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1. 发明申请

WO2005057255A3 COLLIMATOR 审中-公开
公开(公告)号：WO2005057255A3
公开(公告)日：2005-06-23
申请号：PCT/IB2004/052708
申请日：2004-12-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HIKMET, Rifat, A., M. , VAN BOMMEL, Ties , VAN DE WITTE, Peter , WIMBERGER-FRIEDL, Reinhold , BURDINSKI, Dirk
发明人： HIKMET, Rifat, A., M. , VAN BOMMEL, Ties , VAN DE WITTE, Peter , WIMBERGER-FRIEDL, Reinhold , BURDINSKI, Dirk
IPC分类号： G02B5/00
摘要： A collimator panel comprises: a solid panel having a first face for receiving uncollimated radiation and a second opposite face for providing collimated radiation; and a plurality of elongate particles disposed in the panel and orientated to provide the collimating function. A method of manufacturing a collimator panel comprises the steps of: suspending a plurality of elongate particles in a liquid; applying an electric or magnetic field to the suspension to orientate the particles; and solidifying the liquid to fix the orientation of the particles, thereby forming a collimator panel. A method of manufacturing the elongate particles is also provided.

2. 发明申请

WO2012001577A1 SYNTHESIS AND USE OF IRON OLEATE 审中-公开
标题翻译：铁的合成和使用
公开(公告)号：WO2012001577A1
公开(公告)日：2012-01-05
申请号：PCT/IB2011/052708
申请日：2011-06-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BURDINSKI, Dirk , BOHLENDER, Carmen
发明人： BURDINSKI, Dirk , BOHLENDER, Carmen
IPC分类号： C01G49/00 , C01G49/08 , C07F15/02 , B82Y30/00
CPC分类号： C07F15/025 , B82Y30/00 , B82Y40/00 , C01G49/00 , C01G49/02 , C01G49/08 , C01P2002/82 , C01P2004/04 , C01P2004/64 , C01P2006/42 , C07C51/412 , Y10S977/896 , Y10T428/2989 , C07C57/12
摘要： The present invention relates to a method of forming an iron oleate complex comprising the steps of: (a) dissolving an oleate in a low-order alcohol solvent at a temperature of about 35°C to 65°C; (b) adding a non-polar solvent to the solution of step (a); (c) adding an iron salt dissolved in a low-order alcohol to the solution of step (b); (d) agitating the solution of step (c) at a temperature of about 50°C for at least 5 min; (e) cooling the reaction mixture of step (d) to a temperature of about 15°C to 30°C; (f) optionally filtering the reaction mixture of step (e); (g) separating the non-polar solvent phase from the low-order alcohol phase; (h) washing and drying the non-polar solvent phase; (i) removing volatiles from the non-polar solvent phase of step (h) by evaporation; and (j) mixing the product of step (i) with a polar solvent to yield a solid iron oleate complex. The present invention further relates to an iron oleate complex obtainable by the method of the invention, an iron oleate complex of formula I, the use of the iron oleate complex of the invention as precursor for the preparation of nanoparticles, and a method of forming iron oxide nanoparticles comprising the suspension of iron oxide/hydroxide and the iron oleate complex of the invention.
摘要翻译：本发明涉及一种形成油酸铁配合物的方法，包括以下步骤：（a）在约35℃至65℃的温度下将油酸酯溶解在低级醇溶剂中; （b）向步骤（a）的溶液中加入非极性溶剂; （c）将溶解在低级醇中的铁盐加入到步骤（b）的溶液中; （d）在约50℃的温度下搅拌步骤（c）的溶液至少5分钟; （e）将步骤（d）的反应混合物冷却至约15℃至30℃的温度; （f）任选地过滤步骤（e）的反应混合物; （g）将非极性溶剂相与低级醇相分离; （h）洗涤和干燥非极性溶剂相; （i）通过蒸发从步骤（h）的非极性溶剂相中除去挥发物; 和（j）将步骤（i）的产物与极性溶剂混合，得到固体油酸铁配合物。本发明还涉及通过本发明的方法获得的油酸铁配合物，式I的油酸铁配合物，本发明的油酸铁配合物作为制备纳米颗粒的前体的用途，以及形成铁包含本发明的氧化铁/氢氧化物和油酸铁配合物的悬浮液的氧化物纳米颗粒。

3. 发明申请

WO2009069051A2 NON-SPHERICAL CONTRAST AGENTS FOR CEST MRI BASED ON BULK MAGNETIC SUSCEPTIBILITY EFFECT 审中-公开
标题翻译：非球形对比剂基于大块磁性可靠性影响的CEST MRI
公开(公告)号：WO2009069051A2
公开(公告)日：2009-06-04
申请号：PCT/IB2008/054894
申请日：2008-11-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BURDINSKI, Dirk , LANGEREIS, Sander , PIKKEMAAT, Jeroen, A.
发明人： BURDINSKI, Dirk , LANGEREIS, Sander , PIKKEMAAT, Jeroen, A.
IPC分类号： A61K49/18
CPC分类号： A61K49/1812 , A61K49/1815
摘要： In magnetic resonance imaging (MRI) based on chemical exchange-dependent saturation transfer (CEST), a novel carrier for CEST contrast agents is provided. The carrier is non-spherical and comprises a semipermeable shell, wherein the shell comprises a paramagnetic compound. The shell encloses a cavitycomprising an MR analyte, wherein the semipermeable shell allows diffusion of the MR analyte. The CEST effect is based on the 5 bulk magnetic susceptibility effect caused by the anisotropy of the carrier. This leads to a versatile carrier that does not require interaction of the analyte with a paramgnetic chemical shift reagent.
摘要翻译：在基于化学交换依赖性饱和转移（CEST）的磁共振成像（MRI）中，提供了一种用于CEST造影剂的新载体。载体是非球形的并且包含半透性壳，其中壳包含顺磁性化合物。壳体包围一个包含MR分析物的空腔，其中半透膜允许MR分析物的扩散。 CEST效应基于由载体的各向异性引起的5体积磁化率效应。这导致通用载体，其不需要分析物与辅助化学位移试剂的相互作用。

4. 发明申请

WO2008047293A3 STAMPER AND METHOD OF MANUFACTURING A STAMPER 审中-公开
公开(公告)号：WO2008047293A3
公开(公告)日：2008-04-24
申请号：PCT/IB2007/054180
申请日：2007-10-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOS, Mattheus, I. , BURDINSKI, Dirk , VAN DER LEE, Alexander, M. , SAALMINK, Milan , IMMINK, Albert, H., J.
发明人： BOS, Mattheus, I. , BURDINSKI, Dirk , VAN DER LEE, Alexander, M. , SAALMINK, Milan , IMMINK, Albert, H., J.
IPC分类号： G11B7/26 , B29C33/58 , B29C33/60
摘要： The present invention relates to a stamper (10) for optical disc manufacturing, having a stamper substrate (12), a substrate surface (14) comprising Ni and/or NiO, and a self-assembled monolayer (16) at least partly covering the substrate surface. The present invention further relates to manufacturing methods for stampers (10) and optical discs (22).

5. 发明申请

WO2013001438A1 SKIN-CONTACT PRODUCT HAVING MOISTURE AND MICROCLIMATE CONTROL 审中-公开
标题翻译：具有水分和微生物控制的皮肤接触产品
公开(公告)号：WO2013001438A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053201
申请日：2012-06-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WILLARD, Nicolaas Petrus , KLEE, Mareike , BECKERS, Lucas Johannes Anna Maria , BURDINSKI, Dirk , VAN ZANTEN, Joyce , PASVEER, Willem Franke , SREEDHARAN NAIR, Biju Kumar , SMITH, David W. , HENDRIKS, Cornelis Petrus , ASVADI, Sima
发明人： WILLARD, Nicolaas Petrus , KLEE, Mareike , BECKERS, Lucas Johannes Anna Maria , BURDINSKI, Dirk , VAN ZANTEN, Joyce , PASVEER, Willem Franke , SREEDHARAN NAIR, Biju Kumar , SMITH, David W. , HENDRIKS, Cornelis Petrus , ASVADI, Sima
IPC分类号： A61M16/06
CPC分类号： C08G77/28 , A61M16/0057 , A61M16/06 , A61M16/0605 , A61M16/0616 , A61M16/0633 , A61M16/0683 , A61M16/0816 , A61M2205/0205 , A61M2205/0238 , A61M2205/7527 , A61M2205/7536 , C08G77/08 , C08J9/00 , C08J2207/10 , C08J2383/08
摘要： Skin-contact products with a transpiration function such as medical devices or medicinal products, of which face masks, aspirators, ventilators, breast pumps or wound dressings are examples are described especially a skin-contact product with a transpiration function with an improved microclimate at a patient interface material -skin contact area. In an embodiment a material system (10, 20, 30) is described that comprises a hydrophobic silicone base material (11, 21, 31) and a hydrophilic silicone material (12, 22, 32) that is combined with the hydrophobic base material (11, 21, 31). At least a part of the hydrophilic material (12, 22, 32) is in contact with a moist surface (50). The hydrophobic base material (11, 21, 31) provides mechanical and dynamical stability of the material system (10, 20, 30). The hydrophilic material (12, 22, 32) allows for uptake or for diffusion of moisture away from moist surface (50). The material system (10, 20, 30) is utilized to fabricate a patient interface material (41) and forehead pad (42) of a user or patient interface, such as face mask (40), for example, a patient interface mask for positive air pressure therapy. Furthermore, a novel composition for the preparation of hydrophilic silicone materials, suitable for use in the material system (10, 20, 30), is disclosed.
摘要翻译：具有蒸发功能的皮肤接触产品例如医疗设备或医药产品，其中面罩，抽吸器，通风器，吸乳器或伤口敷料是实例，尤其是与皮肤接触的产品，其具有在患者界面材料 - 皮肤接触区域具有改善的微气候的蒸发功能。在一个实施例中，描述了一种材料系统（10,20,30），其包括疏水性硅酮基材料（11,21,31）和亲水性硅酮材料（12,22,32），所述亲水性硅酮材料与疏水性基材 11，21，31）。亲水材料（12,22,32）的至少一部分与潮湿表面（50）接触。疏水基材（11,21,31）提供了材料系统（10,20,30）的机械和动力学稳定性。亲水材料（12,22,32）允许摄取湿气表面（50）或从潮湿表面（50）扩散湿气。利用材料系统（10,20,30）制造用户或患者接口（例如面罩（40））的患者接口材料（41）和前额垫（42），例如患者接口面罩正压空气治疗。此外，公开了用于制备适用于材料体系（10,20,30）的亲水硅氧烷材料的新型组合物。

6. 发明申请

WO2008132666A1 T1 REDUCTION IN 19F MAGNETIC RESONANCE IMAGING (MRI) 审中-公开
标题翻译： 19F磁共振成像中的T1减少（MRI）
公开(公告)号：WO2008132666A1
公开(公告)日：2008-11-06
申请号：PCT/IB2008/051560
申请日：2008-04-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LAMERICHS, Rudolf, M., J., N. , BURDINSKI, Dirk , LANGEREIS, Sander , WEGH, Rene, T. , GRUELL, Holger
发明人： LAMERICHS, Rudolf, M., J., N. , BURDINSKI, Dirk , LANGEREIS, Sander , WEGH, Rene, T. , GRUELL, Holger
IPC分类号： A61K49/08 , A61K49/10 , A61K49/18 , C07C49/167 , C07C49/24 , C07C49/92 , C07F5/00 , A61B5/055
CPC分类号： C07C49/92 , A61K49/106 , A61K49/1818 , B82Y5/00 , G01R33/5601
摘要： Nanoparticles comprising paramagnetic complexes and use thereof are provided which are designed for the purpose of shortening the Tl relaxation time of fluorinated contrast agents in 19 F Magnetic Resonance Imaging. Preferably, the complexes are included in perfluorinated nanoparticle 19 F MRI contrast agents.
摘要翻译：提供包含顺磁性复合物的纳米颗粒及其用途，其被设计用于缩短氟化造影剂在19 F磁共振成像中的T1弛豫时间。优选地，所述复合物包括在全氟化纳米颗粒中的MRI造影剂。

7. 发明申请

WO2006067694A3 NANOFABRICATION BASED ON SAM GROWTH 审中-公开
公开(公告)号：WO2006067694A3
公开(公告)日：2006-06-29
申请号：PCT/IB2005/054250
申请日：2005-12-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BURDINSKI, Dirk , SHARPE, Ruben, B., A.
发明人： BURDINSKI, Dirk , SHARPE, Ruben, B., A.
IPC分类号： G03F7/00
摘要： The present invention relates to a process of nano fabrication based on nucleated SAM growth, to patterned substrates prepared thereby, to a nano wire or grid of nanowires prepared thereby and to electronic devices including the same. In particular, there is provided a process which comprises applying a first SAM- forming molecular species to a first surface region of the substrate surface, so as to provide a first SAM defining a scaffold pattern on the first surface region; and applying a second SAM-forming molecular species to at least a second surface region of said substrate surface which is not covered by the first SAM, whereby a second replica SAM comprising the second SAM-forming molecular species selectively forms on substrate surface adjacent to at least one edge of said first SAM.

8. 发明申请

WO2006067668A1 SURFACE PATTERNING AND VIA MANUFACTURING EMPLOYING CONTROLLED PRECIPITATIVE GROWTH 审中-公开
标题翻译：表面图案和通过制造控制的生产增长
公开(公告)号：WO2006067668A1
公开(公告)日：2006-06-29
申请号：PCT/IB2005/054188
申请日：2005-12-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BURDINSKI, Dirk
发明人： BURDINSKI, Dirk
IPC分类号： G03F7/00 , C30B7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , C30B7/00 , C30B7/005 , H01L51/0021 , H01L51/102
摘要： The present invention is concerned with a process of surface patterning and via manufacturing employing controlled precipitative growth, and patterned substrates prepared by such a process according to the present invention. A process according to the present invention comprises providing a substrate including at least one surface on which it is required to pattern a material, the surface including at least first and second surface regions having distinct surface properties and wherein the first surface region is further provided with protective precipitative growth thereon, and applying at least one material to at least the second surface region, such that the applied material is either substantially not provided to the first surface region, or if provided to the first surface region can be selectively removed therefrom.
摘要翻译：本发明涉及采用受控沉淀生长的表面图案化和通孔制造方法以及通过本发明的这种方法制备的图案化衬底。根据本发明的方法包括提供包括其上需要图案化材料的至少一个表面的基底，所述表面至少包括具有不同表面性质的第一和第二表面区域，并且其中所述第一表面区域进一步具有在其上保护性沉淀生长，并且将至少一种材料施加到至少第二表面区域，使得所施加的材料基本上不提供到第一表面区域，或者如果提供给第一表面区域可以选择性地从其中选择性地除去。

9. 发明申请

WO2005035438A1 METHOD FOR PATTERNING A SUBSTRATE SURFACE 审中-公开
标题翻译：用于绘制基板表面的方法
公开(公告)号：WO2005035438A1
公开(公告)日：2005-04-21
申请号：PCT/IB2004/052009
申请日：2004-10-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BURDINSKI, Dirk , SHARPE, Ruben, B., A.
发明人： BURDINSKI, Dirk , SHARPE, Ruben, B., A.
IPC分类号： B81C1/00
CPC分类号： B82Y30/00 , B05D1/283 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： An elastomeric stamp (10) is provided, which has a bulk surface (12) from which protruding features (14, 14') extend. A barrier layer (20) covers the bulk surface (12) and the protruding features (14, 14'). After applying an ink solution to the elastomeric stamp (10) and drying the elastomeric stamp (10), the elastomeric stamp (10) is brought into contact with a surface (42) of a first substrate (40). The surface (42) of the first substrate (40) has a high affinity with the ink molecules (32), which is utilized to effectively remove the ink molecules (32) from the contact surfaces (16, 16') of the protruding features (14, 14'). Subsequently, the elastomeric stamp (10) is brought into contact with the surface (52) of a second substrate (50). Ink molecules 32 are transferred from the edges (18, 18') of the protruding features (14, 14') to the surface (52) of a second substrate (50), thus forming an ink pattern in the form of a selfassembled monolayer on this surface (52). The patterning method of the present invention allows for the formation of high-definition ink patterns on a substrate (50) using a wide variety of inks.
摘要翻译：提供了弹性体印模（10），其具有突出特征（14,14'）延伸的体表面（12）。阻挡层（20）覆盖主体表面（12）和突出特征（14,14'）。在将墨水溶液施加到弹性体印模（10）上并干燥弹性体印模（10）之后，弹性体印模（10）与第一基底（40）的表面（42）接触。第一衬底（40）的表面（42）与油墨分子（32）具有高亲和力，其用于从突出特征的接触表面（16,16'）有效地去除油墨分子（32）（14,14'）。随后，弹性体印模（10）与第二基底（50）的表面（52）接触。墨水分子32从突出特征（14,14'）的边缘（18,18'）转移到第二基底（50）的表面（52），从而形成自组装单层形式的墨图形在该表面（52）上。本发明的图案化方法允许使用各种各样的油墨在基板（50）上形成高分辨率油墨图案。

10. 发明申请

WO2013001506A2 MEDICAL AND NON-MEDICAL DEVICES MADE FROM HYDROPHILIC RUBBER MATERIALS 审中-公开
标题翻译：医用和非医疗器械由水泥橡胶材料制成
公开(公告)号：WO2013001506A2
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053321
申请日：2012-06-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BURDINSKI, Dirk , VAN ZANTEN, Joyce , BECKERS, Lucas Johannes Anna Maria , HENDRIKS, Cornelis Petrus , PASVEER, Willem Franke , WILLARD, Nicolaas Petrus , KLEE, Mareike , SREEDHARAN NAIR, Biju Kumar , SMITH, David
发明人： BURDINSKI, Dirk , VAN ZANTEN, Joyce , BECKERS, Lucas Johannes Anna Maria , HENDRIKS, Cornelis Petrus , PASVEER, Willem Franke , WILLARD, Nicolaas Petrus , KLEE, Mareike , SREEDHARAN NAIR, Biju Kumar , SMITH, David
IPC分类号： C08G77/392
CPC分类号： A61L31/06 , A61F5/00 , A61F13/2002 , A61K8/0208 , A61K8/895 , A61K2800/10 , A61K2800/54 , A61L31/10 , A61L31/146 , A61M2205/02 , A61Q19/00 , C08G77/12 , C08G77/392 , C08L83/08
摘要： This invention relates to medical, health care and non-medical devices comprising a rubbery or elastomeric polymer material taking up more than 5% by weight of water and at most 500% by weight of water after immersion in demineralized water at room temperature for a sufficient time to reach saturation. The material may be in the form of a foam, or in the form of a coating adapted for adhesion to a substrate, or in the form of a sheet, or in the form of a fiber, and may comprise: - repeating units from one or more hydrophobic organic monomers, and - repeating units from one or more monomers (a) being modified with one or more hydrophilic side groups.
摘要翻译：本发明涉及医疗，保健和非医疗器械，其包括橡胶状或弹性体聚合物材料，其在室温下浸入软化水中达到超过5重量％的水和至多500重量％的水，足够的时间达到饱和。该材料可以是泡沫的形式，或以适于粘附到基底上的片的形式，或以片的形式或纤维的形式，并且可以包括： - 来自一个的重复单元或更多的疏水性有机单体，和 - 来自一个或多个单体（a）的重复单元被一个或多个亲水侧基改性。

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