装置。

3. 发明申请

WO2011080697A3 DYNAMIC NUCLEAR POLARIZATION APPARATUS WITH SAMPLE TRANSPORT SYSTEM 审中-公开
标题翻译：动态核极化装置与样品运输系统
公开(公告)号：WO2011080697A3
公开(公告)日：2011-11-10
申请号：PCT/IB2010056092
申请日：2010-12-28
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , LEUSSLER CHRISTOPH , WIRTZ DANIEL , BOERNERT PETER , KEUPP JOCHEN , EGGERS HOLGER , DAVID BERND , OVERWEG JOHANNES ADRIANUS , ECKART RAINER
发明人： LEUSSLER CHRISTOPH , WIRTZ DANIEL , BOERNERT PETER , KEUPP JOCHEN , EGGERS HOLGER , DAVID BERND , OVERWEG JOHANNES ADRIANUS , ECKART RAINER
IPC分类号： G01R33/28 , G01N24/08 , G01N35/02 , G01N35/04 , G01R33/30 , G01R33/62
CPC分类号： G01R33/62 , G01R33/282 , G01R33/5601 , G01R33/5605 , G01R33/5608 , G01R33/56366 , G01R33/56383
摘要： The invention relates to a dynamic nuclear polarization apparatus (116) for continuous provision of hyperpolarized samples (114) comprising dynamically nuclear polarized nuclear spins, the apparatus (116) comprising a polarization region (106) for polarization of said nuclear spins resulting in said hyperpolarized samples, wherein the apparatus (116) further comprises: a cryostat (102) for cooling the samples (114) in the polarization region (106), a magnet (100) for providing a magnetic field to the cooled samples in the polarization region (106), a radiation source (112) for concurrently to the magnetic field provision providing a nuclear polarizing radiation to the polarization region (106) for receiving the hyperpolarized samples, a sample transport system (104) for continuously receiving unpolarized samples (114), transporting the unpolarized samples to the polarization region (106) for nuclear spin polarization and providing the resulting hyperpolarized samples (114).
摘要翻译：本发明涉及用于连续提供包含动态核极化核自旋的超极化样本（114）的动态核极化装置（116），所述装置（116）包括用于所述核自旋的极化的偏振区域（106），导致所述超极化样品，其中所述设备（116）还包括：用于冷却所述偏振区域（106）中的样品（114）的低温恒温器（102），用于向所述偏振区域中的所述冷却样品提供磁场的磁体（100） 106），用于与磁场提供同时提供用于接收超极化样本的偏振区域（106）的核偏振辐射的辐射源（112），用于连续接收非偏振样本（114）的样本传输系统（104）将非偏振样品运送到用于核自旋极化的偏振区域（106），并提供所得到的超极化样品（114）。

4. 发明申请

WO2011080697A2 DYNAMIC NUCLEAR POLARIZATION APPARATUS 审中-公开
标题翻译：动态核极化装置
公开(公告)号：WO2011080697A2
公开(公告)日：2011-07-07
申请号：PCT/IB2010/056092
申请日：2010-12-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , LEUSSLER, Christoph , WIRTZ, Daniel , BOERNERT, Peter , KEUPP, Jochen , EGGERS, Holger , DAVID, Bernd , OVERWEG, Johannes, Adrianus , ECKART, Rainer
发明人： LEUSSLER, Christoph , WIRTZ, Daniel , BOERNERT, Peter , KEUPP, Jochen , EGGERS, Holger , DAVID, Bernd , OVERWEG, Johannes, Adrianus , ECKART, Rainer
IPC分类号： G01R33/28
CPC分类号： G01R33/62 , G01R33/282 , G01R33/5601 , G01R33/5605 , G01R33/5608 , G01R33/56366 , G01R33/56383
摘要： The invention relates to a dynamic nuclear polarization apparatus (116) for continuous provision of hyperpolarized samples (114) comprising dynamically nuclear polarized nuclear spins, the apparatus (116) comprising a polarization region (106) for polarization of said nuclear spins resulting in said hyperpolarized samples, wherein the apparatus (116) further comprises: a cryostat (102) for cooling the samples (114) in the polarization region (106), a magnet (100) for providing a magnetic field to the cooled samples in the polarization region (106), a radiation source (112) for concurrently to the magnetic field provision providing a nuclear polarizing radiation to the polarization region (106) for receiving the hyperpolarized samples, a sample transport system (104) for continuously receiving unpolarized samples (114), transporting the unpolarized samples to the polarization region (106) for nuclear spin polarization and providing the resulting hyperpolarized samples (114).
摘要翻译：本发明涉及用于连续提供包含动态核极化核自旋的超极化样本（114）的动态核极化装置（116），所述装置（116）包括用于所述核自旋的极化的偏振区域（106），导致所述超极化样品，其中所述设备（116）还包括：用于冷却所述偏振区域（106）中的样品（114）的低温恒温器（102），用于向所述偏振区域中的所述冷却样品提供磁场的磁体（100） 106），用于与磁场提供同时提供用于接收超极化样本的偏振区域（106）的核偏振辐射的辐射源（112），用于连续接收非偏振样本（114）的样本传输系统（104）将非偏振样品运送到用于核自旋极化的偏振区域（106），并提供所得到的超极化样品（114）。

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