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1. 发明申请

WO2009013662A1 MAGNETIC SENSOR DEVICE 审中-公开
标题翻译：磁传感器装置
公开(公告)号：WO2009013662A1
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052818
申请日：2008-07-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
发明人： PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N27/745
摘要： The present invention provides a sensor device (20) and a method for determining the presence and/or amount of target moieties (22) in a sample fluid (27), the target moieties (22) being labeled with magnetic or magnetizable objects (23). The sensor device (20) comprises a magnetic field generating means adapted for applying a retention field for retaining the labeled target moieties (22, 23) to the sensor surface (24) during fluid manipulations. Through this the binding between the labeled target moieties (22, 23) and the sensor surface (24) and/or the magnetic particles (23) and the target moieties (22) is substantially not disturbed during these fluid manipulations. This leads to a reliable and accurate sensor device (20).
摘要翻译：本发明提供一种传感器装置（20）和用于确定样品流体（27）中目标部分（22）的存在和/或数量的方法，目标部分（22）用磁性或可磁化物体（23）标记）。传感器装置（20）包括磁场产生装置，其适于在流体操纵期间施加用于将标记的目标部分（22,23）保持到传感器表面（24）的保持场。通过这一点，标记的目标部分（22,23）和传感器表面（24）和/或磁性颗粒（23）和目标部分（22）之间的结合在这些流体操纵过程中基本上不受干扰。这导致可靠且准确的传感器装置（20）。

2. 发明申请

WO2009150595A1 PARATHYROID HORMONE ASSAY 审中-公开
标题翻译： PARATHYROID HORMONE测定
公开(公告)号：WO2009150595A1
公开(公告)日：2009-12-17
申请号：PCT/IB2009/052393
申请日：2009-06-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, U. , DE KIEVIT, Peggy , PRINS, Menno, W., J.
发明人： DITTMER, Wendy, U. , DE KIEVIT, Peggy , PRINS, Menno, W., J.
IPC分类号： G01N33/543 , G01N33/78
CPC分类号： G01N33/78 , G01N33/54333 , G01N33/54393
摘要： The present invention relates to one-step sandwich immunoassays for the detection of parathyroid hormone (PTH) based on the manipulation of antibodies labelled with magnetic particles under improved assay conditions.
摘要翻译：本发明涉及用于检测甲状旁腺激素（PTH）的一步夹心免疫测定法，其基于在改进的测定条件下用磁性颗粒标记的抗体的操作。

3. 发明申请

WO2008075285A1 MEASURING AGGLUTINATION PARAMETERS 审中-公开
标题翻译：测量参数
公开(公告)号：WO2008075285A1
公开(公告)日：2008-06-26
申请号：PCT/IB2007/055195
申请日：2007-12-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, U. , DE KIEVIT, Peggy , NIEUWENHUIS, Jeroen, H. , PRINS, Menno, W., J. , VAN IJZENDOORN, Leonardus, J. , JANSSEN, Xander, J., A.
发明人： DITTMER, Wendy, U. , DE KIEVIT, Peggy , NIEUWENHUIS, Jeroen, H. , PRINS, Menno, W., J. , VAN IJZENDOORN, Leonardus, J. , JANSSEN, Xander, J., A.
IPC分类号： G01N15/02 , G01N33/543 , G01R33/12
CPC分类号： G01N15/0266 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01N2015/0092 , G01R33/093 , G01R33/1269 , Y10S436/806
摘要： A method and system are described for measuring agglutination in a target- induced agglutination assay with one or more magnetic particles performed in a reaction chamber. After the magnetic particles (3, 15), which are capable of binding to a target (5) are provided in the assay, an agglutination process resulting in agglutinated particles (100) comprising at least one magnetic particle is performed. The method then further comprises applying an alternating current magnetic field (H AC ) to the assay and- measuring an effect of the H AC on the one or more magnetic particles (3,15) unattached to any surface. The measured effect is indicative of one or more agglutination parameters.
摘要翻译：描述了用于在反应室中进行的一种或多种磁性颗粒测量靶诱导的凝集测定中的凝集的方法和系统。在测定中提供能够结合靶（5）的磁性颗粒（3,15）之后，进行产生包含至少一个磁性颗粒的凝集颗粒（100）的凝集过程。该方法然后还包括向测定中施加交流磁场（H SUB AC），并且测量一个或多个磁性颗粒（3）上的H AC的影响，15）不附着在任何表面上。测量的效果表示一个或多个凝集参数。

4. 发明申请

WO2009013668A2 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：WO2009013668A2
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052844
申请日：2008-07-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
发明人： IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01R33/09
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

5. 发明申请

WO2008044174A1 MAGNETIC AND/OR ELECTRIC LABEL ASSISTED DETECTION SYSTEM AND METHOD 审中-公开
标题翻译：磁性和/或电子标签辅助检测系统及方法
公开(公告)号：WO2008044174A1
公开(公告)日：2008-04-17
申请号：PCT/IB2007/054055
申请日：2007-10-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, U. , PRINS, Menno, W., J.
发明人： DITTMER, Wendy, U. , PRINS, Menno, W., J.
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N27/745 , G01N35/0098
摘要： A detection system (100) is described for detecting analytes in a fluid sample. The detection system (100) comprises a transporting means (6) for transporting magnetic and/or electric labels (5) after interaction between the sample fluid and the reagents towards a detection receptacle (1). The detection receptacle (1) is initially substantially magnetic and/or electric label (5) free. By transporting the magnetic and/or electric labels (5) after reaction, interference between unreacted reagents and magnetic and/or electric label-assisted detection can be reduced.
摘要翻译：描述了用于检测流体样品中的分析物的检测系统（100）。检测系统（100）包括用于在样品流体和试剂相互作用后朝向检测容器（1）传送磁性和/或电气标签（5）的传送装置（6）。检测容器（1）最初基本上是磁性和/或电子标签（5）。通过在反应后传送磁性和/或电子标签（5），可以减少未反应试剂与磁性和/或电标签辅助检测之间的干扰。

6. 发明申请

WO2007060601A1 SENSITIVE MAGNETIC CATCH ASSAY BY BUILDING A STRONG BINDING COUPLE 审中-公开
标题翻译：通过建立一个强大的绑定联盟的敏感磁力捕获测量
公开(公告)号：WO2007060601A1
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054348
申请日：2006-11-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno, W., J. , DITTMER, Wendy, U.
发明人： PRINS, Menno, W., J. , DITTMER, Wendy, U.
IPC分类号： G01N33/537 , G01N33/543
CPC分类号： G01N33/54373
摘要： The invention relates to a sensor device for detecting a target in a sample suspected of comprising the target, which device is suitable for use in an assay such as a sandwich assay. The invention further relates to a method for detecting a target in a sample. The device comprises a sensor surface, which is functionalised with one moiety of a strong binding couple, which moiety preferably shows little or no cross reactivity with the target molecule.
摘要翻译：本发明涉及一种用于检测疑似包含靶的样品中的靶的传感器装置，该装置适用于诸如夹心测定法的测定。本发明还涉及一种用于检测样品中靶标的方法。该装置包括传感器表面，其被强结合对的一个部分功能化，该部分优选与目标分子显示很少或不具有交叉反应性。

7. 发明申请

WO2009125339A3 A CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 审中-公开
公开(公告)号：WO2009125339A3
公开(公告)日：2009-10-15
申请号：PCT/IB2009/051454
申请日：2009-04-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , SCHLEIPEN, Johannes, J., H., B. , EVERS, Toon, H. , NIEUWENHUIS, Jeroen, H. , DITTMER, Wendy, U. , BRULS, Dominique, M. , PRINS, Menno, W., J. , NEIJZEN, Jacobus, H., M. , BOURQUIN, Yannyk, P., J.
发明人： SCHLEIPEN, Johannes, J., H., B. , EVERS, Toon, H. , NIEUWENHUIS, Jeroen, H. , DITTMER, Wendy, U. , BRULS, Dominique, M. , PRINS, Menno, W., J. , NEIJZEN, Jacobus, H., M. , BOURQUIN, Yannyk, P., J.
IPC分类号： G01N21/25 , G01N21/41
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (Ll) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.

8. 发明申请

WO2009069009A1 OPTICAL DETECTION OF PARTICLES IN A MAGNETIC BIOSENSOR USING A WAVEGUIDE 审中-公开
标题翻译：使用波导的磁性生物传感器中的颗粒的光学检测
公开(公告)号：WO2009069009A1
公开(公告)日：2009-06-04
申请号：PCT/IB2008/050412
申请日：2008-02-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
发明人： JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
IPC分类号： G01N21/55 , G01N33/543 , G01N33/487
CPC分类号： G01N27/745 , G01N21/552 , G01N21/7703 , G01N33/54333 , G01N33/54373
摘要： The present invention provides a biosensor device comprising a sensor surface and an optical wave guide having an input, an output and first and second surfaces, said optical wave guide (5) being adapted to direct light entering the optical wave guide (5) through the input (20) to the output (21) via multiple reflections on said first and second surfaces (22, 23) including at least one reflection onsaid first surface (22) under an angle fulfilling the condition of total internal reflection, wherein the sensor surface is adjacent to the first surface of total internal reflection.
摘要翻译：本发明提供了一种生物传感器装置，其包括具有输入，输出和第一和第二表面的传感器表面和光波导，所述光波导（5）适于将进入光波导（5）的光引导通过通过在所述第一和第二表面（22,23）上的多个反射将输入（20）输入（20），所述第一和第二表面（22,23）包括在满足全内反射条件的角度下的至少一个反射的第一表面（22），其中传感器表面与全内反射的第一表面相邻。

9. 发明申请

WO2008044214A1 FAST BIOSENSOR WITH REAGENT LAYER 审中-公开
标题翻译：具有试剂层的快速生物传感器
公开(公告)号：WO2008044214A1
公开(公告)日：2008-04-17
申请号：PCT/IB2007/054131
申请日：2007-10-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno, W., J. , VAN DER WIJK, Thea
发明人： PRINS, Menno, W., J. , VAN DER WIJK, Thea
IPC分类号： G01N33/52 , G01N33/543 , G01N33/487 , G01N33/558 , G01N21/78 , G01N21/63
CPC分类号： G01N33/558 , G01N21/6428 , G01N21/658
摘要： A detection system (100) and a sensor chip (1) for detecting target molecules, and thus corresponding analytes in a sample is described. Typically the detection system (100) includes a sensor chip (1). The sensor chip (1) comprises on its detection surface (33) a dissolvable reagent layer (5). When the dissolvable reagent layer (5) is in contact with sample fluid, free reagent is generated, assisting in the interaction between a label and target molecules, thus allowing for label based detection. The sample thereby is exposed to mobile reagents in a burst. The reagent layer may contain an enzyme allowing enzymatic assays.
摘要翻译：描述了用于检测目标分子的检测系统（100）和传感器芯片（1），并因此检测样品中相应的分析物。通常，检测系统（100）包括传感器芯片（1）。传感器芯片（1）在其检测表面（33）上包含可溶解的试剂层（5）。当可溶解试剂层（5）与样品流体接触时，产生游离试剂，有助于标记物与目标分子之间的相互作用，从而允许基于标签的检测。由此将样品暴露于移动试剂中。试剂层可以含有允许酶分析的酶。

10. 发明申请

WO2006134569A3 RAPID MAGNETIC BIOSENSOR WITH INTEGRATED ARRIVAL TIME MEASUREMENT 审中-公开
公开(公告)号：WO2006134569A3
公开(公告)日：2006-12-21
申请号：PCT/IB2006/051914
申请日：2006-06-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno, W., J.
发明人： PRINS, Menno, W., J.
IPC分类号： G01N33/543
摘要： The invention provides a method, a device and a system for determining a concentration of at least one sort of polarizable or polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable of specifically attaching to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising first means for determining the concentration of magnetic labels attached to the binding sites and second means for determining the time of arrival of the fluid .

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