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1. 发明申请

WO2010058361A3 METHOD FOR THE PRODUCTION OF SCAFFOLDS FOR TISSUE ENGINEERING, COMPRISING THE USE OF AN ANCHORING UNIT, AND SCAFFOLD PRODUCED THEREWITH 审中-公开
标题翻译：用于组织工程的支架的生产方法，包括使用锚固单元和支架生产的支架
公开(公告)号：WO2010058361A3
公开(公告)日：2010-07-15
申请号：PCT/IB2009055168
申请日：2009-11-19
申请人： KONINKL PHILIPS ELECTRONICS NV , HALTER DAVID , KURT RALPH , PEETERS EMIEL , PENTERMAN ROEL , BROER DIRK J , LAMERICHS RUDOLF M J N
发明人： HALTER DAVID , KURT RALPH , PEETERS EMIEL , PENTERMAN ROEL , BROER DIRK J , LAMERICHS RUDOLF M J N
IPC分类号： A61L27/54 , A61K49/00 , A61K49/18 , A61K51/04 , A61L27/58 , A61L31/14 , A61L31/18
CPC分类号： A61L27/54 , A61K49/0002 , A61K49/085 , A61K49/126 , A61K51/0491 , A61K51/065 , A61L27/58 , A61L31/148 , A61L31/18 , A61L2300/44
摘要： The present invention relates to a method for the production of scaffold materials and/or scaffolds for tissue and/or organ engineering, said method comprising the addition of at least one anchoring unit for a labelling agent, to at least one scaffold material and/or to at least one scaffold.
摘要翻译：本发明涉及一种用于生产用于组织和/或器官工程的支架材料和/或支架的方法，所述方法包括将用于标记剂的至少一个锚定单元添加到至少一种支架材料和/或到至少一个脚手架。

2. 发明申请

WO2007141767A3 ELIMINATION OF CONTRAST AGENT CONCENTRATION DEPENDENCY IN MRI 审中-公开
公开(公告)号：WO2007141767A3
公开(公告)日：2007-12-13
申请号：PCT/IB2007/052179
申请日：2007-06-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LAMERICHS, Rudolf, M., J., N. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
发明人： LAMERICHS, Rudolf, M., J., N. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger
IPC分类号： A61K49/06
摘要： The present invention relates to a method for MRI imaging to obtain information about a local physiochemical parameter after administration to a patient of a contrast agent comprising at least one non-responsive contrast enhancing entity that does not occur naturally in a human body and at least one responsive contrast enhancing entity attached to or mixed with the non-responsive contrast enhancing entity. By using such non- responsive contrast enhancing entities, a value for the physicochemical parameter can be obtained by acquiring only three images through which the method according to the present invention will be easier to apply in clinical routine since it will be faster and less sensitive to motion or flow artefacts.

3. 发明申请

WO2010058361A2 METHOD FOR THE PRODUCTION OF SCAFFOLDS FOR TISSUE ENGINEERING, COMPRISING THE USE OF AN ANCHORING UNIT, AND SCAFFOLD PRODUCED THEREWITH 审中-公开
标题翻译：用于组织工程的生产方法，包括使用安装单元和生产的SCAFFOLD
公开(公告)号：WO2010058361A2
公开(公告)日：2010-05-27
申请号：PCT/IB2009/055168
申请日：2009-11-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALTER, David , KURT, Ralph , PEETERS, Emiel , PENTERMAN, Roel , BROER, Dirk, J. , LAMERICHS, Rudolf, M., J., N.
发明人： HALTER, David , KURT, Ralph , PEETERS, Emiel , PENTERMAN, Roel , BROER, Dirk, J. , LAMERICHS, Rudolf, M., J., N.
IPC分类号： A61L27/54 , A61L31/18 , A61K49/00 , A61K49/18 , A61K51/04 , A61L27/58 , A61L31/14
CPC分类号： A61L27/54 , A61K49/0002 , A61K49/085 , A61K49/126 , A61K51/0491 , A61K51/065 , A61L27/58 , A61L31/148 , A61L31/18 , A61L2300/44
摘要： The present invention relates to a method for the production of scaffold materials and/or scaffolds for tissue and/or organ engineering, said method comprising the addition of at least one anchoring unit for a labelling agent, to at least one scaffold material and/or to at least one scaffold.
摘要翻译：本发明涉及生产用于组织和/或器官工程的支架材料和/或支架的方法，所述方法包括向至少一种支架材料和/或至少一种支架材料添加至少一个用于标记试剂的锚定单元至少一个支架。

4. 发明申请

WO2008135878A1 MULTIFREQUENCY MAGNETIC RESONANCE DEVICE AND METHOD 审中-公开
标题翻译：多频磁共振装置及方法
公开(公告)号：WO2008135878A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051571
申请日：2008-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , YILDIRIM, Muhammed , LAMERICHS, Rudolf, M., J., N. , KEUPP, Jochen
发明人： YILDIRIM, Muhammed , LAMERICHS, Rudolf, M., J., N. , KEUPP, Jochen
IPC分类号： G01R33/485 , G01R33/48
CPC分类号： G01R33/485 , G01R33/3635 , G01R33/446
摘要： The invention relates to a device for magnetic resonance imaging of a body (14) placed in an examination volume. According to the invention, the device (1) is arranged to a) excite nuclear magnetization from a nuclear spin system having two or more resonance lines by subjecting at least a portion of the body (14) to an MR imaging pulse sequence comprising RF pulses, the RF pulses being generated at two or more different carrier frequencies (f1, f2, f3) corresponding to the resonance frequencies of said nuclear spin system; b) acquire MR signals from the body (14); c) reconstruct an MR image from the acquired MR signals.
摘要翻译：本发明涉及一种放置在检查体中的身体（14）的磁共振成像装置。根据本发明，装置（1）被布置成a）通过使身体（14）的至少一部分经受包括RF脉冲的MR成像脉冲序列来激励具有两个或多个谐振线的核自旋系统的核磁化 RF脉冲在对应于所述核自旋系统的共振频率的两个或更多个不同载波频率（f1，f2，f3）处产生; b）从身体（14）获取MR信号; c）从所获取的MR信号重构MR图像。

5. 发明申请

WO2007141767A2 ELIMINATION OF CONTRAST AGENT CONCENTRATION DEPENDENCY IN MRI 审中-公开
标题翻译：消除MRI中对比剂浓度依赖性
公开(公告)号：WO2007141767A2
公开(公告)日：2007-12-13
申请号：PCT/IB2007052179
申请日：2007-06-08
申请人： KONINKL PHILIPS ELECTRONICS NV , LAMERICHS RUDOLF M J N , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER
发明人： LAMERICHS RUDOLF M J N , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER
CPC分类号： A61K49/0002 , A61K49/06 , G01R33/5601
摘要： The present invention relates to a method for MRI imaging to obtain information about a local physiochemical parameter after administration to a patient of a contrast agent comprising at least one non-responsive contrast enhancing entity that does not occur naturally in a human body and at least one responsive contrast enhancing entity attached to or mixed with the non-responsive contrast enhancing entity. By using such non- responsive contrast enhancing entities, a value for the physicochemical parameter can be obtained by acquiring only three images through which the method according to the present invention will be easier to apply in clinical routine since it will be faster and less sensitive to motion or flow artefacts.
摘要翻译：本发明涉及一种MRI成像方法，用于在给予造影剂的患者之后获得关于局部生理化学参数的信息，该造影剂包括至少一个在人体内不天然存在的至少一个非反应性对比增强实体，以及至少一个响应对比度增强实体附加于非混响对比增强实体或与无响应对比增强实体混合。通过使用这种非反应性对比增强实体，可以通过仅获取三个图像来获得物理化学参数的值，通过该三个图像，根据本发明的方法将更容易应用于临床常规中，因为它将更快和更不敏感运动或流动文物。

6. 发明申请

WO2006114765A3 MRI INVOLVING CONTRAST AGENT WITH TIME MODULATED CONTRAST ENHANCEMENT 审中-公开
标题翻译： MRI涉及具有时间调制对比度增强的对比剂
公开(公告)号：WO2006114765A3
公开(公告)日：2007-05-03
申请号：PCT/IB2006051286
申请日：2006-04-25
申请人： KONINKL PHILIPS ELECTRONICS NV , WILLARD NICOLAAS P , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER , SCHAEFFTER TOBIAS , LAMERICHS RUDOLF M J N
发明人： WILLARD NICOLAAS P , WEGH RENE T , PIKKEMAAT JEROEN A , GRUELL HOLGER , SCHAEFFTER TOBIAS , LAMERICHS RUDOLF M J N
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method of MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent such as a CEST contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts .
摘要翻译：本发明提供一种MRI成像方法。通过对诸如CEST造影剂的MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致在对比度增强区域中具有改善的信噪比的图像，强烈地抑制不需要的信号未增加的地区，减少的文物，如运动文物。

7. 发明申请

WO2007113759A2 MAGNETIC RESONANCE DEVICE AND METHOD 审中-公开
标题翻译：磁共振装置及方法
公开(公告)号：WO2007113759A2
公开(公告)日：2007-10-11
申请号：PCT/IB2007051146
申请日：2007-03-30
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , KEUPP JOCHEM , LAMERICHS RUDOLF M J N , SCHAEFFTER TOBIAS
发明人： KEUPP JOCHEM , LAMERICHS RUDOLF M J N , SCHAEFFTER TOBIAS
IPC分类号： G01R33/485
CPC分类号： G01R33/485
摘要： The invention relates to a device for magnetic resonance imaging of a body (7) placed in an examination volume, the device (1) comprising means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. According to the invention, the device (1) is arranged to a) generate a series of MR echo signals from a nuclear spin species having two or more spectral lines by subjecting at least a portion of the body (7) to an MR imaging pulse sequence using multiple time-encoding echo time values, b) acquire the MR echo signals for reconstructing a series of time- encoded MR images therefrom, each time-encoded MR image being associated with one of the time-encoding echo time values, c) superimpose the MR images for obtaining a final image.
摘要翻译：本发明涉及一种用于放置在检查体积中的身体（7）的磁共振成像装置，该装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），装置（3,4），5），用于产生叠加在主磁场上的开关磁场梯度，用于向身体（7）辐射RF脉冲的装置（6），用于控制磁场梯度和RF脉冲的产生的控制装置（12）用于接收和采样磁共振信号的装置（10），以及用于从信号样本形成MR图像的重构装置（14）。根据本发明，设备（1）被布置成：a）通过使身体（7）的至少一部分经受MR成像脉冲，从而产生具有两条或更多条光谱线的核自旋物种的一系列MR回波信号使用多个时间编码回波时间值的序列，b）获取用于重构一系列时间编码的MR图像的MR回波信号，每个时间编码的MR图像与时间编码回波时间值之一相关联，c）叠加MR图像以获得最终图像。

8. 发明申请

WO2006114765A2 METHOD AND DEVICE FOR IMPROVED DETECTION OF MRI CONTRAST ENHANCEMENT 审中-公开
标题翻译：改善MRI对比增强检测的方法和装置
公开(公告)号：WO2006114765A2
公开(公告)日：2006-11-02
申请号：PCT/IB2006/051286
申请日：2006-04-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger , SCHAEFFTER, Tobias , LAMERICHS, Rudolf, M., J., N.
发明人： WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger , SCHAEFFTER, Tobias , LAMERICHS, Rudolf, M., J., N.
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts.
摘要翻译：本发明提供一种MRI成像方法。通过对MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致对比度增强区域中具有改善的信噪比的图像，强烈地抑制未增强区域中的不需要的信号，并且减少人造物，如运动文物。

9. 发明申请

WO2008132666A1 T1 REDUCTION IN 19F MAGNETIC RESONANCE IMAGING (MRI) 审中-公开
标题翻译： 19F磁共振成像中的T1减少（MRI）
公开(公告)号：WO2008132666A1
公开(公告)日：2008-11-06
申请号：PCT/IB2008/051560
申请日：2008-04-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LAMERICHS, Rudolf, M., J., N. , BURDINSKI, Dirk , LANGEREIS, Sander , WEGH, Rene, T. , GRUELL, Holger
发明人： LAMERICHS, Rudolf, M., J., N. , BURDINSKI, Dirk , LANGEREIS, Sander , WEGH, Rene, T. , GRUELL, Holger
IPC分类号： A61K49/08 , A61K49/10 , A61K49/18 , C07C49/167 , C07C49/24 , C07C49/92 , C07F5/00 , A61B5/055
CPC分类号： C07C49/92 , A61K49/106 , A61K49/1818 , B82Y5/00 , G01R33/5601
摘要： Nanoparticles comprising paramagnetic complexes and use thereof are provided which are designed for the purpose of shortening the Tl relaxation time of fluorinated contrast agents in 19 F Magnetic Resonance Imaging. Preferably, the complexes are included in perfluorinated nanoparticle 19 F MRI contrast agents.
摘要翻译：提供包含顺磁性复合物的纳米颗粒及其用途，其被设计用于缩短氟化造影剂在19 F磁共振成像中的T1弛豫时间。优选地，所述复合物包括在全氟化纳米颗粒中的MRI造影剂。

10. 发明申请

WO2007113759A3 SPECTROSCOPIC MAGNETIC RESONANCE IMAGING 审中-公开
公开(公告)号：WO2007113759A3
公开(公告)日：2007-10-11
申请号：PCT/IB2007/051146
申请日：2007-03-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KEUPP, Jochem , LAMERICHS, Rudolf, M., J., N. , SCHAEFFTER, Tobias
发明人： KEUPP, Jochem , LAMERICHS, Rudolf, M., J., N. , SCHAEFFTER, Tobias
IPC分类号： G01R33/485
摘要： MRI device arranged to a) generate a series of MR echo signals from a nuclear spin series having two or more spectral lines by subjecting at least part of a body (7) to an MR imaging pulse sequence using multiple time-encoding echo time values, b) acquire the MR echo signals for reconstructing a series of time-encoded MR images therefrom, each time-encoded MR image being associated with one of the time-encoding echo time values, c) transform the series of time-encoded MR images into a series of spectral domain MR images on a pixel-by-pixel or voxel-by- voxel basis, d) and superimpose the MR images for obtaining a final image the device being further arranged to apply a time-encoding scheme in step a) such that each spectral line of the nucle'ar spin species is uniquely mapped to one MR image from the series of spectral domain MR images.

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